CN101874778A - Alpha-asarone spraying agent and preparation method thereof - Google Patents
Alpha-asarone spraying agent and preparation method thereof Download PDFInfo
- Publication number
- CN101874778A CN101874778A CN2009102733059A CN200910273305A CN101874778A CN 101874778 A CN101874778 A CN 101874778A CN 2009102733059 A CN2009102733059 A CN 2009102733059A CN 200910273305 A CN200910273305 A CN 200910273305A CN 101874778 A CN101874778 A CN 101874778A
- Authority
- CN
- China
- Prior art keywords
- alpha
- ararin
- asarone
- cosolvent
- spray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses an alpha-asarone spraying agent and a preparation method thereof. The alpha-asarone spraying agent is prepared from the following raw materials in parts by weight: alpha-asarone, a cosolvent, a stabilizer, a correctant, a bacteriostat and a solvent. The preparation method comprises the following steps: A. mixing, stirring and dissolving the cosolvent, the stabilizer, the correctant, the bacteriostat and the solvent; B. adding the alpha-asarone in the formula to solution in step A, and then stirring for dissolution; and C. filtering the solution in step B, filling according to 50ml/bottle, and then sealing to obtain the alpha-asarone spraying agent. The preparation method has simple and feasible preparation procedures, convenient operation, good product uniformity, strong quality control operability and stable product quality under a storage condition; and the method effectively solves the problems of low bioavailability and great toxic and side effects of asarone oral liquid and injection. The alpha-asarone spraying agent has convenient use and fast efficacy, and can be widely applied to anti-inflammation, relieving cough, eliminating phlegm and relieving asthma, tranquilizing, spasmolysis and epileptic seizure clinically.
Description
Technical field
The invention belongs to medical technical field, more specifically relate to a kind of alpha-ararin spray, relate to a kind of alpha-ararin spray preparing process simultaneously, be used for antiinflammatory, antitussive, eliminate the phlegm and relieving asthma, calm, spasmolytic and the large and small outbreak of epilepsy.
Technical background
Along with the change of people life style, (as excessively pursuing luxurious to indoor decoration; The excessive use of central air-conditioning) and mankind's activity to the pollution of environment, (as vehicle exhaust etc.) also has warming of global climate, all these affect generation, the propagation of human some diseases, and the mortality rate that the pollution of suchlike living environment makes respiratory tract disease cause progressively rises, and has become at present to cause dead " No.1 " killer.World Health Organization (WHO) classifies acquired immune deficiency syndrome (AIDS), diarrhoea, pulmonary tuberculosis, malaria and respiratory tract disease (as pneumonia) as 5 kinds of main infectious disease.
Asarone is that (α-Asarone) is the main effective ingredient of Chinese medicine Rhizoma Acori Graminei to alpha-ararin
[1]Since the sixties, the effective ingredient to the Acorus plant has carried out a large amount of comprehensive research both at home and abroad.Confirmed that it has very strong pharmacologically active, had cough-relieving, eliminate the phlegm, relieving asthma, calm, spasmolytic and anticonvulsant action.Diplococcus pneumoniae, staphylococcus aureus and colibacillary growth also there is inhibitory action in various degree
[3] [4]The monomer clinical practice of extracting is achieved good results in pneumonia, asthma, epilepsy grand mal etc.And, at present fully can the synthetic alpha-ararin, thus reduce cost, the probability of its mechanism of action of further understanding and indication scope has been arranged.
Its pharmacological action is: to antihistamine, acetylcholine, alleviate bronchospasm and play antiasthmatic effect, coughing centre is also had stronger inhibitory action; This product can cause that secretions increases, and makes thick sputum thinning, and it is viscid to reduce sputum, is easy to expectoration; This product has the bronchial smooth muscle effect that relaxes of similar aminophylline.This product can also improve corticocerebral electricity irritation threshold, suppresses the synapse conduction of electricity irritation and the diffusion of epilepsy electricity.
At present, the asarone kind of having gone on the market both at home and abroad has tablet, capsule and injection.Be mainly used in the treatment that pneumonia, bronchial asthma, chronic obstructive pulmonary disease companion cough, cough up phlegm, pant etc.Yet there are no mucosa delivery or other form of medication (as spraying, muscle administration or Orally disintegrating).
Summary of the invention
The objective of the invention is to be to provide a kind of alpha-ararin spray, have rapid-actionly, toxic and side effects is little, characteristics easy to use have avoided the injection side effect big, use and bring misery to the patient, oral formulations is then because first pass effect can not play a role medicine effectively.
Another object of the present invention is to be to provide a kind of alpha-ararin spray preparing process, this preparation process is simple, easy to operate, the product homogeneity is good, the quality control strong operability, product is stable under condition of storage, and it has solved effectively, and asarone is oral to be hanged down and toxic and side effects the earth problem with the injection bioavailability.
In order to realize above-mentioned purpose, the present invention adopts following technical measures:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials
Alpha-ararin 1-5
Cosolvent 5-25
Stabilizing agent 0.1-1
Correctives 0.01-1
Antibacterial 0.1-2
Solvent is to 100ml
Described alpha-ararin, its chemical name are α-1,2,4-trimethoxy-5-(1-acrylic) benzene, and its consumption is 1-5;
Described cosolvent is an amide-type, and as nicotiamide, amine is as ethylenediamine, meglumine, amino acids, as glycine, ornithine, nonionic surfactants, as tween 80, alcohols is as propylene glycol, Polyethylene Glycol, and beta-schardinger dextrin-, HP-, its addition are 5-25;
Described stabilizing agent is a sulfites, as sodium sulfite, sodium sulfite, enediol class, as vitamin C, sulfur-containing compound is as thioglycerol, thiourea, polyatomic phenol, amino acids, as L-cysteine, L-valine, and propyl gallate, tert-butyl alcohol p-hydroxyanisole, its addition is 0.1-1;
Described tender flavor agent is, the sweeting agent class, as Folium Stevlae Rebaudianae, cyclamate, sucralose, xylitol, fructose, the aromatic class, as Oleum Cinnamomi, oleum Citri sinensis, menthol, flavoring orange essence,, Fructus Citri Limoniae volatile oil, addition is 0.01-1%;
Described antibacterial is neutral class, as benzyl alcohol, and eucalyptus oil, acid and its esters, as benzoic acid, sodium benzoate, sorbic acid and salt thereof, methyl hydroxybenzoate, ethyl hydroxybenzoate, addition is 0.1-2.
Described solvent is a water, ethanol or both mixture.
A kind of alpha-ararin spray, it makes (preferable range) by the following weight parts raw material:
Parts by weight of raw materials
Alpha-ararin 1.5-4.5
Cosolvent 8-20
Stabilizing agent 0.2-1
Correctives 0.02-0.9
Antibacterial 0.3-1.8
Solvent is to 100ml
A kind of alpha-ararin spray, it makes (preferably scope) by the following weight parts raw material:
Parts by weight of raw materials
Alpha-ararin 2-4
Cosolvent 10-18
Stabilizing agent 0.4.-0.8
Correctives 0.05-0.7
Antibacterial 0.8-1.5
Solvent is to 100ml
A kind of alpha-ararin spray, it makes (optimum range) by the following weight parts raw material:
Parts by weight of raw materials
Alpha-ararin 3.5
Cosolvent 15
Stabilizing agent 0.8
Correctives 0.7
Antibacterial 1
Solvent is to 100ml
A kind of alpha-ararin spray preparing process the steps include:
A, the cosolvent in will filling a prescription, stabilizing agent, correctives, antibacterial and solvent are stirred to dissolving;
B, the alpha-ararin in will filling a prescription add the solution in the A step, are stirred to dissolving;
C, the solution in the B step is filtered, press the fill of 50ml/ bottle, seal, promptly.
The present invention compared with prior art has the following advantages and effect:
The alpha-ararin spray is owing to adopt the mucosa delivery mode, and local drug concentration height, medicine absorb rapidly in vivo, owing to not by gastrointestinal tract, avoided first pass effect, medicine can more effectively be played a role in vivo.This product adopts the lucifuge packing, and stability of drug is greatly improved.The spray delivery mode portably uses conveniently, patient's no pain; And oral formulations (tablet, capsule) reduces the interior bioavailability of body of medicine owing to the first pass effect of liver, and oral administration belongs to systemic administration, and the process that medicine arrives focus is longer, and onset is slow, and causes the gastrointestinal untoward reaction easily; Though bioavailability height in the drug administration by injection body, rapid-action, untoward reaction is bigger, and uses inconvenience, brings misery to the patient easily.This shows that the alpha-ararin spray can be clinical use a new approach is provided, and should have wide market application prospect.
The characteristics of alpha-asarone spraying agent are 1, this dosage form not all both at home and abroad; 2, asarone belongs to fat-soluble medicine, is fit to very much do spray-type; 3, the suitable indication of this dosage form all is some acute shallow diseases (as cough, asthma etc.), requires therapeutic process short, rapid-action (being similar to first aid a little); 4, this product use, easy to carry, no pain, patient's better tolerance.
The specific embodiment
Embodiment 1:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Tween 80 2500g
Sodium sulfite 50g
Mannitol 5g
Benzoic acid 50g
Water 50000ml
Asarone 500g.
A kind of alpha-ararin spray preparing process the steps include:
A, take by weighing tween 80, sodium sulfite, mannitol, benzoic acid in proportion and join in the 50000ml water, be stirred to dissolving;
B, the alpha-ararin in will filling a prescription add the solution in the A step, stir 20 minutes to dissolving in room temperature (20-25 ℃);
C, the solution in the B step is filtered, press the fill of 50ml/ bottle, seal, promptly.
Embodiment 2:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Tween 80 7500g
Sodium sulfite 125g
Mannitol 12.5g
Benzoic acid 125g
Water 50000ml
Asarone 1500g.
Its preparation process is identical with embodiment 1.
Embodiment 3:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Take by weighing nicotiamide 12500g
Sodium sulfite 250g
Mannitol 25g
Benzoic acid 250g
Water 50000ml
Asarone 2500g.
Its preparation process is identical with embodiment 1.
Embodiment 4:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Nicotiamide 2500g
Sodium sulfite 50g
Menthol 5g
Ethyl hydroxybenzoate 50g
Water 50000ml
Asarone 500g.
Its preparation process is identical with embodiment 1.
Embodiment 5:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
HP-7500g
Sodium sulfite 125g
Menthol 25g
Ethyl hydroxybenzoate 125g
Water 50000ml
Asarone 1500g.
Its preparation process is identical with embodiment 1.
Embodiment 6:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Glycine 12500g
Sodium sulfite 250g
Menthol 25g
Benzyl alcohol 250g
Water 50000ml
Asarone 2500g.
Its preparation process is identical with embodiment 1.
Embodiment 7:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Ethylenediamine 2500g
Sodium sulfite 500g
Menthol 500g
Sodium benzoate 1000g
Water 50000ml
Asarone 500g.
Its preparation process is identical with embodiment 1.
Embodiment 8:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Meglumine 7500g
Sodium sulfite 500g
Fructus Citri Limoniae volatile oil 5g
Methyl hydroxybenzoate 50g
Water 50000ml
Asarone 1500g.
Its preparation process is identical with embodiment 1.
Embodiment 9:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Ornithine 12500g
Sodium pyrosulfite 50g
Xylitol 5g
Sorbic acid 50g
Water 50000ml
Asarone 500g.
Its preparation process is identical with embodiment 1.
Embodiment 10:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Nicotiamide 2500g
Sodium pyrosulfite 50g
Fructose 5g
Benzyl alcohol 50g
Water 50000ml
Asarone 2500g.
Its preparation process is identical with embodiment 1.
Embodiment 11:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Propylene glycol 7500g
Sodium sulfite 50g
Menthol 5g
Sodium benzoate 50g
Water 50000ml
Asarone 500g.
Its preparation process is identical with embodiment 1.
Embodiment 12:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Polyethylene Glycol 2500g
Sodium sulfite 50g
Menthol 5g
Benzyl alcohol 50g
Water 50000ml
Asarone 1500g.
Its preparation process is identical with embodiment 1.
Embodiment 13:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Propylene glycol 12500g
Sodium pyrosulfite 50g
Cyclamate 5g
Sodium benzoate 50g
Water 50000ml
Asarone 500g.
Its preparation process is identical with embodiment 1.
Embodiment 14:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Beta-schardinger dextrin-2500g
Vitamin C 50g
Sucralose 5g
Methyl hydroxybenzoate 50g,
Water 50000ml
Asarone 1500g.
Its preparation process is identical with embodiment 1.
Embodiment 15:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
HP-12500g
Sodium sulfite 250g
Sucralose 5g
Ethyl hydroxybenzoate 50g
Water 50000ml
Asarone 2500g.
Its preparation process is identical with embodiment 1.
Embodiment 16:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Polyethylene Glycol 2500g
Vitamin E 50g
Folium Stevlae Rebaudianae 5g
Sodium benzoate 50g
Water 50000ml
Asarone 500g.
Its preparation process is identical with embodiment 1.
Embodiment 17:
A kind of alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials (g)
Polyethylene Glycol 7500g
Vitamin E 50g
Xylitol 25g
Eucalyptus oil 50g
Water 50000ml
Asarone 1500g.
Its preparation process is identical with embodiment 1.
Embodiment 18:
Pharmacodynamics test-antiasthmatic effect.Choose 50 of regular grade Hartley Cavia porcelluss, male and female half and half, body weight 150～200g divides 5 groups at random, 10 every group.Be made as large, medium and small 3 the dosage groups of model control group, budesonide positive controls and alpha-ararin spray (1.8mg/kg, 0.9mg/kg, 0.45mg/kg) respectively.With 10% ovalbumin normal saline solution sensitization, 13d begins spray delivery, continuously 3d.15d sucks to lure with the atomizing of 1% ovalbumin normal saline solution again and breathes heavily, and observes Cavia porcellus (being accurate to s) and the number of falling take place dyspneic incubation period, and the animal that asthma does not take place in the 6min is calculated by 6min incubation period.The result shows, sucks the alpha-ararin spray and all can the significant prolongation Cavia porcellus draws and breathe heavily incubation period, with model control group significant difference arranged relatively, has tangible antiasthmatic effect (P＜0.01, P＜0.05).
Table 1 alpha-ararin spray is to the influence of guinea pig bronchial asthma
Annotate: compare △ P＜0.05, ▲ P＜0.01 with model control group.
Embodiment 19:
Pharmacodynamics test-antitussive effect.Get 50 of Cavia porcelluss, male and female half and half, body weight 150～200g divides 5 groups at random, 10 every group.Be made as large, medium and small 3 the dosage groups of model control group, KETAI (0.078mg/kg) positive controls and alpha-ararin spray (1.8mg/kg, 0.9mg/kg, 0.45mg/kg) respectively.Administration group spray delivery, every day 1 time, 3d puts into glass bell jar with Cavia porcellus behind the last administration 1h, each 1 continuously.The ultrasound atomizer constant voltage sprays into 17.5% citric acid aerosol 10s, each treated animal cough latent period of observed and recorded, and the difference of administration group and matched group is compared in statistical disposition, and the result shows that the alpha-ararin spray can prolong cough latent period.Alpha-ararin spray height, in compare with model control group with low dose group that there were significant differences, have obvious antitussive effect.
Table 2 alpha-ararin spray to guinea pig cough's influence (± s, n=10)
Annotate: compare △ P＜0.05, ▲ P＜0.01 with model control group.
About with the comparison of injection result of use, because drug effect and route of administration are directly related, different preparations to medicine of the same race mainly are its intravital bioavailability of comparison, and injection is the interior bioavailability the highest (generally being 100%) of body in all preparations, therefore spray can't compare on this problem, and the characteristics of spray are to use conveniently, the local drug concentration height (because of medicine-feeding part in the part, and do not resemble tablet, capsule, injections etc. belong to the whole body administration), therefore relatively good for some acute shallow disease effects (as cough, asthma etc.), in addition because transdermal (or mucosa) absorption, do not pass through gastrointestinal tract, and the protective effect of mucosa is arranged, so untoward reaction is less; Using does not have misery yet, zest is arranged easily or cause inflammation in the injection site (as vasculitis) unlike injection.
Claims (5)
1. alpha-ararin spray, it is made by the following weight parts raw material:
Parts by weight of raw materials
Alpha-ararin 1-5
Cosolvent 5-25
Stabilizing agent 0.1-1
Correctives 0.01-1
Antibacterial 0.1-2
Solvent is to 100ml;
Described alpha-ararin is α-1,2,4-trimethoxy-5-(1-acrylic) benzene;
Described cosolvent is an amide-type: nicotiamide, amine is ethylenediamine, meglumine, amino acids is glycine, ornithine, and nonionic surfactants is that tween 80, alcohols are propylene glycol, Polyethylene Glycol and beta-schardinger dextrin-, HP-;
Described stabilizing agent is a sulfites: sodium sulfite, sodium sulfite, enediol class are that vitamin C, sulfur-containing compound are thioglycerol, thiourea, polyatomic phenol, amino acids is L-cysteine, L-valine, and propyl gallate, tert-butyl alcohol p-hydroxyanisole;
Described tender flavor agent is the sweeting agent class: Folium Stevlae Rebaudianae, cyclamate, sucralose, xylitol, fructose, aromatic class are Oleum Cinnamomi, oleum Citri sinensis, menthol, flavoring orange essence, Fructus Citri Limoniae volatile oil;
Described antibacterial is neutral class: benzyl alcohol, eucalyptus oil, acid and its esters are benzoic acid, sodium benzoate, sorbic acid and salt thereof, methyl hydroxybenzoate, ethyl hydroxybenzoate;
Described solvent is a water, ethanol or both mixture.
2. a kind of alpha-ararin spray according to claim 1 is characterized in that it is made by the following weight parts raw material:
Parts by weight of raw materials
Alpha-ararin 1.5-4.5
Cosolvent 8-20
Stabilizing agent 0.2-1
Correctives 0.02-0.9
Antibacterial 0.3-1.8
Solvent is to 100ml.
3. a kind of alpha-ararin spray according to claim 1 is characterized in that it is made by the following weight parts raw material:
Parts by weight of raw materials
Alpha-ararin 2-4
Cosolvent 10-18
Stabilizing agent 0.4.-0.8
Correctives 0.05-0.7
Antibacterial 0.8-1.5
Solvent is to 100ml.
4. a kind of alpha-ararin spray according to claim 1 is characterized in that it is made by the following weight parts raw material:
Parts by weight of raw materials
Alpha-ararin 3.5
Cosolvent 15
Stabilizing agent 0.8
Correctives 0.7
Antibacterial 1
Solvent is to 100ml.
5. the described a kind of alpha-ararin spray preparing process of claim 1 the steps include:
A, cosolvent, stabilizing agent, correctives, antibacterial and solvent are stirred to dissolving;
B, alpha-ararin is added solution in the A step, be stirred to dissolving;
C, the solution in the B step is filtered, press the fill of 50ml/ bottle, seal, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102733059A CN101874778A (en) | 2009-12-18 | 2009-12-18 | Alpha-asarone spraying agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102733059A CN101874778A (en) | 2009-12-18 | 2009-12-18 | Alpha-asarone spraying agent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101874778A true CN101874778A (en) | 2010-11-03 |
Family
ID=43017525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102733059A Pending CN101874778A (en) | 2009-12-18 | 2009-12-18 | Alpha-asarone spraying agent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101874778A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133212A (en) * | 2011-01-17 | 2011-07-27 | 北京世纪博康医药科技有限公司 | Asarone medical composition |
| CN102335132A (en) * | 2011-10-12 | 2012-02-01 | 中山大学 | Asarin inhalation aerosol and preparation method thereof |
| CN104666281A (en) * | 2015-03-12 | 2015-06-03 | 陈长潭 | Asarin aerosol inhalant and preparation method thereof |
| CN108066327A (en) * | 2016-11-11 | 2018-05-25 | 广州中大南沙科技创新产业园有限公司 | Alpha-ararin Foradil Aerolizer formoterol fumarate |
| CN110755414A (en) * | 2019-11-12 | 2020-02-07 | 南京华盖制药有限公司 | Arformoterol tartrate aerosol and preparation method thereof |
-
2009
- 2009-12-18 CN CN2009102733059A patent/CN101874778A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133212A (en) * | 2011-01-17 | 2011-07-27 | 北京世纪博康医药科技有限公司 | Asarone medical composition |
| CN102133212B (en) * | 2011-01-17 | 2012-10-31 | 北京世纪博康医药科技有限公司 | Asarone medical composition |
| CN102335132A (en) * | 2011-10-12 | 2012-02-01 | 中山大学 | Asarin inhalation aerosol and preparation method thereof |
| CN104666281A (en) * | 2015-03-12 | 2015-06-03 | 陈长潭 | Asarin aerosol inhalant and preparation method thereof |
| CN108066327A (en) * | 2016-11-11 | 2018-05-25 | 广州中大南沙科技创新产业园有限公司 | Alpha-ararin Foradil Aerolizer formoterol fumarate |
| CN110755414A (en) * | 2019-11-12 | 2020-02-07 | 南京华盖制药有限公司 | Arformoterol tartrate aerosol and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107789340B (en) | Solution preparation for andrographis paniculata aerosol inhalation and preparation method thereof | |
| CN101874778A (en) | Alpha-asarone spraying agent and preparation method thereof | |
| CN102389423A (en) | Medicinal composition containing ibuprofen sodium salt | |
| CN101801346A (en) | anti-insomnia compositions and methods | |
| CN101780038A (en) | Zolpidem tartrate oral spraying agent and preparation method thereof | |
| CN107789556A (en) | A kind of Juhong Tanke Neulized inhalation pharmaceutical solutions and preparation method thereof | |
| CN101396364B (en) | Zaleplon oral-cavity administration system or composition and preparation method thereof | |
| CN103462942B (en) | A kind of suction ambroxol hydrochloride solution | |
| CN102133175A (en) | Amygdalin gel and preparation method and medicinal application thereof | |
| CN105193837A (en) | Cream preparation for preventing and treating joint diseases and preparation method thereof | |
| CN100512829C (en) | Silktree albizzia general saponin and its extraction method, pharmaceutical use of the said composition and medicine preparation | |
| CN102240341A (en) | Asthma-relieving composite and preparation method and application thereof | |
| CN102283944A (en) | Technology for preparing novel integrated dosage form of lung heat expelling powder and production method thereof | |
| CN112999204A (en) | Shuanghuanglian aerosol inhalation solution preparation and preparation method thereof | |
| CN100493501C (en) | Scopolamine hydrobromide dry powder inhalant for nose and preparing method | |
| CN102008461A (en) | Ibuprofen drug composite for injection | |
| CN107773593A (en) | A kind of infantile heat-clearing and antitussive Neulized inhalation pharmaceutical solutions and preparation method thereof | |
| CN101920017B (en) | Composite for promoting glycyrrhetinic acid to realize percutaneous permeation | |
| CN103028095A (en) | Preparation technology and production method of integrated new dosage form of dry ginger and Radix aconiti lateralis preparata decoction | |
| CN109745460A (en) | A kind of fresh bamboo sap Neulized inhalation pharmaceutical solutions and preparation method thereof | |
| CN102526647A (en) | Preparation technology and production method of novel dual-purpose decoction integrated dosage form | |
| CN107616977A (en) | A kind of compound preparation for treating antimigraine and preparation method thereof | |
| CN102058613B (en) | The purposes of anti-tumor active ingredient compositions in Herba Solani Nigri | |
| CN113209056A (en) | Trollius chinensis solution preparation for aerosol inhalation and preparation method thereof | |
| CN101269108A (en) | Tripterygium wilfordii total terpene sustained-release dropping pill and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Open date: 20101103 |
|
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20101103 |