CN101863808B - New preparation method for important fenticonazole nitrate intermediate - Google Patents
New preparation method for important fenticonazole nitrate intermediate Download PDFInfo
- Publication number
- CN101863808B CN101863808B CN200910082255.6A CN200910082255A CN101863808B CN 101863808 B CN101863808 B CN 101863808B CN 200910082255 A CN200910082255 A CN 200910082255A CN 101863808 B CN101863808 B CN 101863808B
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- CN
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- Prior art keywords
- compound
- formula
- reaction
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- fenticonazole nitrate
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229960001337 fenticonazole nitrate Drugs 0.000 title abstract description 11
- FJNRUWDGCVDXLU-UHFFFAOYSA-N fenticonazole nitrate Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1C(OCC=1C=CC(SC=2C=CC=CC=2)=CC=1)CN1C=NC=C1 FJNRUWDGCVDXLU-UHFFFAOYSA-N 0.000 title abstract description 11
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 150000001875 compounds Chemical class 0.000 claims abstract description 34
- 230000000977 initiatory effect Effects 0.000 claims abstract description 3
- 238000006243 chemical reaction Methods 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 10
- 239000012043 crude product Substances 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 6
- -1 N-halogenated succinimide imide Chemical class 0.000 claims description 5
- 238000005286 illumination Methods 0.000 claims description 5
- 238000004821 distillation Methods 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000003568 thioethers Chemical class 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 230000035484 reaction time Effects 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 4
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract description 3
- RBDDRTHNIQZYPD-UHFFFAOYSA-N 2-[4-(chloromethyl)phenyl]thiophene Chemical compound C1=CC(CCl)=CC=C1C1=CC=CS1 RBDDRTHNIQZYPD-UHFFFAOYSA-N 0.000 abstract description 2
- ZZLCFHIKESPLTH-UHFFFAOYSA-N 4-Methylbiphenyl Chemical group C1=CC(C)=CC=C1C1=CC=CC=C1 ZZLCFHIKESPLTH-UHFFFAOYSA-N 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical class O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000002904 solvent Substances 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical class [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 2
- 239000003429 antifungal agent Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000000967 suction filtration Methods 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- 238000010189 synthetic method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 229940073608 benzyl chloride Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910082255.6A CN101863808B (en) | 2009-04-20 | 2009-04-20 | New preparation method for important fenticonazole nitrate intermediate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN200910082255.6A CN101863808B (en) | 2009-04-20 | 2009-04-20 | New preparation method for important fenticonazole nitrate intermediate |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101863808A CN101863808A (en) | 2010-10-20 |
CN101863808B true CN101863808B (en) | 2014-05-07 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910082255.6A Active CN101863808B (en) | 2009-04-20 | 2009-04-20 | New preparation method for important fenticonazole nitrate intermediate |
Country Status (1)
Country | Link |
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CN (1) | CN101863808B (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3242193A (en) * | 1961-03-13 | 1966-03-22 | Merck & Co Inc | Indolyl aliphatic acids |
CN101195575A (en) * | 2006-12-08 | 2008-06-11 | 西北师范大学 | process for producing (E)-3-dimethoxy-4'-acetoxy diphenyl ethylene |
-
2009
- 2009-04-20 CN CN200910082255.6A patent/CN101863808B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3242193A (en) * | 1961-03-13 | 1966-03-22 | Merck & Co Inc | Indolyl aliphatic acids |
CN101195575A (en) * | 2006-12-08 | 2008-06-11 | 西北师范大学 | process for producing (E)-3-dimethoxy-4'-acetoxy diphenyl ethylene |
Non-Patent Citations (3)
Title |
---|
李丽娟,叶昌伦.卤取代反应.《药物合成反应技术与方法》.化学工业出版社,2005, * |
相转移催化法合成硝酸芬替康唑;陈宝泉;《中国药物化学杂志》;20070228;第17卷(第1期);第52-53页 * |
陈宝泉.相转移催化法合成硝酸芬替康唑.《中国药物化学杂志》.2007,第17卷(第1期), |
Also Published As
Publication number | Publication date |
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CN101863808A (en) | 2010-10-20 |
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Effective date of registration: 20201202 Address after: No. 279 Nanhai Road, Xiuying District 570314 Hainan city of Haikou Province Patentee after: AVENTIS PHARMA (HAINAN) Co.,Ltd. Address before: 100097, Wanquan mansion, 3 Jin Zhuang, Haidian District, Beijing, Sijiqing Patentee before: BEIJING D-VENTUREPHARM TECHNOLOGY DEVELOPMENT Co.,Ltd. |
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DD01 | Delivery of document by public notice |
Addressee: Song Xuemei Document name: Notice of conformity |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A New Preparation Method for Important Intermediate of Nitrofenticonazole Nitrate Granted publication date: 20140507 Pledgee: Sanya Rural Commercial Bank Co.,Ltd. Pledgor: AVENTIS PHARMA (HAINAN) Co.,Ltd. Registration number: Y2024980014810 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |