CN101896197B - 来自艰难梭菌的新型多糖免疫原 - Google Patents

来自艰难梭菌的新型多糖免疫原 Download PDF

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Publication number
CN101896197B
CN101896197B CN2008801155182A CN200880115518A CN101896197B CN 101896197 B CN101896197 B CN 101896197B CN 2008801155182 A CN2008801155182 A CN 2008801155182A CN 200880115518 A CN200880115518 A CN 200880115518A CN 101896197 B CN101896197 B CN 101896197B
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cell surface
polysaccharide
mixture
clostridium difficile
surface polysaccharide
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Chinese (zh)
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CN101896197A (zh
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M·A·蒙蒂罗
J·加内沙皮莱
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University of Guelph
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University of Guelph
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0066—Isolation or extraction of proteoglycans from organs
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CN2008801155182A 2007-09-11 2008-09-11 来自艰难梭菌的新型多糖免疫原 Active CN101896197B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97141107P 2007-09-11 2007-09-11
US60/971,411 2007-09-11
PCT/CA2008/001593 WO2009033268A1 (en) 2007-09-11 2008-09-11 Novel polysaccharide immunogens from clostridium difficile

Publications (2)

Publication Number Publication Date
CN101896197A CN101896197A (zh) 2010-11-24
CN101896197B true CN101896197B (zh) 2013-10-23

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CN2008801155182A Active CN101896197B (zh) 2007-09-11 2008-09-11 来自艰难梭菌的新型多糖免疫原

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US (1) US8597663B2 (cg-RX-API-DMAC7.html)
EP (2) EP2195018B1 (cg-RX-API-DMAC7.html)
JP (1) JP5501969B2 (cg-RX-API-DMAC7.html)
CN (1) CN101896197B (cg-RX-API-DMAC7.html)
AU (1) AU2008299536B2 (cg-RX-API-DMAC7.html)
CA (2) CA2698157C (cg-RX-API-DMAC7.html)
ES (2) ES2534671T3 (cg-RX-API-DMAC7.html)
NZ (1) NZ583750A (cg-RX-API-DMAC7.html)
WO (1) WO2009033268A1 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ583750A (en) * 2007-09-11 2012-05-25 Univ Guelph Novel polysaccharide immunogens from clostridium difficile
EP2655389A2 (en) * 2010-12-24 2013-10-30 Novartis AG Compounds
WO2012119769A1 (en) 2011-03-08 2012-09-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. Oligosaccharides and oligosaccharide-protein conjugates derived from clostridium difficile polysaccharide ps-ii, methods of synthesis and uses thereof, in particular as a vaccine
US9815889B2 (en) 2011-08-02 2017-11-14 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Antibodies for prevention and treatment of diseases caused by clostridium difficile
EP2554549A1 (en) * 2011-08-02 2013-02-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Oligosaccharides and oligosaccharides-protein conjugates derived from clostridium difficile polysaccharide PS-I, methods of synthesis and uses thereof, in particular as vaccines and diagnostic tools
EP2780351B1 (en) 2011-11-18 2019-12-18 National Research Council of Canada (NRC) Clostridium difficile lipoteichoic acid and uses thereof
US9777076B2 (en) 2012-07-16 2017-10-03 Pfizer Inc. Saccharides and uses thereof
HUE038212T2 (hu) * 2014-07-25 2018-10-29 Biosynth Srl Többszörös beépített epitópokat kifejezõ molekuláris konstrukt bázikus egységeket tartalmazó glikokonjugátum vakcinák enteropatogén baktériumok által okozott fertõzések elleni szélesspektrumú vakcina elõállításához
WO2019119134A1 (en) * 2017-12-19 2019-06-27 The Governors Of The University Of Alberta Clostridium perfringens surface glycans and uses thereof
US10933126B2 (en) 2018-05-03 2021-03-02 The Board Of Regents Of The University Of Oklahoma Clostridium difficile immunogenic compositions and methods of use
EP3880240A4 (en) * 2018-11-16 2022-08-03 Matrivax, Inc. Clostridium difficile multi-component vaccine
AU2019383549B2 (en) * 2018-11-22 2025-05-22 Idorsia Pharmaceuticals Ltd Stable vaccine against Clostridium difficile

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN1518456A (zh) * 2001-06-20 2004-08-04 溶解和结合荚膜多糖的疫苗

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US4673574A (en) 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
CA1331443C (en) 1987-05-29 1994-08-16 Charlotte A. Kensil Saponin adjuvant
US5283185A (en) 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5562909A (en) 1993-07-12 1996-10-08 Massachusetts Institute Of Technology Phosphazene polyelectrolytes as immunoadjuvants
GB9326174D0 (en) 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
US20030072774A1 (en) 1994-06-10 2003-04-17 Diane M. Gajewczyk Proteinaceous adjuvants
US6019982A (en) 1994-08-26 2000-02-01 The Administrators Of The Tulane Educational Fund Mutant enterotoxin effective as a non-toxic oral adjuvant
FR2726764B1 (fr) 1994-11-14 1997-01-31 Pasteur Merieux Serums Vacc Adjuvant pour composition vaccinale
US6284884B1 (en) * 1995-06-07 2001-09-04 North American Vaccine, Inc. Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof
EP1073667A2 (en) * 1998-04-28 2001-02-07 Galenica Pharmaceuticals, Inc. Polysaccharide-antigen conjugates
FI20011403A7 (fi) * 2001-06-29 2002-12-30 Carbion Oy Menetelmä ja koostumukset vatsan sairauksien hoitoon
US7541043B2 (en) * 2002-01-16 2009-06-02 The United States Of America As Represented By The Department Of Health And Human Services Vaccine for protection against Shigella sonnei disease
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GB0713880D0 (en) * 2007-07-17 2007-08-29 Novartis Ag Conjugate purification
NZ583750A (en) * 2007-09-11 2012-05-25 Univ Guelph Novel polysaccharide immunogens from clostridium difficile

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CN1518456A (zh) * 2001-06-20 2004-08-04 溶解和结合荚膜多糖的疫苗

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Title
J. Ganeshapillai 等.Clostridium difficile Cell-Surface Polysaccharides:Towards a Carbohydrate-Based Vaccine.《Abstracts of The General Meeting of American Society for Microbiology》.2007,第107卷第232页第三栏第7-13行. *
王思一.艰难梭菌荚膜的研究.《微生物学通报》.1988,(第4期),26-28页. *
范子文 等.艰难梭菌荚膜多糖单糖组成的气相色谱分析.《微生物学通报》.1994,第21卷(第4期),224-227页. *
范子文 等.艰难梭菌荚膜致病作用的初步研究.《中国微生态学杂志》.1993,第5卷(第4期),18-21页. *

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Publication number Publication date
US20100330125A1 (en) 2010-12-30
EP2195018A1 (en) 2010-06-16
US8597663B2 (en) 2013-12-03
AU2008299536A1 (en) 2009-03-19
ES2534671T3 (es) 2015-04-27
CA2941174A1 (en) 2009-03-19
JP5501969B2 (ja) 2014-05-28
CA2941174C (en) 2018-05-08
EP2674169B1 (en) 2015-01-28
CA2698157C (en) 2016-10-11
JP2010539256A (ja) 2010-12-16
EP2195018A4 (en) 2011-01-12
AU2008299536B2 (en) 2014-06-12
CN101896197A (zh) 2010-11-24
WO2009033268A1 (en) 2009-03-19
NZ583750A (en) 2012-05-25
EP2195018B1 (en) 2014-11-12
CA2698157A1 (en) 2009-03-19
EP2674169A1 (en) 2013-12-18
ES2528648T3 (es) 2015-02-11

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