CN101879387A

CN101879387A - Autonomous filter element

Info

Publication number: CN101879387A
Application number: CN201010141672.6A
Authority: CN
Inventors: A·伯克; A·迪莱奥; T·奥布里恩
Original assignee: Millipore Corp
Current assignee: EMD Millipore Corp
Priority date: 2009-02-13
Filing date: 2010-02-12
Publication date: 2010-11-10
Anticipated expiration: 2030-02-12
Also published as: JP5427634B2; EP2223737A1; US20140091020A1; US20120318738A1; EP2223738A3; US20130186275A1; US20100237013A1; JP2013049058A; EP2347817A1; US20130008838A1; JP5457534B2; CN101879387B; SG164329A1; JP2011005478A; EP2223738A2

Abstract

The present invention relates to a kind of autonomous filter device and a kind of method that is used to improve filter life and performance.This filter cell is equipped with one or more sensors, is used to measure one or more characteristics or the parameter of fluid, for example temperature, pressure or flow rate.According to measured characteristic or parameter, the control logic in this filter cell can be determined an appropriate responsive.For example, this control logic can determine on filter film, to have taken place a burst, but be temporary obstruction.As the response to it, this control logic can start one and be specifically designed to the response that slows down this obstruction.This response can be other action of variation of temperature, vibration, change in fluid flow path or some.This control logic can be determined the success of this response based on any variation of monitoring stream bulk properties then.Based on this, this control logic can be reported to the police to operating personnel should change this filter cell.Another kind of situation is, when this response has successfully solved this obstruction, this control logic does not need the notifying operation personnel, because this filter cell has been got back to normal mode of operation.

Description

Autonomous filter element

The cross reference of related application

The application advocates the U.S. Provisional Patent Application sequence number 61/152 that on February 13rd, 2009 submitted to, the U.S. Provisional Patent Application sequence number 61/241 that on September 10th, 329 and 2009 submitted to, 053 priority, the disclosed content of above-mentioned application is incorporated herein by reference with integral body at this.

Technical field

The present invention relates to autonomous filter element.

Background technology

Filter is widely used, and the crystallization from remove red wine to the impurity of removing in drinking water and the dynamo oil, to from bioreactor, is removed particle in fermentation tank or other chemical process.

The filter that is used in these each application of using all can have the problem relevant with its purposes.In some cases, these problems may be at by its special-purpose.For example, the container of some includes but not limited to the pharmacy container, and for example bioreactor and surge tank need its gas inside to be discharged in the external environment condition or from external container to obtain live gas.For reaching this purpose and keeping germ-free condition, has an aseptic ventilation filter on the container usually.In some cases, the excessive gas that in reaction, produces, for example carbon dioxide or water vapour must be discharged from container.In other cases, spray or blanketing gas,, be added in the container wittingly such as oxygen or air.

The distinctive problem of these ventilation filters is to keep a kind of gratifying gas flow.Common problem is the material in the container, normally water vapour may be easy to condense, because in major applications, gas temperature in the operating process is higher than environment temperature (for example be generally 35 ℃ for bioreactor, and be generally 80 ℃ for the WFI groove).If this material condenses on the ventilation filter, will limit gas flow between container and the external environment condition because of the hole of blocking filter, reduce it thus and be used for the effective surface area that gas is carried.

In addition, steeping oneself-meeting for natural that produces in the biological manufacture process accumulates on the filter and the limit air transmission.These foams are controlled by one of following several method usually.At first, can in container, add anti-foaming agent (anti-foaming agent) thus can not produce foam to reduce surface tension.Selectable another kind of method is exactly, and container or filter housings can be designed to be able to destroy before moving on to filter film on the foam formation of foam.These means have all increased the complexity of ventilation filter and course of reaction design.

In order to eliminate these phenomenons, ventilation filter is usually by preventing that the hydrophobic film that condenses in the filter hole structure from making.Yet, although used hydrophobic film, as can be known be still can to condense or stop up on the ventilation filter element.A kind of scheme that may address this problem is to use extra heating element heater, and it is used for promoting the temperature of filter cell, reduces condensing on this element thus.

These external heat elements are implemented after filter is installed usually again, and may run into several failure modes.In some cases, the temperature sensor on the external heat element can lose efficacy, and causes overheated filter, and jeopardizes the integrality of filter potentially.In other cases, sensor failure can cause heater not worked, and can not realize required function.In other cases, heating element heater can only be monitored the filter cell temperature of Stainless Steel Shell on every side.Therefore, the variable effect of the air-flow by filter is to the temperature of filter, but the variation of air-flow can not measure or detect by the external heat element.According to the flow rate of fluid in the filter, this may cause lacking enough heats or over-heating.

Another kind of situation is, in tun, ventilation filter can be physically away from operating personnel, and for example on the different floors of building, and operating personnel can not easily check filter thus.Therefore, the problem of integrality or flow rate can continue for some time before they are detected by current conventional means.

May there be other distinctive problem in other filter application.For example, tangential flow filter (TFF filter) may be stopped up by the protein of its filtration.Keep suitable back pressure can help to slow down this problem.

Except that the specific question in application, all there is total problem in whole filters.For example, all there is the problem of integrality in all application.The tiny cut of filter film can cause particle to pass through filter.Such cut may be catastrophic with regard to its application.For example, if this filter is to be used to guarantee sterile port or border, then such cut is unacceptable.

Second kind of total problem is to catch the flow rate reduction that causes owing to excessive particle is filtered the device film.This problem makes many filter provider suggestions regularly replace filters.For example, the oil strainer of automobile should or use the interval of mileage decision to change according to service time.Similarly, the water filter of refrigerator also has a life cycle of counting according to the gallonage of month number that uses or filtered water.

Today, most filter has two kinds of operator schemes.First kind of pattern is normal manipulation mode.Under this pattern, the filter normal running is by expectedly removing the target particles thing.In many specific embodiment, this is the default action of filter, need not other and guarantees that filter remains on this pattern.Yet, in some applications, may must carry out extra maintenance measure and guarantee that filter remains on operator scheme.For example, may remain on a particular state (for example liquid state or gaseous state) with the fluid of guaranteeing to be filtered to filter cell heating, as above about ventilation filter described.

Common second kind of termination that operator scheme is the life-span for whole filters.Under this pattern, filter has surpassed its service life.The generation of such situation may be because the excessive accumulation of particle on filter film.Normally, the filter cell ability that under an acceptable flow rate fluid passed through suffers damage.Under opposite extreme situations, flowing of fluid stops fully.Causing the another kind inefficacy of life termination is the destruction of integrality.If filter cell is no longer complete, it just can not exercise its function, and reaches the termination in its life-span thus.Filter must be replaced when reaching its life termination.

Although filter only uses under these two kinds of patterns usually, the appearance of the third operator scheme is very favorable, and this pattern is called as regeneration mode.Under this pattern, filter is not in optimum performance, but the in fact also termination in its life-span of no show still.Its performance may be under the treatment conditions outside the routine operation deterioration to some extent, for example stopped up by bigger particle or a large amount of particles is when arriving at simultaneously when film.Though filter film self is not blocked as yet, particle a large amount of or unexpected quantity has damaged the ability of filter valid function.Under the situation of ventilation filter, this springs up and can take place accidentally during the splash protein foam on filter film when gas jet spraying in bioreactor.In most filter application, be difficult for difference between this pattern and the life termination pattern, and solve by similar mode thus, normally change filter.

A kind of equipment that improves to some extent and the method that can monitor, detect and control these three kinds of operator schemes more reliably is useful.Such equipment and method can be by making filter cell lifetime and minimize the reduction expense downtime that is associated by making to change with filter.

Summary of the invention

The present invention has overcome the problem that prior art exists, and the present invention discloses a kind of autonomous filter equipment and a kind of method that is used to improve filter life and performance.This filter cell is equipped with one or more sensors, is applicable to one or more characteristics or the parameter of measuring fluid, for example temperature, pressure or flow rate.In response to measured characteristic or parameter, the control logic in this filter cell can be determined an appropriate responsive.For example this control logic can determine on filter film, to take place a burst but for temporary obstruction.As the response to it, this control logic can start one and be specifically designed to the response that slows down this obstruction.This response can be other action of variation of temperature, vibration, change in fluid flow path or some.This control logic will be determined the success of this response based on the monitoring of any variation of fluid properties then.Based on this kind situation, this control logic can give the alarm to operating personnel and inform and should change this filter cell.Another kind of situation is, when this response is successfully to have solved this obstruction, this control logic needn't the notifying operation personnel, because this filter cell has been got back to normal mode of operation.In other embodiment, control logic is also adjusted the operator scheme of filter, for example guarantees that the fluid that wherein passes through has predetermined temperature or pressure.

In other embodiments, filter cell combines and works to realize required function with on every side supporting mechanism.For example, in certain embodiment, filter may be determined: particle has made flow rate reduce.In response, filter can be communicated with the supporting mechanism that is associated, and the fluid that the latter can change the filter of flowing through flows.

Description of drawings

Fig. 1 shows flow chart of the present invention;

Fig. 2 illustrates a kind of representative schematic diagram of the present invention;

Fig. 3 illustrates a kind of container with ventilation filter;

Fig. 4 illustrates the ventilation filter that has the integral type heating element heater of the present invention;

Fig. 5 illustrates the representative schematic diagram of one embodiment of the present invention;

Fig. 6 shows a kind of phasor;

Fig. 7 illustrates a kind of representative flow diagram, and it can use for processing unit under the normal manipulation mode of one embodiment of the present invention;

Fig. 8 illustrates the operation of a plurality of fluid sensors in filter element;

Fig. 9 a to 9d illustrates the flow rate figure of different filter cells;

Figure 10 illustrates the filter according to second kind of embodiment of the present invention;

Figure 11 illustrates the flow path that passes dissimilar filters;

Figure 12 shows the flow path of tangential flow filter (TFF);

Figure 13 shows second kind of embodiment of TFF filter flow path;

Figure 14 shows the active force that is applied on the TFF filter;

Figure 15 illustrates the TFF filter according to one embodiment of the present invention.

The specific embodiment

As indicated above, filter cell preferentially has three kinds of operator schemes.These three kinds of operator schemes as shown in Figure 1.Operator scheme 10 was used in most of period of filter life.In most of the cases, what not needing to carry out moves and guarantees that filter remains under the operator scheme.But, in some embodiments, may need to carry out continuously or periodically service action 12, keep mode of operation to guarantee filter.Such action may be thermal cycle, vibration, and pressure or fluid reflux or other remedial action.

Through after a certain amount of use, parameter that certain of filter is measured or characteristic, the flow rate of fluid after filtering for example, the pressure in upstream and/or downstream, or the temperature of fluid may depart from acceptable scope.If at the time after date or incident 27 has taken place as manufacturer is expected of an elongated segment, then filter may arrive the termination in its life-span at this point.In this case, the pattern of filter becomes life termination mode 30 via the loss path 27 of nature by operator scheme 10.

Another kind of situation is that parameter may change suddenly, shows that the problem of globality has appearred in filter, and no longer can filtration of particulate matters.Such incident 27 becomes the pattern of filter into life termination mode 30 by operator scheme 10 through the path equally.

Yet, sometimes may be unexpectedly or deterioration event 15 takes place with bursting.In the case, this incident causes filter capability to descend, as with may being that unexpected variation by one of measured parameter or characteristic decides.The unexpected variation of measured parameter is inconsistent with the loss of routine, and may represent to have taken place certain unusual or temporary obstruction thus.For example, the remarkable reduction of fluid flow rate may be represented the filter obstruction of having burst.In this case, filter can transfer regeneration mode 20 to by operator scheme 10.

Regeneration mode 20 times, filter is attempted by carrying out one or more correction or correcting step and correct obstruction.These steps may comprise the raising temperature, change the fluid circulating path, and the vibration filters film changes or puts upside down transmembrane pressure (transmembrane pressure) or other.These are corrected action and can disposablely carry out, and can successfully measured parameter or characteristic be returned to acceptable value if correct action, and then filter transforms back into operator scheme 10 by path 18.

In some embodiments, correct action and can carry out several times, shown in path 13.If after the correction effort through pre-determined number, parameter is not got back to acceptable value yet, then filter is converted to the termination 30 in life-span subsequently by path 25.

Be used to show under the situation of filter pattern of the present invention having defined general flow chart, will the diagram of expression filtration device structure be described below.

Fig. 2 has represented the representative schematic diagram of filter cell 100 of the present invention.This filter cell 100 comprises control logic 140 so that it can be understood and change between pattern mentioned above.For the intelligence of this level is provided, must provide a power supply.In certain embodiment, use battery or electric power delivery outlet to supply with the required energy of heating element heater.Yet in other embodiment, filter is (self-contained) that controls oneself and wirelessly accepts energy.In certain embodiment, use the magnetic induction electric power coupling circuit 110 that combines with magnetic field to produce required power supply.By such mode, filter no longer is subjected to the constraint of external power source, and filter interior does not have initiatively power supply or active electrical source existence yet.Connect and the method for integrated magnetic field is the explanation of 12/079,396 co-applications referring to patent application serial numbers, its content is hereby incorporated by reference.

In one embodiment, using magnetic induction electric power coupling circuit 110 to produce voltage uses for any interlock circuit of sensor, actuator and filter interior.Anyly be used to operate the required voltage change of filter cell and all carry out by the circuit of ventilation filter inside.In another embodiment, by electric power coupling circuit 110 changes of magnetic field is converted into the variation of voltage.

In some embodiments, use one or more sensors 120,121,122 to monitor at least one parameter or the characteristic of filter cell.Coupling circuit 110 is used for from external magnetic field generation induced voltage.This voltage is as AC voltage 112, and this voltage is subsequently by using rectification circuit 113 to carry out rectification and filtering to produce dc voltage 115.This dc voltage 115 is used for any active circuit subsequently energy is provided, tuner for example, sensor, CPUs or the like.

Sensor 120 is used to monitor the parameter or the characteristic of filter cell, and passes this information relaying back processing unit 140, for example central processor unit (CPU).This processing unit 140 comprises a memory device, semiconductor memory for example, and it is used for the storage of cpu instruction and various parameter and setting.Sensor 120 can be wired, wireless, and this depends on its position in filter.For example, if sensor 120 close control circuit in housing, so wired or wireless configuration can be used.If but sensor 120 be positioned to control circuit away from, use the wireless sensor may be more favourable so.

In one embodiment, wireless senser 120 is embedded in the end cap of filter cell 100.In other embodiments, the difference place of filter cell 100 is fixed or be embedded into to sensor 120, for example on the downstream of filter core element.In some applications, the temperature of filter cell may surpass 145 ℃, therefore should use the sensor that can bear this temperature.Similarly, the temperature in the container 100 may be reciprocal from low temperature to the high temperature circulation, so sensor should bear such temperature cycles.

In one embodiment, wireless transmitter also is close to sensor 120 and locatees or become one with sensor 120.In preferred embodiment, wireless transmitter and sensor 120 are encapsulated in the single integrated form parts.Another kind of situation is that transmitter can separate with sensor 120, and communication each other, for example passes through the signal of telecommunication.Various types of wireless telecommunications systems all may use, and comprise RFID, Zigbee, 802.11a/b/g and other agreement.

Processor unit 140 is with measured value and hope or the acceptable value of sensor 120, or span, parameter area or characteristic range compare.The value that sensor 120 returns can be for example with the proportional analogue value of measured parameter, perhaps can be a data signal.Based on the value of returning, whether processor 140 decision filters still are in operator scheme, perhaps whether should be transformed into different patterns.

As shown in Figure 1, in some embodiments, can adopt service action 12 to make filter can remain on operator scheme 10.This action can be adopted many forms, includes but not limited to temperature or backpressure regulation.In these embodiments, processing unit 140 is being controlled actuator 150, and the latter finishes required service action.

If when measured parameter or characteristic departed from permissible value or scope, as what see from sensor 120, CPU 140 can be transformed into regeneration mode 20.Under this pattern, filter is corrected action 13 by using actuator 160 to carry out.This actuator can be same actuator with the actuator that is used to realize to correct action 13, perhaps can be different actuators.The suitable action that can adopt comprises temperature or back pressure correction, circulating path correction, filter vibration, or other similar action.

After CPU had controlled actuator 160, it checked the measured value that sensor 120 returns once more.If this value has been got back to normal range (NR), then the CPU termination is corrected action 13 and return operation 10.If measured value still can not be accepted, CPU 140 may select to repeat this correction action 13 one or many.If measured value is got back to tolerance interval during this period, CPU 140 return operations 10 then.If yet measured value still can not accept, CPU 140 is transformed into life termination state 30.

In some embodiments, filter 100 can use more than a sensor 120.For example, filtration can have temperature sensor 120, upstream pressure sensor 121 and downstream pressure sensor 122.In other embodiments, can use the different combination of a plurality of sensors.In these embodiments, CPU 140 can use and judge from the measured value of one or more sensors and will enter which kind of pattern and to determine suitable action.For example, CPU 140 can use the output of several sensors (for example temperature and pressure) to control service action 12.But it also can use single-sensor (for example flow rate) to judge whether the correction action is successful.

In some embodiments, indicator 170 is used for the termination 30 that the alert operator filter has arrived the life-span.This indicator 170 can be a vision, the sense of hearing, touch or some other means.When arriving the termination 30 in life-span, CPU 140 can start indicator 170.

In some embodiments, actuator 150 and/or actuator 160 can not be positioned at filter 100 inside in the physical sense.For example, in the application of the change of the change of having carried out pressure or circulating path, CPU140 can by-pass valve control or other equipment of separating with filter in the physical sense.This control can be undertaken by wired or wireless communication modes.

State diagram mentioned above can be used in many different application with structure.During these are used some will be discussed hereinafter.But these are enumerated and non exhaustive, and those skilled in the art will be appreciated that other application also can use the disclosed instruction of this paper.

Embodiment 1-ventilation filter

In first kind of embodiment, used ventilation filter.In first kind of embodiment, this filter is used as ventilation filter.

Fig. 3 shows the container with such ventilating opening.In general, container 201 is to be made of rigid material, for example stainless steel and rigidity plastics.In other embodiments, container can be flexible plastic material.For gas can be passed, use ventilation filter 200 usually between container 201 inside and external environment condition.In embodiment shown in Figure 3, filter cell 200 is positioned at the end face place of container 201, thereby the material that itself and container 201 inside are held is separated.

The ventilation filtration system not only is used for bioreactor, also can be used for somatomedin, cushioning liquid, WFI (water for injection) preparation system and fill application.By using suitable technology, high-pressure sterilizing pot for example, the such gaseous sterilization of ETO (oxirane) gas is for example used in on-site steam sterilization (Steam-In-Place), or radiated by gamma-ray, and these filters are by asepticize.

Ventilation filter is usually with a kind of installation the in two kinds of configurations.In embodiment shown in Figure 3, a removable filter cylinder is installed in the Stainless Steel Shell, and whole assembly is fixed to container.A kind of such filter is can be from Millipore Corporation of Billerica, and Massachusetts buys Filter.Second kind of configuration commonly used is to use the self-holding plastic bag that self has plastic casing.A kind of such filter is can be from Millipore Corporation of Billerica, and Massachusetts buys has the AERVENT hydrophobic membrane

Bag type filter.

Fig. 4 shows a kind of ventilation filter that integrates the formula heating element heater that has.This ventilation filter 200 can be the type of any appropriate, such as but not limited to disposable filter capsule or replaceable filter filter cylinder.Ventilation filter has outside porous plastics housing or lining 210, film 220 and inner core 230 usually.Housing 210 and inner core 230 are porous, preferably have a series of big opening (being respectively 212 and 232) and arrive outlet (not shown) from the filter outside by housing 210 via its opening 212 and the opening that passes on the core 230 of film 220 and porous to allow fluid, this outlet is connected to core 230 and pedestal 240.Heating element heater is positioned at the inside of ventilation filter 200, for example is integrated in the plastic casing 210 or in the inner core 230.In some embodiments, film 220 is centered on by a supporting layer (not shown).This supporting layer can be comparatively firm perforated membrane, nonwoven web lattice or weave mesh.In some embodiments, this heating element heater is placed in this supporting layer.This ventilation filter has a pedestal 240 that is attached to container.This ventilation filter 200 also has the top 250 of a sealing.

Fig. 5 shows a representative schematic diagram of ventilation filter.Under its form of simplifying most, heating element heater 330 comprise one be connected to power supply, with the lead of surrounding environment electric insulation.Electric current is used for to wire-heated through lead, has promoted the temperature of surrounding environment thus.By the electric current of change, provide a kind of mechanism in order to the control temperature through lead.Thereby, just can reach higher temperature by more electric current on the lead.Another kind method is, electric current can be maintained fixed, and dutycycle change during applying electric current.In other embodiments, the magnitude of current and combining of duration are used to adjust the temperature of filter.

Another heating element heater can be with the form of the grid of conduction or screen cloth or porous pad and can produce the required thermal effect that adds.It can be made by metal or other conductive of material, for example carbon, graphite or CNT.

In order to influence variation of temperature, must provide a power supply.In certain embodiment, use battery or electrical socket (or being called the electric power line outlet) to supply with required energy as heating element heater.But, in other embodiments, this ventilation filter be control oneself and receive electric power with wireless mode.In certain embodiment, use the magnetic induction electric power coupling circuit that combines with magnetic field to produce required power supply.By such mode, filter no longer is subjected to the constraint of external power source, and filter interior does not have initiatively yet or active electrical source exists.Be used to connect method with integrated magnetic field and referring to patent application serial numbers be the explanation of 12/079,396 co-applications, its content is hereby incorporated by reference.

In one embodiment, using magnetic induction electric power coupling circuit to produce voltage uses for heating element heater and any interlock circuit of filter interior.Any required voltage change of temperature that is used for changing heating element heater is all carried out by the circuit of ventilation filter inside.In another embodiment, change magnetic field so that change the received voltage of electric power coupling circuit.

In some embodiments, use one or more temperature sensors to control and monitor the temperature of heating element heater and surrounding environment thereof.Fig. 5 shows a kind of representative schematic diagram that is subjected to the ventilation filter circuitry needed of ACTIVE CONTROL.Coupling circuit 310 is used for from external magnetic field generation induced voltage.This voltage is as AC voltage 312, carries out rectification and filtering to produce dc voltage 315 by rectification circuit 313 subsequently.This dc voltage 315 is used for any active circuit subsequently energy is provided, tuner for example, sensor, CPU or the like.

Use the temperature of a temperature sensor 320 arriving control heating element heaters 330, and pass this information relaying back processing unit 340, for example central processor unit (CPU).This temperature sensor can be wired or wireless, and this depends on its position in filter.For example, if sensor is positioned at housing near control circuit, so wired or wireless configuration can be used.If but sensor is positioned to away from control circuit, use wireless sensor more favourable so.

The sensor that is suitable for comprises thermistor, and it is the resistance with very high temperature-coefficient of electrical resistance, and the transducer as integrated circuit.This sensor can be other type also, includes but not limited to: diode, RTD (resistance temperature detector) or thermocouple.

In one embodiment, radio temperature sensor 320 is embedded in the end cap of filter cell 300.In other embodiments, the difference place of filter cell is fixed or be embedded into to sensor, preferably on the downstream.In some applications, the temperature of filter cell may surpass 145 ℃, therefore should use a kind of sensor that can monitor this temperature.Similarly, the temperature in the container 100 may be reciprocal from low temperature to the high temperature circulation, so temperature sensor should have one period response time that is enough to measure this temperature cycles.

In one embodiment, a wireless transmitter also is positioned near the temperature sensor 320 or with temperature sensor 320 and integrates.In preferred embodiment, wireless transmitter and sensor 320 are encapsulated in the single integrated parts.Another kind of situation is that transmitter can separate with sensor 320, and communication each other, for example passes through the signal of telecommunication.Various types of wireless telecommunications systems all may use, and comprise RFID, Zigbee, 802.11a/b/g and other agreement.

Temperature value that processor unit 340 is measured with temperature sensor subsequently and the electric current that the temperature of hope compares and correspondingly heating element heater 330 is passed through in adjustment.The value that temperature sensor returned can be for example with the proportional analogue value of detected temperature, perhaps can be a data signal.Processing unit is employed can be any suitable means in order to the method for making this adjustment, includes but not limited to PID control, proportion control or any other method.

Processing unit 340 changes electric current by using current control circuit 350.Circuit 350 uses conventional means to control the magnitude of current of process heating element heater 330.In some embodiments, control circuit 350 changes the dutycycle of the electric current of process heating element heater 330.In other embodiments, circuit 350 changes the size of the electric current of process heating element heater 330.

In some embodiments, use second temperature sensor 360 as fault-tolerant equipment, for example electrothermal relay or switch are to guarantee that ventilation filter can be not overheated under the situation that first sensor 320 lost efficacy.

Preferably, these temperature sensors are settled near heating element heater 330, so that accurately report the temperature of filter cell.

In another embodiment, the circuit in the ventilation filter is oversimplified very much, only comprises a radio temperature sensor and an induction coil.In this embodiment, finish the filter outside that is controlled at of voltage, and magnetic field is subjected to regulating the electric current that changes through heating element heater.This embodiment requires filter interior that less electronic device is arranged, but needs extra external logic and control.

As indicated above, because the internal state that external heater can not detection filter, so external heater only provides the heat of constant value to filter cell.In one embodiment, use heater circuit as shown in Figure 3, it has an intelligent processing unit.For example, can add pressure sensor 370 to this filter cell, it is suitable for the pressure in the measuring vessel.

As described about temperature sensor, pressure sensor can be wired or wireless.This sensor 370 can produce an output, and it is as the function of the pressure of surrounding environment and change.In another embodiment, sensor 370 is differential pick-ups, and its output is the function of pressure differential between two zones thus.This output can be the form of aanalogvoltage or electric current, maybe can be digital value or pulse.In preferred embodiment, output changes linearly with pressure, however this optional condition.Can use any output that has known relation with ambient pressure, for example logarithmic relationship or exponential relationship.In this case, can carry out conversion to output to determine actual measured pressure.

In some applications, the temperature of filter cell may surpass 145 ℃, therefore should use sensor stable under this temperature.Similarly, also should use the transmitter that can bear this temperature.At last, the temperature in the container 100 may be reciprocal from low temperature to the high temperature circulation, so this pressure sensor should bear such temperature cycles.

This pressure sensor 370 has numerous embodiments.For example, this sensor can use MEMS (MEMS) technology to make up, and it can be piezoelectric element, inductance or resistive polymer (comprising elastomer and printing ink) or a transducer.These embodiment are intended to the sensor type that illustrates that some can use; This is not to be exhaustive to all sensors that are suitable for like this.In addition, these sensors can use and cover the manufacturing of silicon (SOI) technology on the silicon-on-insulator, as described in the co-applications 12/502,259 like that.

In addition, alarm mechanism 380 can carry out communication with processing unit 340.This makes filter cell to report to the police and informs operating personnel: filter has arrived the termination in its life-span and has needed and changed.

This filter can be used by the described mode of Fig. 1.Under operator scheme, ventilation filter must guarantee that the fluid that is filtered remains in gas phase.Fig. 6 has represented a traditional phasor.By monitor temperature and/or pressure, the CPU in the ventilation filter can judge the residing phase of fluid.By changing the electric current through heating element heater, CPU can guarantee to keep this gas phase state.

Thus, in this embodiment, exist service action 12 (as shown in Figure 1).

Fig. 7 has represented under operator scheme in order to adjust a representational flow chart through the required control loop of the electric current of heating element heater.At first, processing unit inquiry pressure sensor is to determine the pressure in the container, shown in square frame 500.Processing unit inquiry temperature sensor is to determine the temperature in the container, shown in square frame 510 then.Processing unit compares the phasor of this class value and given material then.In some embodiments, in the storage unit of processing unit, store the formula of representing gas/liquid line 400.In other embodiments, store one group of corresponding point of coordinate and gas/liquid line 400 in the memory element of processing unit.Processing unit compares those points of storing in the reading of reality and the memory element.Based on this comparison, processing unit can judge whether operating conditions at that time can make this material be in gaseous state.If can not, the electric current in the processing unit increase heating element heater is to promote temperature, shown in square frame 540.In another embodiment, if this material is to be in gaseous state, then processing unit compares numerical value and gas/liquid line 400.If the point that this numerical value forms is near line 400, to be used to keep the value of the heat of environment be suitable in explanation so, shown in square frame 570.Yet if this is away from line 400, this can reduce temperature and needn't worry to condense with regard to meaning.In the case, the electric current in the heating element heater reduces, shown in square frame 560.

The flow chart of execution graph 7 repeatedly is so that maintain a suitable temperature with heating element heater.Can be for the adjusting of electric current based on control algolithm arbitrarily.For example, can the usage ratio algorithm, P-I algorithm (ratio-integration), P-D (ratio-differential) or P-I-D algorithm (proportional-integral-differential) determine the adjustment of electric current.Other algorithm also is known and belongs in the scope of the present invention.

CPU continues to carry out this flow chart, as long as measured parameter keeps within the acceptable range.Filter starts from operator scheme 10.By pressure sensor 370 and temperature sensor 320 are read, processing unit can be judged the phase that plugging material may be in, as shown in Figure 6.The target of control system is to guarantee that this material remains in gas form.Therefore, it monitors the pressure and temperature in the container continuously, and the electric current of adjustment process heating element heater is to guarantee to satisfy this condition.

Use such algorithm to make the container setting very flexible.In other words, native system is applicable to different operating conditions (cold, warm or high temperature), and can be correspondingly and hot filtration apparatus efficiently.

In another embodiment, in ventilation filter, be associated with the flow rate detection device.Fig. 8 illustrates a filter 600, has wherein indicated flowing of material with arrow.Fluid enters core 610, passes film 620, and flows out to the outside of filter.In some embodiments, heating element heater be placed in film 620 inner or its near, for example be placed on core, in housing or the supporting layer.A temperature sensor (not shown) is placed in the core, measures the temperature of fluid before fluid passes film.The temperature sensor 630 of a corresponding pairing is positioned in the outside of filter, passes film 620 and coexistence one place and the temperature of fluid after the heating element heater of locating with measurement.As indicated above, these two temperature differences that sensor observed make it possible to measure the flow rate at this some place.In embodiment shown in Figure 8, shown three flow rate sensors, wherein each all is suitable for measuring the flow rate at filter element difference portion section place.

Fig. 9 a to 9d show figure solve filter in life cycle become when stopping up by three sensors observe to the curve map of flow rate.After a new filter was installed, all parts of film were the saturable mistakes of equal extent.At this moment, the flow rate at all part places of filter may be to equate generally, shown in Fig. 9 a.In addition, the sensor place on the limit that keeps left most as can be seen has higher flow rate, and this is owing to this most close source of sensor, and because this flow path has minimum resistance and the shortest distance, fluid can flow out through this sensor.This point is shown in Fig. 9 b.Along with the use of filter cell, the sputter and the foam of material begin precoat filter, usually from the position near filter inlet.Thus, decrease, force the mobile increase of other position, shown in Fig. 9 c as the viewed flow rate of sensor by the limit that keeps left most.Along with filter continues to begin to stop up, the flow rate at middle part sensor place also begins to reduce, and forces the part on the limit of keeping right most of the more process filter that flows, as shown in Fig. 9 d.

The value of such configuration is to require absolute flow rate value.On the contrary, different sensors along with the relative flow rate value of time is enough to understand the permeability (permeability) of electric current and the situation of filter.For example, do not comprise actual flow rate value on Fig. 9 a to 9d.Yet, the relation between the flowing of overall situation among the figure and each point place, whether allow the situation that allows those of ordinary skill in the art understand film and judge needs to change.

In other embodiments, can use a simple hot-wire anemometer.In this embodiment, a thin wire is placed fluid stream.This root lead is applied energy by the electric current of process wherein then, thereby heats this lead.The fluid that flows through this lead is removed the heat that is just producing on this lead, thereby cools off this lead.Therefore, fluid flows remarkable more, and the temperature of lead is low more.The variations in temperature of lead causes the similar variation of conductor resistance.Thus, just can determine flow rate by the resistance of measuring lead.In certain embodiment, known constant current mode current meter (CCAs), be exactly on lead by a constant electric current, and measure its resistance by the voltage that lead is traversed in measurement.In other embodiments, known constant voltage current meter (CVAs) was crossed over exactly on the lead and was kept a constant voltage, and measured electric current.In these two kinds of situations any down can both be measured the resistance of lead, thereby and can calculate fluid and flow.

Thus, flow rate can be used to judge whether filter stops up.In other words, as shown in Figure 1, if flow rate reduces gradually, this may be the indication to loss.Such situation can cause CPU 340 to be transformed into life termination mode 30.

Flow rate sensor is not only useful when judging the obstruction of filter interior, but also can be used to judge the integrality of filter.For example, if significant increasing occur, just may there be the problem of integrality by the determined flow rate of one of sensor.The unexpected increase of the flow rate that one or more sensors place measures may mean that the film of filter breaks, increases between at once thus and flows.So the increase of flow rate can cause CPU to be transformed into life termination mode 30.The problem of integrality also can detect by the working pressure sensor.As known to those skilled in the art, can be used to determine the to flow through flow rate of the fluid between these 2 of the pressure differential between 2.Thereby these pressure sensors can be connected to processing unit makes processor can monitor the sign that the pressure differential of crossing over whole film thickness is sought integrity issue.

But obstruction is not the problem of our unique concern.Under certain situation, temporary transient obstruction may take place.Under some environment (for example in fermentation reactor), the material of reaction or byproduct as protein foam, may accumulate on the top surface and upwards pushed away.When it arrived the surface, foam can break when touching this surface, and foam is along with the release of gas may be splashed.Sometimes, this material may be splashed on the filter cell, causes its obstruction.In some embodiments, this obstruction and volatile, and it can evaporate the material of sputter by abundant heating to be adjusted.Under such situation, processing unit 340 can monitor the unexpected variation by the flow rate of certain specific part of filter.Based on this, processing unit can be considered as it unexpected deterioration of certain measured parameter, as shown in Figure 1.CPU 340 moves to regeneration mode 20 subsequently, wherein will attempt remedial action.In this embodiment, if this variation of hypothesis is to cause that then CPU 340 can apply a large amount of electric currents to heating element heater owing to splash.Subsequently, processing unit will continue monitoring by this a part of flow rate of filter.If flow rate is improved, this hypothesis is correct so, and processing unit will return operation 10.

Yet if in the preset time section, flow rate is not improved as a certain particular value, thereby processing unit can be judged that this filter has fully been stopped up and makes and only depends on the heating can not be in order to remedy this state of affairs.Under such situation, processing unit can be transformed into life termination mode 30, and by using alarm 380 to inform operating personnel.

In another embodiment, can monitor a unexpected increase that is occurred in the pressure in the container by using a pressure sensor, thereby detect this unexpected deterioration 15.This increase may be owing to cause in response to temporary obstruction as indicated above.After detecting such pressure variation, can carry out above-mentioned step to attempt evaporating material from filter cell.If situation does not obtain correcting, processing unit can be informed operating personnel by using an alarm.

According to embodiment shown in Figure 5, processor can carry out communication with the sensors of various types of some.As mentioned before, temperature sensor can be used to keep the predetermined temperature of filter and be used to calculate flow rate.Pressure sensor can be used for flow rate or integrity test.Can also use the sensor of other type.For example, in bioreactor, what can know is that the hydrophobicity to filter film produces injurious effects to the subcompound of reaction by changing surface energy.In order to tackle this situation,, the liquid level of the material in the bioreactor can not arrive ventilation filter thereby being held enough low.But too much foam or sputter meeting make material arrive ventilation filter.Can use a conductivity sensor that combines with processing unit to forecast this situation, and prepare to handle coming contact.

Embodiment 2-material thing filter

In another embodiment, technology mentioned above can be used in the particle filtration system, and particle for example comes from the cell debris in the bioreactor or comes from crystalline solid in the red wine.

Figure 10 has shown the filtration system that is used for particle, and particle is for example from the cell debris of bioreactor or from the crystalline solid of red wine.It comprises housing 702, and this housing comprises one or more filters 704.Thereby filter 704 is attached to the outlet 706 of housing makes the whole filter liquors that arrive outlet 706 at first pass through filter 704 before this.Housing 702 also has an inlet 708, and it comes from the source of fluid to be filtered.The downstream of outlet 706 is recirculation circuits 710, and it is carried out valve 714 (for example magnetic valve) and be connected to outlet 706 via first electronics, and is connected to the side of housing 702 via second electronic control valve 718.In normal closed position, the filter liquor of leaving outlet 706 is expelled to next position 718 downstream, for example a hold-up vessel or an extra purifying step.Import 708 also has one being close to the electronic control valve 732 that housing 702 is installed.

Filter 704 has the first sensor 720 and second sensor 722 that is installed in the filter material downstream that are installed on the filter material upstream side.Two

sensors

720 and 722 can comprise a wireless telecommunications system, for example RFID label.Extra computational logic equipment is PID controller or CPU 724 keeps in communication with these two sensors 720,722 for example.This CPU 724 can will compare and contrast from the known parameter of the signal of these two sensors 720,722 and group.Processing unit 724 can also control

valve

714 and 718, for example respectively via the wireless telecommunications system 726,728,734 that is included separately in each valve 714,718 and 732, or via wire communication.This wireless telecommunications system can be any suitable type, includes but not limited to RFID equipment and Zigbee equipment.CPU724 can activate or the described valve 714,718,732 of deactuate as required.Sensor 720,722 and processing unit 724 can be powered by remote control, for example the induction Coupling device (inductive couplingdevice) in the exit by being arranged on housing 702.Wireless telecommunications system 726,728 in the valve 714,718 and 732 and 734 and valve 714,718 and 732 self all can be electrically connected and fetch power supply by the hardware lead that leads to the system power supply (not shown).

The red wine that contains the filtered that remains to be removed crystal 708 enters housing 702 from entering the mouth, and (for example can buy from Millipore Corporation by filter Filter) outlet 706 of arrival system.These first and second sensors, 720,722 processed unit 724 come to be monitored by certain hour at interval, and for example per 2 minutes once.In this embodiment, do not need service action to keep filter to be in operator scheme 10.

But the difference that exists between the force value of finding between two sensors 720,722 is greater than certain scheduled volume, and for example during 2psig, processing unit 724 starts a remedial action.Processing unit 724 sends a signal makes valve 712 and 718 open and valve 732 cuts out.In this embodiment, in fact actuator shown in Figure 2 is positioned at the filter cell outside, yet but they are subjected to being positioned at the control of the processing unit of filter cell inside.But, thereby another kind of embodiment is arranged in the inner sensitivity that has improved response time and measurement and corrected action of filter housings with actuator and valve.

This correction action makes the filter liquor changed course from outlet 706, and flow back into housing 702 via recirculation circuit 710 being adjacent to some place filter 704 outsides, that valve 718 is positioned at.This makes the sediment of all accumulation all get rid of from the outer surface of filter 704.Such flushing can continue regular time length, for example 30 seconds.Passing through preset time week after date, processing unit 724 close with post command valve 712 and 718 and valve 732 open.Valve 744 is opened subsequently with dump circuit 710.Processing unit 724 will compare and contrast from signal and one group of known parameter of two sensors 720,722 then, and system reset this moment is to its sequence that flows forward/filter.

When flushing can not improve filtration (by keeping pressure differential in the regulation pressure differential range), processing unit 724 can be attempted remedial action (for example flushing) once more and measure once more and pressure differential and established standards are compared.

If this difference does not still belong in the prescribed limit, processing unit will be transformed into life termination mode 30 subsequently so, send the alarm (not shown), and indication operating personnel filter needs to change.

If when flushing made pressure differential be returned to acceptable value, then processing unit 724 return operations 10 just continued the differential pressure between

monitoring sensor

720 and 722.

In the different embodiment of a kind of this example, pressure sensor 720,722 is substituted by flow rate sensor.The flow rate of processing unit 724 monitoring this moment by filter is so that make its judgement about pattern conversion and remedial action aspect.Except this difference, the function of system and aforementioned content are equal to.In another embodiment, an independent flow rate sensor is arranged on the downstream of filter, and is subjected to the monitoring of processing unit 724.Processing unit 724 is not a difference of measuring flow rate, but processing unit 724 is only monitored the absolute flow rate by filter.

Embodiment 3-TFF filter

Tangential flow filter (TFF) is generally used for isolated protein from filter liquor.Because protein can stop up film, so fluid stream passes through film with tangential direction.Figure 11 a illustrates flowing of conventional filter, wherein direction of flow film surface or mobile perpendicular to the film surface.Figure 11 b illustrates the operation of TFF filter, and wherein flow in fluid and film surface tangently.This makes does not almost have particle to gather on the film, has reduced thus to stop up to take place.

Figure 12 shows traditional concentrated TFF system.Fluid from feeder trough 800 is pumped into TFF filter 810 and turns back to feeder trough 800 in circuitous path.The filter liquor that TFF filter 810 filters from fluid, and pass through filtrate flow 820 and the discharge system.Along with the continuation of this process, the concentration of trapped substance increases.In that fluid is during passing through on the filter film surface each time, institute's applied pressure forces a part of fluid to pass film and enters filtrate flow 820.The result is a gradient that forms input concentration, its wall condition (wall conditions) from the total concentration of channel center to the higher concentration of film surface.And pass and arrive the filter liquor side along with more fluid gradually, also exist a concentration gradient that exports (trapped substance) along feeding-passage length from entering the mouth to.

Figure 14 illustrates mentioned above flowing with stressed, and wherein parameter-definition is as follows:

Q _F: feed flow rate (L/h)

Q _R: trapped substance flow rate (L/h)

Q _f: filter liquor flow rate (L/h)

C _b: the concentration of component in the bulk solution (g/L)

C _w: the concentration of component of film surface (g/L)

C _F: the concentration of component in the filtrate flow (g/L)

TMP: cross on the described film and applied pressure (bar)

The pressure differential that transmembrane pressure (TMP) is defined as crossing over TFF film both sides.As shown in figure 12, it is the average pressure on the fluid side, is defined as the mean value of feeding pressure 830 and trapped substance pressure 840 usually, is lower than the pressure on the filter liquor side.

People recognize, TMP are maintained operation and the performance that can improve the TFF filter in certain scope.Usually, especially at the initial period of technology, very high wall concentration and serious film fouling can take place.In order to reduce the filter liquor flow rate and to make TMP can be controlled in a desired lower value of reliable TFF operation, must flow to filter liquor and control.

In a kind of filter operation of controlled flow, pump or valve 860 on the filter liquor pipeline are limited in a setting value with filtrate flow, as shown in figure 13.Except reducing filtrate flow keeping the enough slipstream, it produces pressure in the filter liquor pipeline feeding pressure and trapped substance pressure are maintained fixed constant with reduction TMP.

By monitoring feeding pressure and trapped substance pressure, just might judge the optimum pressure on the filter liquor side of filter.Adjust subsequently and leach liquid pump or valve 860 to reach this pressure.

After the typical operation of TFF filter being limited, will the use of autonomous TFF filter be illustrated below.

As shown in figure 15, filter 900 has a first sensor 920 and second sensor 922 that is installed in the filter film downstream that is installed on the filter film upstream side.Two sensors are all near the opposite side of filter, need not and contact membranes itself not preferably, so that do not make filtering function demote.For example they can be positioned at feed and the filter liquor passage contiguous with the filter opposite side.They can also be installed in two passages on any inwall or similar position.Two sensors 920,922 all can comprise a wireless telecommunications system, for example RFID label.An additional computational logic equipment such as PID controller or CPU 924, carries out communication with these two sensors 920,922.This CPU 924 can compare signal and the one group of known parameter from these two sensors 920,922 and contrast.Such as the wireless telecommunications system 926 that contains by valve or pump 914 or by wire communication, processing unit 924 can also control valve or pump 914.This wireless telecommunications system can be any suitable type, includes but not limited to RFID equipment, bluetooth equipment and Zigbee equipment.CPU 924 can activate or deactuate valve or pump 914 as required.Sensor 920,922 and processing unit 924 can be powered by remote control, for example by the induction Coupling device in the housing outlet.The wireless telecommunications system 926 of valve or pump 914 and valve or pump 914 self can be by the hardware lead power supplies of leading to the system power supply (not shown).

As indicated above, fluid is tangentially by the filter film top.Filter liquor is passed film and is become the part of filtrate flow.In some embodiments, this TFF filter does not need service action 12.But, in other embodiments, the processing unit in the TFF filter can be via sensor 920,922 pressure of continuous monitoring upstream and downstream.Based on the difference between these measured values, processing unit can control valve or pump 914, thereby controls downstream pressure and TMP indirectly.

Sometimes, may reach can not be by can't be by adjusting the degree that valve or pump 914 are corrected for upstream pressure or TMP.In this case, filter can forward regeneration mode 20 to, carries out one and corrects action.In one embodiment, filter has one or more piezoelectric devices on the film or near the film, and it can vibration when energising.In this embodiment, controller 924 can activate this piezoelectric device 930.These piezoelectric devices are positioned on the filter cell, preferably near or attached on the film.When being driven, these equipment 930 vibrates in response to electric current.The feasible particle that is accumulated on the film of the vibration that produces freely comes off and takes away with slipstream, has reduced the pressure of upstream thus.Although piezoelectric device has produced required vibration and made that thus the material of accumulation is loosening, can also use other mechanism or electronic equipment.For example, people's known protein matter is electropolar when being used for gel electrophoresis, therefore can protein be extracted out provisionally from the film surface by using an interim electromotive force.

If this situation takes place, processing unit 924 returns normal manipulation mode 10 subsequently.Yet if use the not success when removing particle of vibration or other method, processing unit can be attempted the regeneration action in one or many ground.If after the trial of pre-determined number, this action can not be removed particle, and processor 924 can be transformed into life termination mode 30.Under this pattern, processing unit is reported to the police to operating personnel, and is such as previously described.

In selectable layout, can use fluid to pass film to the back flush that feed side carries out from the filter liquor side, come to dredge the particle of being accumulated from the feed side surface of film.Leaching liquid pump 860 can antiport and draw back filter liquor and make it pass film.When needs or requirement realization back flush, material pump 850 both can cut out also and can be lowered rotating speed.The filter liquor of back flush subsequently is back to feeder trough by the trapped substance pipeline.As the selectable layout of another kind, cushioning liquid can and pass film and come film is carried out back flush from filter liquor side feed, thereby makes filter liquor not need to be filtered twice.

If after this took place, processing unit 924 returned normal manipulation mode 10 subsequently.Yet if back flush does not successfully remove particle, processing unit can be attempted the regeneration action in one or many ground.If after the trial of pre-determined number, this action can not be removed particle, and processor 924 can be transformed into the termination mode 30 in life-span.Under this pattern, processing unit is reported to the police to operating personnel, and is such as previously described.

Under each such situation, the present invention detects problem and this problem of alert operator.This alarm mechanism can be all kinds.In some embodiments, use the sense organ of the vision for example or the sense of hearing to report to the police.In these cases, LED can be lighted or equipment can send the sound and indicates the situation that must be intervened by operating personnel.In other embodiments, be transmitted wirelessly a remote control equipment about the information of mistake, this equipment receives this wireless transmission, and alert operator subsequently, for example finishes by a figure on video display unit.

Filter of the present invention is suitable for keeping the operating conditions of filter element, recovers under temporary transient erroneous condition, and reports uncorrectable error to operating personnel.

Processing unit can also detect the variation of the burst aspect flow rate and/or pressure, and this variation may hint an instantaneous mistake, for example material sputter.On the basis of this assumption, processing unit can use regeneration techniques to attempt addressing this problem, for example by promoting temperature.

At last, under the situation that plugged filter and processing unit can not be corrected, can send alarm, this means that this filter element needs repairing to operating personnel.

The above embodiments have shown several embodiments of the present invention.In whole embodiments, filter cell comprises processing unit and at least one sensor that can operate under three kinds of different modes.This sensor can be pressure sensor, temperature sensor, flow rate sensor, pH sensor or other any suitable type.In addition, this processing unit can be controlled at least one actuator, and this actuator uses during regeneration mode.In some embodiments, this processing unit can also be controlled at least one actuator, uses during the service action under the normal mode.It is pointed out that in some cases for example embodiment 1, processing unit, sensor and actuator all are comprised in filter interior.Under other embodiment, for example embodiment 2, and actuator and filter are placed apart., still be subjected to the control of the processing unit of filter interior.At last, in embodiment 3, an actuator is installed on the filter, and second actuator and filter are placed apart.

Term and wording are to be illustrative rather than definitive thereof as used herein, and other equivalents is not got rid of in the use of these terms and wording.It is also recognized that the various possible variation in the claim scope simultaneously.Other improvement, variation and selection also are possible.Therefore, just describe by way of example and unrestricted before.

Claims

1. autonomous filter plant comprises:

A. filter cell, this element have a film that passes through for fluid and have in order to support the housing of described film; And

B. at least one is positioned at the sensor of described filter cell, is suitable for monitoring at least one parameter relevant with described filter plant;

C, an alarm mechanism that is used for showing alarm to operating personnel; And

D, a processing unit, it is communicated with described sensor and described mechanism, and be suitable for controlling an actuator, wherein said processing unit is suitable for operating in three kinds of patterns each, wherein first kind of pattern is used for normal running, second kind of pattern is used to control described actuator, and the third pattern is used to activate described alarm mechanism.

2. as the element in the claim 1, wherein said actuator is selected from and comprises among the following group: piezoelectric device, electromotive force equipment, heating element heater, valve and pump.

3. as the element in the claim 1, wherein said processing unit is based on the output of described sensor and change between described pattern.

4. as the element in the claim 3, wherein when the output of described sensor was in outside the acceptable scope, described processing unit was transformed into described second kind of pattern from described first kind of pattern.

5. as the element in the claim 4, wherein said processing unit is controlled described actuator, and described actuator is suitable for influencing the described parameter by described sensor monitoring.

6. as the element in the claim 5, in the time of wherein within described signal of sensor is got back to acceptable scope, described processing unit is transformed into described first kind of pattern from described second kind of pattern.

7. as the element in the claim 5, wherein when the output of described sensor was not got back within the acceptable scope, described processing unit was transformed into described the third pattern from described second kind of pattern.

8. equipment that is used to discharge fluid, it comprises:

A. filter cell, this element have the film that passes through for fluid and in order to support the housing of described film; And

B. be positioned at the heating element heater of described filter cell, be suitable for heating described film.

9. as the equipment in the claim 8, wherein said equipment is suitable for discharging from container fluid.

10. as the equipment in the claim 9, wherein said fluid comprises gas.

11. as the equipment in the claim 8, it also comprises loop inductance, is suitable for energy of electromagnetic field is converted into electric power.

12. as the equipment in the claim 8, it also comprises first temperature sensor, is suitable for measuring the temperature of described filter cell.

13. as the equipment in the claim 12, it also comprises processing unit, is suitable for regulating the temperature of described filter cell.

14. as the equipment in the claim 13, wherein said processing unit is based on the temperature of regulating described filter cell from the data of described first temperature sensor.

15. as the equipment in the claim 14, wherein said adjusting comprises the electric current that changes by described heating element heater.

16. as the equipment in the claim 13, it also comprises pressure sensor, wherein said processing unit is based on from the data of described first temperature sensor and described pressure sensor and the temperature of regulating described filter cell.

17. as the equipment in the claim 16, wherein said processing unit compares described data and a predefined class value to regulate the temperature of described filter cell.

18. as the equipment in the claim 17, it also comprises memory element, a wherein said predefined class value is stored in the described memory element, and a described predefined class value comprises a phasor.

19. as the equipment in the claim 13, it also comprises second temperature sensor.

20. as the equipment in the claim 19, wherein said heating element heater and described filter cell are positioned between described first temperature sensor and described second temperature sensor, so that constitute flow rate sensor.

21. as the equipment in the claim 20, wherein said processing unit is based on measuring flow rate from the data of described first temperature sensor and second temperature sensor.

22. as the equipment in the claim 20, wherein said equipment comprises a plurality of flow rate sensors, the difference place measurement fluid that is suitable in described filter cell flows.

23. as the equipment in the claim 13, it comprises that also a current meter is used to measure the flow rate of described fluid.

24. as the equipment in the claim 23, wherein said equipment comprises a plurality of current meters, the difference place measurement fluid that is suitable in described filter cell flows.

25. as the equipment in the claim 13, it also comprises an alarm mechanism that is connected with described processing unit, wherein said processing unit is suitable for erroneous condition notifying operation personnel.

26. as the equipment in the claim 13, wherein said first temperature sensor is connected with described processing unit by wireless mode.

27. a method that prevents that filter cell from stopping up may further comprise the steps:

A, provide filter cell, this element has the film that passes through for fluid and supports the housing of this film and be positioned at the heating element heater that is suitable for heating described film of described filter cell; And

The temperature of the heating element heater in b, the described filter cell of adjusting is to minimize the cohesion on the described film.

28. as the method in the claim 27, it also comprises provides near the temperature sensor of described filter cell and the processing unit that is connected with described sensor and described heating element heater, described processing unit is suitable for accepting the data from described sensor.

29. as the method in the claim 28, wherein said heating element heater includes the resistive element that electric current passes through, and described processing unit is by changing the temperature of regulating described filter through the electric current of described heating element heater.

30. as the method in the claim 28, pressure sensor that provides near described filter cell also is provided for it, described pressure sensor also is connected with described processing unit.

31. as the method in the claim 30, wherein said processing unit will compare from the reading and a predefined class value of described pressure sensor and described temperature sensor, and based on the described electric current of relatively regulating by described heating element heater.

32. as the method in the claim 31, a wherein said predefined class value comprises a phasor.

33. the method that the filter cell situation is provided may further comprise the steps:

A, provide filter cell, this element has the film and the housing that supports this film that pass through for described fluid, be positioned at described filter cell and be suitable for heating the heating element heater of described film and lay respectively at described film and these both sides of described heating element heater on first temperature sensor and second temperature sensor and the processing unit that is connected with described sensor and described heating element heater;

B, based on the temperature difference between described first temperature sensor and described second temperature sensor monitoring flow rate by described film;

C, when flow rate is reduced to when being lower than predeterminated level, report to the police to operating personnel, described reduction has indicated described film blocked.

34. as the method in the claim 33, it also comprises when flow rate and being increased to when being higher than predeterminated level, reports to the police to operating personnel, the filter integrity existing problems have been indicated in described increase.