CN101940209B - Sterilizing composition containing cyproconazole and validamycin A and preparation method thereof - Google Patents
Sterilizing composition containing cyproconazole and validamycin A and preparation method thereof Download PDFInfo
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- CN101940209B CN101940209B CN 201010193560 CN201010193560A CN101940209B CN 101940209 B CN101940209 B CN 101940209B CN 201010193560 CN201010193560 CN 201010193560 CN 201010193560 A CN201010193560 A CN 201010193560A CN 101940209 B CN101940209 B CN 101940209B
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- cyproconazole
- jinggangmycin
- bactericidal composition
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- validamycin
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Abstract
The invention provides a sterilizing composition containing cyproconazole and validamycin A and a preparation method thereof. Cyproconazole and validamycin A are used as main components, and deionized water and an auxiliary agent are assisted to form a suspending agent or the main components, the auxiliary agent and a carrier form wettable powder; and the compounding of the cyproconazole and the validamycin A can generate higher synergistic effect, expand the disease preventing and treating range, delay the generation of drug resistance, obviously improve the pesticide effect, lightens the burden on peasants and guarantees the safe production of agriculture and ecological environment. The invention is applied to the field of chemical protection of agricultural plants and has excellent and efficient protecting and treating effects on fruit trees, vegetables, wheat, rice, and the like with pathogenic bacterial damages.
Description
Technical field
The present invention relates to bactericidal composition that contains Cyproconazole and jinggangmycin A and preparation method thereof.
Background technology
Cyproconazole: chemical name is: 2-(4-chlorphenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl) fourth-2-alcohol.This product belongs to triazole bactericidal agent, former medicine is clear crystal, be sterol demethylation inhibitor, the Erysiphales on cereal crop, coffee, beet, fruit tree and the grape, Uredinales, the mould genus of genus spore, Rhynchosporium spp．, Septoria, Venturia bacterium are had preventive and therapeutic action.Be used for the seed treatment of Important Economic crop or the efficient germicide that face sprays, but single dose usage amount and cost are higher, long-term use can make plant produce resistance.
Jinggangmycin A: chemical name is: N-[(1S)-and (Isosorbide-5-Nitrae, 6/5)-3-methylol-4,5,6-trihydroxy-2-cyclohexenyl group] [O-β-D-glucopyranosyl-(1 → 3)]-(1S)-(1,2,4 ,/3,5)-2,3,4-trihydroxy-5-methylol cyclo-hexylamine.Sterling is white powder, is the very strong agricultural antibiotic of systemic action, after the mycelia of germ touches jinggangmeisu, can be absorbed by somatic cells very soon and conduct in thalline, disturbs and the growth of inhibition somatic cells normal growth, thereby plays therapeutic action.To rice sheath blight disease especially special efficacy.But because it belongs to conventional sterilization agent kind, the long-term frequent use of large tracts of land has produced serious resistance, affects its drug effect.
Summary of the invention
The present invention will provide a kind of can significantly improve drug effect, reduce cost, solving the bactericidal composition that contains Cyproconazole and jinggangmycin A of the problem that Cyproconazole or jinggangmycin A single dose cost accounting are high, pathogen easily produces resistance, action spectrum is narrow, and the preparation method of such bactericidal composition.
First technical scheme of the present invention is: a kind of bactericidal composition that contains Cyproconazole and jinggangmycin A is characterized in: be suspending agent, the percentage by weight of each component consists of:
Cyproconazole 1%～40%,
Jinggangmycin A 1%～50%,
Auxiliary agent 2%～15%,
Deionized water 40%～60%.
Described auxiliary agent is the mixture that any one or more arbitrary proportions in dispersant, wetting agent, antifreeze, thickener, the defoamer form.
Described dispersant is selected from any in sodium lignin sulfonate, naphthalenesulfonic acid-formaldehyde condensate sodium salt, naphtholsulfonic acid formaldehyde condensation products sodium salt, the alkylphenol polyoxyethylene phosphate; Described wetting agent is selected from any in lignosulfonates, alkylaryl polyoxyethylene ether, lauryl sodium sulfate, aliphatic alcohol polyethenoxy base ether, Negel, the alkylphosphonic; Described antifreeze is any in glycerine, propane diols, ethylene glycol, sodium chloride, the urea; Described thickener is xanthans, aluminium-magnesium silicate, polyethylene glycol, carboxymethyl cellulose, polyvinylpyrrolidone, any in the polyvinyl alcohol; Described defoamer is silicone defoaming agent.
The preparation method of above-mentioned bactericidal composition suspending agent joins in the sand cylinder after comprising the steps: at first by the each component percentage by weight Cyproconazole, jinggangmycin A, auxiliary agent and deionized water to be mixed, and stirs; Start and stir lower pre-dispersed 30min, stop pre-dispersed; Add sand milling medium zirconium oxide bead, the beginning sand milling makes particle diameter 98% below 3 μ m; Sand milling filters after finishing, and removes zirconium oxide bead, namely makes the bactericidal composition suspending agent that contains Cyproconazole and jinggangmycin A.
Second technical scheme of the present invention is: a kind of bactericidal composition that contains Cyproconazole and jinggangmycin A is characterized in: be wetting powder, the percentage by weight of each component consists of:
Cyproconazole 1%～40%,
Jinggangmycin A 1%～50%,
Auxiliary agent 5%～15%,
Carrier 10%～80%.
Described auxiliary agent is the mixture that any one or more arbitrary proportions in dispersant, the wetting agent form.
Described dispersant is selected from any in sodium lignin sulfonate, naphthalenesulfonic acid-formaldehyde condensate sodium salt, naphtholsulfonic acid formaldehyde condensation products sodium salt, the alkylphenol polyoxyethylene phosphate; Described wetting agent is selected from any in lignosulfonates, alkylaryl polyoxyethylene ether, lauryl sodium sulfate, aliphatic alcohol polyethenoxy base ether, Negel, the alkylphosphonic.
Described carrier is the mixture that any one or more arbitrary proportions in clay, carclazyte, kaolin, bentonite, diatomite, white carbon, the precipitated calcium carbonate form.
The preparation method of the wetting powder of described bactericidal composition, comprise the steps: at first according to the each component percentage by weight Cyproconazole, jinggangmycin A, auxiliary agent and carrier through premixed, coarse crushing, again mixing, airslide disintegrating mill are pulverized, material after the pulverizing joins in the cone-type mixer again, mixed fineness of materials reaches 99% material can pass through 325 mesh standard sieves, namely makes the wetting powder of the bactericidal composition that contains Cyproconazole and jinggangmycin A.
Useful technique effect of the present invention is referring to shown in the table 1,2
Table 1, Cyproconazole and jinggangmycin A complex preparation and single preparation are to rice sheath blight disease indoor antibacterial test result
| Treatment combination | Weight proportion Cyproconazole: jinggangmycin A | Virulence regression equation | Concentration IC in the inhibition 50 | Co-toxicity coefficient CTC |
| Complex treatment 1 | 1∶5 | Y＝1.596+1.20X R＝0.9893 | 50.35mg/L | 218.16 |
| Complex treatment 2 | 2∶5 | Y＝2.2571+2.0299X R＝0.9873 | 22.45mg/L | 194.87 |
| Complex treatment 3 | 2∶1 | Y＝1.9264+1.913X R＝0.9906 | 34.11mg/L | 102.47 |
| Cyproconazole | --- | Y＝4.074+2.013X R＝0.9949 | 2.8837mg/L | |
| Jinggangmycin A | --- | Y＝3.5489+0.8722X R＝0.9605 | 46.102mg/L |
Table 2, Cyproconazole and jinggangmycin A complex preparation and single preparation are to rice green smut indoor antibacterial test result
| Treatment combination | Weight proportion Cyproconazole: jinggangmycin A | Virulence regression equation | Concentration IC in the inhibition 50 | Co-toxicity coefficient CTC |
| Complex treatment 1 | 1∶5 | Y＝4.8131+4.2394X R＝0.9504 | 1.107mg/L | 469.11 |
| Complex treatment 2 | 2∶5 | Y＝6.1595+2.7375X R＝0.9487 | 0.377mg/L | 485.66 |
| Complex treatment 3 | 2∶1 | Y＝5.1589+2.1329X R＝0.9827 | 0.8424mg/L | 156.04 |
| Cyproconazole | --- | Y＝5.9627+0.9851X R＝0.9928 | 0.1053mg/L | |
| Jinggangmycin A | --- | Y＝1.8526+1.9834X R＝0.9921 | 38.63mg/L |
Co-toxicity coefficient (CTC) is obviously greater than 100 for synergy, and less than 100 being antagonism, about 100 is summation action.Composite rear CTC is obviously greater than 100 as seen from the above table, and synergistic effect is obvious, and actual production can obviously reduce usage amount when using, and preventive effect is remarkable.
Table 3, chemical control rice disease field control effectiveness test result of the present invention
| Reagent agent | Mu dosage (ml) | Sheath blight disease controlling effect (%) | False smut control efficiency (%) |
| The present composition | 24 | 80.65 | 75.85 |
| 10% jinggangmycin A AS | 75 | 75.57 | 35.8 |
| 40% Cyproconazole SC | 35 | 78.49 | 78.07 |
| The clear water contrast | / | / | / |
In the upper table, the present composition is 40% Cyproconazole jinggangmycin A suspending agent, and Cyproconazole and jinggangmycin A are composite by weight 1: 5, see embodiment one for details.As seen said composition has good control efficiency to rice sheath blight disease and false smut.
The present invention can produce higher synergistic function owing to adopt above-mentioned prescription.Compare with single dose Cyproconazole or jinggangmycin A control corps diseases, enlarged the disease scope of preventing and treating, can delay drug-fast generation.Obviously improve drug effect, reduced dosage and the spraying times of every mu of use, alleviated peasant burden, promote peasant's increasing both production and income, ensured better agriculture safety in production and protected ecotope.Be applied to agricultural plant chemoproection field, the harm of the germs such as fruit tree, vegetables, wheat, paddy rice is had excellence, efficiently protection and therapeutic action.
Embodiment
Below in conjunction with specific embodiment technical scheme of the present invention is further described, but the present invention should not only limit to these embodiment.
Embodiment one:
Be respectively that 6.7% Cyproconazole, 33.3% jinggangmycin A, 5% alkylphenol polyoxyethylene phosphate, 5% alkylaryl polyoxyethylene ether and 50% deionized water join in the sand cylinder with percentage by weight, after stirring, use again the high shear machine pre-dispersed, then change the sand mill sand milling over to, add sand milling medium zirconium oxide bead, the beginning sand milling makes particle diameter 98% below 3 μ m; Stop sand milling after 6 hours, filter, remove zirconium oxide bead, namely make the bactericidal composition suspending agent that contains Cyproconazole and jinggangmycin A.
Embodiment two:
Be respectively 11.4% Cyproconazole, 28.6% jinggangmycin A with percentage by weight, 9% naphthalenesulfonic acid-formaldehyde condensate sodium salt, 6% alkylaryl polyoxyethylene ether, 45% white carbon, through premixed, coarse crushing, again mixing, airslide disintegrating mill are pulverized, and the material after the pulverizing joins in the cone-type mixer again, mixed fineness of materials reaches 99% material can pass through 325 mesh standard sieves, namely makes the wetting powder of the bactericidal composition that contains Cyproconazole and jinggangmycin A.
Embodiment three:
Be respectively that 26.7% Cyproconazole, 13.3% jinggangmycin A, 11% naphthalenesulfonic acid-formaldehyde condensate sodium salt, 4% lauryl sodium sulfate and 45% deionized water join in the sand cylinder with percentage by weight, after stirring, use again the high shear machine pre-dispersed, then change the sand mill sand milling over to, add sand milling medium zirconium oxide bead, the beginning sand milling makes particle diameter 98% below 3 μ m; Stop sand milling after 6 hours, filter, remove zirconium oxide bead, namely make the bactericidal composition suspending agent that contains Cyproconazole and jinggangmycin A.
Embodiment four:
Be respectively 40% Cyproconazole, 1% jinggangmycin A with percentage by weight, 6% alkylphenol polyoxyethylene phosphate, 3% lauryl sodium sulfate, 50% diatomite soil, through premixed, coarse crushing, again mixing, airslide disintegrating mill are pulverized, and the material after the pulverizing joins in the cone-type mixer again, mixed fineness of materials reaches 99% material can pass through 325 mesh standard sieves, namely makes the wetting powder of the bactericidal composition that contains Cyproconazole and jinggangmycin A.
Embodiment five:
Be respectively that 50% Cyproconazole, 1% jinggangmycin A, 8% alkylphenol polyoxyethylene phosphate, 5% aliphatic alcohol polyethenoxy base ether and 36% deionized water join in the sand cylinder with percentage by weight, after stirring, use again the high shear machine pre-dispersed, then change the sand mill sand milling over to, add sand milling medium zirconium oxide bead, the beginning sand milling makes particle diameter 98% below 3 μ m; Stop sand milling after 6 hours, filter, remove zirconium oxide bead, namely make the bactericidal composition suspending agent that closes Cyproconazole and jinggangmycin A.
Embodiment six:
Be respectively 1% Cyproconazole, 50% jinggangmycin A with percentage by weight, 10% sodium lignin sulfonate, 3% aliphatic alcohol polyethenoxy base ether, 24% kaolin, 12% white carbon is through premixed, coarse crushing, and again mixing, airslide disintegrating mill are pulverized, and the material after the pulverizing joins in the cone-type mixer again, mixed fineness of materials reaches 99% material can pass through 325 mesh standard sieves, namely makes the wetting powder of the bactericidal composition that contains Cyproconazole and jinggangmycin A.
Claims (4)
1. contain the bactericidal composition of Cyproconazole and jinggangmycin A, it is characterized in that: described bactericidal composition is suspending agent, and the percentage by weight of each component consists of:
Cyproconazole 1% ~ 40%,
Jinggangmycin A 1% ~ 50%,
Auxiliary agent 2% ~ 15%,
Deionized water 40% ~ 60%,
Wherein: the weight ratio of Cyproconazole and jinggangmycin A is 1:5.
2. described bactericidal composition according to claim 1, it is characterized in that: described auxiliary agent is the mixture that any one or more arbitrary proportions in dispersant, wetting agent, antifreeze, thickener, the defoamer form.
3. described bactericidal composition according to claim 2, it is characterized in that: described dispersant is selected from any in sodium lignin sulfonate, naphthalenesulfonic acid-formaldehyde condensate sodium salt, naphtholsulfonic acid formaldehyde condensation products sodium salt, the alkylphenol polyoxyethylene phosphate; Described wetting agent is selected from any in lignosulfonates, alkylaryl polyoxyethylene ether, lauryl sodium sulfate, aliphatic alcohol polyethenoxy base ether, Negel, the alkylphosphonic; Described antifreeze is any in glycerine, propane diols, ethylene glycol, sodium chloride, the urea; Described thickener is any in xanthans, aluminium-magnesium silicate, polyethylene glycol, carboxymethyl cellulose, polyvinylpyrrolidone, the polyvinyl alcohol; Described defoamer is silicone defoaming agent.
4. preparation method such as the described bactericidal composition of arbitrary claim in the claim 1 to 3, it is characterized in that: step is as follows: join in the sand cylinder after at first by the each component percentage by weight Cyproconazole, jinggangmycin A, auxiliary agent and deionized water being mixed, stir; Start and stir lower pre-dispersed 30min, stop pre-dispersed; Add sand milling medium zirconium oxide bead, the beginning sand milling makes particle diameter 98% below 3 μ m; Sand milling filters after finishing, and removes zirconium oxide bead, namely makes the bactericidal composition suspending agent that contains Cyproconazole and jinggangmycin A.
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| CN102007918B (en) * | 2010-11-25 | 2013-11-27 | 陕西美邦农药有限公司 | Bactericidal composition containing cyproconazole and jinggangmycin |
| CN102138558B (en) * | 2011-02-17 | 2014-08-13 | 陕西美邦农药有限公司 | Antibacterial composition containing fenbuconazole and antibiotic compounds |
| CN103563910B (en) * | 2013-10-23 | 2015-04-01 | 江苏丰登作物保护股份有限公司 | Bactericidal composition containing prothioconazole and validamycin and application thereof |
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| CN101700026B (en) * | 2009-11-11 | 2013-02-27 | 陕西上格之路生物科学有限公司 | Bactericidal composition containing cyproconazole |
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