CN101932592B - 抗肿瘤化合物 - Google Patents
抗肿瘤化合物 Download PDFInfo
- Publication number
- CN101932592B CN101932592B CN200880126032.9A CN200880126032A CN101932592B CN 101932592 B CN101932592 B CN 101932592B CN 200880126032 A CN200880126032 A CN 200880126032A CN 101932592 B CN101932592 B CN 101932592B
- Authority
- CN
- China
- Prior art keywords
- substituted
- methyl
- carbamate
- unsubstituted
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(C)(C)OC(N[C@](CN(C)C([C@](CSC)N(C)C(C12N(C)C(CNC([C@@](CN(C)C([C@](CSC)N(C)C(C3(C4C3)NC)=O)=O)NC(OC(C)(C)C)=O)=O)=*4SC1C2)=O)=O)C(NCC(O)=O)=O)=O Chemical compound CC(C)(C)OC(N[C@](CN(C)C([C@](CSC)N(C)C(C12N(C)C(CNC([C@@](CN(C)C([C@](CSC)N(C)C(C3(C4C3)NC)=O)=O)NC(OC(C)(C)C)=O)=O)=*4SC1C2)=O)=O)C(NCC(O)=O)=O)=O 0.000 description 1
- HMGDYOGQRIIJMM-STEQQKHMSA-N CN(C[C@H](C(NCC(N(C)[C@@H](CSSC[C@@H](C(N(C)[C@H]1CSC)=O)N(C)C(CNC([C@@H](C(N(C)C([C@H](CSC)N2C)=O)=C)NC(c3nc4ccccc4cc3O)=O)=O)=O)C2=O)=O)=O)NC(c2nc3ccccc3cc2O)=O)C1=O Chemical compound CN(C[C@H](C(NCC(N(C)[C@@H](CSSC[C@@H](C(N(C)[C@H]1CSC)=O)N(C)C(CNC([C@@H](C(N(C)C([C@H](CSC)N2C)=O)=C)NC(c3nc4ccccc4cc3O)=O)=O)=O)C2=O)=O)=O)NC(c2nc3ccccc3cc2O)=O)C1=O HMGDYOGQRIIJMM-STEQQKHMSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07380361 | 2007-12-14 | ||
| EP07380361.1 | 2007-12-14 | ||
| PCT/EP2008/067189 WO2009077401A1 (en) | 2007-12-14 | 2008-12-10 | Antitumoral compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101932592A CN101932592A (zh) | 2010-12-29 |
| CN101932592B true CN101932592B (zh) | 2014-02-26 |
Family
ID=40290734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880126032.9A Expired - Fee Related CN101932592B (zh) | 2007-12-14 | 2008-12-10 | 抗肿瘤化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8748388B2 (https=) |
| EP (1) | EP2231695B1 (https=) |
| JP (1) | JP5577256B2 (https=) |
| CN (1) | CN101932592B (https=) |
| AU (1) | AU2008337605B2 (https=) |
| CA (1) | CA2708080C (https=) |
| ES (1) | ES2406107T3 (https=) |
| WO (1) | WO2009077401A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110027417A1 (en) | 2009-07-31 | 2011-02-03 | Patrick Joseph Corrigan | Process for Dusting Animal Food |
| US10370409B2 (en) * | 2011-10-25 | 2019-08-06 | The Scripps Research Institute | Synthesis of libraries of peptide tertiary amides |
| KR102491180B1 (ko) | 2017-04-27 | 2023-01-20 | 파르마 마르 에스.에이. | 항종양 화합물 |
| CN111777668B (zh) * | 2020-07-28 | 2022-02-25 | 安徽工程大学 | 一种基于海洋环肽Samoamide A的改造多肽、合成方法及应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002049577A2 (en) * | 2000-12-21 | 2002-06-27 | The Scripps Research Institute | Analogues of thiocoraline and be-22179 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681813A (en) * | 1994-04-06 | 1997-10-28 | Pharma Mar, S.A. | Thiodepsipeptide isolated from a marine actinomycete |
-
2008
- 2008-12-10 WO PCT/EP2008/067189 patent/WO2009077401A1/en not_active Ceased
- 2008-12-10 JP JP2010537432A patent/JP5577256B2/ja not_active Expired - Fee Related
- 2008-12-10 CN CN200880126032.9A patent/CN101932592B/zh not_active Expired - Fee Related
- 2008-12-10 AU AU2008337605A patent/AU2008337605B2/en not_active Ceased
- 2008-12-10 CA CA2708080A patent/CA2708080C/en not_active Expired - Fee Related
- 2008-12-10 ES ES08861840T patent/ES2406107T3/es active Active
- 2008-12-10 EP EP08861840A patent/EP2231695B1/en active Active
- 2008-12-10 US US12/746,957 patent/US8748388B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002049577A2 (en) * | 2000-12-21 | 2002-06-27 | The Scripps Research Institute | Analogues of thiocoraline and be-22179 |
Non-Patent Citations (4)
| Title |
|---|
| Björn Dietrich et al.Synthesis of Cyclopeptidic Analogues of Triostin A with Quinoxalines or Nucleobases as Chromophores.《Eur. J. Org. Chem》.2005,第147-153页. * |
| Dale L. Boger et al..Development of a Solution-Phase Synthesis of Minor Groove Binding Bis-Intercalators Based on Triostin A Suitable for Combinatorial Synthesis.《J. Org. Chem.》.2000,第65卷(第19期),第5996-6000页. * |
| Núria Bayó-Puxan et al..Beyond Azathiocoraline: Synthesis of Analogues.《International Journal of Peptide Research and Therapeutics》.2007,第13卷(第1-2期),第295-306页. * |
| Núria Bayó-Puxan et al..Total Solid-Phase Synthesis of the Azathiocoraline Class of Symmetric Bicyclic Peptides.《Chemistry- A European Journal》.2006,第12卷(第35期),第9001-9009页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101932592A (zh) | 2010-12-29 |
| JP2011506393A (ja) | 2011-03-03 |
| HK1149022A1 (en) | 2011-09-23 |
| CA2708080C (en) | 2016-06-14 |
| EP2231695B1 (en) | 2013-02-13 |
| US8748388B2 (en) | 2014-06-10 |
| AU2008337605A1 (en) | 2009-06-25 |
| US20100292163A1 (en) | 2010-11-18 |
| WO2009077401A1 (en) | 2009-06-25 |
| AU2008337605B2 (en) | 2013-08-29 |
| JP5577256B2 (ja) | 2014-08-20 |
| ES2406107T3 (es) | 2013-06-05 |
| US20110207674A2 (en) | 2011-08-25 |
| EP2231695A1 (en) | 2010-09-29 |
| CA2708080A1 (en) | 2009-06-25 |
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| EP3615544B1 (en) | Antitumoral compounds | |
| CN101932592B (zh) | 抗肿瘤化合物 | |
| HK1149022B (en) | Antitumoral compounds | |
| HK40069341B (en) | Antitumoral compounds | |
| HK40080330A (en) | Antitumoral compounds | |
| HK40080330B (en) | Antitumoral compounds | |
| HK40023315B (en) | Antitumoral compounds | |
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| EP3898613A1 (en) | Anticancer compounds | |
| EA048329B1 (ru) | Противоопухолевые соединения |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140226 Termination date: 20161210 |