CN101904804A

CN101904804A - Skin whitening complex prepared from algae serving as main raw materials

Info

Publication number: CN101904804A
Application number: CN2010101951059A
Authority: CN
Inventors: 蒋丽刚
Original assignee: Proya Huzhou Cosmetics Co Ltd
Current assignee: Proya Huzhou Cosmetics Co Ltd
Priority date: 2010-06-09
Filing date: 2010-06-09
Publication date: 2010-12-08

Abstract

The invention discloses a skin whitening complex prepared from algae serving as main raw materials, which comprises Whitonyl and EXO-T in a weight part ratio of 3:5-7:1. After the optimal proportion range, the produced cosmetics are added with 0 to 5 percent of the mixed complex at room temperature, and is stirred uniformly and bottled. Experimental results show that: on the premise of controlling 4 percent of total active substances, when the complexing ratio of the Whitonyl to the EXO-T exceeds 3:5, the monophenyl oxidase inhibiting capacity is higher than any single substance therein; when the complexing ratio of the Whitonyl to the EXO-T is 3:5, the monophenyl oxidase inhibiting capacity is the highest; and when the complexing ratio of the Whitonyl to the EXO-T exceeds 3:1, the monophenyl oxidase inhibiting capacity begins reducing.

Description

A kind of is the skin-whitening compound of primary raw material with the algae

Technical field

The present invention relates to cosmetics, relating in particular to the algae is the skin-whitening compound of primary raw material.

Background technology

Cosmetics industry is constantly sought technological break-through for many years, and purpose is to release the class raw material of whitening of highly effective and safe.The predominating path that dermal melanin forms is that the tryrosinase in the skin is converted into DOPA with tyrosine, further transforms into the DOPA quinone, forms melanin at last.Common skin-whitening method all is the activity by restraint of tyrosinase, thereby reaches the effect of skin whitening.

Use the whitening composition of more synthetic to have at present, vitamin C and derivant thereof, arbutin, kojic acid etc., but their common shortcomings are its unstable properties, oxidized easily, can flavescence gradually in storage process, thus cause product in storage process, to extend gradually xanthochromia and lose commercial value.For the other plant extract, such as glabridin, mulberry root extract, lemon yellow melon extract, but this class material whitening function a little less than, being difficult to proves its actual effect of whitening with experimental data.

Bibliographical information seldom be the material of whitening from the ocean, consider that marine resources are very abundant, raw material sources are abundant, if can therefrom seek the material of really effectively whitening, then are a very significant job.Read up the literature and can learn, existing abroad this respect is attempted, and as a Japanese ball company three kinds of specific marine algae productions of selection extract of whitening is arranged, and is used for cosmetics industry; Also there is the extract that comes from Atlantic Ocean red algae in the rich company of France's hila, and the class cosmetics are used to whiten.In addition, seldom other documents are mentioned the progress of this respect.

Summary of the invention

By the tyrosinase inhibition rate test experiments, after the composite application of raw material of proof with two kinds of different purposes that come from marine algae, experimental results show that it can be than the activity of only using the more effective restraint of tyrosinase of wherein a kind of energy, and then can infer that this material uses wherein a kind of to have more white-skinned face function (tyrosinase inhibition rate test be standard be used to test the method for testing of active substance whitening function of whitening) than simple.

White clever Whitonyl of algae and Ai Ke head are used in cosmetics for two kinds of raw materials of EXO-T are composite, and after determining its best ratio range, in the cosmetics of making, add 0～5% above-mentioned mixing compound under room temperature, the back bottling that stirs gets final product.

Selection sends the first EXO-T of replacing of love section of UNIPEX company to make up from the white clever Whitonyl of algae of the rich SILAB company of French hila with from the excellent Buddhist nun of Canada, wherein the white preferred proportion clever and that the head of love section replaces of algae is 3: 5～7: 1, the whiten weight range that contains of raw material of this mixing is 0～5% in final products, the white spirit of algae of the rich company of wherein French hila is the oligosaccharide that comes from Palmaria palmate red algae, this raw material can limit melanic generation, effectively stop the operation of melanosome and the calmness of control photoinduction pigment, thereby senile plaque and brown macules desalination that illumination is caused are the class materials of whitening that a usefulness has obtained confirming; The love section of Canada UNIPEX company is first to be the vibrio alginolyticus extracellular polysaccharide Vibrio Exopolysaccharide that comes from French Polynesia corallineae surface attachment for EXO-T, this raw material can impel skin cell differentiation, horny layer breaks away from, and itself there is no the white-skinned face function of real meaning.

The concrete grammar of tyrosinase inhibition rate test is:

1. the potassium phosphate solution that adds the 0.1M of 500 μ l in the tyrosine solution of 0.3mg/ml adds the tester of 450 μ l, mix homogeneously in test tube, and constant temperature is at 37 degree;

2. add 50 μ l tryrosinase solution (concentration is 1250unit/ml), under 37 degree environment, cultivated 10 minutes;

3. test the absorbance of 480nm with the UV-VIS spectrophotometer.

The composition of tester is according to hereinafter described:

Add the raw material of following content in deionized water respectively, its meansigma methods and standard deviation are measured in every kind of sample test 3 times.

Sample 1 4% algae is spirit in vain

Sample 2 4% head of love section replace

Sample 3 0.5% algaes are spirit in vain, and 3.5% head of love section replaces

Sample 4 1% algaes are spirit in vain, and 3% head of love section replaces

Sample 5 1.5% algaes are spirit in vain, and 2.5% head of love section replaces

Sample 6 2% algaes are spirit in vain, and 2% head of love section replaces

Sample 7 3% algaes are spirit in vain, and 1% head of love section replaces

Sample 8 3.25% algaes are spirit in vain, and 0.75% head of love section replaces

Sample 9 3.5% algaes are spirit in vain, and 0.5% head of love section replaces

Sample 10 blank deionized waters

The result of the test that this product experienced is as follows:

Tryrosinase suppresses data

Sample number 480nm absorbance meansigma methods standard deviation suppresses %

Sample 10 0.4715 0.4633 0.4826 0.472 0.009686-

Sample 1 0.6026 0.5973 0.5422 0.581 0.033447 33.1

Sample 2 0.7933 0.7249 0.7999 0.773 0.041527 11.0

Sample 3 0.7213 0.6785 0.6967 0.699 0.02148 19.5

Sample 4 0.3492 0.3527 0.3653 0.356 0.008468 24.6

Sample 5 0.5512 0.5437 0.5268 0.541 0.012498 34.6

Sample 6 0.2692 0.2764 0.2685 0.271 0.004373 42.5

Sample 7 0.3778 0.3563 0.3423 0.359 0.017882 58.7

Sample 8 0.1855 0.1785 0.1816 0.182 0.003508 57.9

Sample 9 0.4123 0.4298 0.4256 0.423 0.009136 48.8

The above results shows: is controlled at active substance under the prerequisite of 4% total amount,

1. when the white spirit of algae with love section is first when surpassing 3: 5 for compound proportion, its tryrosinase inhibition ability has been better than any independent use a kind of material wherein;

2. replace compound proportion in 3: 1 in white spirit of algae and the head of love section, it is the strongest that its tryrosinase suppresses ability;

When the white spirit of algae and love section is first surpass 3: 1 for compound proportion after, its tryrosinase inhibition ability begins decline.

Claims

1. one kind is the skin-whitening compound of primary raw material with the algae, it is characterized in that it comprises that white spirit of algae and the head of love section replace, and the ratio of weight and number that white spirit of described algae and the head of love section replace was respectively 3: 5～7: 1.