CN101930531A - Gene chip reader and gene chip interpretation method - Google Patents
Gene chip reader and gene chip interpretation method Download PDFInfo
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- CN101930531A CN101930531A CN 201010248568 CN201010248568A CN101930531A CN 101930531 A CN101930531 A CN 101930531A CN 201010248568 CN201010248568 CN 201010248568 CN 201010248568 A CN201010248568 A CN 201010248568A CN 101930531 A CN101930531 A CN 101930531A
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Abstract
The invention discloses a gene chip reader comprising a casing, a power supply, a control circuit, a tray, a scanner and a data interface. A gene chip is treated by a chemical staining method and positioned between the tray and the scanner; the scanner is electrically connected with the control circuit and used for scanning the gene chip to obtain an information image; the control circuit is used for interpreting the information image to obtain an interpretation result; the data interface is used for connecting an external PC (Personal Computer) to carry out data communications so that storage of the information image on the gene chip and printing of a report sheet can be realized; and the tray is movably connected with the shell and used for carrying the gene chip treated by the chemical staining method. The gene chip reader automatically interprets the gene chip, has the advantages of accurate interpretation and high interpretation efficiency, and can convert the information of the gene chip into the visual report sheet and print the report sheet by using a printer.
Description
Technical field
The present invention relates to medical instruments field, relate in particular to a kind of gene chip reader instrument and genetic chip interpretation method.
Background technology
Genetic chip (gene chip) claims DNA chip (DNA chip) again.It is to develop on the basis of gene probe, and so-called gene probe is the base sequence of one section synthetic, connects some detectable materials on probe, according to the principle of base complementrity, utilizes gene probe to discern specific gene in the gene potpourri.It is fixed in a large amount of probe molecules on the holder, hybridizes with the sample of mark then, by detecting intensity of hybridization signal and analyzing.
Genetic chip is applied to the diagnosis of disease as a kind of advanced person, extensive, high throughput testing technology, and its advantage has the following aspects: the one, and the sensitivity and the accuracy of height; The 2nd, fast and convenient; The 3rd, can detect multiple disease simultaneously.
The interpretation of existing genetic chip is general adopts artificial interpretation method that genetic chip is carried out interpretation, and it has following defective:
One, genetic chip is generally judged testing result with colour developing position and colour developing degree, and human eye is vulnerable to the influence of subjective factor to the judgement of value of chromatism, is easy to generate erroneous judgement and reads, thereby produce the not high problem of accuracy rate;
Two, because artificial interpretation genetic chip efficiency ratio is lower, and to the differentiation of genetic chip is a scissors and paste, tired easily in the interpretation process of extensive most genetic chips of measuring.
Therefore, need a kind of robotization, high accuracy, high efficiency gene chip reader instrument badly, it can significantly improve the work efficiency and the accuracy rate of genetic chip interpretation, and can carry out the management of science to genetic chip information.
Summary of the invention
The purpose of this invention is to provide a kind of robotization, high accuracy and high efficiency gene chip reader instrument, this reading apparatus can carry out interpretation to genetic chip rapidly and accurately.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is: a kind of gene chip reader instrument is provided, comprises housing, power supply, control circuit, pallet, scanner and data-interface; Described power supply, control circuit, pallet, scanner place in the housing;
Described genetic chip was handled through the chemical colour reaction method, and between described pallet and described scanner; Described scanner is electrically connected with described control circuit, is used to scan described genetic chip and obtains frame; Described control circuit is used for that described frame is carried out interpretation and obtains sentence read result; Described data-interface is positioned on the housing, and the one end is electrically connected with control circuit, and the other end is used for being connected to carry out data communication with external computing machine; Described pallet and housing flexibly connect and are used to carry the genetic chip of handling through molecular hyridization, chemical colour reaction method.
Wherein, described pallet and housing are that drawer type is slidingly connected.
Wherein, described housing comprises drain pan and loam cake, and this drain pan and loam cake are enclosed a box body with inner chamber, and described genetic chip is positioned at described pallet on the surface of loam cake, and described genetic chip has the one side of frame towards loam cake, and the scanning plane of described scanner is towards drain pan.
Wherein, described data-interface is at least one, and described data-interface is the usb data interface, and is used to connect the PC computer.
Wherein, the card of described pallet has 32 little lattice to lower recess, genetic chip of the corresponding carrying of each little lattice.
Wherein, the genetic chip of carrying is that Human infectious warts virus Genotyping Chip, hepatitis type B virus somatotype and medicament-resistant mutation detect genetic chip or the Much's bacillus medicament-resistant mutation detects genetic chip in the little lattice of described pallet.
For solving the problems of the technologies described above, another technical solution used in the present invention is: a kind of genetic chip interpretation method is provided, may further comprise the steps:
A. connect and load: the gene chip reader instrument is connected with the PC computer, and the PC computer is connected with printer; Open the pallet of gene chip reader instrument, the testing gene chip is put in the little lattice in the pallet, push pallet, the one side that makes genetic chip have frame is in state to be scanned, opens the gene chip reader instrument;
B. start: the genetic chip interpretation software in the operation PC computer sends scan command to the gene chip reader instrument;
C. scanning: the scanner in the gene chip reader instrument is started working, and scans the image information of genetic chip and the genetic chip view data that scanning obtains is sent to the PC computer through the usb data interface;
D. interpretation: genetic chip interpretation software compares the color value in the genetic chip image site of receiving and the image site color value of standard, and whether develop the color according to the site draws sentence read result;
E. print: the PC computer outputs to printer with sentence read result, and printer prints goes out report.
Wherein, described testing gene chip is that Human infectious warts virus Genotyping Chip, hepatitis type B virus somatotype and medicament-resistant mutation detect genetic chip or the Much's bacillus medicament-resistant mutation detects genetic chip.
Wherein, in the described steps d, at the image pixel blue component greater than 110 image-region, when the difference of the red color component value of the red color component value of background color and site signal more than or equal to 40 the time, the site signal is effectively by interpretation, and promptly software is discerned this site and is the colour developing site; When the difference of the red color component value of the red color component value of background color and site signal less than 40 the time, the site signal is invalid by interpretation, promptly software is discerned this site and is the site of not developing the color.
Wherein, between described step c and the steps d, comprise that also a step c1. adjusts: described genetic chip interpretation software is adjusted the location parameter of scan image upper and lower, left and right, makes the image that draws after the scanning just cover and overlap with genetic chip image display box on the image analysis software operation interface.
The invention has the beneficial effects as follows: gene chip reader instrument of the present invention can the automatic interpretation genetic chip, has easy and simple to handlely, and interpretation accurately and the high advantage of interpretation efficient.In addition, the invention allows for a kind of genetic chip interpretation method, not only interpretation quickly and easily goes out the expressed information of genetic chip, these chip informations can also be converted to report intuitively, and comes out with printer prints.And can with the information stores on the genetic chip with computing machine that the gene chip reader instrument is connected on and permanent the storage.
Description of drawings
Fig. 1 is the block diagram of gene chip reader instrument embodiment of the present invention;
Fig. 2 is the schematic perspective view of gene chip reader instrument embodiment of the present invention;
Fig. 3 is the pallet synoptic diagram of gene chip reader instrument embodiment of the present invention;
Fig. 4 is the process flow diagram of genetic chip interpretation method embodiment one of the present invention;
Fig. 5 is the process flow diagram of genetic chip interpretation method embodiment two of the present invention;
Fig. 6 is a subtype of human papilomavirus gene detection chip film bar pictorial diagram;
Fig. 7 is that the automatic genetic chip test results report that generates of gene chip reader instrument is single;
Fig. 8 is the genetic chip test results report single two that the gene chip reader instrument generates automatically;
Fig. 9 is the genetic chip test results report single three that the gene chip reader instrument generates automatically.
Embodiment
By describing technology contents of the present invention, structural attitude in detail, realized purpose and effect, give explanation below in conjunction with embodiment and conjunction with figs. are detailed.
See also Fig. 1, gene chip reader instrument of the present invention comprises housing 1, power supply 2, control circuit 3, pallet 4, scanner 5, data-interface 6; Described power supply 2, control circuit 3, pallet 4, scanner 5 place in the housing 1; The described scanner 5 that is used to scan the genetic chip frame is electrically connected with described control circuit 3; Described data-interface 6 is positioned on the housing 1, and the one end is electrically connected with control circuit 3, and the other end is used for being connected to carry out data communication with external computing machine 7; The described pallet 4 and housing 1 flexible connection that is used for carrying the genetic chip of handling through the chemical colour reaction method, described genetic chip is between described pallet 4 and described scanner 5.
Described external computing machine 7 inside are equipped with gene chip reader software, and this computing machine 7 can store the frame on the genetic chip, and are connected with printer 8, are used to print gene chip reader result or report.
Referring to Fig. 2, described pallet 4 is slidingly connected for drawer type with housing 1.Described housing 1 comprises drain pan 11 and loam cake 12, this drain pan 11 and loam cake 12 are enclosed a box body with inner chamber, described genetic chip is positioned at described pallet on the surface of loam cake 12, and described genetic chip has the one side of frame towards loam cake 12, and the scanning plane of described scanner 5 is towards drain pan 11.
Described pallet 4 also can be fixedlyed connected with housing 1.As adopt the connected mode of printer arrangement, genetic chip is sent into scanning position, the frame of cdna collection chip by document feeder.Perhaps as the connected mode of copier structure, pallet can upwards be raised, the fixing frame that scans genetic chip up of scanner.
Described data-interface 6 is at least one, and described data-interface 6 is the usb data interface, and is used to connect the PC computer.
Referring to Fig. 3, the card of described pallet 4 has 32 little lattice to lower recess, genetic chip of the corresponding carrying of each little lattice.The genetic chip of carrying is Human infectious warts virus Genotyping Chip, hepatitis type B virus somatotype and drug resistant mutant genes chip or drug resistant mutant genes of mycobacterium tuberculosis chip in the little lattice of described pallet.
Consult Fig. 4, first embodiment of genetic chip interpretation method of the present invention may further comprise the steps:
The first step. connect and load: the gene chip reader instrument is connected with the PC computer, and the PC computer is connected with printer; Open the pallet of gene chip reader instrument, the testing gene chip is put in the little lattice in the pallet, push pallet, the one side that makes genetic chip have frame is in state to be scanned, opens the gene chip reader instrument;
Second step. start: the genetic chip interpretation software in the operation PC computer sends scan command to the gene chip reader instrument;
The 3rd step. scanning: the scanner in the gene chip reader instrument is started working, and scans the image information of genetic chip and the genetic chip view data that scanning obtains is sent to the PC computer through the usb data interface;
The 4th step. interpretation: genetic chip interpretation software compares the color value in the genetic chip image site of receiving and the image site color value of standard, and whether develop the color according to the site draws sentence read result;
The 5th step. print: the PC computer outputs to printer with sentence read result, and printer prints goes out report.
Referring to Fig. 5, second embodiment of genetic chip interpretation method of the present invention may further comprise the steps:
The first step. connect and load: the gene chip reader instrument is connected with the PC computer, and the PC computer is connected with printer; Open the pallet of gene chip reader instrument, the testing gene chip is put in the little lattice in the pallet, push pallet, the one side that makes genetic chip have frame is in state to be scanned, opens the gene chip reader instrument;
Second step. start: the genetic chip interpretation software in the operation PC computer sends scan command to the gene chip reader instrument;
The 3rd step. scanning: the scanner in the gene chip reader instrument is started working, and scans the image information of genetic chip and the genetic chip view data that scanning obtains is sent to the PC computer through the usb data interface;
The 4th step. adjust: genetic chip interpretation software is adjusted the location parameter of scan image upper and lower, left and right, makes the image that draws after the scanning just cover and overlap with genetic chip image display box on the image analysis software operation interface;
The 5th step. interpretation: genetic chip interpretation software compares the color value in the genetic chip image site of receiving and the image site color value of standard, and whether develop the color according to the site draws sentence read result;
The 6th step. print: the PC computer outputs to printer with sentence read result, and printer prints goes out report.
Described testing gene chip is Human infectious warts virus Genotyping Chip, hepatitis type B virus somatotype and drug resistant mutant genes chip or drug resistant mutant genes of mycobacterium tuberculosis chip.
At the image pixel blue component greater than 110 image-region, when the difference of the red color component value of the red color component value of background color and site signal more than or equal to 40 the time, the site signal is effectively by interpretation, promptly software is discerned this site and is the colour developing site; When the difference of the red color component value of the red color component value of background color and site signal less than 40 the time, the site signal is invalid by interpretation, promptly software is discerned this site and is the site of not developing the color.
The interpretation method in colour developing site is specially: the subtype of human papilomavirus gene detection chip is faced up to be placed on the groove that scans on the pallet and flattening, open image analysis software, click beginning, the gene chip reader instrument promptly begins chip is scanned, when beginning to scan, the machine inner light source sends uniform light and illuminates the chip that scans on the pallet, produces the reflected light or the transmitted light of presentation video feature.Reflected light is divided into 3 kinds of colors of RGB (RGB) and converges on the CCD photo-sensitive cell through a glass plate and a set of shots, is accepted by CCD.CCD changes the rgb light band into analog electronic signal, and this signal is changed into the binary digit electronic signal that computing machine can be accepted by A/D converter again, is transferred in the computing machine by USB interface.Image analysis software can be organized reduction of data to this, and the rgb value of each point pixel on the matrix of analyzing gene chip judges by the critical difference of the site signal that configured whether the site on each matrix develops the color.
Drawing of testing result is specially: for guaranteeing the accuracy of sentence read result, image analysis software has one the picture position Parameter File that scanning obtains is set specially, just cover and overlap with genetic chip image display box on the image analysis software operation interface by adjusting the parameter of upper and lower, left and right, can make the image that draws after the scanning.One group of matrix is arranged in the genetic chip image display box, identical with the size of chip with the matrix on it, whether each site that each zone so just can be set be on the film chip develops the color respectively represented what clinical detection information, thereby draws the film chip detection result who is read.Be the gene chip reader instrument to the reading result of film chip be according to where drawing in the image display box of the colour developing site on the film chip on the image analysis software operation interface.
Specifically can comprise information such as genetic chip image, name, sex, age, section office, bed label, admission number, outpatient service number, Interventions Requested, detection method, sample, sample numbering, sample state, date received, detection date and testing result in the examining report.
Following table is: subtype of human papilomavirus gene detection chip site matrix.
| 42 | 43 | 44 | 53 | 66 | 73 | 83 | MM4 |
| 6 | 11 | 16 | 18 | 31 | 33 | 35 | 39 |
| 45 | 51 | 52 | 56 | 58 | 59 | 68 | PC |
Following table is: hepatitis type B virus (HBV) somatotype and medicament-resistant mutation detect genetic chip site matrix.
| rt180L | rt204M | rt207M | rt207V | rt181A | rt236N | HBV-B | HBV-D |
| rt180M | rt204V | rt204I | rt207I | rt181V | rt236T | HBV-C |
Following table is: Much's bacillus (TB) medicament-resistant mutation detects genetic chip site matrix.
| N1 | N2 | N3 | N4 | N5 | 315N | -15N | PC |
| D516V | D516G | H526Y | H526D | S531L | S531W | 315M | -15M |
| 43N | 88N | 306N | 43M | 88M | 306M1 | 306M2 | 306M |
Referring to Fig. 6, be Human infectious warts virus Genotyping Chip film bar pictorial diagram.
Referring to Fig. 7, be drug resistant mutant genes of mycobacterium tuberculosis chip detection report, it comprises name, sample numbering, sex, section office, age, outpatient service number, lesion, bed label, censorship doctor, sample type, sample state, detection method, normal reference value, detection content, testing result and contents such as interpretation of result and prompting.
Referring to Fig. 8, be hepatitis type B virus somatotype and drug resistant mutant genes chip detection report.It comprises name, sample numbering, sex, section office, age, outpatient service number, lesion, bed label, censorship doctor, sample type, sample state, detection method, normal reference value, detection content, testing result and contents such as interpretation of result and prompting.
Referring to Fig. 9, be subtype of human papilomavirus gene examining report list.It comprises name, sample numbering, sex, section office, age, outpatient service number, lesion, bed label, censorship doctor, sample type, sample state, detection method, normal reference value, detection content, testing result and contents such as interpretation of result and prompting.
The above only is embodiments of the invention; be not so limit claim of the present invention; every equivalent structure or equivalent flow process conversion that utilizes instructions of the present invention and accompanying drawing content to be done; or directly or indirectly be used in other relevant technical fields, all in like manner be included in the scope of patent protection of the present invention.
Claims (10)
1. a gene chip reader instrument is characterized in that, comprises housing, power supply, control circuit, pallet, scanner and data-interface; Described power supply, control circuit, pallet, scanner place in the housing;
Described genetic chip was handled through the chemical colour reaction method, and between described pallet and described scanner; Described scanner is electrically connected with described control circuit, is used to scan described genetic chip and obtains frame; Described control circuit is used for that described frame is carried out interpretation and obtains sentence read result; Described data-interface is positioned on the housing, and the one end is electrically connected with control circuit, and the other end is used for being connected to carry out data communication with external computing machine; Described pallet and housing flexibly connect and are used to carry the genetic chip of handling through molecular hyridization, chemical colour reaction method.
2. gene chip reader instrument according to claim 1 is characterized in that: described pallet and housing are that drawer type is slidingly connected.
3. gene chip reader instrument according to claim 2 is characterized in that: described housing comprises drain pan and loam cake, and this drain pan and loam cake are enclosed a darkroom box body with inner chamber; Described genetic chip is positioned at described pallet on the surface of loam cake, and the one side of described genetic chip corresponding informance image is towards loam cake; The scanning plane of described scanner is towards drain pan.
4. gene chip reader instrument according to claim 3 is characterized in that: described data-interface is one, and described data-interface is the usb data interface, and is used to connect the PC computer.
5. according to the described gene chip reader instrument of claim 1～4, it is characterized in that: the card of described pallet has 32 little lattice to lower recess, genetic chip of the corresponding carrying of each little lattice.
6. gene chip reader instrument according to claim 5 is characterized in that: the genetic chip of carrying can be subtype of human papilomavirus gene detection chip, hepatitis type B virus somatotype and medicament-resistant mutation and detects genetic chip, Much's bacillus medicament-resistant mutation detection genetic chip in the little lattice of described pallet.
7. genetic chip interpretation method is characterized in that: may further comprise the steps:
A. connect and load: the gene chip reader instrument is connected with the PC computer, and the PC computer is connected with printer; Open the pallet of gene chip reader instrument, the testing gene chip is put in the little lattice in the pallet, push pallet, the one side that makes genetic chip have frame is in state to be scanned, opens the gene chip reader instrument;
B. start: the genetic chip interpretation software in the operation PC computer sends scan command to the gene chip reader instrument;
C. scanning: the scanner in the gene chip reader instrument is started working, and scans the image information of genetic chip and the genetic chip view data that scanning obtains is sent to the PC computer through the usb data interface;
D. interpretation: genetic chip interpretation software compares the color value in the genetic chip image site of receiving and the image site color value of standard, and whether develop the color according to the site draws sentence read result;
E. print: the PC computer outputs to printer with sentence read result, and printer prints goes out report.
8. genetic chip interpretation method according to claim 7 is characterized in that: described testing gene chip is that Human infectious warts virus Genotyping Chip, hepatitis type B virus somatotype and medicament-resistant mutation detect genetic chip or the Much's bacillus medicament-resistant mutation detects genetic chip.
9. genetic chip interpretation method according to claim 8, it is characterized in that: in the described steps d, at the image pixel blue component greater than 110 image-region, when the difference of the red color component value of the red color component value of background color and site signal more than or equal to 40 the time, the site signal is effectively by interpretation, and promptly software is discerned this site and is the colour developing site; When the difference of the red color component value of the red color component value of background color and site signal less than 40 the time, the site signal is invalid by interpretation, promptly software is discerned this site and is the site of not developing the color.
10. genetic chip interpretation method according to claim 9, it is characterized in that: between described step c and the steps d, comprise that also a step c1. adjusts: described genetic chip interpretation software is adjusted the location parameter of scan image upper and lower, left and right, makes the image that draws after the scanning just cover and overlap with genetic chip image display box on the image analysis software operation interface.
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| CN102354398A (en) * | 2011-09-22 | 2012-02-15 | 苏州大学 | Gene chip processing method based on density center and self-adaptation |
| CN102943032A (en) * | 2012-08-15 | 2013-02-27 | 港龙生物技术（深圳）有限公司 | Biochip reading instrument and typing method therefor |
| CN106479880A (en) * | 2016-11-01 | 2017-03-08 | 上海市同仁医院 | A kind of HPV result interpretation device |
| CN109299798A (en) * | 2017-07-25 | 2019-02-01 | 阿里巴巴集团控股有限公司 | Processing method, device and the electronic equipment of travel information |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102354398A (en) * | 2011-09-22 | 2012-02-15 | 苏州大学 | Gene chip processing method based on density center and self-adaptation |
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| CN106479880A (en) * | 2016-11-01 | 2017-03-08 | 上海市同仁医院 | A kind of HPV result interpretation device |
| CN106479880B (en) * | 2016-11-01 | 2019-06-04 | 上海市同仁医院 | A kind of human papilloma virus result interpretation device |
| CN109299798A (en) * | 2017-07-25 | 2019-02-01 | 阿里巴巴集团控股有限公司 | Processing method, device and the electronic equipment of travel information |
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Application publication date: 20101229 |