CN101861519B - 具有就座的离子交换珠的屏障和方法 - Google Patents
具有就座的离子交换珠的屏障和方法 Download PDFInfo
- Publication number
- CN101861519B CN101861519B CN200880116470.7A CN200880116470A CN101861519B CN 101861519 B CN101861519 B CN 101861519B CN 200880116470 A CN200880116470 A CN 200880116470A CN 101861519 B CN101861519 B CN 101861519B
- Authority
- CN
- China
- Prior art keywords
- ion
- chamber
- ion exchange
- flow channel
- bead
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000011324 bead Substances 0.000 title claims abstract description 205
- 238000005342 ion exchange Methods 0.000 title claims abstract description 80
- 230000004888 barrier function Effects 0.000 title claims description 49
- 238000000034 method Methods 0.000 title claims description 35
- 150000002500 ions Chemical class 0.000 claims abstract description 88
- 239000007788 liquid Substances 0.000 claims abstract description 52
- 239000003480 eluent Substances 0.000 claims abstract description 48
- 230000037427 ion transport Effects 0.000 claims abstract description 47
- 230000000903 blocking effect Effects 0.000 claims abstract description 19
- 238000004255 ion exchange chromatography Methods 0.000 claims abstract description 11
- 239000012530 fluid Substances 0.000 claims description 44
- 239000000523 sample Substances 0.000 claims description 32
- 239000002253 acid Substances 0.000 claims description 31
- 150000001450 anions Chemical class 0.000 claims description 25
- 238000004891 communication Methods 0.000 claims description 19
- 150000001768 cations Chemical class 0.000 claims description 18
- 150000007513 acids Chemical class 0.000 claims description 8
- 230000008569 process Effects 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000012488 sample solution Substances 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims 1
- 230000032258 transport Effects 0.000 abstract description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 156
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 38
- 239000012528 membrane Substances 0.000 description 31
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 22
- 239000003014 ion exchange membrane Substances 0.000 description 20
- 239000003729 cation exchange resin Substances 0.000 description 16
- 239000012508 resin bead Substances 0.000 description 16
- 239000000243 solution Substances 0.000 description 16
- -1 hydronium ions Chemical class 0.000 description 14
- 239000003957 anion exchange resin Substances 0.000 description 13
- 239000004696 Poly ether ether ketone Substances 0.000 description 11
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 description 11
- 229920002530 polyetherether ketone Polymers 0.000 description 11
- 238000005341 cation exchange Methods 0.000 description 10
- 239000003792 electrolyte Substances 0.000 description 10
- 230000008901 benefit Effects 0.000 description 9
- 239000011347 resin Substances 0.000 description 8
- 229920005989 resin Polymers 0.000 description 8
- 239000004743 Polypropylene Substances 0.000 description 7
- 239000003456 ion exchange resin Substances 0.000 description 7
- 229920003303 ion-exchange polymer Polymers 0.000 description 7
- 229920001155 polypropylene Polymers 0.000 description 7
- 238000007789 sealing Methods 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 238000004587 chromatography analysis Methods 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 239000004816 latex Substances 0.000 description 5
- 229920000126 latex Polymers 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- 238000000909 electrodialysis Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000004811 liquid chromatography Methods 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 4
- 239000004810 polytetrafluoroethylene Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 230000001629 suppression Effects 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000003491 array Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- HGAZMNJKRQFZKS-UHFFFAOYSA-N chloroethene;ethenyl acetate Chemical compound ClC=C.CC(=O)OC=C HGAZMNJKRQFZKS-UHFFFAOYSA-N 0.000 description 3
- 230000005684 electric field Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000004065 semiconductor Substances 0.000 description 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000005349 anion exchange Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 239000005350 fused silica glass Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 229910000510 noble metal Inorganic materials 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- CHRJZRDFSQHIFI-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;styrene Chemical compound C=CC1=CC=CC=C1.C=CC1=CC=CC=C1C=C CHRJZRDFSQHIFI-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 239000004831 Hot glue Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229920000557 Nafion® Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000010349 cathodic reaction Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 229920006332 epoxy adhesive Polymers 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000008384 membrane barrier Effects 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N nitrate group Chemical group [N+](=O)([O-])[O-] NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-O oxonium Chemical group [OH3+] XLYOFNOQVPJJNP-UHFFFAOYSA-O 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000012492 regenerant Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/166—Fluid composition conditioning, e.g. gradient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/30—Polyalkenyl halides
- B01D71/32—Polyalkenyl halides containing fluorine atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/02—Column or bed processes
- B01J47/06—Column or bed processes during which the ion-exchange material is subjected to a physical treatment, e.g. heat, electric current, irradiation or vibration
- B01J47/08—Column or bed processes during which the ion-exchange material is subjected to a physical treatment, e.g. heat, electric current, irradiation or vibration subjected to a direct electric current
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/12—Ion-exchange processes in general; Apparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
- B01J49/50—Regeneration or reactivation of ion-exchangers; Apparatus therefor characterised by the regeneration reagents
- B01J49/57—Regeneration or reactivation of ion-exchangers; Apparatus therefor characterised by the regeneration reagents for anionic exchangers
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B1/00—Electrolytic production of inorganic compounds or non-metals
- C25B1/01—Products
- C25B1/14—Alkali metal compounds
- C25B1/16—Hydroxides
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B1/00—Electrolytic production of inorganic compounds or non-metals
- C25B1/01—Products
- C25B1/22—Inorganic acids
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B13/00—Diaphragms; Spacing elements
- C25B13/04—Diaphragms; Spacing elements characterised by the material
- C25B13/08—Diaphragms; Spacing elements characterised by the material based on organic materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
- G01N2030/965—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange suppressor columns
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Metallurgy (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/940,892 | 2007-11-15 | ||
| US11/940,892 US7632404B2 (en) | 2007-11-15 | 2007-11-15 | Barrier with a seated ion exchange bead and method |
| PCT/US2008/083256 WO2009064797A2 (en) | 2007-11-15 | 2008-11-12 | Barrier with a seated ion exchange bead and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101861519A CN101861519A (zh) | 2010-10-13 |
| CN101861519B true CN101861519B (zh) | 2014-12-17 |
Family
ID=40639421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880116470.7A Active CN101861519B (zh) | 2007-11-15 | 2008-11-12 | 具有就座的离子交换珠的屏障和方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7632404B2 (enExample) |
| EP (1) | EP2210089B1 (enExample) |
| JP (1) | JP5562247B2 (enExample) |
| CN (1) | CN101861519B (enExample) |
| WO (1) | WO2009064797A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8293099B2 (en) * | 2008-02-28 | 2012-10-23 | Dionex Corporation | Ion detector and system |
| US8133373B2 (en) | 2008-08-15 | 2012-03-13 | Dionex Corporation | Electrochemically driven pump |
| DE102012019105A1 (de) * | 2012-09-28 | 2014-04-03 | Carl Freudenberg Kg | Steckstück |
| US10048233B2 (en) | 2012-11-12 | 2018-08-14 | Dionex Corporation | Suppressor device |
| US9914651B2 (en) | 2013-05-08 | 2018-03-13 | Dionex Corporation | Current efficient electrolytic device and method |
| US10550148B2 (en) | 2014-06-16 | 2020-02-04 | Emd Millipore Corporation | Methods for increasing the capacity of flow-through processes |
| WO2015195452A2 (en) | 2014-06-16 | 2015-12-23 | Emd Millipore Corporation | Single-pass filtration systems and processes |
| SG11201508171RA (en) | 2014-06-25 | 2016-01-28 | Emd Millipore Corp | Compact spiral-wound filter elements, modules and systems |
| US9400268B2 (en) * | 2014-08-08 | 2016-07-26 | Dionex Corporation | Method for reducing suppressor noise |
| US10350518B2 (en) | 2014-08-29 | 2019-07-16 | Emd Millipore Corporation | Processes for filtering liquids using single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate |
| KR102188947B1 (ko) | 2014-08-29 | 2020-12-09 | 이엠디 밀리포어 코포레이션 | 잔류물의 재순환을 이용한 싱글 패스 접선 유동 여과 시스템 및 접선 유동 여과 시스템 |
| US10175211B2 (en) | 2014-12-31 | 2019-01-08 | Dionex Corporation | Current-efficient suppressor and pretreatment device and method |
| EP4066927B1 (en) | 2016-06-09 | 2024-10-09 | EMD Millipore Corporation | Methods of using radial-path filter elements |
| US10416137B2 (en) * | 2016-09-07 | 2019-09-17 | Board Of Regents, University Of Texas System | Electrodialytic capillary suppressor for suppressed conductometric ion chromatography |
| US10948466B2 (en) | 2017-03-03 | 2021-03-16 | Dionex Corporation | Flow control in an electrolytic reagent concentrator for ion chromatography |
| GB201709306D0 (en) * | 2017-06-12 | 2017-07-26 | Univ Oxford Innovation Ltd | Seperation methods |
| US11105782B2 (en) * | 2017-10-10 | 2021-08-31 | Dionex Corporation | Fast startup ion chromatography system and methods |
| CN109136975B (zh) | 2018-07-05 | 2020-10-09 | 华东理工大学 | 双膜型酸或碱溶液在线发生器 |
| US11243194B2 (en) | 2019-01-25 | 2022-02-08 | Dionex Corporation | Suppressors with eluent screens for use in ion chromatography |
| US11988649B2 (en) | 2020-10-06 | 2024-05-21 | Board Of Regents, The University Of Texas System | On-line suppressor |
| WO2023154901A2 (en) * | 2022-02-11 | 2023-08-17 | Beaver Creek Analytical, Llc | Particle-packed membrane inlet for high-pressure chemical measurements |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4187333A (en) * | 1973-05-23 | 1980-02-05 | California Institute Of Technology | Ion-exchange hollow fibers |
| US4253900A (en) * | 1977-02-28 | 1981-03-03 | Allied Chemical Corporation | Method of making novel two component bipolar ion exchange membranes |
| US5045204A (en) * | 1990-02-13 | 1991-09-03 | Dionex Corporation | Method and apparatus for generating a high purity chromatography eluent |
| US6682701B1 (en) * | 1998-02-02 | 2004-01-27 | Dionex Corporation | Large capacity acid or base generator apparatus |
| US6716629B2 (en) * | 2000-10-10 | 2004-04-06 | Biotrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
| CN1703269A (zh) * | 2002-09-11 | 2005-11-30 | 迪奥尼克斯公司 | 电解洗脱液产生器和使用方法 |
| CN101044399A (zh) * | 2004-09-16 | 2007-09-26 | 迪奥尼斯公司 | 毛细管离子色谱 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2903406A (en) | 1956-06-28 | 1959-09-08 | Clayton Manufacturing Co | Conducting diaphragms |
| US4500430A (en) | 1982-09-22 | 1985-02-19 | Dasgupta Purnendu K | Continuously rejuvenated ion exchanger |
| US4647380A (en) | 1982-09-22 | 1987-03-03 | Dasgupta Purnendu K | Annular dual membrane permselective device and method |
| AU587988B2 (en) * | 1984-10-04 | 1989-09-07 | Dionex Corporation | Modified membrane suppressor and method of use |
| US4999098A (en) | 1984-10-04 | 1991-03-12 | Dionex Corporation | Modified membrane suppressor and method for use |
| CA2087481C (en) * | 1992-02-10 | 2001-09-04 | John R. Stillian | Ion chromatography system using electrochemical suppression and detector effluent recycle |
| US5248426A (en) | 1992-02-10 | 1993-09-28 | Dionex Corporation | Ion chromatography system using electrochemical suppression and detector effluent recycle |
| US6325976B1 (en) * | 1998-02-26 | 2001-12-04 | Dionex Corporation | Continuous electrolytically regenerated packed bed suppressor for ion chromatography |
| US6077434A (en) * | 1999-01-15 | 2000-06-20 | Dionex Corporation | Current-efficient suppressors and method of use |
| US6562628B1 (en) * | 2000-07-07 | 2003-05-13 | Dionex Corporation | Electrolytic suppressor and separate eluent generator combination |
| US20030127392A1 (en) | 2002-01-10 | 2003-07-10 | Kannan Srinivasan | Eluent purifier and method of use |
| US7390386B2 (en) | 2002-01-10 | 2008-06-24 | Dionez Corporation | Aqueous stream purifier and method of use |
| US7288176B2 (en) * | 2003-04-23 | 2007-10-30 | Dionex Corporation | Method and apparatus for generating high purity eluant |
| US7303671B2 (en) * | 2004-02-11 | 2007-12-04 | Dionex Corporation | Ion exchange particle-bound flow-through porous monolith |
| US7329346B2 (en) * | 2005-02-23 | 2008-02-12 | Dionex Corporation | Ion chromatography system using catalytic gas elimination |
| US8293099B2 (en) * | 2008-02-28 | 2012-10-23 | Dionex Corporation | Ion detector and system |
-
2007
- 2007-11-15 US US11/940,892 patent/US7632404B2/en active Active
-
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- 2008-11-12 CN CN200880116470.7A patent/CN101861519B/zh active Active
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- 2008-11-12 EP EP08848986.9A patent/EP2210089B1/en active Active
- 2008-11-12 JP JP2010534147A patent/JP5562247B2/ja not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4187333A (en) * | 1973-05-23 | 1980-02-05 | California Institute Of Technology | Ion-exchange hollow fibers |
| US4253900A (en) * | 1977-02-28 | 1981-03-03 | Allied Chemical Corporation | Method of making novel two component bipolar ion exchange membranes |
| US5045204A (en) * | 1990-02-13 | 1991-09-03 | Dionex Corporation | Method and apparatus for generating a high purity chromatography eluent |
| US6682701B1 (en) * | 1998-02-02 | 2004-01-27 | Dionex Corporation | Large capacity acid or base generator apparatus |
| US6716629B2 (en) * | 2000-10-10 | 2004-04-06 | Biotrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
| CN1703269A (zh) * | 2002-09-11 | 2005-11-30 | 迪奥尼克斯公司 | 电解洗脱液产生器和使用方法 |
| CN101044399A (zh) * | 2004-09-16 | 2007-09-26 | 迪奥尼斯公司 | 毛细管离子色谱 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011504411A (ja) | 2011-02-10 |
| WO2009064797A3 (en) | 2009-09-24 |
| JP5562247B2 (ja) | 2014-07-30 |
| WO2009064797A2 (en) | 2009-05-22 |
| CN101861519A (zh) | 2010-10-13 |
| EP2210089B1 (en) | 2016-01-06 |
| EP2210089A2 (en) | 2010-07-28 |
| US7632404B2 (en) | 2009-12-15 |
| US20090127200A1 (en) | 2009-05-21 |
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