CN101935286A - Method for producing quaternary ammonium salt having adamantyl group - Google Patents
Method for producing quaternary ammonium salt having adamantyl group Download PDFInfo
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- CN101935286A CN101935286A CN2010102140111A CN201010214011A CN101935286A CN 101935286 A CN101935286 A CN 101935286A CN 2010102140111 A CN2010102140111 A CN 2010102140111A CN 201010214011 A CN201010214011 A CN 201010214011A CN 101935286 A CN101935286 A CN 101935286A
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- diamantane
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- 150000003242 quaternary ammonium salts Chemical class 0.000 title claims abstract description 26
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 title claims abstract description 19
- 238000004519 manufacturing process Methods 0.000 title abstract description 5
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims abstract description 66
- 239000002904 solvent Substances 0.000 claims abstract description 55
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims abstract description 47
- -1 ammonium halide salt Chemical class 0.000 claims abstract description 43
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims abstract description 33
- WOLHOYHSEKDWQH-UHFFFAOYSA-N amantadine hydrochloride Chemical compound [Cl-].C1C(C2)CC3CC2CC1([NH3+])C3 WOLHOYHSEKDWQH-UHFFFAOYSA-N 0.000 claims abstract description 25
- 235000019253 formic acid Nutrition 0.000 claims abstract description 17
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims abstract description 16
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims abstract description 13
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims abstract description 9
- 239000000376 reactant Substances 0.000 claims abstract description 6
- 238000006243 chemical reaction Methods 0.000 claims description 65
- 238000002360 preparation method Methods 0.000 claims description 52
- ZICQBHNGXDOVJF-UHFFFAOYSA-N diamantane Chemical compound C1C2C3CC(C4)CC2C2C4C3CC1C2 ZICQBHNGXDOVJF-UHFFFAOYSA-N 0.000 claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 21
- 239000000126 substance Substances 0.000 claims description 15
- BJAARRARQJZURR-UHFFFAOYSA-N trimethylazanium;hydroxide Chemical compound O.CN(C)C BJAARRARQJZURR-UHFFFAOYSA-N 0.000 claims description 15
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical group BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 claims description 14
- SODQFLRLAOALCF-UHFFFAOYSA-N 1lambda3-bromacyclohexa-1,3,5-triene Chemical compound Br1=CC=CC=C1 SODQFLRLAOALCF-UHFFFAOYSA-N 0.000 claims description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical group IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 claims description 10
- 238000005342 ion exchange Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 125000001475 halogen functional group Chemical group 0.000 claims description 9
- 229910001854 alkali hydroxide Inorganic materials 0.000 claims description 8
- 229910052783 alkali metal Inorganic materials 0.000 claims description 8
- 229910052728 basic metal Inorganic materials 0.000 claims description 7
- 150000003818 basic metals Chemical class 0.000 claims description 7
- 229910052736 halogen Inorganic materials 0.000 claims description 7
- 229940102396 methyl bromide Drugs 0.000 claims description 7
- 150000001340 alkali metals Chemical class 0.000 claims description 6
- 229910052751 metal Inorganic materials 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 6
- 125000005843 halogen group Chemical group 0.000 claims description 5
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 claims description 5
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 4
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 4
- 150000001339 alkali metal compounds Chemical class 0.000 claims description 4
- 229940006461 iodide ion Drugs 0.000 claims description 4
- 229910052740 iodine Inorganic materials 0.000 claims description 4
- 229920006324 polyoxymethylene Polymers 0.000 claims description 4
- 230000001476 alcoholic effect Effects 0.000 claims description 3
- 125000001246 bromo group Chemical group Br* 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 150000003333 secondary alcohols Chemical class 0.000 claims description 3
- 239000003957 anion exchange resin Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- AISMNBXOJRHCIA-UHFFFAOYSA-N trimethylazanium;bromide Chemical compound Br.CN(C)C AISMNBXOJRHCIA-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 12
- 229930040373 Paraformaldehyde Natural products 0.000 abstract description 8
- 229920002866 paraformaldehyde Polymers 0.000 abstract description 8
- UZVPIZJYRHXUSI-UHFFFAOYSA-N [1-(aminomethyl)-2-adamantyl]methanamine Chemical compound C1C(C2)CC3CC1C(CN)C2(CN)C3 UZVPIZJYRHXUSI-UHFFFAOYSA-N 0.000 abstract 2
- 229960001280 amantadine hydrochloride Drugs 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 54
- 239000000243 solution Substances 0.000 description 46
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 21
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 14
- 238000003756 stirring Methods 0.000 description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 239000011347 resin Substances 0.000 description 12
- 229920005989 resin Polymers 0.000 description 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 10
- 238000001816 cooling Methods 0.000 description 10
- 238000010992 reflux Methods 0.000 description 10
- 239000002994 raw material Substances 0.000 description 9
- 238000005406 washing Methods 0.000 description 9
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 8
- 238000010792 warming Methods 0.000 description 8
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- NFBYCNFAXLUGBT-UHFFFAOYSA-N n,n-dimethyladamantan-1-amine Chemical compound C1C(C2)CC3CC2CC1(N(C)C)C3 NFBYCNFAXLUGBT-UHFFFAOYSA-N 0.000 description 6
- 238000002425 crystallisation Methods 0.000 description 5
- 230000008025 crystallization Effects 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 210000003608 fece Anatomy 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 229910021536 Zeolite Inorganic materials 0.000 description 4
- 239000000908 ammonium hydroxide Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 4
- QNVRIHYSUZMSGM-UHFFFAOYSA-N hexan-2-ol Chemical compound CCCCC(C)O QNVRIHYSUZMSGM-UHFFFAOYSA-N 0.000 description 4
- ZOCHHNOQQHDWHG-UHFFFAOYSA-N hexan-3-ol Chemical compound CCCC(O)CC ZOCHHNOQQHDWHG-UHFFFAOYSA-N 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- QQZOPKMRPOGIEB-UHFFFAOYSA-N n-butyl methyl ketone Natural products CCCCC(C)=O QQZOPKMRPOGIEB-UHFFFAOYSA-N 0.000 description 4
- 239000012074 organic phase Substances 0.000 description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 4
- 125000001453 quaternary ammonium group Chemical group 0.000 description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
- 239000010457 zeolite Substances 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 125000004429 atom Chemical group 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000012043 crude product Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 239000012044 organic layer Substances 0.000 description 3
- 150000003141 primary amines Chemical class 0.000 description 3
- 238000010189 synthetic method Methods 0.000 description 3
- QNVRIHYSUZMSGM-LURJTMIESA-N 2-Hexanol Natural products CCCC[C@H](C)O QNVRIHYSUZMSGM-LURJTMIESA-N 0.000 description 2
- MXLMTQWGSQIYOW-UHFFFAOYSA-N 3-methyl-2-butanol Chemical class CC(C)C(C)O MXLMTQWGSQIYOW-UHFFFAOYSA-N 0.000 description 2
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 2
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 2
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical class C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 2
- 239000007810 chemical reaction solvent Substances 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229940043265 methyl isobutyl ketone Drugs 0.000 description 2
- JYVLIDXNZAXMDK-UHFFFAOYSA-N methyl propyl carbinol Natural products CCCC(C)O JYVLIDXNZAXMDK-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- XNLICIUVMPYHGG-UHFFFAOYSA-N pentan-2-one Chemical compound CCCC(C)=O XNLICIUVMPYHGG-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- YKYONYBAUNKHLG-UHFFFAOYSA-N propyl acetate Chemical compound CCCOC(C)=O YKYONYBAUNKHLG-UHFFFAOYSA-N 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 150000003335 secondary amines Chemical class 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 238000004611 spectroscopical analysis Methods 0.000 description 2
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- VLDBEZDOSUKOBS-UHFFFAOYSA-O 2-(3-hydroxyphenyl)ethyl-trimethylazanium Chemical compound C[N+](C)(C)CCC1=CC=CC(O)=C1 VLDBEZDOSUKOBS-UHFFFAOYSA-O 0.000 description 1
- MHNNAWXXUZQSNM-UHFFFAOYSA-N 2-methylbut-1-ene Chemical compound CCC(C)=C MHNNAWXXUZQSNM-UHFFFAOYSA-N 0.000 description 1
- MSXVEPNJUHWQHW-UHFFFAOYSA-N 2-methylbutan-2-ol Chemical class CCC(C)(C)O MSXVEPNJUHWQHW-UHFFFAOYSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- KDPMIBMNNGCWTF-UHFFFAOYSA-N C(CCC)O.CC1(CC(C(=O)O)=CC=C1)C(=O)O Chemical class C(CCC)O.CC1(CC(C(=O)O)=CC=C1)C(=O)O KDPMIBMNNGCWTF-UHFFFAOYSA-N 0.000 description 1
- 0 CC1(CC(C*C2)CC2C1)[N+](C)(C)C Chemical compound CC1(CC(C*C2)CC2C1)[N+](C)(C)C 0.000 description 1
- LDFURFLLGORJMO-UHFFFAOYSA-N CC1(CC(CC2C3)CC2C3C1)[N+](C)(C)C Chemical compound CC1(CC(CC2C3)CC2C3C1)[N+](C)(C)C LDFURFLLGORJMO-UHFFFAOYSA-N 0.000 description 1
- 238000006824 Eschweiler-Clarke methylation reaction Methods 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- OKJPEAGHQZHRQV-UHFFFAOYSA-N Triiodomethane Natural products IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001312 dry etching Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 description 1
- 150000004674 formic acids Chemical class 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000012770 industrial material Substances 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 239000003444 phase transfer catalyst Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 150000003112 potassium compounds Chemical class 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 125000004436 sodium atom Chemical group 0.000 description 1
- 150000003388 sodium compounds Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000001149 thermolysis Methods 0.000 description 1
- XKFPGUWSSPXXMF-UHFFFAOYSA-N tributyl(methyl)phosphanium Chemical compound CCCC[P+](C)(CCCC)CCCC XKFPGUWSSPXXMF-UHFFFAOYSA-N 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
Abstract
The present invention relates to a method for producing a quaternary ammonium salt having an adamantyl group. The present invention provides a method for efficiently producing a quaternary ammonium salt having an adamantyl group in a short time and industrially with high yield and high purity. The method for producing the quaternary ammonium salt having an adamantyl group is characterized by comprising the following steps A and B in this order: a step of reacting a reactant of amantadine hydrochloride and an alkali metal hydroxide dissolved in a solvent a having a relative dielectric constant of 10.0 to 20.0 with formic acid and formaldehyde or paraformaldehyde, a step of reacting 1-aminoadamantane dissolved in the solvent a with formic acid and formaldehyde or paraformaldehyde, a step of preparing 1-adamantanedimethylamine [ the following formula ] in the step of reacting 1-haloadamantane with dimethylamine, and a step B: a step of preparing a 1-adamantanetrimethyl ammonium halide salt by reacting the 1-adamantanedimethylamine obtained in the step A dissolved in the solvent b with a methyl halide.
Description
Technical field
The present invention relates to have the preparation method of the quaternary ammonium salt of adamantyl, more particularly, relate to the method that has the quaternary ammonium salt of adamantyl with high yield, prepared in high purity.
Background technology
Diamantane has the structure that four cyclohexane rings condense into cage type, and the symmetry height is stable compound, and its derivative shows special function, and therefore known raw material as medicine material, high functionality Industrial materials etc. is useful.
For example, adamantane derivative is attempted being used for (for example with reference to patent documentations 1 and 2) such as optic disc base board, optical fiber or lens owing to have optical characteristics, thermotolerance etc.
In addition,, attempt utilizing its acid-sensitive, dry etching patience, ultraviolet perviousness etc., as photo-resist resin raw material (for example with reference to patent documentation 3) for diamantane ester class.
In the adamantane derivative, the quaternary ammonium salt with adamantyl is used as zeolite template (agent of structure regulation), and importance improves (for example with reference to patent documentation 4～6).
In these patent documentations,, put down in writing N as quaternary ammonium salt with adamantyl, N, N-trimethylammonium-1-diamantane ammonium hydroxide is as its synthetic method, put down in writing the 1-Symmetrel has been dissolved in the mixture of tributylamine and dimethyl formamide, with the method for iodomethane reaction.
But, when utilizing this synthetic method, generate tributyl-methyl phosphonium amine iodide salt, can not improve purity.
In addition, in non-patent literature 1, put down in writing by aminoadamantan through dimethylization, use the method for the halogen of the synthetic quaternary ammonium of methyl halide, but when utilizing this synthetic method owing to long reaction time be difficult to use in industrial since raw material not complete reaction, can not purifying and can not obtain object with high purity, high yield.
On the other hand, cationic quaternary ammonium salt, for example raw material, phase-transfer catalyst or the ionizing solvent etc. as tensio-active agent, antiseptic-germicide, medicine, accurate medicine and makeup are very important compounds.
[prior art document]
[patent documentation]
[patent documentation 1] Japanese kokai publication hei 6-305044 communique
[patent documentation 2] Japanese kokai publication hei 9-302077 communique
[patent documentation 3] Japanese kokai publication hei 4-39665 communique
[patent documentation 4] TOHKEMY 1987-191418 communique
[patent documentation 5] TOHKEMY 1987-202814 communique
[patent documentation 6] TOHKEMY 1987-216914 communique
[non-patent literature 1] Russian Journal of Applied Chemistry, 74 (11), 1892-1898 (2001)
Summary of the invention
The present invention proposes in view of above-mentioned condition, and its purpose is, the industrial preparation method that is suitable for that can prepare quaternary ammonium salt with adamantyl with high yield, high purity effectively is provided.
The inventor has carried out further investigation and found that, by by the compound in virofral, 1-aminoadamantan and the 1-halo diamantane of being selected from as starting raw material, the method that has the quaternary ammonium salt of adamantyl with 1-diamantane dimethyl amine as intermediate preparation can be reached above-mentioned purpose, thereby has finished the present invention.
That is, the invention provides following quaternary ammonium salt preparation method.
1. have the preparation method of the quaternary ammonium salt of adamantyl, it is characterized in that, contain following steps A and B successively,
Steps A: the preparation process that is selected from the 1-diamantane dimethyl amine [following formula (2)] in the following step:
Making and being dissolved in relative permittivity is the virofral [following formula (1-1)] among 10.0～20.0 the solvent a and the step of the alkali-metal reactant of hydroxide and formic acid and formaldehyde or polyformaldehyde reaction,
Make the step of the 1-aminoadamantan [following formula (1-2)] that is dissolved among the solvent a and formic acid and formaldehyde or polyformaldehyde reaction,
The step that 1-halo diamantane [following formula (1-3)] and dimethyl amine are reacted,
Step B: make the preparation process of the 1-diamantane dimethyl amine [following formula (2)] that obtains in the steps A that is dissolved among the solvent b and the 1-diamantane trimethyl-ammonium halide salt [following formula (3)] of methyl halide reaction,
[Chemical formula 1]
2. as above-mentioned 1 described preparation method, wherein, the methyl halide among the step B is methyl bromide or methyl iodide.
3. as above-mentioned 1 or 2 described preparation methods, wherein, the solvent a in the steps A is that relative permittivity is 10.0～18.7 alcohol.
4. as above-mentioned 3 described preparation methods, wherein, described alcohol is secondary alcohol.
5. as above-mentioned 1 or 2 described preparation methods, wherein, the 1-halo diamantane in the steps A is a 1-bromine diamantane.
6. any described preparation method as in above-mentioned 1～5, wherein, the solvent b among the step B be selected from relative permittivity be in 4.0～20.0 alcoholic solvent, esters solvent and the ether solvent more than a kind.
As above-mentioned 1～6 in any described preparation method, it further contains following step C,
Step C: will be dissolved in the preparation process that the 1-diamantane trimethyl-ammonium halide salt [following formula (3)] that obtains among the step B among the solvent c carries out the 1-diamantane trimethylammonium hydroxide salt [following formula (4)] of ion-exchange,
[Chemical formula 2]
Step C
8. as above-mentioned 7 described preparation methods, wherein, the ion-exchange among the step C uses the alkali hydroxide metal to carry out.
9. as above-mentioned 8 described preparation methods, wherein, the alkali hydroxide metal is a potassium hydroxide.
10. as above-mentioned 7 described preparation methods, wherein, the ion-exchange among the step C uses basic anion exchange resin (OH type) to carry out.
11. as above-mentioned 7～10 in any described preparation method, wherein, the solvent c among the step C is water and/or alcohol.
12. as any described preparation method in above-mentioned 7～11, wherein, the alcohol that contains in the 1-diamantane trimethylammonium hydroxide salt that obtains among the step C is below the 5 quality %, basic metal and alkali metal compound are scaled below the 2 quality % according to alkali metal atom, and the halogen ion is scaled below the 2 quality % according to halogen atom.
13. as above-mentioned 1～6 in any described preparation method, it further contains following step D,
Step D: with the step of the 1-diamantane trimethyl-ammonium halide salt purifying that obtains among the step B.
14. as above-mentioned 13 described preparation methods, wherein, methyl halide among the step B is a methyl bromide, the bromide anion that contains in the sublimed 1-diamantane trimethylammonium bromide salt in step D is scaled more than the 28.3 quality % according to bromine atoms, 1-diamantane dimethyl amine is below the 0.5 quality %, and basic metal is below the 1000ppm.
15. as above-mentioned 13 described preparation methods, wherein, methyl halide among the step B is a methyl iodide, the iodide ion that contains in the sublimed 1-diamantane trimethylammonium iodate ammonium salt in step D is scaled more than the 38.2 quality % according to the iodine atom, 1-diamantane dimethyl amine is below the 0.5 quality %, and basic metal is below the 1000ppm.
By preparation method of the present invention, can effectively and industrial prepare as 1-diamantane trimethyl-ammonium halide salt or 1-diamantane trimethylammonium hydroxide salt with high yield at short notice with quaternary ammonium salt of adamantyl.
Under the situation of 1-diamantane trimethyl-ammonium halide salt, can prepare bromide anion in this quaternary ammonium salt is scaled more than the 28.3 quality % according to atom or iodide ion is scaled more than the 38.2 quality % according to atom, intermediate 1-diamantane dimethyl amine is below the 0.5 quality %, and basic metal is scaled highly purified quaternary ammonium salt below the 1000ppm according to atom.
Under the situation of 1-diamantane trimethylammonium hydroxide salt, the alcohol that can prepare in this quaternary ammonium salt is below the 5 quality %, basic metal and alkali metal compound are scaled below the 2 quality % according to alkali metal atom, and the halogen ion is scaled highly purified quaternary ammonium salt below the 2 quality % according to halogen atom.
Embodiment
Preparation method with quaternary ammonium salt of adamantyl of the present invention is characterised in that, contains steps A and step B successively.
[steps A]
Steps A is the step that is selected from the step shown in the following reaction formula, comprise the manufacturing step that is selected from the following step: with virofral [following formula (1-1)] during as initial substance, make and be dissolved in reactant and formic acid and formaldehyde or the polyformaldehyde reaction that relative permittivity is alkali such as virofral among 10.0～20.0 the solvent a and alkali hydroxide metal, form the step of 1-diamantane dimethyl amine [following formula (2)], or with 1-aminoadamantan [following formula (1-2)] during as initial substance, make the 1-aminoadamantan and formic acid and formaldehyde or the polyformaldehyde reaction that are dissolved among the solvent a, form the step of 1-diamantane dimethyl amine [following formula (2)], and then with 1-halo diamantane [following formula (1-3)] during as initial substance, make the reaction of this 1-halo diamantane and dimethyl amine, form the step of 1-diamantane dimethyl amine [following formula (2)].
[chemical formula 3]
Steps A
During as raw material, steps A carries out importing the ammoxidation of the reductibility of methyl in primary amine, i.e. Ai Xi Wei Le-Clarke reaction (Eschweiler-Clarke methylates) with virofral or 1-aminoadamantan.
Ai Xi Wei Le-Clarke reaction is for adding excessive formic acid and excessive formaldehyde (HCOH) or Paraformaldehyde 96 [OH (CH in primary amine
2O)
nH], heat, be reduced into the reaction of secondary amine.
Thus, import methyl, utilize same reaction mechanism that secondary amine is imported methyl, can effectively and with high purity and high yield obtain tertiary amine for primary amine.
Initial substance virofral [1-adamantanamine hydrochloride] aspect that is easy to get is calmly considered, can use commercially available product.
The relative permittivity of the solvent a that uses in the steps A is 10.0～20.0, and preferred relative permittivity is 10.0～18.7 alcohol, and more preferably relative permittivity is 15.0～18.7 alcohol.
If more than 10.0, then if the favorable solubility of virofral below 20.0, then can be used as reaction solvent usually.
In addition, as the alcohol of relative permittivity in above-mentioned scope, for example can enumerate, 1-propyl alcohol, 2-propyl alcohol, 1-butanols, isopropylcarbinol, sec-butyl alcohol, the trimethyl carbinol, 1-amylalcohol, sec.-amyl alcohol, 3-amylalcohol, 2-methyl-1-butene alcohol, 3-methyl isophthalic acid-butanols, 2-methyl-2-butanols, 3-methyl-2-butanols, 2,2-dimethyl-1-propyl alcohol, 1-hexanol, 2-hexanol, 3-hexanol, 1-enanthol, 2-enanthol, 3-enanthol etc.
Wherein, as solvent a, more preferably use secondary alcohol such as 2-propyl alcohol, sec-butyl alcohol, sec.-amyl alcohol, 3-amylalcohol, 3-methyl-2-butanols, 2-hexanol, 3-hexanol, 2-enanthol and 3-enanthol.They can use separately or use mixing more than 2 kinds.
Because preferred dissolution or be dispersed among the solvent a, the consumption of solvent a is with respect to virofral by virofral deutero-reactant or 1-aminoadamantan, and doubly, more preferably 1～10 quality is doubly to be preferably 0.5～20 quality usually.If 0.5 quality doubly more than, then above-mentioned reactant or the dissolving of 1-aminoadamantan and reaction well, if 20 quality doubly below, then Zheng Ti volume can be not excessive, is an amount of.
When initial substance was virofral, the alkali as using was preferably alkali hydroxide metal etc., can enumerate for example sodium hydroxide and potassium hydroxide etc., preferred sodium hydroxide.
Sodium hydroxide joins in the reaction system with aqueous solution form usually, and the concentration of aqueous sodium hydroxide solution is preferably about 50～80 quality % usually.
If the concentration that 50 quality % are above, the favorable solubility of virofral then is if 80 quality % are with the next insoluble resolvent that can not produce sodium hydroxide.
The consumption of sodium hydroxide is preferably 0.9～1.1 mole doubly usually with respect to virofral.
In addition, make virofral and alkali reaction after, need not the separation, purifying of reactant etc., react and can directly in reaction system, add formic acid and formaldehyde or Paraformaldehyde 96.
The formic acid that uses in the steps A preferably joins in the reaction system with the aqueous formic acid form about 80～97 quality % usually.If in above-mentioned scope, then Zheng Ti volume is little, and preparation efficiency is good.
The consumption of formic acid is preferably 0.3～0.7 mole doubly usually with respect to formaldehyde or Paraformaldehyde 96, more preferably 0.4～0.5 mole times.
If more than 0.3 mole times, then react well, even more than 0.7 mole times reaction is not had to influence yet, so 0.7 mole times following optimum.
Formaldehyde that uses in the steps A or Paraformaldehyde 96 preferably join in the reaction system with the aqueous solution form about 30～50 quality % usually.If in above-mentioned scope, then Fan Ying heat release is little, preparation efficiency good.
The consumption of formaldehyde or Paraformaldehyde 96 is preferably 2～20 moles doubly usually with respect to virofral or 1-aminoadamantan, more preferably 3～8 moles times.If 2 moles doubly more than, then react at short notice, though more than 20 moles of times of reaction times also roughly the same, therefore 20 moles of doubly following getting final product.
In steps A, add the temperature that has in formic acid and formaldehyde or the Paraformaldehyde 96 reaction system afterwards and be preferably about 50～90 ℃.If then reaction is carried out fast in this temperature, reaction product can thermolysis.
During as raw material, for example can carry out steps A with virofral according to following order.
Add virofral in reaction vessel, the 2-propyl alcohol that adds 50 ℃ dissolves.Then, add 50 quality % aqueous sodium hydroxide solutions (is same molar with respect to virofral), reacted 2 hours.
Slowly drip 97 quality % aqueous formic acids (with respect to virofral is 3 moles doubly), slowly drip 37 quality % formalins (with respect to virofral is 4 moles doubly), be warming up to 80 ℃ after, reacted 3 hours.
After confirming that with gas-chromatography etc. virofral disappears, with 25 quality % aqueous sodium hydroxide solutions reaction solution is adjusted to pH 10, adding solvent b divides and gets.
Divide the solvent b that gets to be directly used in the following steps.Owing in steps A, can obtain 1-diamantane dimethyl amine, need not purifying and just can directly crude product be used for following steps with high yield and high purity.
When purity was hanged down, the purifying that can also carry out 1-diamantane dimethyl amine in addition was used for following steps with its separation.
With 1-halo diamantane during as raw material, initial substance 1-chlorine diamantane, the 1-bromine diamantane aspect that is easy to get is calmly considered, can use commercially available product.
Under the situation of 1-bromine diamantane, reaction is carried out fast, so preferred.
Not necessarily leave no choice but use solvent, but as required, can use tetrahydrofuran (THF), dimethyl sulfoxide (DMSO), N, dinethylformamide etc.
Temperature of reaction is preferably about 150 ℃～250 ℃.Reduce if cross low then speed of response, if the too high yield that then produces side reaction, 1-diamantane dimethyl amine reduces.
The consumption of dimethyl amine is preferably 2～10 moles doubly usually with respect to 1-halo diamantane, more preferably 2.5～7 moles times.
If cross becoming slowly of reaction at least, add-on reduces, production efficiency reduces if cross at most.
During as raw material, for example can carry out steps A with 1-bromine diamantane according to following order.
In voltage-resistant reactor, add 1-bromine diamantane, dimethyl amine (with respect to 1-bromine diamantane is 3 moles doubly), be warming up to 200 ℃ after, reacted 8 hours.
After being cooled to room temperature, add water and 50 quality % aqueous sodium hydroxide solutions (is 1.2 moles times with respect to 1-bromine diamantane as sodium hydroxide) with 1-bromine diamantane equal in quality, adding quality with respect to 1-bromine diamantane is 2 times ethyl acetate, divides and gets organic layer.
Divide the organic layer of getting to be directly used in the following steps.Owing in steps A, can obtain 1-diamantane dimethyl amine, need not purifying and can directly crude product be used for following steps with high yield and high purity.
When purity was hanged down, the purifying that can carry out 1-diamantane dimethyl amine in addition separated it to be used for following steps.
[step B]
Step B is the step that following reaction formula is represented, for making the preparation process of the 1-diamantane dimethyl amine [following formula (2)] that obtains in the steps A that is dissolved among the solvent b and the 1-diamantane trimethyl-ammonium halide salt [following formula (3)] of methyl halide reaction.
[chemical formula 4]
Step B
In the following formula, X represents halogen atom, and the methyl halide that reacts with 1-diamantane dimethyl amine is preferably methyl bromide or methyl iodide.
The consumption of methyl halide is preferably 0.9～5 mole doubly usually with respect to 1-diamantane dimethyl amine, more preferably 1.1～2 moles times.
If then reaction is good more than 0.9 mole times, if below 5 moles times, then can reduce generation from the by product of halogen.
As the solvent b that uses among the step B, be preferably relative permittivity and be 4.0～20.0 solvent.If relative permittivity is more than 4.0, then if the favorable solubility of 1-diamantane dimethyl amine below 20.0, then can be used as reaction solvent usually.
In addition, solvent b is preferably alcoholic solvent, esters solvent, ketones solvent, ether solvent, for example can enumerate, 2-propyl alcohol, propyl carbinol, sec-butyl alcohol, the trimethyl carbinol, 2-amylalcohol, methyl-formiate, ethyl formate, ethyl acetate, n-propyl acetate, methylethylketone, methyl n-propyl ketone, methyl n-butyl ketone, methyl iso-butyl ketone (MIBK), 1,2-glycol dimethyl ether etc.They can use separately or use mixing more than 2 kinds.
Temperature of reaction is preferably about-60～100 ℃ when joining methyl halide in the reaction system usually, more preferably-20 ℃～50 ℃.
If temperature of reaction is in above-mentioned scope, then reaction is carried out well, and object forms crystallization, so can prepare effectively, can not produce the quality that causes because of heat and reduce.
In addition, during the reaction of 1-diamantane dimethyl amine and methyl halide, because heat release, preferably drip appropriate means such as methyl halide when keeping above-mentioned temperature of reaction and add.
For example, can carry out step B according to following order.
The 1-diamantane dimethyl amine that obtains in the steps A is dissolved in the 2-propyl alcohol, be cooled to 0 ℃ after, drip methyl halide (with respect to 1-diamantane dimethyl amine is 1.1 moles doubly) react.
After affirmation 1-diamantane dimethyl amine disappearances such as gas-chromatography, underpressure distillation removes and desolvates, and obtains 1-diamantane leptodactyline with the crude product form.
[step C]
Step C is the step shown in the following reaction formula, carries out the preparation process of the 1-diamantane trimethylammonium hydroxide salt [following formula (4)] of ion-exchange for being dissolved in the 1-diamantane trimethyl-ammonium halide salt [following formula (3)] that obtains among the step B among the solvent c.
[chemical formula 5]
Step C
As the method for ion-exchange, add alkali hydroxide metal-salts such as sodium hydroxide, potassium hydroxide in the solution of oriented 1-diamantane trimethyl-ammonium halide salt, remove the alkali-metal halid method of separating out, or the method that contacts with OH type anionite-exchange resin etc.
When using the alkali hydroxide metal-salt, when being dissolved in 1-diamantane trimethyl-ammonium halide salt among the solvent c, for example can doubly measure the solution that directly adds the solvent c of potassium hydroxide or potassium hydroxide with 0.8～5 mole of 1-diamantane trimethyl-ammonium halide salt, after removing by filter the neutral inorganic of separating out, obtain solution, obtain 1-diamantane trimethylammonium hydroxide salt by this solution that obtains.
As solvent c, be preferably the solubleness height of 1-diamantane trimethyl-ammonium halide salt, 1-diamantane trimethylammonium hydroxide salt and the low solvent of the solubleness of neutral inorganic for example makes water and/or alcohol.As alcohol, can enumerate methyl alcohol, ethanol, n-propyl alcohol, 2-propyl alcohol, propyl carbinol, sec-butyl alcohol, the trimethyl carbinol and their mixture etc.
It is liquid and for about-30 ℃～120 ℃ that temperature of reaction preferably makes solvent, more preferably 0 ℃～100 ℃.
If in this scope, then ion exchange reaction is carried out well, can implement reaction under the good temperature of efficient removing of neutral inorganic, operation such as can also concentrate as required, can not produce the quality reduction that causes because of heat.
When using OH type anionite-exchange resin, after can in the solution of the solvent c of 1-diamantane trimethyl-ammonium halide salt, adding OH type anionite-exchange resin, remove OH type anionite-exchange resin by filtration etc. and obtain solution, obtain 1-diamantane trimethylammonium hydroxide salt by this solution that obtains, or in the post that is filled with OH type anionite-exchange resin, add the solution of the solvent c of 1-diamantane trimethyl-ammonium halide salt, use solvent c as launching solvent, flow out solution from column outlet, obtain 1-diamantane trimethylammonium hydroxide salt by this effusive solution, but the latter can obtain the few 1-diamantane trimethylammonium hydroxide salt of residual halogens.
As OH type anionite-exchange resin, if alkaline resin then can use, for example can enumerate, ア Application バ one ラ イ ト IRA400J (オ Le ガ ノ society system), ダ イ ヤ イ オ Application SA10A (Mitsubishi Chemical society system) etc. are as representational OH type anionite-exchange resin.
If the OH type then can directly use,, uses by the Cl type if then earlier being exchanged for the OH type with basic ion.
As solvent c, special preferably water is used but also the solvent of enumerating as other solvent c can be mixed more than 2 kinds.
The use temperature of OH type anionite-exchange resin is preferably about 0～80 ℃, removes after the OH type anionite-exchange resin, operation such as similarly can also concentrate when using an alkali metal salt as required, can not produce the quality reduction that causes because of heat.
[purity of quaternary ammonium hydroxide]
By the 1-diamantane trimethylammonium hydroxide salt of the method preparation that contains steps A, step B and step C of the present invention, can make that the alcohol that contains in the 1-diamantane trimethylammonium hydroxide salt is that 5 quality % are following, basic metal and alkali metal compound according to alkali metal atom be scaled below the 2 quality %, the halogen ion is scaled below the 2 quality % according to halogen atom.
As mentioned above, can prepare highly purified quaternary ammonium hydroxide by preparation method of the present invention.
And, if not the quaternary ammonium hydroxide of above-mentioned purity during then as the agent of zeolite die for preparation plate, is difficult to use owing to yield reduces.
And, as required, after steps A, step B and step C, can further improve purity by purifying 1-diamantane trimethylammonium hydroxide salt such as crystallizatioies.
[step D]
Preparation method with quaternary ammonium salt of adamantyl of the present invention preferably after steps A and step B, carries out the step D of the 1-diamantane trimethyl-ammonium halide salt purifying that will obtain among the step B.
In the step of purifying, contain the step of separating out salt by recrystallization, further contain filtration or washing etc.Purifying can carry out several and improve until the purity of quaternary ammonium halides salt.
Recrystallization for example uses acetone as solvent, can obtain high yield, highly purified 1-diamantane trimethyl-ammonium halide salt thus.
[purity of quaternary ammonium halides salt]
By the 1-diamantane trimethyl-ammonium halide salt that contains the method preparation of steps A, step B and step D of the present invention, when using methyl bromide as methyl halide, the content of bromide anion converts according to bromine atoms can be for more than the 28.3 quality %, when using methyl iodide as methyl halide, the content of iodide ion converts according to the iodine atom can be for more than the 38.2 quality %.
In addition, as the impurity that contains in the 1-diamantane trimethyl-ammonium halide salt, the content of unreacted 1-diamantane dimethyl amine can be for below the 0.5 quality % among the step B, and further, alkali-metal content can be for below the 1000ppm.
As mentioned above, can prepare highly purified quaternary ammonium halides salt by preparation method of the present invention.And, if not the quaternary ammonium halides salt of above-mentioned purity during then as the agent of zeolite die for preparation plate, is difficult to use owing to yield reduces.
[embodiment]
Then, by embodiment the present invention is carried out more specific description, but the present invention is not limited by these examples.
[embodiment 1]
In 500ml three-necked flask, add virofral 39.4g[FW:187.11,0.21mol with reflux condensing tube, thermometer, stirrer], the 2-propyl alcohol (relative permittivity: 18) 200mL, dissolve.The temperature of solution is risen to 50 ℃, and then, slowly Dropwise 50 quality % aqueous sodium hydroxide solution 17g stirred 1 hour, slowly dripped 97 quality % aqueous formic acid 30ml[FW:46.03,0.77mol].When stirring, with 30 minutes droppings 37 quality % formalin 85g[FW:30.03,1.05mol].After dripping end, be warming up to 80 ℃, carry out reaction in 3 hours.With the reaction solution cooling, use 25 quality % aqueous sodium hydroxide solutions, be adjusted to pH 10.Add ethyl acetate 250ml, divide and get organic phase.
In 500ml three-necked flask, add and divide the thick 1-adamantyl dimethyl amine solution of getting, be cooled to 0 ℃ with reflux condensing tube, thermometer, stirrer.Ice-cooled down, in the time of stirring with 4 hours dropping methyl bromide 19.9g[FW:94.94,0.21mol].After dripping end, make reaction solution reaction 5 hours.After the reaction solution cooling, filter solids component, and then, carry out drying with behind the washing with acetone, obtain object adamantyl trimethylammonium bromide 51.8g[FW:274.24, yield 90.0%] (white powder).
[embodiment 2]
In 500ml three-necked flask, add virofral 39.4g[FW:187.11,0.21mol with reflux condensing tube, thermometer, stirrer], 2-propyl alcohol 200mL, dissolve.The temperature of solution is risen to 50 ℃, and then, slowly Dropwise 50 quality % aqueous sodium hydroxide solution 17g stirred 1 hour, slowly dripped 97 quality % aqueous formic acid 30ml[FW:46.03,0.77mol].When stirring, with 30 minutes droppings 37 quality % formalin 85g[FW:30.03,1.05mol].After dripping end, be warming up to 80 ℃, carry out reaction in 3 hours.The cooling reaction solution uses 25 quality % aqueous sodium hydroxide solutions, is adjusted to pH 10.Add ethyl acetate 250ml, divide and get organic phase.
In 500ml three-necked flask, add and divide the thick 1-adamantyl dimethyl amine solution of getting, be cooled to 0 ℃ with reflux condensing tube, thermometer, stirrer.Ice-cooled down, in the time of stirring with 4 hours dropping methyl iodide 29.8g[FW:141.94,0.21mol].After dripping end, make reaction solution reaction 5 hours.After the reaction solution cooling, filter solids component, and then, carry out drying, obtain object adamantyl trimethylammonium ammonium iodide 58g[FW:312.2, yield 86% with behind the washing with acetone] (white powder).
The spectroscopic data of the quaternary ammonium salt shown in the following formula that obtains among embodiment 1 and the embodiment 2 is as follows.
[chemical formula 6]
Spectroscopic data
Nuclear magnetic resonance spectrum (solvent: CDCl
3) the system JNM-ECA500 of Jeol Ltd.
1H-NMR(500MHz)：1.69(b，6H)、2.05(c，6H)、2.35(d，6H)、3.3(a，9H)
13C-NMR(125MHz)：30.0(e)、35.0(d、c)、48.0(a)、72.5(b)
[embodiment 3]
In 500ml three-necked flask, add 1-aminoadamantan 31g[FW:151.25,0.21mol with reflux condensing tube, thermometer, stirrer], 2-propyl alcohol 200mL, dissolve.The temperature of solution is risen to 50 ℃, slowly drip 97 quality % aqueous formic acid 30ml[FW:46.03,0.77mol].When stirring, with 30 minutes droppings 37 quality % formalin 85g[FW:30.03,1.05mol].After dripping end, be warming up to 80 ℃, carry out reaction in 3 hours.The cooling reaction solution uses 25 quality % aqueous sodium hydroxide solutions, is adjusted to pH 10.Add ethyl acetate 250ml, divide and get organic phase.
In 500ml three-necked flask, add and divide the thick 1-adamantyl dimethyl amine solution of getting, be cooled to 0 ℃ with reflux condensing tube, thermometer, stirrer.Ice-cooled down, in the time of stirring with 4 hours dropping methyl iodide 31.3g[FW:141.94,0.22mol].After dripping end, make reaction solution reaction 5 hours.After the reaction solution cooling, filter solids component, and then, carry out drying, obtain object adamantyl trimethylammonium ammonium iodide 61g[FW:312.2, yield 93% with behind the washing with acetone] (white powder).
[embodiment 4]
In 30mL pressurized vessel, add 1-bromine diamantane 6.65g[FW:215.13,30.9mmol with thermometer, stirrer], dimethyl amine 4.18g[FW:45.08,92.7mmol].Be warming up to 200 ℃ when stirring, reacted 8 hours down at 200 ℃.Reaction is cooled to 25 ℃ after finishing, and slowly adds the aqueous sodium hydroxide solution 2.97g of entry 5ml, 50 quality %.Further, add ethyl acetate 10ml, divide and get organic layer.
In 50ml three-necked flask, add and divide the thick 1-adamantyl dimethyl amine solution of getting, be cooled to 0 ℃ with reflux condensing tube, thermometer, stirrer.Ice-cooled down, in the time of stirring with 1 hour dropping methyl bromide 2.93g[FW:94.94,0.21mol].After dripping end, reacted 5 hours.After the reaction solution cooling, filter solids component, and then, carry out drying, obtain object adamantyl trimethylammonium bromide 7.54g[FW:274.24, yield 89.0% with behind the washing with acetone] (white powder).
[embodiment 5]
In 200ml pressurized vessel, add the adamantyl trimethylammonium bromide 20.0g[FW:274.24, the 73mmol that obtain among the embodiment 1 with thermometer, stirrer], methyl alcohol 66ml dissolves.When cooling, stirring are below 30 ℃, make 85 quality % potassium hydroxide 4.82g[FW:56.11,73mmol to wherein dripping with 30 minutes] be dissolved in the solution that forms among the methyl alcohol 10ml, then along with the inorganic salt that carry out of ion exchange reaction are separated out.Then, after carrying out stirring in 30 minutes under 25 ℃, be cooled to 5 ℃, filter.Filtrate is concentrated, does admittedly, obtain trimethylammonium adamantyl ammonium hydroxide salt 14.62g[FW:211.35,69mmol, yield 95mol%].
[embodiment 6]
In post, fill anionite-exchange resin (ア Application バ one ラ イ ト IRA402BL OHAG (オ Le ガ ノ society system)) 350ml, use the pure water thorough washing.Make the adamantyl trimethylammonium bromide 20.0g[FW:274.24, the 73mmol that obtain among the embodiment 1] be dissolved among the pure water 20ml, and flow through packed column, then with the pure water of 40ml/min circulation as the expansion solvent, recovery pH value is the effluent liquid more than 12.The aqueous solution that reclaims is concentrated down at 40 ℃, does admittedly, obtain trimethylammonium adamantyl ammonium hydroxide salt 15.0g[FW:211.35,71mmol, yield 97mol%].
[comparative example 1]
In the 200ml three-necked flask, add 1-aminoadamantan 10.0g (66mmol), tributylamine 29.0g (156mmol), dimethyl formamide 60ml, after dissolving, cool off with ice bath.Wherein drip methyl iodide 28.4g (200mmol) with 30 fens clockwise.See after a few hours that crystalline separates out, remove ice bath after 15 hours, return to room temperature.After the crystallization filtration of separating out,, and then after the Anaesthetie Ether washing with 60ml, carry out vacuum-drying and obtain adamantyl trimethylammonium ammonium iodide 12.8g (40mmol, the 1st crystallization) with the tetrahydrofuran (THF) washing of 60ml.
For filtrate, add Anaesthetie Ether 60ml, acetone 60ml, in refrigerator, place a night, and then filter the crystallization of separating out, carry out recovery same as described above, obtain the adamantyl trimethylammonium ammonium iodide 2.5g (8mmol, the 2nd crystallization) of purpose.[total receipts amount 15.3g (48mol), yield 73%].
[comparative example 2]
In 500ml three-necked flask, add 1-aminoadamantan 31g[FW:151.25,0.21mol with reflux condensing tube, thermometer, stirrer], ethanol (relative permittivity: 24.3) 200mL, dissolve.The temperature of solution is risen to 50 ℃, then, slowly drip 97 quality % aqueous formic acid 30ml[FW:46.03,0.64mol].When stirring, with 30 minutes droppings 37 quality % formalin 85g[FW:30.03,0.84mol].After dripping end, be warming up to 80 ℃, carry out reaction in 3 hours.The cooling reaction solution uses 25 quality % aqueous sodium hydroxide solutions, is adjusted to pH 10.Add ethyl acetate 250ml, divide and get organic phase.
In 500ml three-necked flask, add and divide the thick 1-adamantyl dimethyl amine solution of getting, be cooled to 0 ℃ with reflux condensing tube, thermometer, stirrer.Ice-cooled down, in the time of stirring with 4 hours dropping methyl iodide 31.3g[FW:141.94,0.22mol].After dripping end, make reaction solution reaction 5 hours.After the reaction solution cooling, filter solids component, and then, carry out drying, obtain object adamantyl trimethylammonium ammonium iodide 19.7g[FW:312.2, yield 30% with behind the washing with acetone] (white powder).
[comparative example 3]
In 500ml three-necked flask, add virofral 39.4g[FW:187.11,0.21mol with reflux condensing tube, thermometer, stirrer], 2-propyl alcohol 200mL, dissolve.The temperature of solution is risen to 50 ℃, slowly drip 97 quality % aqueous formic acid 30ml[FW:46.03,0.77mol].When stirring, with 30 minutes droppings 37 quality % formalin 85g[FW:30.03,1.05mol].After dripping end, be warming up to 80 ℃, but do not see carrying out to the reaction of 1-diamantane dimethyl amine.
The content ion chromatography of bromide anion that contains in the quaternary ammonium salt that obtains in embodiment and the comparative example (bromine composition, bromine atoms scaled value) and iodide ion (iodine composition, iodine atom scaled value), the content of sodium and sodium compound (sodium atom scaled value) and potassium and potassium compound (potassium atom scaled value) is measured by ICP mass analysis (ICP-MS), and 1-adamantyl dimethyl amine, methanol content are measured by FID-GC.By measuring, the content of 1-diamantane dimethyl amine and the purity of object quaternary ammonium salt are analyzed in addition with high performance liquid chromatography (HPLC-RI method).The said determination result is as shown in table 1.
[table 1]
Industrial applicability
According to the present invention, can be at short notice effectively and have a quaternary ammonium salt of adamantyl in industrial with high yield preparation. In addition, the quaternary ammonium salt that obtains by method of the present invention is because the purity height, can be used for template that zeolite prepares usefulness, surfactant, antiseptic etc.
Claims (15)
1. have the preparation method of the quaternary ammonium salt of adamantyl, it is characterized in that, contain following steps A and B successively,
Steps A: the preparation process that is selected from the 1-diamantane dimethyl amine [following formula (2)] in the following step:
Making and being dissolved in relative permittivity is the virofral [following formula (1-1)] among 10.0～20.0 the solvent a and the step of the alkali-metal reactant of hydroxide and formic acid and formaldehyde or polyformaldehyde reaction,
Make the step of the 1-aminoadamantan [following formula (1-2)] that is dissolved among the solvent a and formic acid and formaldehyde or polyformaldehyde reaction,
The step that 1-halo diamantane [following formula (1-3)] and dimethyl amine are reacted,
Step B: make the preparation process of the 1-diamantane dimethyl amine [following formula (2)] that obtains in the steps A that is dissolved among the solvent b and the 1-diamantane trimethyl-ammonium halide salt [following formula (3)] of methyl halide reaction,
[Chemical formula 1]
2. preparation method as claimed in claim 1, wherein, the methyl halide among the step B is methyl bromide or methyl iodide.
3. preparation method as claimed in claim 1 or 2, wherein, the solvent a in the steps A is that relative permittivity is 10.0～18.7 alcohol.
4. preparation method as claimed in claim 3, wherein, described alcohol is secondary alcohol.
5. preparation method as claimed in claim 1 or 2, wherein, the 1-halo diamantane in the steps A is a 1-bromine diamantane.
6. as any described preparation method in the claim 1～5, wherein, the solvent b among the step B be selected from relative permittivity be in 4.0～20.0 alcoholic solvent, esters solvent and the ether solvent more than a kind.
7. as any described preparation method in the claim 1～6, it further contains following step C,
Step C: will be dissolved in the preparation process that the 1-diamantane trimethyl-ammonium halide salt [following formula (3)] that obtains among the step B among the solvent c carries out the 1-diamantane trimethylammonium hydroxide salt [following formula (4)] of ion-exchange,
[Chemical formula 2]
Step C
8. preparation method as claimed in claim 7, wherein, the ion-exchange among the step C uses the alkali hydroxide metal to carry out.
9. preparation method as claimed in claim 8, wherein, the alkali hydroxide metal is a potassium hydroxide.
10. preparation method as claimed in claim 7, wherein, the ion-exchange among the step C uses basic anion exchange resin (OH type) to carry out.
11. as any described preparation method in the claim 7～10, wherein, the solvent c among the step C is water and/or alcohol.
12. as any described preparation method in the claim 7～11, wherein, the alcohol that contains in the 1-diamantane trimethylammonium hydroxide salt that obtains among the step C is below the 5 quality %, basic metal and alkali metal compound are scaled below the 2 quality % according to alkali metal atom, and the halogen ion is scaled below the 2 quality % according to halogen atom.
13. as any described preparation method in the claim 1～6, it further contains following step D,
Step D: with the step of the 1-diamantane trimethyl-ammonium halide salt purifying that obtains among the step B.
14. preparation method as claimed in claim 13, wherein, methyl halide among the step B is a methyl bromide, the bromide anion that contains in the 1-diamantane trimethylammonium bromide salt of purifying among the step D is scaled more than the 28.3 quality % according to bromine atoms, 1-diamantane dimethyl amine is below the 0.5 quality %, and basic metal is below the 1000ppm.
15. preparation method as claimed in claim 13, wherein, methyl halide among the step B is a methyl iodide, the iodide ion that contains in the 1-diamantane trimethylammonium iodate ammonium salt of purifying among the step D is scaled more than the 38.2 quality % according to the iodine atom, 1-diamantane dimethyl amine is below the 0.5 quality %, and basic metal is below the 1000ppm.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102659603A (en) * | 2012-04-23 | 2012-09-12 | 上海博康精细化工有限公司 | Method for reducing concentration of ions in quaternary ammonium base |
| CN103420853A (en) * | 2013-08-27 | 2013-12-04 | 天津民祥生物医药科技有限公司 | Method for preparing N, N, N-mono-methyl diethyl adamantane quaternary ammonium base |
| CN103420852A (en) * | 2013-08-27 | 2013-12-04 | 天津民祥药业有限公司 | Method for preparing N, N, N-trimethyl adamantane quaternary ammonium base |
| CN103450032A (en) * | 2013-08-27 | 2013-12-18 | 天津民祥生物医药科技有限公司 | Preparation method of N, N, N-dimethyl-ethyl adamantane quaternary ammonium base |
| CN107721862A (en) * | 2017-10-17 | 2018-02-23 | 浙江工业大学 | The synthetic method of the adamantyl ammonium halide of N, N, N trimethyl 1 |
| CN109535004A (en) * | 2018-10-25 | 2019-03-29 | 上海国瓷新材料技术有限公司 | A kind of N, N, the preparation method of N- trimethyl -1- adamantyl ammonium hydroxide |
| CN110699700A (en) * | 2019-10-30 | 2020-01-17 | 肯特催化材料股份有限公司 | Preparation method of adamantyl trimethyl ammonium hydroxide |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2014155118A1 (en) * | 2013-03-27 | 2014-10-02 | Johnson Matthey Public Limited Company | Method for preparing 1 -adamantyltrimethylammonium hydroxide |
| RU2680406C2 (en) * | 2013-08-28 | 2019-02-21 | Джонсон Мэтти Плс | Method of making templating agent |
| JP2016108293A (en) * | 2014-12-09 | 2016-06-20 | イビデン株式会社 | Method for producing trimethyladamantyl ammonium hydroxide |
| MX2017016331A (en) * | 2015-06-15 | 2018-09-05 | Qaam Pharmaceuticals Llc | Glycopyrronium fatty acid salts and methods of making same. |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102659603A (en) * | 2012-04-23 | 2012-09-12 | 上海博康精细化工有限公司 | Method for reducing concentration of ions in quaternary ammonium base |
| CN103420853A (en) * | 2013-08-27 | 2013-12-04 | 天津民祥生物医药科技有限公司 | Method for preparing N, N, N-mono-methyl diethyl adamantane quaternary ammonium base |
| CN103420852A (en) * | 2013-08-27 | 2013-12-04 | 天津民祥药业有限公司 | Method for preparing N, N, N-trimethyl adamantane quaternary ammonium base |
| CN103450032A (en) * | 2013-08-27 | 2013-12-18 | 天津民祥生物医药科技有限公司 | Preparation method of N, N, N-dimethyl-ethyl adamantane quaternary ammonium base |
| CN107721862A (en) * | 2017-10-17 | 2018-02-23 | 浙江工业大学 | The synthetic method of the adamantyl ammonium halide of N, N, N trimethyl 1 |
| CN109535004A (en) * | 2018-10-25 | 2019-03-29 | 上海国瓷新材料技术有限公司 | A kind of N, N, the preparation method of N- trimethyl -1- adamantyl ammonium hydroxide |
| CN109535004B (en) * | 2018-10-25 | 2020-03-10 | 上海国瓷新材料技术有限公司 | Preparation method of N, N, N-trimethyl-1-adamantyl ammonium hydroxide |
| CN110699700A (en) * | 2019-10-30 | 2020-01-17 | 肯特催化材料股份有限公司 | Preparation method of adamantyl trimethyl ammonium hydroxide |
| CN110699700B (en) * | 2019-10-30 | 2020-06-30 | 肯特催化材料股份有限公司 | Preparation method of adamantyl trimethyl ammonium hydroxide |
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