CN101870787B - Heat-resistance antibacterial polypropylene oral liquid medicament bottle and preparation method thereof - Google Patents
Heat-resistance antibacterial polypropylene oral liquid medicament bottle and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a heat-resistance antibacterial polypropylene oral liquid medicament bottle and a preparation method thereof. The medicament bottle is made of a polypropylene composite modified material which is prepared by blending 80 to 100 parts of high-melt strength polypropylene and 10 to 30 parts of impact-resistance polypropylene and 0.5 to 2 parts of nano antibacterial agent to modify the high-melt strength polypropylene. The preparation method solves the problems of low PP container production efficiency and uneven container wall thickness, and allows PP to replace PET to be used for making liquid medicament bottles (particularly oral liquid bottles). The medicament bottle of the invention has antibacterial effects on germs and moulds, can ensure that containers are sterile when used for packaging a medicament or food, and can keep antibacterial performance in a whole circulation process, prolong the quality guarantee period of the medicament and improve the medicament administration safety of patients.
Description
Technical field
The present invention relates to a kind of medicine bottle and preparation method thereof, particularly a kind of heat-resistance antibacterial polypropylene oral liquid medicament bottle and preparation method thereof.
Background technology
Along with the development of economy and technology, packing business demonstrates vitality in recent years.Medicine is protection because of its Main Function and improves human health, thereby the Main Function that has determined drug packaging is security, validity and the stability that guarantees for a long time under various conditions medicine.These several years, human to the concern of health and the enhancing of environmental consciousness because of technical progress, make drug packaging towards safer, more comprehensively with pollution-free future development.At present, the oral liquor medicine on the market, healthcare products packing are still used vial, PET bottle more than 90%, but above-mentioned packing has its congenital defect.As: vial is more crisp, and is broken easily, can not push, and makes troubles through production and transportation; Secondly, before can, must clean, dry, disinfect, both increase production cost, increase again the production management of drug manufacturing enterprise and the requirement of quality control.The anti-PET(polyethylene terephthalate that rushes is called for short PET) bottle can not guarantee it is sterile state in bottle manufacturing enterprise in this process of circulation of can medicine, this so that after the packing security of medicine can not be guaranteed fully.The quality guaranteed period of oral liquid similar drug is relatively short, and heavy dose of liquid oral medicine particularly owing to contain sugar in the medicine, therefore is easy to breed bacteria once making when toing many or too much for use, and patient's health is threatened.Adopt simultaneously PET bottle packing and since the PET material heat-drawn wire (under the 1.85Mpa) be 85 ℃, so when using PET bottle packing medicine, enterprises carries out can after can only carrying out the sterilization of medicine before can at normal temperatures, has increased the production cycle; On the other hand, can not adopt steam sterilizing to process behind the bottled good medicine of PET, this has just proposed very high requirement to production unit and environment, has increased production cost.The PP(polypropylene) has heat-resisting, good physics, chemical property and splendid Bc, can satisfy oral liquor medicine and under 121 ℃ of temperature, carry out the requirement that steam sterilizing was processed in 15 minutes.But because the specific heat capacity of PP is higher, be difficult in process of production heat radiation, cause the production efficiency of PP bottle than low about 25% of PET bottle; On the other hand, the molecular structure of PP has determined that its melt strength is low, the container became uneven of producing, and scrap rate is high; Again on the one hand, the rigidity of PP is low, the transparency is relatively poor.The drawbacks limit of above several respects the development of PP bottle on the pharmaceutical pack container be difficult to replace the PET bottle always.
Summary of the invention
Technical problem to be solved by this invention is to provide heat-resistance antibacterial polypropylene oral liquid medicament bottle that a kind of anti-microbial property is good, height is transparent, height is heat-resisting, production efficiency is higher and preparation method thereof, thereby overcomes the deficiencies in the prior art.
For solving the problems of the technologies described above, technical scheme of the present invention is as follows: heat-resistance antibacterial polypropylene oral liquid medicament bottle, this medicine bottle adopt the Composite Modification for Polypropylene material to make; Described Composite Modification for Polypropylene material rushes polypropylene (PP) and the nano antibacterial agent blending and modifying forms by high melt strength, propylene (HMSPP) with anti-, and its raw material forms and is by weight: 80～100 parts of high melt strength, propylenes, anti-10～30 parts of polypropylene, 0.5～2 part of the nano antibacterial agent of rushing.
In the above-mentioned heat-resistance antibacterial polypropylene oral liquid medicament bottle, the best group of each raw material becomes by weight: 90 parts of high melt strength, propylenes, anti-20 parts of polypropylene, 1 part of the nano antibacterial agent of rushing
In the aforesaid heat-resistance antibacterial polypropylene oral liquid medicament bottle, described nano antibacterial agent is the mixture of nano titanic oxide sol and nanometer silver, and the blending ratio of nano titanic oxide sol and nanometer silver is nano titanic oxide sol: nanometer silver=1～3:4～6.
In the aforesaid heat-resistance antibacterial polypropylene oral liquid medicament bottle, the optimum mixture ratio of nano titanic oxide sol and nanometer silver example is nano titanic oxide sol: nanometer silver=1:4.
The preparation method of aforementioned heat-resistance antibacterial polypropylene oral liquid medicament bottle.The method is that high melt strength, propylene (HMSPP), anti-polypropylene (PP), nano titanic oxide sol and the nanometer silver of rushing are mixed in proportion the single screw rod of rear usefulness or twin screw extruder blending and modifying, obtain the Composite Modification for Polypropylene material, then adopt this Composite Modification for Polypropylene material, according to the conventional preparation method of medicine bottle through plasticate, the technique such as injection moulding, blowing and demoulding makes the medicine bottle finished product.
The preparation method of above-mentioned heat-resistance antibacterial polypropylene oral liquid medicament bottle specifically, may further comprise the steps;
A, raw material prepare: take by weighing raw material high melt strength, propylene (HMSPP), anti-ly rush polypropylene (PP), nano titanic oxide sol and nanometer silver, and be mixed in proportion;
B, blending and modifying: mixed material is sent into single screw rod or twin screw extruder blending and modifying, obtain the Composite Modification for Polypropylene material; The extruder barrel temperature is followed successively by from the head to the feed opening: 215 ℃, 205 ℃, 195 ℃, 185 ℃, 175 ℃, 170 ℃;
C, plasticate, injection moulding: above-mentioned Composite Modification for Polypropylene material is plasticated under 150～180 ℃ of conditions, then sends into injecting preform in the injection moulding machine; The die temperature of injection moulding is 60 ℃;
D, blowing: forward blow molding station after injecting preform is just cold to and carry out the blowing typing, then send into the demoulding station demoulding, obtain finished product.
Beneficial effect of the present invention: high melt strength, propylene (HMSPP) is the polypropylene that a kind of resin contains long-chain branch, long-chain branch is initiation grafting in post polymerization, the melt strength of this homopolymer is to have 9 times of similar flow characteristics plain polypropylene homopolymer, in the density situation close with melt flow rate (MFR), the yield strength of high melt strength, propylene, modulus in flexure and heat-drawn wire and fusing point all are higher than plain polypropylene, but notched Izod impact strength is lower than plain polypropylene.High melt strength, propylene is under hot-forming temperature, and the sagging time is than the long 20～30s of plain polypropylene; Its melt strength is respectively than the melt strength of the homo-polypropylene with identical MFR large 102%～95%; The ability of its sag resistant almost is 2 times of general purpose polypropylene.They can moulding in wider temperature range, and especially Sag Resistance is fine, is suitable for vacuum forming processing.Because medicine bottle adopts the mode of blow molding behind the injection molding bottle embryo, the present invention adopts high melt strength, propylene to rush polypropene blendedly with anti-, and high melt strength, propylene provides the Sag Resistance of excellence, is conducive to blow molding; The anti-PP of punching then provides flowability to be beneficial to injection molding bottle embryo, and improves the impact property of matrix material.The present invention rushes polyacrylic different proportioning to the impact of system heat-drawn wire, Tc, crystallization velocity by the research high melt strength, propylene from anti-, draw high melt strength, propylene and anti-ly rush polyacrylic best proportion relation, thereby produce the PP liquid medicine bottle of the transparency height, good rigidly, low contraction, anti-boiling.The different usage ratios of simultaneously the present invention by research nano titanic oxide sol and nanometer silver are carried out the nano level dispersion of nano combined acquisition titanium dioxide in PP to the antibiotic ageing impact of PP bottle and nano titanic oxide sol and PP, and then become the crystallization behavior of nuclear effect regulation and control matrix material by its nanometer, significantly improved its thermotolerance and barrier.The present invention passes through the research nano antibacterial agent as the impact of nano material on the PP crystal property, and the different proportionings of the two have solved the dispersion problem of inorganic nano antiseptic in material of main part PP in the processing to the promoter action of PP bottle transparency.
The present invention adopts high melt strength, propylene (HMSPP) and the anti-PP of punching and nano titanic oxide sol to carry out blend coextrusion modification, utilize the nanometer of nano titanic oxide sol in PP to become nuclear effect, obtain the nano level nucleation site, the strain hardening capacity of HMSPP and higher Tc and short crystallization time, higher rigidity, production efficiency and the container wall thickness homogeneity question of producing the PP container have been solved all the time, obtain the heat-resisting PP matrix material of superelevation, make PP replace PET to become possibility at liquid medicine bottle (particularly oral liquid).Utilize the sanitation-grade nanometer silver that meets the food and medicine requirement that PP is carried out modification among simultaneously the present invention, give on the one hand medicine bottle and in environment for use, keep self cleaning by the breeding that suppresses microorganism, increased medicine particularly quality guaranteed period and the security of liquid oral medicine; Utilize on the other hand the nano material characteristic of inorganic nano-silver, in the moulding of PP, as nucleator it is carried out modification, increased thermotolerance, transparency, rigidity and the hardness of container, make wall of a container thick controlled, reduced material cost.PP liquid medicine bottle by above modification and the moulding of optimization Shooting Technique condition, has high strength, high transparent, suitable rigidity and hardness, can be anti-the characteristics of 110 ℃ of high temperature steamings sterilizations, also have the antibiotic and bacteriostatic action to various bacteria and mould, be particularly suitable for the packing of oral liquid.With respect to common PP, the PP material after the above modification has produces strong adaptability, characteristics that production efficiency is high, has reached the production efficiency suitable with PET, greatly reduces production cost.Product of the present invention is mainly used on the packing of oral medicinal liquor, healthcare products, can after the medicine can, carry out again the steam sterilizing sterilising treatment, avoid the secondary pollution risk that packing is brought after the sterilization, simplify simultaneously the pharmaceutical factory packet assembler, requirement to environment and equipment is lower, and production cost reduces.Employed inorganic nano-silver, the anti-biotic material of genus safety non-toxic
,Can inhibition and killing action be arranged to various bacteria and mould, like this oral liquid, the security of healthcare products after unlatching of large packing had higher guarantee, product can be used for food product pack simultaneously, can increase the quality guaranteed period of food.The present invention carries out physically modified by applying nano TiO 2 sol and nano silver antimicrobials to PP, by giving the PP material antibacterial and bactericidal property, the PP oral liquid medicine bottle that obtains has the function that the bacterium that will be bonded within a certain period of time on the plastics killed or suppressed its breeding, guarantee that medicine bottle is in sterile state when entering the enterprises packing, after drug packaging, has simultaneously lasting anti-microbial effect, guarantee the security of human consumer's medication, prolonged the quality guaranteed period of medicine.On the other hand, because the nano effect of nano titanic oxide sol so that after the modification PP material have heat-resisting, good physics, chemical property, barrier property and splendid Bc, can carry out hot filling with the PP bottle as the liquid oral pharmaceutical packing, improve the enterprises packaging efficiency, shorten wrapping cycle; The medicine bottle that obtains simultaneously can be 120 ℃ of steam sterilizings 15 minutes, and enterprises can adopt the mode of overall disinfection behind the packing medicine, has greatly improved the security of medicine and has prolonged the quality guaranteed period.This product is mainly used in the packing of liquid drug, particularly on the packing of liquid oral medicine, healthcare products, can realize
Medicine bottle is packed the medicine link and is in sterile state from producing to, improves the quality guarantee period of medicine;
Medicine bottle produces anti-microbial effect to bacterium and mould in patient's use procedure, guarantee the security of medication process;
Realize the overall disinfection of medicine and packaging material, for the pharmaceutical factory saves production cost;
Medicine is realized the sterilization process under the high heat in wrapping process, shorten sterilizing time, enhances productivity.This product can also be applied in food service industry, be mainly used in the packing of sauce based food, chilli products etc., the packaging field that replaces vial or PET bottle, can with realize medicine or food and the packing integral body sterilization process that carries out disinfection, save the production cost of enterprises or food enterprise, enhance productivity.Medicine bottle of the present invention carries out for meeting customer need, can guarantee that container is in sterile state when packing medicine or food, and give full play to its anti-microbial effect in the whole process of circulation, the quality guaranteed period of food prolongs greatly, guarantees the security of medicine and food.
Medicine bottle of the present invention also has the killing action of various bacteria, mould and suppresses the effect of its growth except the routine that satisfies YBB00082002 (liquid oral medical polypropylene bottle national standard) requires, and specific targets see the following form.
This product sees the following form with the performance comparison of PET bottle and common PP bottle.
Illustrate: because doleiform is different, used material weight is namely different, and unit cost is that supposition PET bottle is in the situation of 1 unit cost in the upper table, and the cost contrast the during use properties considering to reach same is a comprehensive measurement index.As can be seen from the above table, medicine bottle of the present invention has the anti-microbial effect to bacterium, mould, compares with common PP bottle, and its properties of transparency improves greatly, and near the PET bottle, and material cost is lower more than 20% than PET bottle to the barrier property of oxygen.Medicine bottle customer value of the present invention is high, have very strong market competition advantage, replace the PET liquid medicine bottle not only at cost larger advantage to be arranged with medicine bottle of the present invention, and to enlarging produce market, improve the market competitiveness, improving on the added value of product has very large advantage.
Medicine bottle of the present invention is to realize that its germ resistance is as major objective; guarantee when entering the drug packaging link, to be in sterile state; and all can play a role the whole process of its anti-microbial property when medicine uses to the patient from producing, guarantee the security of patient's medication.The design of this product is to reduce client's production cost and to improve its production efficiency as starting point, it adopts polypropylene as base-material, rather than carry out antibacterial modified to existing PET bottle, be because the PET material heat-drawn wire (under the 1.85Mpa) be 85 ℃, so when using PET bottle packing medicine, can only before can, carry out the sterilization of medicine, can not adopt steam sterilizing to process after installing medicine, this has just proposed very high requirement to production unit and environment, has increased production cost.And the PP bottle has heat-resisting, good physics, chemical property and splendid Bc, can carry out the overall disinfection sterilising treatment with medicine, and the security of medicine steps to a new level again when simplifying the pharmaceutical factory production process.If the pharmaceutical factory is being unwilling to change under the prerequisite of canning means simultaneously, then can the can temperature can be increased to more than 100 ℃ by improving sterilising temp, production efficiency improves greatly.Medicine bottle of the present invention carries out modification with nanometer silver and nano titanic oxide sol to PP, when giving PP medicine bottle anti-microbial property, utilizes the nano material characteristic of the two that PP is carried out the lifting of the transparency, obtains the PP liquid medicine bottle of high transparency and high heat resistance.Because the PP specific heat capacity is high, be difficult to absorb and heat dispersing than PET, cause common PP bottle than the production efficiency low nearly 25% of PET bottle, for these characteristics, the present invention is by high fondant-strength PP(HMSPP) PP is carried out modification, improved the Tc of system, shortened the crystallization time of system, made production efficiency near the production efficiency of PET bottle.And the PP quality is light, and the market value of PP material is lower than PET, and the comprehensive cost of the antibiotic PP liquid medicine bottle of high-barrier that therefore adopts above modification to obtain is also low than PET bottle.Concerning the manufacturing enterprise of this product, in the situation that reduces cost, can offer the more product of high-quality of client, enterprises need not increase the wrapping material purchase cost can obtain high performance wrapping material, realized enterprise and client and patient's multi-win pattern, therefore, can adopt this product to replace the PET bottle of now selling on the market fully.
Innovative point of the present invention: (1) carries out composite (determining best proportion relation) by nano titanic oxide sol and sodium rice silver, obtains the nano level of titanium dioxide in PP and disperses, and then regulate and control its crystallization behavior, obtains high heat resistance and high barrier.By blend, the processing condition of extruding, injecting are uniformly dispersed composite anti-biotic material in polypropylene, utilize nano titanic oxide sol to make up with the antibacterial ability of sodium rice money kind antiseptic-germicide for different bacteriums, obtain wide spectrum, stable, long-acting antimicrobial oral liquid medicine bottle, make medicine bottle self play the restraining and sterilizing bacteria effect from producing in the whole process that enters drug packaging, guarantee to be in sterile state when the packing medicine, the pharmaceutical factory does not need medicine bottle is carried out sterilising treatment again; Because the sustained release performance of nano silver antibacterial material can guarantee that medicine bottle all can keep anti-microbial property in the whole process of circulation, prolonged the quality guaranteed period of medicine simultaneously, patient's drug safety improves.The antimicrobial spectrum contrast of two kinds of anti-biotic materials sees the following form.
The PP medicine bottle of producing after the two is composite has the germ resistance of above two kinds of antiseptic-germicides concurrently, makes more wide spectrum of its germ resistance.(2) the present invention utilizes the nano material characteristic of nano antibacterial agent that PP is carried out modification simultaneously, make nano antibacterial agent in molding process, serve as the heterogeneous nucleation agent, crystallization to PP is controlled: according to the growth theory of crystal, PP size of crystal in crystallisation process depends on the size of its growing space, that is to say single crystal in process of growth until can stop growing when running into another crystal, the PP bottle mist degree of macrocrystal size is large, opaque.According to this theory, as long as nucleus quantity is abundant in the PP material, amount of crystals is just many, and crystal space in growth is little, and crystalline size is just little.The PP crystallization nucleating agent has been introduced in the adding of nano antibacterial agent, can make crystalline size below visible wavelength, greatly improves the transparency of PP bottle, makes it the transparency near PET, reaches oral liquid medicament bottle to the requirement of transparency.(3) the present invention carries out blending and modifying by using high melt strength, propylene (HMSPP) with the anti-PP of punching, the melt strength of increase system, utilize the tension strain sclerosis behavior of HMSPP, make the PP bottle in blow-moulding process, improve melt strength and the extensional viscosity of system, make the vertical property increase of refractory of system, distributing homogeneity is good; Improve simultaneously the Tc of system, shortened crystallization time, made goods at high temperature get final product the demoulding, greatly shortened molding time, reduced scrap rate.HMSPP, the anti-PP of punching and HMSPP/PP co-mixing system performance comparison see the following form.
Characteristics of the present invention: the goods properties of transparency that (1) obtains after the blend modification to the anti-PP of punching by composite nano germicide and HMSPP reaches the oral liquid medicament bottle standard-required, simultaneously can guarantee that every chamber throughput hourly reaches 1000 (common PP bottle can only reach per hour 600 in every chamber), near the throughput of PET; The PP bottle rigidity that obtains and hardness strengthen, and need not increase thickness and can reach the rigidity identical with PET when producing the liquid medicine bottle of 1000ml, greatly reduce material cost.The antibiotic PP bottle that obtains can improve the temperature of medicine sterilization 121 ℃ of lower boilings 15 minutes, shortens sterilizing time; Medicine and the sterilization of Medical Packing Materials overall disinfection can be realized in the pharmaceutical factory, and the quality guaranteed period of medicine is prolonged.Product mainly replaces the PET bottle to be used for the packing of liquid oral medicine, healthcare products, has the advantage that cost is low, performance is high with respect to the existing PET bottle that generally uses.(2) product is except the routine that satisfies YBB00082002 (liquid oral medical polypropylene bottle national standard) requires, and has killing and suppressing its growth of various bacteria, mould, and specific targets see the following form.
(3) the antibiotic medicine bottle of PP that obtains through above modification has excellent physicals and good processing characteristics, and specific targets are as follows: mist degree＜=15%; Tou Guang Shuais＞=and 80%; Hot texturing temperature＞=120 ℃; Tie brilliant Wen Du＞=120 ℃; The brilliant Shi Jian of Jie＜=1 second; Sheng produces Su, and Du＞=1000 bottles of every chambeies per hour; Cooking characteristic: 121 ℃ of lower boilings 15 minutes, bottle does not shrink indeformable.
Description of drawings
Fig. 1 is production technological process of the present invention.
The present invention is further illustrated below in conjunction with the drawings and specific embodiments.
Embodiment
Embodiment 1.Heat-resistance antibacterial polypropylene oral liquid medicament bottle, this medicine bottle adopt the Composite Modification for Polypropylene material to make; Composite Modification for Polypropylene material wherein rushes polypropylene (PP) and the nano antibacterial agent blending and modifying forms by high melt strength, propylene (HMSPP) with anti-, and its raw material forms and is by weight: 90 parts of high melt strength, propylenes, 20 parts of polypropylene, 1 part of nano antibacterial agent.Nano antibacterial agent is the mixture of nano titanic oxide sol and nanometer silver, and the blending ratio of nano titanic oxide sol and nanometer silver is nano titanic oxide sol: nanometer silver=1:4.Employed nano titanic oxide sol, sodium rice silver antibacterial agent are tested domestic and international authoritative health organ of the many families Test Application such as center, SGS, ITS by Chinese medicine prison, material non-toxic, to the person poultry safety.HMSPP, the PP that uses all through the FDA approval, belongs to food grade materials.High melt strength, propylene (HMSPP) refers to contain in the molecule polypropylene (PP) of long branched chain structure, and these long-chain branchs initiation grafting in post polymerization, the melt strength of this homopolymer are 9 times of plain polypropylene (PP).The preparation method of heat-resistance antibacterial polypropylene oral liquid medicament bottle of the present invention (as shown in Figure 1) may further comprise the steps; A, raw material prepare: take by weighing raw material high melt strength, propylene (HMSPP), anti-ly rush polypropylene (PP), nano titanic oxide sol and nanometer silver, and be mixed in proportion; B, blending and modifying: mixed material is sent into the twin screw extruder blending and modifying, obtain the Composite Modification for Polypropylene material; The extruder barrel temperature is followed successively by from the head to the feed opening: 215 ℃, 205 ℃, 195 ℃, 185 ℃, 175 ℃, 170 ℃; C, plasticate, injection moulding: above-mentioned Composite Modification for Polypropylene material is plasticated under 150～180 ℃ of conditions, then send into injecting preform in the injection moulding machine, the injection mold temperature is 60 ℃; D, blowing: forward blow molding station after injecting preform is just cold to and carry out the blowing typing, then send into the demoulding station demoulding, obtain finished product.
Embodiments of the present invention are not limited to above-described embodiment, and the various variations of making under the prerequisite that does not break away from aim of the present invention all belong within protection scope of the present invention.
Claims (5)
1. a heat-resistance antibacterial polypropylene oral liquid medicament bottle is characterized in that: this medicine bottle employing Composite Modification for Polypropylene material making; Described Composite Modification for Polypropylene material is by high melt strength, propylene and anti-ly rush polypropylene and the nano antibacterial agent blending and modifying forms, and its raw material forms and is by weight: 80～100 parts of high melt strength, propylenes, anti-10～30 parts of polypropylene, 0.5～2 part of the nano antibacterial agent of rushing; The density of described high melt strength, propylene is 0.91g/cm
3, melt flow rate (MFR) is 2.0g/10min, and tensile yield strength is 40Mpa, and modulus in flexure is 2206Mpa, and heat-drawn wire 455Kpa is 135 ℃, and fusing point is 168 ℃, and Tc is 125 ℃, and crystallization time is 0.7min, shock strength is 2.0; It is anti-that to rush polyacrylic density be 0.90g/cm
3, melt flow rate (MFR) is 8.0 g/10min, and tensile yield strength is 17Mpa, and modulus in flexure is 1200Mpa, and heat-drawn wire 455Kpa is 110 ℃, and fusing point is 157 ℃, and Tc is 107 ℃, and crystallization time is 2.3min, shock strength is 50; Described nano antibacterial agent is the mixture of nano titanic oxide sol and nanometer silver, and the blending ratio of nano titanic oxide sol and nanometer silver is nano titanic oxide sol: nanometer silver=1～3:4～6.
2. heat-resistance antibacterial polypropylene oral liquid medicament bottle according to claim 1 is characterized in that: raw material forms and is by weight: 90 parts of high melt strength, propylenes, anti-20 parts of polypropylene, 1 part of the nano antibacterial agent of rushing.
3. heat-resistance antibacterial polypropylene oral liquid medicament bottle according to claim 1, it is characterized in that: the blending ratio of nano titanic oxide sol and nanometer silver is nano titanic oxide sol: nanometer silver=1:4.
4. such as the preparation method of the described heat-resistance antibacterial polypropylene oral liquid medicament bottle of any one in the claim 1～3, it is characterized in that: high melt strength, propylene, anti-polypropylene, nano titanic oxide sol and the nanometer silver of rushing are mixed in proportion the rear twin screw extruder blending and modifying of using, obtain the Composite Modification for Polypropylene material, then adopt this Composite Modification for Polypropylene material, according to the conventional preparation method of medicine bottle through plasticate, injection moulding, blowing and releasing process make the medicine bottle finished product.
5. the preparation method of heat-resistance antibacterial polypropylene oral liquid medicament bottle according to claim 4 is characterized in that: may further comprise the steps;
A, raw material are prepared: take by weighing raw material high melt strength, propylene, anti-polypropylene, nano titanic oxide sol and the nanometer silver of rushing, be mixed in proportion;
B, blending and modifying: mixed material is sent into the twin screw extruder blending and modifying, obtain the Composite Modification for Polypropylene material; The extruder barrel temperature is followed successively by from the head to the feed opening: 215 ℃, 205 ℃, 195 ℃, 185 ℃, 175 ℃, 170 ℃;
C, plasticate, injection moulding: above-mentioned Composite Modification for Polypropylene material is plasticated under 150～180 ℃ of conditions, then send into injecting preform in the injection moulding machine, the injection mold temperature is 60 ℃;
D, blowing: forward blow molding station after injecting preform is just cold to and carry out the blowing typing, then send into the demoulding station demoulding, obtain finished product.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1397591A (en) * | 2002-08-15 | 2003-02-19 | 上海交通大学 | Process for preparing photodegradable antibacterial polyolefine plastics |
| CN101089038A (en) * | 2007-06-08 | 2007-12-19 | 深圳市科聚新材料有限公司 | Antibacterial polypropylene material and its prepn process |
| CN101205329A (en) * | 2006-12-20 | 2008-06-25 | 上海日之升新技术发展有限公司 | High-effectively antibiotic polypropylene master batch and preparation thereof |
| CN101519512A (en) * | 2009-03-24 | 2009-09-02 | 山东威高集团医用高分子制品股份有限公司 | Polypropylene composite material |
| WO2010049371A1 (en) * | 2008-10-27 | 2010-05-06 | Borealis Ag | Extrusion blown molded bottles with high stiffness and transparency |
| WO2010074394A2 (en) * | 2008-12-26 | 2010-07-01 | 호남석유화학 주식회사 | Polypropylene resin compositions having high melt tension and method for preparing the same |
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2010
- 2010-07-20 CN CN2010102314626A patent/CN101870787B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1397591A (en) * | 2002-08-15 | 2003-02-19 | 上海交通大学 | Process for preparing photodegradable antibacterial polyolefine plastics |
| CN101205329A (en) * | 2006-12-20 | 2008-06-25 | 上海日之升新技术发展有限公司 | High-effectively antibiotic polypropylene master batch and preparation thereof |
| CN101089038A (en) * | 2007-06-08 | 2007-12-19 | 深圳市科聚新材料有限公司 | Antibacterial polypropylene material and its prepn process |
| WO2010049371A1 (en) * | 2008-10-27 | 2010-05-06 | Borealis Ag | Extrusion blown molded bottles with high stiffness and transparency |
| WO2010074394A2 (en) * | 2008-12-26 | 2010-07-01 | 호남석유화학 주식회사 | Polypropylene resin compositions having high melt tension and method for preparing the same |
| CN101519512A (en) * | 2009-03-24 | 2009-09-02 | 山东威高集团医用高分子制品股份有限公司 | Polypropylene composite material |
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| CN101870787A (en) | 2010-10-27 |
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