CN101904973B - External ointment for treating fire burn and scald and preparation method thereof - Google Patents
External ointment for treating fire burn and scald and preparation method thereof Download PDFInfo
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- CN101904973B CN101904973B CN2010102172767A CN201010217276A CN101904973B CN 101904973 B CN101904973 B CN 101904973B CN 2010102172767 A CN2010102172767 A CN 2010102172767A CN 201010217276 A CN201010217276 A CN 201010217276A CN 101904973 B CN101904973 B CN 101904973B
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Abstract
The invention discloses an external ointment for treating fire burn and scald and a preparation method thereof. The external ointment consists of the following raw materials in part by weight: 25 to 35 parts of baical skullcap root, 15 to 25 parts of golden thread, 13 to 22 parts of amur corktree bark, 10 to 20 parts of rhubarb, 15 to 25 parts of charred garden burnet root, 15 to 25 parts of carbonized human hair, 10 to 20 parts of asparagus, 10 to 20 parts of pollen, 25 to 35 parts of common andrographis herb, 90 to 110 parts of sinkiang arnebia root, 10 to 20 parts of safflower, 15 to 25 parts of frankincense, 10 to 20 parts of myrrh, 10 to 20 parts of root of rehmannia, 25 to 35 parts of calcite, 15 to 25 parts of lycopodium cernuum L., 10 to 20 parts of rosemary, 15 to 25 parts of honeysuckle flower, 10 to 20 parts of cutch, 20 to 30 parts of calcined dragon's bone, 32 to 47 parts of centella asiatica, 5 to 15 parts of borneol and 100 to 150 parts of beeswax, wherein the medicinal materials are prepared by extracting essential oil; and the weight ratio of the essential oil to the medicinal materials is 4-6:1.5-3. Then medical azone accounting for 0.1 to 0.5 percent of the total weight of the medicaments is added.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, be specifically related to treat water, burn external cream of scalding and preparation method thereof.
Background technology
Burn, scald are a kind of common human epidermal injuries, and the patient suffering behind the burn can't bear, and as untimely effective enforcement treatment, not only can strengthen patient's misery, and can stay cicatrix to the patient.The processing of burn wound surface runs through the overall process of burn treatment, and the use of burn medicine for external use is the important component part in the processing of burn wound surface.The burn medicine for external use generally is meant to put and stays in the burn wound surface, the medicine that continues to play a role, its effect should comprise the following aspects: the one, and prevention and control infection, the 2nd, quicken the wound healing process, comprise links such as slough solution-off, granulation formation and epithelium regeneration; The 3rd, the energy quick pain relief; The 4th, can make the wound surface preventing from scar.At present, it is a lot of to be used to the medicine for external use of burning, scalding, but no matter from price, still therapeutic effect differs greatly, especially can take into account price, the medicine for external use (comprising can control infection, quicken wound healing, analgesic effect is fast etc.) that has above-mentioned all functions again is rare, therefore, a kind of burn that can possess multiple performance simultaneously of development, to scald medicine for external use very necessary.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of external cream for the treatment of water, burning scald, has the potent sterilization and the function that relieves the pain, and can effectively prevent traumatic infection, promotes wound healing, alleviate the patient suffering, and have anti-cicatrix effect.Another technical problem that the present invention will solve provides this treatment water, burns the preparation method of the external cream of scalding
The present invention is achieved through the following technical solutions:
A kind of external cream for the treatment of water, burning scald is made up of following materials of weight proportions, and medical material wherein makes after plants essential oil extracts, and the weight ratio of plants essential oil and medical material is 4-6: 1.5-3; Radix Scutellariae 25-35 part, Rhizoma Coptidis 15-25 part, Cortex Phellodendri 13-22 part, Radix Et Rhizoma Rhei 10-20 part, charred Radix Sanguisorbae 15-25 part, Crinis Carbonisatus 15-25 part, Radix Asparagi 10-20 part, pollen 10-20 part, Herba Andrographis 25-35 part, Radix Arnebiae (Radix Lithospermi) 90-110 part, Flos Carthami 10-20 part, Olibanum 15-25 part, Myrrha 10-20 part, Radix Rehmanniae 10-20 part, Mirabilitum crystallina 25-35 part, Cortex Ampelopsis Aconitifoliae Radicis 15-25 part, Herba Rosmarini Officinalis 10-20 part, Flos Lonicerae 15-25 part, catechu 10-20 part, Os Draconis (calcined) 20-30 part, collapse jorum 32-47 part, Borneolum Syntheticum 5-15 part, Cera Flava 100-150 part, the 0.1-0.5% by the said medicine gross weight adds medical azone again.
The further improvement project of the present invention is, is made up of following materials of weight proportions, and medical material wherein makes after plants essential oil extracts, and the weight ratio of plants essential oil and medical material is 5: 2; 30 parts of Radix Scutellariaes, 20 parts of Rhizoma Coptidis, 18 parts of Cortex Phellodendris, 15 parts of Radix Et Rhizoma Rhei, 20 parts of charred Radix Sanguisorbae, 20 parts of Crinis Carbonisatus, 15 parts of Radix Asparagis, 15 parts of pollen, 30 parts of Herba Andrographis, 100 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts on Flos Carthami, 20 parts of Olibanums, 15 parts of Myrrhas, 15 parts in the Radix Rehmanniae, 30 parts of Mirabilitum crystallinas, 20 parts of Cortex Ampelopsis Aconitifoliae Radiciss, 15 parts of Herba Rosmarini Officinaliss, 20 parts of Flos Lonicerae, 15 parts in catechu, 25 parts of Os Draconis (calcined)s, collapse 40 parts of jorumes, 10 parts of Borneolum Syntheticums, 125 parts in Cera Flava, add medical azone by 0.3% of said medicine gross weight again.The amount that Cera Flava is put winter can be lacked, and summer is some more slightly, because mellisic fusing point is low, winter, temperature was low, and Cera Flava is put promptly plastic less, summer the temperature height, the Cera Flava multiple spot can molding.
A kind of preparation method for the treatment of water, burning the external cream of scalding comprises the following steps:
With Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, charred Radix Sanguisorbae, Crinis Carbonisatus, Radix Asparagi, pollen, Herba Andrographis, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Olibanum, Myrrha, the Radix Rehmanniae, Mirabilitum crystallina, Cortex Ampelopsis Aconitifoliae Radicis, Herba Rosmarini Officinalis, Flos Lonicerae, catechu, Os Draconis (calcined), collapse jorum, Borneolum Syntheticum is by above-mentioned weight proportion or by the described weight proportion of further improvement project, putting into plants essential oil soaked after 24 hours, reuse 5-6 at a simmer hour, withered and yellow to medicine, remove medicinal residues then, filter repeatedly and obtain medicinal liquid, again by above-mentioned weight proportion, in medicinal liquid, add Cera Flava, after treating that Cera Flava melts fully, again by above-mentioned weight proportion, in medicinal liquid, add medical azone, stir, and after cooling, obtain.
Described plants essential oil is pure Oleum Sesami or olive oil.
Pharmacological action of the present invention: effective ingredient mainly comprises baicalin (extracting) from Radix Scutellariae, has the effect of antiinflammatory, antioxidant radical, anti allergic reaction, anti-catecholamine and raise immunity.Xiao Tiller alkali (being present in a large number in Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, the Radix Et Rhizoma Rhei) has antiinflammatory and lax arrectores pilorum, smooth muscle, removes the effect of microcirculation spasm.Triterpenoid saponin (be present in and collapse in the jorum) has the growth that promotes stem cell, helps the healing of wound surface, and the effect of anti-cicatrix is arranged.Cupreol (be present in Herba Andrographis, Radix Arnebiae (Radix Lithospermi), Herba Rosmarini Officinalis, Flos Lonicerae in) has antiinflammatory, control and bacteria growth, antiulcer effect.Cera Flava is the polysaccharide of frame structure, and vegetable oil is a fatty acid, with boiling hot tissue of burn generation hydrolysis, enzymolysis, become sour, saponification four mcroorganism chemical reactions, and supply with the desired substance that the wound surface cell has vitality simultaneously, thereby reach the effect of removing the necrotic tissue and promoting granulation.Azone has the function of transdermal, helps drug osmotic in tissue, is convenient to absorb.
Using method: be made into ointment yarn (or claiming oily yarn) with external cream of the present invention, external cream be coated in (it is soaked into gets final product) on the antiseptic gauze equably with the inferior hyoplastron of sterilization, with the ointment yarn that makes through high-temperature sterilization, standby.To the sterilization earlier of various burns, scald wound, do not destroy epidermis as far as possible, run into vesicle arranged to after sterilization, cut an osculum, bleed off bleb liquid, and then chrisma yarn, even chrisma on the ointment yarn again.The order of using generally is: use 3mm left and right sides ointment thickness in early days, just only with oily yarn apply (need not again chrisma) with 2mm left and right sides ointment thickness, the later stage mid-term.After having applied medicine, should adopt sterile gauze to wrap up outward, how many dressing change frequencies is decided on the exudate amount, in general 24 hours, should change dressings once.Regardless of the degree of burn and scald, if external application external cream of the present invention, its wound surface all is more exsiccant.For eschar burn, its wound surface needn't be cut crust, and the cream yarn that available ointment thickness is 4 millimeter applies, and it heals automatic molten crust more gradually.
The present invention is through clinical use, and it is evident in efficacy, and concrete characteristics are as follows: 1, pain relieving is fast, gets final product pain relieving after the general medication in 3-5 minute; 2, recover fast, the healing time of I °-blister burn was at 3-10 days, and the healing time of eschar burn was at 18-26 days; 3, cicatrix is few, and I °-blister burn does not stay any cicatrix, and the spot of eschar burn is few, (cicatrix body constitution except); 4, the wound surface of eschar burn does not need excision of eschar; 5, widely applicable, obvious to the effect of chronic ulcer, decubital ulcer, anorectal postoperative.
From 1998--since-2009 years, my institute accepts scald patient totally 450 examples altogether for medical treatment, and the fire burn patient is totally 360 examples, and molten steel, molten iron fire victim be totally 240 examples, and the acid burn patient is totally 15 examples.Area minimum 1.5%, maximum 26%.First degree burn 257 examples wherein, blister burn 518 examples, eschar burn 290 examples.First degree burn treatment natural law 2-5 days, average 3 days, blister burn treatment natural law 5-13 days, average 7.5 days, eschar burn treatment natural law 16-33 days, average 22 days.Therapeutic effect: I °, blister burn do not have any cicatrix, and eschar burn does not have cicatrix 246 examples that heal, and has 37 examples to stay a small amount of cicatrix, need not do special handling, and 5 examples stay cicatrix because of cicatrix body constitution, 2 examples because of burn of tendon than overline tendon transplantation and skin flap grafting.All patients do not have dysfunction.
Model case:
Patient Wang, man, 39 years old, the workman of steel mill, in June, 2004, because of back part and buttocks are scalded by 800 ℃ of silicon steel sheets, area totally 14.5%, blister burn 5%, eschar burn 9.5% (with salve oil yarn flap coverage, is coated 3mm left and right sides ointment earlier through this external pasting exterior-applied therapeutic, continuous 5 days, change dressings every day 2 times; Reuse salve oil yarn flap coverage is coated 1mm left and right sides ointment, and logotype 4 days is changed dressings 1 every day; Afterwards, all wound surface all with the ointment yarn flap coverage of thick about 0.5mm, are changed dressings 1 time every day, heal fully until wound surface.), cooperating treatments such as TAT injection, fluid infusion, antiinflammatory again, healing in 23 days is left hospital.Pay a return visit after 1 year, former burn position skin smooth, about 0.3% area skin pigment comes off.
Patient Liu, man, 26 years old, the workman of steel mill, in October, 2008 is because of the oxygen tempering, cause facial area, two forearm, two lower limb about 21% burn surface area altogether, wherein blister burn 14%, eschar burn 7%, after being admitted to hospital, give the routine disinfection debridement, (with ointment yarn flap coverage, coat 3mm left and right sides ointment earlier with this external pasting exterior-applied therapeutic, continuous 4 days, changed dressings 1-2 every day; Reuse ointment yarn flap coverage is coated 1mm left and right sides ointment, and logotype 4 days is changed dressings 1 every day; Afterwards, all wound surface all with the ointment yarn flap coverage of thick about 0.5mm, are changed dressings 1 time every day, heal fully until wound surface.), cooperating treatments such as TAT injection, fluid infusion, antiinflammatory again, healing in 20 days is left hospital.Pay a return visit March, do not have any cicatrix.
The patient river, man, 48 years old, the peasant, is total to about 13% burn surface area by 50% dilute sulfuric acid burn head, face, chest in May, 2009, wherein blister burn 8%, and eschar burn 5% gives flushing with clean water after being admitted to hospital, 3% soda water flushing, the routine disinfection debridement (with ointment yarn flap coverage, is coated 3mm left and right sides ointment earlier with this external pasting exterior-applied therapeutic, continuous 6 days, changed dressings 1-2 every day; Reuse ointment yarn flap coverage is coated 1mm left and right sides ointment, and logotype 6 days is changed dressings 1 every day; Afterwards, all wound surface all with the ointment yarn flap coverage of thick about 0.5mm, are changed dressings 1 time every day, heal fully until wound surface.), cooperating treatments such as TAT injection, fluid infusion, antiinflammatory again, healing in 18 days is left hospital.Pay a return visit April, do not have any cicatrix.
The patient military certain, woman, 64 years old, the retired worker, is total to about 14.5% scalding area by 80-90 ℃ of boiled water scald back part and buttocks in November, 2006, wherein I ° scalds 5%, II ° scald 9.5% after being admitted to hospital, gives the routine disinfection debridement, (use ointment yarn flap coverage earlier with this external pasting exterior-applied therapeutic, coat 3mm left and right sides ointment, continuous 2 days, changed dressings 1-2 every day; Reuse ointment yarn flap coverage is coated 1mm left and right sides ointment, and logotype 2 days is changed dressings 1 every day; Afterwards, all wound surface all with the ointment yarn flap coverage of thick about 0.5mm, are changed dressings 1 time every day, heal fully until wound surface.) cooperating treatments such as TAT injection, fluid infusion, antiinflammatory again, healing in 10 days is left hospital.Pay a return visit February, do not have any cicatrix.
The specific embodiment
Embodiment 1
By weight, get 30 parts of Radix Scutellariaes, 20 parts of Rhizoma Coptidis, 18 parts of Cortex Phellodendris, 15 parts of Radix Et Rhizoma Rhei, 20 parts of charred Radix Sanguisorbae, 20 parts of Crinis Carbonisatus, 15 parts of Radix Asparagis, 15 parts of pollen, 30 parts of Herba Andrographis, 100 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts on Flos Carthami, 20 parts of Olibanums, 15 parts of Myrrhas, 15 parts in the Radix Rehmanniae, 30 parts of Mirabilitum crystallinas, 20 parts of Cortex Ampelopsis Aconitifoliae Radiciss, 15 parts of Herba Rosmarini Officinaliss, 20 parts of Flos Lonicerae, 15 parts in catechu, 25 parts of Os Draconis (calcined)s, collapse 40 parts of jorumes, 10 parts of Borneolum Syntheticums, putting into plants essential oil soaks after 24 hours (according to medical material weight: plants essential oil weight=2: 5), reuse 5-6 at a simmer hour, withered and yellow to medicine, remove medicinal residues then, filter repeatedly and obtain medicinal liquid, in medicinal liquid, add 125 parts in Cera Flava again, after treating that Cera Flava melts fully, in medicinal liquid, add medical azone by 0.3% of said medicine gross weight again, stir, and after cooling, obtain external cream.
Embodiment 2
By weight, get 27 parts of Radix Scutellariaes, 16 parts of Rhizoma Coptidis, 14 parts of Cortex Phellodendris, 11 parts of Radix Et Rhizoma Rhei, 17 parts of charred Radix Sanguisorbae, 16 parts of Crinis Carbonisatus, 12 parts of Radix Asparagis, 12 parts of pollen, 25 parts of Herba Andrographis, 92 parts of Radix Arnebiae (Radix Lithospermi)s, 12 parts on Flos Carthami, 16 parts of Olibanums, 12 parts of Myrrhas, 12 parts in the Radix Rehmanniae, 24 parts of Mirabilitum crystallinas, 16 parts of Cortex Ampelopsis Aconitifoliae Radiciss, 12 parts of Herba Rosmarini Officinaliss, 16 parts of Flos Lonicerae, 12 parts in catechu, 21 parts of Os Draconis (calcined)s, collapse 35 parts of jorumes, 7 parts of Borneolum Syntheticums, putting into plants essential oil soaks after 24 hours (according to medical material weight: plants essential oil weight=1.5: 4), reuse 5-6 at a simmer hour, withered and yellow to medicine, remove medicinal residues then, filter repeatedly and obtain medicinal liquid, in medicinal liquid, add 120 parts in Cera Flava again, after treating that Cera Flava melts fully, in medicinal liquid, add medical azone by 0.2% of said medicine gross weight again, stir, and after cooling, obtain external cream.
Embodiment 3
By weight, get 33 parts of Radix Scutellariaes, 23 parts of Rhizoma Coptidis, 21 parts of Cortex Phellodendris, 18 parts of Radix Et Rhizoma Rhei, 23 parts of charred Radix Sanguisorbae, 23 parts of Crinis Carbonisatus, 18 parts of Radix Asparagis, 18 parts of pollen, 35 parts of Herba Andrographis, 108 parts of Radix Arnebiae (Radix Lithospermi)s, 18 parts on Flos Carthami, 23 parts of Olibanums, 18 parts of Myrrhas, 18 parts in the Radix Rehmanniae, 35 parts of Mirabilitum crystallinas, 23 parts of Cortex Ampelopsis Aconitifoliae Radiciss, 18 parts of Herba Rosmarini Officinaliss, 23 parts of Flos Lonicerae, 18 parts in catechu, 29 parts of Os Draconis (calcined)s, collapse 45 parts of jorumes, 13 parts of Borneolum Syntheticums, putting into plants essential oil soaks after 24 hours (according to medical material weight: plants essential oil weight=3: 6), reuse 5-6 at a simmer hour, withered and yellow to medicine, remove medicinal residues then, filter repeatedly and obtain medicinal liquid, in medicinal liquid, add 130 parts in Cera Flava again, after treating that Cera Flava melts fully, in medicinal liquid, add medical azone by 0.4% of said medicine gross weight again, stir, and after cooling, obtain external cream.
Plants essential oil in above-mentioned three embodiment is Oleum Sesami or olive oil.
Claims (3)
1. the external cream for the treatment of water, burning scald is characterized in that being mixed, treat to get with medical azone is mixed after Cera Flava melts fully with the Cera Flava of weight proportion after plants essential oil extracts by the medical material of following weight proportion again;
The weight ratio of described plants essential oil and medical material is 4-6: 1.5-3;
Radix Scutellariae 25-35 part, Rhizoma Coptidis 15-25 part, Cortex Phellodendri 13-22 part, Radix Et Rhizoma Rhei 10-20 part, charred Radix Sanguisorbae 15-25 part, Crinis Carbonisatus 15-25 part, Radix Asparagi 10-20 part, pollen 10-20 part, Herba Andrographis 25-35 part, Radix Arnebiae (Radix Lithospermi) 90-110 part, Flos Carthami 10-20 part, Olibanum 15-25 part, Myrrha 10-20 part, Radix Rehmanniae 10-20 part, Mirabilitum crystallina 25-35 part, Cortex Ampelopsis Aconitifoliae Radicis 15-25 part, Herba Rosmarini Officinalis 10-20 part, Flos Lonicerae 15-25 part, catechu 10-20 part, Os Draconis (calcined) 20-30 part, collapse jorum 32-47 part, Borneolum Syntheticum 5-15 part, Cera Flava 100-150 part, the 0.1-0.5% by the said medicine gross weight adds medical azone again.
2. a kind of external cream for the treatment of water, burning scald according to claim 1 is characterized in that being mixed, treat to get with medical azone is mixed after Cera Flava melts fully with the Cera Flava of weight proportion after plants essential oil extracts by the medical material of following weight proportion again;
The weight ratio of described plants essential oil and medical material is 5: 2;
30 parts of Radix Scutellariaes, 20 parts of Rhizoma Coptidis, 18 parts of Cortex Phellodendris, 15 parts of Radix Et Rhizoma Rhei, 20 parts of charred Radix Sanguisorbae, 20 parts of Crinis Carbonisatus, 15 parts of Radix Asparagis, 15 parts of pollen, 30 parts of Herba Andrographis, 100 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts on Flos Carthami, 20 parts of Olibanums, 15 parts of Myrrhas, 15 parts in the Radix Rehmanniae, 30 parts of Mirabilitum crystallinas, 20 parts of Cortex Ampelopsis Aconitifoliae Radiciss, 15 parts of Herba Rosmarini Officinaliss, 20 parts of Flos Lonicerae, 15 parts in catechu, 25 parts of Os Draconis (calcined)s, collapse 40 parts of jorumes, 10 parts of Borneolum Syntheticums, 125 parts in Cera Flava, add medical azone by 0.3% of said medicine gross weight again.
3. treat water for one kind, burn the preparation method of the external cream of scalding, it is characterized in that comprising the following steps: with Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, charred Radix Sanguisorbae, Crinis Carbonisatus, Radix Asparagi, pollen, Herba Andrographis, Radix Arnebiae (Radix Lithospermi), Flos Carthami, Olibanum, Myrrha, the Radix Rehmanniae, Mirabilitum crystallina, Cortex Ampelopsis Aconitifoliae Radicis, Herba Rosmarini Officinalis, Flos Lonicerae, catechu, Os Draconis (calcined), collapse jorum, Borneolum Syntheticum is put into the plants essential oil immersion after 24 hours by claim 1 or 2 described weight proportions, reuse 5-6 at a simmer hour, withered and yellow to medicine, remove medicinal residues then, filter repeatedly and obtain medicinal liquid, again by claim 1 or 2 described weight proportions, in medicinal liquid, add Cera Flava, after treating that Cera Flava melts fully, again by claim 1 or 2 described weight proportions, in medicinal liquid, add medical azone, stir, and after cooling, obtain.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102552689A (en) * | 2012-01-12 | 2012-07-11 | 颜颖 | Medicament for curing burn and scald and preparation method thereof |
| CN102526492A (en) * | 2012-02-21 | 2012-07-04 | 常熟市方塔涂料化工有限公司 | Medicament for treating burn and scald and preparation method thereof |
| CN103223077B (en) * | 2013-04-25 | 2015-04-22 | 苏州谷力生物科技有限公司 | Traditional Chinese medicine composition for treating burn and scald |
| CN103656593A (en) * | 2013-12-17 | 2014-03-26 | 青岛中科菲力工程技术研发有限公司 | Externally-applied medicine paste for treating burns and preparation method of paste |
| CN104621196B (en) * | 2015-03-15 | 2015-12-02 | 江阴市红柳被单厂有限公司 | A kind of formulation for room cure of termite of printing and dyeing |
| CN105145688B (en) * | 2015-03-15 | 2017-08-29 | 荆门市万博翻译有限公司 | A kind of preparation method for the formulation that termite is killed for the room of printing and dyeing |
| CN104758341B (en) * | 2015-04-22 | 2018-07-17 | 孙启芳 | A kind of wound, scald, ointment for treating pressure ulcers and its prepare application method |
| CN106236900A (en) * | 2016-08-10 | 2016-12-21 | 马春兰 | A kind of for compound medicine treating burn and preparation method thereof |
| CN109464542A (en) * | 2019-01-22 | 2019-03-15 | 浴康中医保健养生（江苏）有限公司 | A kind of external application is used to treat the external-use ointment of burn and scald |
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| CN1180796C (en) * | 2000-12-01 | 2004-12-22 | 庞传举 | Plaster for treaitng burn and its preparing process |
| CN1899441B (en) * | 2006-06-28 | 2010-08-04 | 广东皮宝制药股份有限公司 | Chinese medicine paste for burn and its preparing method |
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