CN101862422B - Chinese medicinal composition for removing internal damp-heat and application thereof in relieving alcoholism and preserving health - Google Patents
Chinese medicinal composition for removing internal damp-heat and application thereof in relieving alcoholism and preserving health Download PDFInfo
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Abstract
The invention provides a Chinese medicinal composition for removing internal damp-heat and belongs to the field of Chinese medicaments. Raw materials such as wrinkled gianthyssop herb, coix seed, Indian buead, gardenia and citron are combined so that the effects of the medicaments cooperate with one another to act the effects of resolving dampness, excreting dampness and eliminating dampness, promoting the circulation of qi, tonifying spleen and normalizing the functions of the stomach and spleen, clearing away heat, purging intense heat and clearing away dampness and removing damp-heat of liver, gallbladder, spleen and stomach. Clinical tests prove that the Chinese medicinal composition plays a role in removing damp-heat from liver, gallbladder, spleen and large intestine and the damp-heat from a drinker. Since the composition takes wrinkled gianthyssop herb, coix seed, Indian buead, gardenia and citron which are medicinal and edible as the raw materials, the composition has no toxic or side effect, does not cause secondary damage to a human body and is a good health-care product for relieving alcoholism and removing damp-heat.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine composition that is used for removing internal damp-heat; The invention still further relates to the application of this Chinese medicine composition in dealcoholization health-preserving.
Technical background
" dampness " " steam " is that recent two decades comes the popular a kind of noun of southern china, and promptly damp and hot gas influences human body physiological function and a series of symptoms and the sign that occur in the body.Press differential diagnosis in tcm and sort out genus " liver and gall taste damp-heat in the large intestine ", having a strong impact on health.
It is a lot of that " damp-heat " produces reason, is summarized as follows:
1. region factor: southern china ground vapour heat, aqueous vapor are hot.
2. physical factors: because human body difference is contained from the gas of health endogenous dampness heat partially.
3. dietary factor: acidophilia's food, greasy meat, sweet food and fried food, pluck, seafood and other unclean food partially, dinner overfeed or too assorted or too late or too full.
4. it is irregular to live: irregularity in daily life, operating pressure are greatly or too easy.
5. climatic factor: weather is variable, biological clock is upset in atmospheric pollution.
6. emotional factor: the miscellaneous nothing fixed number of emotion, life lacks happiness, upsets biological clock.
7. tonic uses too assorted too much.
8. physical work or quantity of motion reduce.
9. be addicted to drink.
Above-mentioned factor causes taste liver and gall large intestine function reduction, and as if removing dampness effectively, eliminating dampness by diuresis, dampness removing, then hot and suffocating for a long time lighting a fire impels damp-heat to spread unchecked.
The clinical manifestation that damp-heat occurs:
1. bitter taste, mouthful sticking, xerostomia, mouthful in tart flavour, mouthful in steam, mouthful in dry and astringent, or white and greasy fur or yellow greasy, thick fur are prone to get angry.
2. canthus secretions is many, blurred vision, vexed or head is wrapped up in like thing or is nose heave, dreaminess or bad dream, drowsiness, sleep do not recover from fatigue or have a sleepless night, scorching in the heart.
3. feel sick or tending to vomit or anorexia or have a liking for food and stimulate food, feeling thirst but no desire to drink or polydipsia are had a nasty taste or are not had hunger sensation.
4. uncomfortable in chest, abdominal distention, borborygmus.
5. constipation with dry stool or loose stool, burning sensation of the anus after an action of the bowels, feces is filthy, defecation is not well.
6. skin surface heating but body temperature is normal or not smooth tired or the spiritual not good enough or bradykinesia of sweating.
7. the women then shows as the unusual or gynecological inflammation of leukorrhagia.
Drinking is a kind of culture, a kind of especially life attitudes.Have dual character but drink, no matter Chinese liquor, red wine or medicated beer, the excessive gas that all can produce liver and gall taste damp-heat in the large intestine of drinking very then causes alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis, but also can cause taste liver and gall large intestine function reduction.Therefore drink and directly can cause occurring the clinical manifestation of above-mentioned damp-heat.
Be used for the antialcoholic medicine at present and totally can be divided into three kinds of chemical drugss, Chinese medicine preparation, health product, its sober-up function has relation with property of medicine speed.
Chemical drugs: be mostly compositions such as analeptic, vitamin and aminoacid, can play fast relieve the effect of alcohol, sobering-up functions, but most chemical drugs relieving mechanism is only to promote ethanol to decompose, and plays temporary mitigation, is difficult to play liver protection effect.As: the RU21 of KGB antialcoholic drug, the powerful Soboring-up liver-protecting ball of the companion of wine, wine does not have kinds such as the end.
Chinese medicine preparation: mostly composition is Semen Hoveniae (Fructus Hoveniae), flower of Radix Puerariae, the Radix Paeoniae Alba, Semen Myristicae, and these Chinese medicines can play fine antialcoholism action, the effect of whole body conditioning simultaneously, but effect is slow a little.Be free from side effects, also liver and gall diseases had better curative effect simultaneously at Dealcoholic sobering-up.As: the relieving alcoholism and protecting the liver ball, the king's sheet of sobering up, Chinese medicine preparation such as flower of Radix Puerariae, Fructus Tsaoko, Rhizoma Alpiniae Officinarum, Flos Chrysanthemi, Caulis Bambusae In Taenia, Radix Sophorae Flavescentis, Semen Myristicae also can finely relieve the effect of alcohol.
Health product: the health product of the relieving alcoholism and protecting the liver of selling on the market now are a lot, should these effects be limited.Mostly the relieving alcoholism and protecting the liver medicine is Chinese patent medicine, and composition still is Flos puerariae lobatae, Radix Puerariae, the Radix Paeoniae Alba, Radix Bupleuri, Semen Hoveniae (Fructus Hoveniae), Fructus Mori and rich selenium wild camellia etc., and these Chinese medicines truly have the relieving alcoholism and protecting the liver effect.
It should be noted that the somebody is a deficiency of liver-YIN, the somebody is hot-tempered, and the medication effect is just different.Also have part producer to add diuretic, analeptic, hormone etc. inside at antialcoholic drug, these compositions people eaten can feel in the later short time to regain consciousness, excited, appetite holds greatly, but takes for a long time injuring health.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition that is used for removing internal damp-heat.
Another object of the present invention provides the application of this Chinese medicine composition in dealcoholization health-preserving.
The present invention is used for the Chinese medicine composition of removing internal damp-heat, is to be crude drug with Herba Pogostemonis, Semen Coicis, Poria, Fructus Gardeniae, Fructus Citri, and the oral preparations that is prepared into by the common process and the adjuvant of pharmaceutics.
Herba Pogostemonis, hot, tepor are returned spleen, stomach, lung meridian, removing dampness, expelling summer-heat, preventing or arresting vomiting.Usually the clinical retention of dampness in middle-JIAO card that is used for, syndrome of summer-heat-dampness, hygropyrexia card, vomiting card." Bencao Tujing ": " control taste and tell contraryly, be the medicine of wanting most." " book on Chinese herbal medicine justice ": " and Herba Pogostemonis ... can dispel the haze damp, and help taste healthy energy is the wet spleen resistance that is stranded, fatigue and weakness, and diet is bad, and the turbid dirty person of tongue fur is the medicine of victory.”
Semen Coicis, sweet, light, be slightly cold, return spleen, stomach, lung meridian, promoting diuresis to eliminate damp pathogen, spleen invigorating, eliminating impediment, clearing away heat and discharging pus.Clinically can be used in diarrhea due to hypofunction of the spleen, acute appendicitis, the humidity hysteresis burnt card." herbal steel order ": " Semen Coicis, positive bright medicine also can invigorating spleen and reinforcing stomachs." " book on Chinese herbal medicine newly organized ": " all persons that is contained in the lower part of the body of wetting should use it for the kind diuretic of Semen Coicis, the gas of its moon of unlikely consume.”
Poria, sweet, light, flat, GUIXIN, spleen, kidney channel, are calmed the nerves at promoting diuresis to eliminate damp pathogen, spleen invigorating.The clinical water damp syndrome that is used for more, the spleen-asthenia with excessive damp card." medicineization justice ": " Poria is diuretic dehumidifying key medicine the most, and book is said spleen invigorating, promptly water go and spleen from strong meaning also." " generation is mended the vegetarian medical book ": " Poria can be gone wet again.”
Fructus Gardeniae, bitter, cold, GUIXIN, lung, stomach, tri-jiao channel, pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Be used for dampness-heat in the liver and gallbladder pent-up card, be used for calentura vexed, gloomy, do not bother rather card.Modern study has hepatic cholagogic, strengthens pancreas resistance against diseases, antipyretic and anti-inflammatory effect, can treat acute, chronic hepatitis and fever of children.
Fructus Citri, liver, spleen, lung meridian are returned in hot, bitter, acid, warm, liver-smoothing, qi-regulating and in reduce phlegm.Be used for stagnation of liver-QI and stomach-QI, breast side of body disorder of QI, gastral cavity abdomen feeling of fullness, vomiting eructation, abundant expectoration cough.Modern scientific research has the antiinflammatory antivirus action, can be used for treating superficial gastritis.
The present invention is that raw material makes up with Herba Pogostemonis, Semen Coicis, Poria, Fructus Gardeniae, Fructus Citri, and it is collaborative that the effect of each medicine is produced, play altogether its removing dampness eliminating dampness by diuresis dampness removing, circulation of qi promoting spleen invigorating and in, the effect of clearing away heat-fire diuretic, and then the gas of dispeling liver and gall taste damp-heat in the large intestine.
Lot of test and clinical summary find, each crude drug of Chinese medicine composition of the present invention in the scope of following weight portion, effective removing internal damp-heat:
1～5 part of Herba Pogostemonis, 1～5 part of Semen Coicis, 1～5 part in Poria, 1～5 part of Fructus Gardeniae, 1～5 part of Fructus Citri.
Optimum ratio: 2～3 parts of Herba Pogostemoniss, 2～3 parts of Semen Coiciss, 2～3 parts in Poria, 2～3 parts of Fructus Gardeniaes, 2～3 parts of Fructus Citris.
Chinese medicine composition of the present invention can be prepared into various oral preparations by the common process and the adjuvant of pharmacy of Chinese materia medica.Like capsule, tablet, granule, powder, pill (comprising the watered pill, honeyed pill, dragee, soft gelatin capsule, enteric coated pill or drop pill) or oral liquid.
Be the clinical test results of Chinese medicine composition removing internal damp-heat of the present invention below.
1, clinical observation object
1. xerostomia or bitter taste or mouth odor, thick fur or greasy in vain or yellow greasy person: observe 20 examples, wherein man, each 10 example of women are the adult entirely.
2. canthus secretions is many, and blurred vision, vexed or head as thing wrap up in, nose heave, dreaminess or bad dream, drowsiness, sleep do not recover from fatigue or have a sleepless night, scorching person in the heart: observe 20 examples, wherein male, women is 10 examples respectively, are the adult entirely.
3. feel sick or tending to vomit or anorexia or have a liking for food and stimulate food, feeling thirst but no desire to drink or polydipsia, have a nasty taste or the person that do not have the hunger sensation: observe 20 examples, wherein man, each 10 example of women are the adult entirely.
4. constipation with dry stool or loose stool, burning sensation of the anus after an action of the bowels, feces is filthy, the not well person of defecation: observe 20 examples, wherein man, each 10 example of women are the adult entirely.
5. skin surface heating but body temperature is normal or not smooth tired or the spiritual not good enough or bradykinesia person of sweating: observe 20 examples, wherein man, each 10 example of women are the adult entirely.
2, Therapeutic Method
Capsule medicine of the present invention: every 0.25g.Method for using: 3 times on the one, once obey 4.Serveing on 15 days is a course of treatment, observes for 3 courses of treatment at most.Eat meat product and seafood during the treatment less, alcohol prohibition.Effect is judged: clinical manifestation all eliminate and follow up a case by regular visits to 1 year not the recidivist be recovery from illness; Though eliminate 30% or more and follow up a case by regular visits to recurrence in 1 year but more preceding alleviator for effective; Other is invalid.
3, therapeutic outcome
1. xerostomia or bitter taste or mouth odor, thick fur or greasy in vain or yellow greasy person: 17 examples of fully recovering account for 85%; Effective 3 examples account for 15%; Invalid 0 example.
2. canthus secretions is many, blurred vision, vexed or head as thing wrap up in, nose heave, dreaminess or bad dream, drowsiness, sleep do not recover from fatigue or have a sleepless night, scorching person in the heart: 16 examples of fully recovering account for 80%; Effective 3 examples account for 15%; Invalid 1 example accounts for 5%.
3. feel sick or tending to vomit or anorexia or have a liking for food and stimulate food, feeling thirst but no desire to drink or polydipsia, have a nasty taste or the person that do not have the hunger sensation: 18 examples of fully recovering account for 90%; Effective 2 examples account for 10%; Invalid 0 example.
4. constipation with dry stool or loose stool, burning sensation of the anus after an action of the bowels, feces is filthy, the not well person of defecation: 14 examples of fully recovering account for 70%; Effective 3 examples account for 15%; Invalid 3 examples account for 15%.
5. skin surface generates heat or not smooth tired or the spiritual not good enough or bradykinesia person of sweating: 13 examples of fully recovering, account for 65%, and effective 7 examples account for 35%; Invalid 0 example.
Above-mentioned clinical trial shows, damp-heat all has well and dispels, takes good care of effect in the human body that pharmaceutical composition of the present invention causes various situation.
Vast amount of clinical proves that pharmaceutical composition of the present invention has damp and hot gas in the back body of drinking well takes good care of health-care effect, and medicine promptly of the present invention can be used for dealcoholization health-preserving.
Be the clinical test results that medicine of the present invention is used for dealcoholization health-preserving below.
1, clinical observation object
History of drinking history is greater than half a year; Drink weekly greater than five times; Drink greater than 200ml (Chinese liquor, alcoholic strength is greater than 38 °) at every turn; Xerostomia or bitter taste or mouth odor at ordinary times, thick fur or greasy in vain or yellow greasy, nose heave or head as wrap up in thing, uncomfortable in the stomach, the low person of appetite; The above-mentioned reaction in back of drinking increases the weight of and Yi Zuizhe.Observe 30 examples altogether, male's 21 examples wherein, women's 9 examples are the adult entirely.
2, Therapeutic Method
Capsule medicine of the present invention: every 0.25g.Method for using: clothes are 4 before the wine, obey 4 after drinking, and originally living habit is constant.Serveing on 10 days is a course of treatment.
3, therapeutic outcome
The same day, the person's of taking effect 26 examples accounted for 86.7%, and main conscious drinking is difficult for liquor-saturatedly, and mouth odor reduces, and dry mouth with bitter taste alleviates, and the greasy fur on tongue shape alleviates, and did not have uncomfortablely in the stomach, and self-induction does not have the sensation of drinking after drinking.
One the course of treatment person's of taking effect 29 examples, account for 93.33%, do not have uncomfortablely in mouthful, the tongue fur attenuation is white, brains is salubrious, comfortable in the stomach, appetite is normal, and is difficult for liquor-saturated.
In sum, Chinese medicine composition of the present invention has the effect of well taking good care of to damp and hot gas in the gas of liver and gall taste damp-heat in the large intestine and the body of drinking.
In addition, medicine of the present invention, adopting Herba Pogostemonis, Semen Coicis, Poria, Fructus Gardeniae, the Fructus Citri of integration of edible and medicinal herbs is raw material, no side effects can not cause the secondary injury to human body.
The specific embodiment
The preparation of embodiment 1, tablet medicine of the present invention
Prescription: in weight portion:
3 parts of Herba Pogostemoniss, 3 parts in 3 parts of Poria of Semen Coicis, 3 parts of Fructus Gardeniaes, 3 parts of Fructus Citris.
Technology: common process and adjuvant by Chinese drugs agentia methodology tablet are prepared into tablet medicine.
The preparation of embodiment 2, capsule medicine of the present invention
Prescription: in weight portion:
5 parts of Herba Pogostemoniss, 4 parts of Semen Coiciss, 3 parts in Poria, 2 parts of Fructus Gardeniaes, 2 parts of Fructus Citris.
Technology: common process and adjuvant by Chinese drugs agentia methodology capsule are prepared into capsule medicine.
The preparation of embodiment 3, powder agent medicine of the present invention
Prescription: in weight portion:
5 parts of Herba Pogostemoniss, 5 parts of Semen Coiciss, 3 parts in Poria, 3 parts of Fructus Gardeniaes, 3 parts of Fructus Citris.
Technology: common process and adjuvant by Chinese drugs agentia methodology powder are prepared into powder agent medicine.
The preparation of embodiment 4, granules medicine of the present invention
Prescription: in weight portion:
5 parts of Herba Pogostemoniss, 4 parts of Semen Coiciss, 4 parts in Poria, 2 parts of Fructus Gardeniaes, 2 parts of Fructus Citris.
Technology: common process and adjuvant by Chinese drugs agentia methodology granule are prepared into granules medicine.
The preparation of embodiment 5, drop pill medicine of the present invention
Prescription: in weight portion:
4 parts of Herba Pogostemoniss, 3 parts of Semen Coiciss, 3 parts in Poria, 2 parts of Fructus Gardeniaes, 2 parts of Fructus Citris.
Technology: common process and adjuvant by Chinese drugs agentia methodology drop pill are prepared into the drop pill medicine.
The preparation of embodiment 6, watered pill medicine of the present invention
Prescription: in weight portion:
3 parts of Herba Pogostemoniss, 4 parts of Semen Coiciss, 4 parts in Poria, 3 parts of Fructus Gardeniaes, 3 parts of Fructus Citris.
Technology: common process and adjuvant by Chinese drugs agentia methodology watered pill are prepared into the watered pill medicine.
The preparation of embodiment 7, honey pill agent medicine of the present invention
Prescription: in weight portion:
2 parts of Herba Pogostemoniss, 5 parts of Semen Coiciss, 4 parts in Poria, 3 parts of Fructus Gardeniaes, 2 parts of Fructus Citris.
Technology: common process and adjuvant by Chinese drugs agentia methodology honey pill agent are prepared into the honey pill agent medicine.
The preparation of embodiment 8, oral medicine liquid of the present invention
Prescription: in weight portion:
2 parts of Herba Pogostemoniss, 3 parts of Semen Coiciss, 4 parts in Poria, 5 parts of Fructus Gardeniaes, 5 parts of Fructus Citris.
Technology: common process and adjuvant by Chinese drugs agentia methodology oral liquid are prepared into oral liquid.
The preparation of embodiment 9, enteric coated pill medicine of the present invention
Prescription: in weight portion:
5 parts of Herba Pogostemoniss, 2 parts of Semen Coiciss, 2 parts in Poria, 4 parts of Fructus Gardeniaes, 5 parts of Fructus Citris.
Technology: common process and adjuvant by Chinese drugs agentia methodology enteric coated pill are prepared into the enteric coated pill medicine.
The preparation of embodiment 10, microencapsulation agent medicine of the present invention
Prescription: in weight portion:
2 parts of Herba Pogostemoniss, 3 parts of Semen Coiciss, 4 parts in Poria, 5 parts of Fructus Gardeniaes, 5 parts of Fructus Citris.
Technology: common process and adjuvant by Chinese drugs agentia methodology microencapsulation are prepared into microcapsule.
Claims (3)
1. Chinese medicine composition that is used for removing internal damp-heat is to be crude drug with Herba Pogostemonis, Semen Coicis, Poria, Fructus Gardeniae, Fructus Citri, the oral preparations that is prepared into by the common process and the adjuvant of pharmaceutics;
Said each raw material carries out proportioning with following weight parts:
1～5 part of Herba Pogostemonis, 1～5 part of Semen Coicis, 1～5 part in Poria, 1～5 part of Fructus Gardeniae, 1～5 part of Fructus Citri.
2. be used for the Chinese medicine composition of removing internal damp-heat according to claim 1, it is characterized in that: said each raw material medicines in portions by weight is following:
2～3 parts of Herba Pogostemoniss, 2～3 parts of Semen Coiciss, 2～3 parts in Poria, 2～3 parts of Fructus Gardeniaes, 2～3 parts of Fructus Citris.
3. be used for of the application of the Chinese medicine composition of removing internal damp-heat according to claim 1 at preparation dealcoholization health-preserving medicine.
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| CN102885307B (en) * | 2012-09-29 | 2013-09-18 | 山东东阿阿胶股份有限公司 | Composition for damp-heat constitutions, preparation method and applications thereof |
| CN103251855B (en) * | 2013-05-27 | 2014-11-12 | 刘爱香 | Traditional Chinese medicine composition for treating damp-heat-downward-flow type haemorrhoids |
| CN104399047B (en) * | 2014-12-09 | 2018-01-02 | 兰州古驰生物科技有限公司 | It is a kind of to be used to recuperate under medical treatment with lower abnormal Chinese medicine preparation |
| CN106075339A (en) * | 2016-07-09 | 2016-11-09 | 信阳农林学院 | A kind of sleep promoting tea |
| CN107373821B (en) * | 2017-08-31 | 2018-12-28 | 南阳理工学院 | A kind of relieving summer-heat mask |
| CN109453324B (en) * | 2018-12-14 | 2021-05-25 | 曾钟德 | Preparation method of traditional Chinese medicine formula preparation for clearing liver, regulating spleen and harmonizing stomach |
| CN111375027B (en) * | 2018-12-27 | 2021-07-13 | 广州白云山潘高寿药业股份有限公司 | Traditional Chinese medicine composition for conditioning damp-heat constitution, lotus leaf and coix seed beverage and preparation method thereof |
| CN111671030A (en) * | 2020-07-23 | 2020-09-18 | 广东致公药业有限公司 | Honeysuckle citron solid beverage |
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| 高学敏.《中药学》.《中药学》.2003,(第1版),第101,235,244-246,302,303页. * |
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Effective date of registration: 20170224 Address after: The East, Peng Jia Ping Road No. B224 planning of Gansu Province, Lanzhou city Qilihe District 730050 West Road No. T226 planning Patentee after: Gansu indigo hundred years health management Limited by Share Ltd Address before: Tan Xiang Yan Chengguan District zhangsutan 730010 Gansu city of Lanzhou province No. 579 Patentee before: Lanzhou Guchi Biological Technology Co., Ltd. |