CN101939644A - 免疫系统模拟装置和方法 - Google Patents
免疫系统模拟装置和方法 Download PDFInfo
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- CN101939644A CN101939644A CN2009801043497A CN200980104349A CN101939644A CN 101939644 A CN101939644 A CN 101939644A CN 2009801043497 A CN2009801043497 A CN 2009801043497A CN 200980104349 A CN200980104349 A CN 200980104349A CN 101939644 A CN101939644 A CN 101939644A
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- cell
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- immune
- biological barrier
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/58—Reaction vessels connected in series or in parallel
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
Abstract
Description
Claims (21)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2031008P | 2008-01-10 | 2008-01-10 | |
US61/020,310 | 2008-01-10 | ||
PCT/US2009/030686 WO2009089512A2 (en) | 2008-01-10 | 2009-01-10 | Immune system modeling devices and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101939644A true CN101939644A (zh) | 2011-01-05 |
CN101939644B CN101939644B (zh) | 2014-06-11 |
Family
ID=40853783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980104349.7A Active CN101939644B (zh) | 2008-01-10 | 2009-01-10 | 免疫系统模拟装置和方法 |
Country Status (8)
Country | Link |
---|---|
US (1) | US9535056B2 (zh) |
EP (1) | EP2238447B1 (zh) |
JP (1) | JP5579620B2 (zh) |
CN (1) | CN101939644B (zh) |
CA (1) | CA2713352C (zh) |
ES (1) | ES2535956T3 (zh) |
HK (1) | HK1150174A1 (zh) |
WO (1) | WO2009089512A2 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103502426A (zh) * | 2011-02-28 | 2014-01-08 | 哈佛大学校长及研究员协会 | 细胞培养系统 |
CN106520537A (zh) * | 2016-10-21 | 2017-03-22 | 南通大学 | 一种t细胞免疫应答的微流控光学分析系统及分析方法 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5415538B2 (ja) | 2008-07-16 | 2014-02-12 | チルドレンズ メディカル センター コーポレーション | マイクロチャネルを有する臓器模倣装置ならびにその使用および製造方法 |
US20140213466A1 (en) * | 2010-11-19 | 2014-07-31 | Rutgers, The State University Of New Jersey | High-throughput assessment method for contact hypersensitivity |
GB2485816A (en) * | 2010-11-25 | 2012-05-30 | Alcyomics Ltd | In vitro model for the prediction of immunogenicity, hypersensitivity or allergenicity |
WO2013086486A1 (en) | 2011-12-09 | 2013-06-13 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
EP2834345B1 (en) * | 2012-04-06 | 2024-03-27 | Corsolutions, LLC | Apparatus, system,&method providing fluid flow for cell growth |
KR101354227B1 (ko) | 2012-10-26 | 2014-01-23 | 현대자동차주식회사 | 에어탱크 퍼지 제어 방법 |
US9995412B2 (en) | 2013-03-01 | 2018-06-12 | Wave 80 Biosciences, Inc. | Long-throw microfluidic actuator |
WO2014137940A1 (en) * | 2013-03-01 | 2014-09-12 | Wave 80 Biosciences, Inc. | Methods and systems for enhanced microfluidic processing |
US9656262B2 (en) * | 2013-06-11 | 2017-05-23 | Euveda Biosciences, Inc. | Microfluidic grid-based design for high throughput assays |
WO2015013332A1 (en) | 2013-07-22 | 2015-01-29 | President And Fellows Of Harvard College | Microfluidic cartridge assembly |
AU2014386209B2 (en) | 2013-12-20 | 2021-03-11 | President And Fellows Of Harvard College | Low shear microfluidic devices and methods of use and manufacturing thereof |
CA2955172C (en) | 2014-07-14 | 2021-07-20 | President And Fellows Of Havard College | Systems and methods for improved performance of fluidic and microfluidic systems |
WO2016112245A1 (en) | 2015-01-08 | 2016-07-14 | Hackensack University Medical Center | Ex vivo methods for minimizing risks and maximizing benefits of allogeneic blood and marrow transplantation |
WO2016190939A2 (en) * | 2015-03-04 | 2016-12-01 | Daniel Levner | Fluidic device for quantifying the dynamic permeability and hydraulic conductivity of living tissue layers |
US10202569B2 (en) | 2015-07-24 | 2019-02-12 | President And Fellows Of Harvard College | Radial microfluidic devices and methods of use |
FR3045664A1 (fr) | 2015-12-17 | 2017-06-23 | Oreal | Membrane pour tissu reconstruit comprenant des pores de plusieurs diametres |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4436824A (en) * | 1981-06-09 | 1984-03-13 | Ortho Diagnostic Systems, Inc. | Leukocyte migration through antigen containing agaroses for immunocompetence testing |
US4835102A (en) * | 1987-03-31 | 1989-05-30 | Eugene Bell | Tissue equivalent test systems |
US5962477A (en) * | 1994-04-12 | 1999-10-05 | Adolor Corporation | Screening methods for cytokine inhibitors |
US5627025A (en) * | 1994-08-12 | 1997-05-06 | The Rockefeller University | Method for the identification of compounds capable of abrogating human immunodeficiency virus (HIV) infection of dendritic cells and T-lymphocytes |
US6921660B2 (en) * | 2000-11-08 | 2005-07-26 | Surface Logix, Inc. | Cell motility and chemotaxis test device and methods of using same |
US6653124B1 (en) * | 2000-11-10 | 2003-11-25 | Cytoplex Biosciences Inc. | Array-based microenvironment for cell culturing, cell monitoring and drug-target validation |
CA2445458C (en) * | 2001-04-25 | 2016-12-13 | Cornell Research Foundation, Inc. | Devices and methods for pharmacokinetic-based cell culture system |
US7741116B2 (en) * | 2002-03-06 | 2010-06-22 | University Of Cincinnati | Surgical device for skin therapy or testing |
EP1490088A4 (en) | 2002-03-18 | 2006-02-15 | Sciperio Inc | DENTRIC CELL KNOTS |
WO2004031361A2 (en) | 2002-10-03 | 2004-04-15 | University Of Rochester | Three-dimensional peripheral lymphoid organ cell cultures |
CA2564512C (en) | 2004-04-28 | 2014-03-18 | Vaxdesign Corporation | Artificial immune system: methods for making and use |
US7709256B2 (en) | 2004-04-28 | 2010-05-04 | Vaxdesign Corp. | Disease model incorporation into an artificial immune system (AIS) |
US7855074B2 (en) | 2004-04-28 | 2010-12-21 | Vaxdesign Corp. | Artificial immune system: methods for making and use |
US7785883B2 (en) | 2004-04-28 | 2010-08-31 | Vax Design Corp. | Automatable artificial immune system (AIS) |
US7771999B2 (en) | 2004-04-28 | 2010-08-10 | Vaxdesign Corp. | Disease model incorporation into an artificial immune system (AIS) |
US7785806B2 (en) | 2004-04-28 | 2010-08-31 | Vaxdesign Corporation | Method for determining the immunogenicity of an antigen |
US8030070B2 (en) | 2004-04-28 | 2011-10-04 | Sanofi Pasteur Vaxdesign Corp. | Artificial lymphoid tissue equivalent |
US20080257735A1 (en) * | 2004-09-24 | 2008-10-23 | Regents Of The University Of California | Microfluidic Device for Enabling the Controlled Growth of Cells and Methods Relating to Same |
JP2008539787A (ja) | 2005-05-18 | 2008-11-20 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 生物学的な障壁を有する薬物動態学ベース培養システム |
-
2009
- 2009-01-10 JP JP2010542397A patent/JP5579620B2/ja active Active
- 2009-01-10 CN CN200980104349.7A patent/CN101939644B/zh active Active
- 2009-01-10 US US12/812,225 patent/US9535056B2/en active Active
- 2009-01-10 CA CA2713352A patent/CA2713352C/en active Active
- 2009-01-10 EP EP09700218.2A patent/EP2238447B1/en active Active
- 2009-01-10 ES ES09700218.2T patent/ES2535956T3/es active Active
- 2009-01-10 WO PCT/US2009/030686 patent/WO2009089512A2/en active Application Filing
-
2011
- 2011-03-28 HK HK11103099.1A patent/HK1150174A1/zh unknown
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103502426A (zh) * | 2011-02-28 | 2014-01-08 | 哈佛大学校长及研究员协会 | 细胞培养系统 |
CN103502426B (zh) * | 2011-02-28 | 2018-03-13 | 哈佛大学校长及研究员协会 | 细胞培养系统 |
CN106520537A (zh) * | 2016-10-21 | 2017-03-22 | 南通大学 | 一种t细胞免疫应答的微流控光学分析系统及分析方法 |
CN106520537B (zh) * | 2016-10-21 | 2018-10-23 | 南通大学 | 一种t细胞免疫应答的微流控光学分析系统及分析方法 |
Also Published As
Publication number | Publication date |
---|---|
EP2238447A4 (en) | 2012-02-08 |
EP2238447B1 (en) | 2015-02-25 |
ES2535956T3 (es) | 2015-05-19 |
US9535056B2 (en) | 2017-01-03 |
EP2238447A2 (en) | 2010-10-13 |
HK1150174A1 (zh) | 2011-11-04 |
JP5579620B2 (ja) | 2014-08-27 |
WO2009089512A2 (en) | 2009-07-16 |
CN101939644B (zh) | 2014-06-11 |
CA2713352A1 (en) | 2009-07-16 |
CA2713352C (en) | 2018-01-09 |
US20110027804A1 (en) | 2011-02-03 |
WO2009089512A3 (en) | 2009-10-08 |
JP2011509658A (ja) | 2011-03-31 |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: L OREAL CO., LTD. |
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C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Yarmush Martin L. Inventor after: R. Freideman Inventor after: DELBEFARO.A Inventor after: TEYSSIER S. Inventor after: MEUSNIER J.R. Inventor before: Yarmush Martin L. Inventor before: R. Freideman |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: YARMUSH MARTIN L. FREEDMAN ROBERT TO: YARMUSH MARTIN L. FREEDMAN ROBERT DELBYFALLOT A. TESSIER S. MAUNIER J-R. |
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TA01 | Transfer of patent application right |
Effective date of registration: 20110330 Address after: American California Applicant after: Hurel Corp. Co-applicant after: L'OREAL GROUP Address before: American California Applicant before: Hurel Corp. |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant |