CN101849818B - Device for checking type of cerebral edema - Google Patents
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- CN101849818B CN101849818B CN2010101906570A CN201010190657A CN101849818B CN 101849818 B CN101849818 B CN 101849818B CN 2010101906570 A CN2010101906570 A CN 2010101906570A CN 201010190657 A CN201010190657 A CN 201010190657A CN 101849818 B CN101849818 B CN 101849818B
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Abstract
The invention discloses a device for checking the type of cerebral edema, comprising a computer system, an excitation circuit 1, an excitation circuit 2 and an excitation circuit 3; the output ends of the excitation circuit 1, the excitation circuit 2 and the excitation circuit 3 are connected with the computer system; the input end of the detection circuit 1 is connected with the excitation circuit 1, and the output end is connected with the computer system; the input end of a detection circuit 2 is connected with the excitation circuit 2, and the output end is connected with the computer system. Information reflecting physiological and pathological state of cerebral edema tissues can be obtained according to the function of biological tissue cell membranes and the change of water contents in and out of the tissue cell membranes, thus providing information about cerebral edema, severity of cerebral edema and characteristics of the type of cerebral edema. The invention has the advantages of reasonable design, simple structure, small size, low production cost, accurate detected data and the like, the device of the invention can be utilized as a diagnosis and monitoring apparatus for detecting the type and level of cerebral edema.
Description
Technical field
The invention belongs to biomedical technical field of medical instruments, be specifically related to the testing fixture of neural Medicine and Surgery type of cerebral edema.
Background technology
Brain Medicine and Surgery diseases such as all kinds of craniocerebral trauma, cerebral tumor excision, cerebral ischemia, the cerebral tumor, encephalitis disease and HACE, its M & M has got into the common lethal pathological changes of front three.These brain Medicine and Surgery diseases all are attended by the symptom of cerebral edema.Different according to the pathogenesis of cerebral edema and pathological change are divided into the angiogenic and are main extracellular edema and are two big types of main intracellular edemas with the cytotoxicity.The correct type of distinguishing cerebral edema is that the doctor grasps conditions of patients, confirms therapeutic scheme, the important evidence of correctly taking drugs and treatment.
Human brain is the most complicated, a most important parts in the organization of human body.Cerebral edema is the pathological reaction that the different causes of disease (like ischemia, hemorrhage, damage, poisoning, tumor etc.) cause cerebral tissue.When cerebral edema took place, the increase of cerebral tissue capacity caused intracranial hypertension, and cerebral blood flow reduces, and makes cerebral hypoxia ischemia increase the weight of edema again conversely, makes intracranial pressure higher, and so vicious cycle finally can cause death.So, estimate, judge generation, the state of development of cerebral edema timely and accurately, and it is in time handled it, most important to anxious critical illness patient's life security.
And cerebral tissue is to the pathological manifestations form more complicated of the different causes of disease, and corresponding, its electrical characteristics also can be along with pathological changes changes, and these have comprised structural information and function information in changing.If can understand, decode these information, and utilize they to cerebral edema more in depth study, significant to effective treatment of cerebral edema.
The maturing apparatus of observing cerebral edema at present is representative with C T, conventional nuclear magnetic resonance, and they are to change through the iconography to tissue to observe.Early stage to cerebral edema; Have only positron emission imaging (PET) or single photon emission capacitor C T imaging (SPE capacitor C T) to be carried out to picture at present to edema; But these equipment are huge; The diagnostic imaging price is very expensive, and China's great majority can not bear nearly ten thousand yuan inspection fee per capita, more can not use these detections and custodial care facility counterweight danger patient and carry out the other monitoring in real time of bed for a long time.
Electroencephalogram is a kind of custodial care facility that is fit to detect cerebral lesion.The electroencephalogram monitoring can be used to detect pathological change relevant with brain injury and trend.But there is contact type measurement in it, installing electrodes is many and the complicated defective of feature extraction.
Transcranial doppler is that noinvasive research cerebral circulation has been started new method, but this equipment still exist can not be in early days and the technical problem of detection by quantitative.
Adopt brain impedance detection equipment that cerebral edema is guarded, have the advantage of simple, the easy and simple to handle and dynamic monitoring of method, but existence needs contact electrode and skull electric current to be had the problem of barrier action.
Micro-wound encephalic pressure strain monitoring appearance is measured the skull distortion through foil gauge, reaches the purpose that the monitoring intracranial pressure changes, but has the simple characteristics with continuous monitoring of measuring method, but its traumatic and the foil gauge that contact be need solution problem.
To the deficiency of existing cerebral edema checkout facility and the needs of clinical disease of brain diagnosis and treatment and field first aid brain trauma; Subject knowledges such as dielectric property based on pathophysiological mechanism, cytopathology, cytobiology, biological tissue and the cell of cerebral edema; And biomedical basis such as the demand of clinical medicine Neurology Department and neurosurgery and clinical medicine background; Develop that a kind of product price is low, non-invasive, bed other uses, equipment that can the on-line monitor cerebral edema, is the task of top priority.
Summary of the invention
Technical problem to be solved by this invention is to overcome the shortcoming of above-mentioned cerebral edema inspection apparatus, provide a kind of reasonable in design, simple in structure, volume is little, production cost is low, the data of surveying device for checking type of cerebral edema accurately.
Solving the problems of the technologies described above the technical scheme that is adopted is: it comprises the computer system of the signal of being gathered being carried out date processing; It comprises exciting circuit 1, exciting circuit 2, the exciting circuit 3 of the different frequency that is connected with computer system; It also comprises testing circuit 1, testing circuit 2, testing circuit 3, the output termination computer system of testing circuit 1, testing circuit 2, testing circuit 3.
Power amplification circuit of the present invention is: inverting input 5 feet of integrated circuit U14 connect capacitor C 112 an end and resistance R 18 an end and the termination 35V power cathode, 2 feet of an end and capacitor C 14 that connect outfan 5 feet, in-phase input end 4 foot ground connection, 6 feet and the capacitor C 13 of integrated circuit U13 through resistance R 12 connects through resistance R 13 that 35V positive source, 3 feet connect that 35V positive source, 7 feet connect through resistance R 14 that two ends, outfan 1 foot that 35V power cathode, 8 feet and outfan 1 foot connect capacitor C 111 connect the other end of capacitor C 112 through resistance R 17 and connect the end of excitation coil L11 through resistance R 15; One termination 35V positive source, the other end ground connection of capacitor C 11 and capacitor C 12; One termination 35V power cathode, the other end ground connection of capacitor C 13 and capacitor C 14, the other end of another termination excitation coil L11 of resistance R 18 is through resistance R 16 ground connection.The model of integrated circuit U14 is PA19.
The present invention obtains the information of the physiological and pathological state of reflection cerebral edema tissue according to the change of water content inside and outside the function of biological tissue cell film and the cell membranes in tissue, and the characteristic of cerebral edema, the cerebral edema order of severity and type of cerebral edema is provided.Adopt excitation coil and magnetic test coil; Overcome in the impedance bioelectrical measurement skull to the barrier action of exciting current; Magnetic field excitation does not directly contact with scalp; Overcome in the impedance bioelectrical measurement scalp to the shunting action of exciting current, solved the difficult problem that after injury of head and the operation contact electrode can't be installed.The excitation field that excitation coil produces passes the edema cerebral tissue; Because biological tissue has electric conductivity, the excitation field of alternation can produce eddy current in biological tissue, and eddy current produces the disturbed magnetic field of alternation again; Excitation field is produced disturbance, and turbulent size reflects the variation of biological tissue's electrical conductivity.When the frequency of excitation field was hanged down, the eddy current of generation can not pass cell membrane, is merely able to pass from iuntercellular, and the eddy current that obtains is less, and the disturbed magnetic field of generation is less; When the frequency of excitation field was higher, the eddy current of generation can pass cell membrane, can pass from iuntercellular again, can obtain bigger eddy current, produced big disturbed magnetic field.Through measuring the size of disturbed magnetic field under the different frequency, distinguish in the cell and extracellular cerebral tissue edema.
That the present invention has is reasonable in design, simple in structure, volume is little, production cost is low, advantages such as the data of surveying are accurate, after clinical trial, can be used as the type that detects cerebral edema, the diagnosis and the monitor of degree of cerebral edema.
Description of drawings
Fig. 1 is an electrical principle block diagram of the present invention.
Fig. 2 is the electrical principle block diagram of exciting circuit 1 among Fig. 1.
Fig. 3 is the electronic circuit schematic diagram of exciting circuit 1.
Fig. 4 is the electrical principle block diagram of testing circuit 1 among Fig. 1.
Fig. 5 is the electronic circuit schematic diagram of testing circuit 2 among Fig. 1.
Fig. 6 is the electrical principle block diagram of testing circuit 3 among Fig. 1
Fig. 7 is the electronic circuit schematic diagram of testing circuit 1 among Fig. 1.
Fig. 8 is the electronic circuit schematic diagram of testing circuit 2.
Fig. 9 is the electronic circuit schematic diagram of testing circuit 3.
Figure 10 is the structural representation of computer system among Fig. 1.
The specific embodiment
To further explain of the present invention, but the invention is not restricted to these embodiment below in conjunction with accompanying drawing and embodiment.
Fig. 1 is an electrical principle block diagram of the present invention, referring to Fig. 1.In Fig. 1, the present invention is connected and composed by exciting circuit 1, testing circuit 1, exciting circuit 2, testing circuit 2, exciting circuit 3, testing circuit 3, computer system.The output termination testing circuit 1 of exciting circuit 1; The output termination testing circuit 2 of exciting circuit 2; The output termination testing circuit 3 of exciting circuit 3; The output termination computer system of testing circuit 1 and testing circuit 2 and testing circuit 3, exciting circuit 1, exciting circuit 2, exciting circuit 3 link to each other with computer system.Exciting circuit 1, testing circuit 1 are connected a cerebral edema detection system with computer system; Exciting circuit 2, testing circuit 2 are connected a cerebral edema detection system with computer system; Exciting circuit 3, testing circuit 3 are connected a cerebral edema detection system with computer system, three separate cerebral edemas of carrying out of detection system detect, and the power of three detection systems is inequality; When detecting clinically and guarding, select the detection system of different capacity arbitrarily according to patient's different situations.Computer system is carried out phase contrast relatively with the testing circuit 1 of input and the signal and the corresponding reference signal of testing circuit 2 and testing circuit 3; Carry out the software phase demodulation; Obtain the phase contrast (detection signal and reference signal) of two paths of signals; Judge in the cell and the bullate size of extracellular brain water, type and position, demonstrate result of calculation.
In Fig. 2,3, present embodiment exciting circuit 1 is connected and composed by oscillating circuit, output regulating circuitry, amplifying circuit, voltage follower, power amplification circuit.The output termination output regulating circuitry of oscillating circuit, the output termination amplifying circuit of output regulating circuitry, the output termination voltage follower of amplifying circuit, the output termination power amplification circuit of voltage follower.
Oscillating circuit is made up of crystal oscillator Y1, and 4 feet of crystal oscillator Y1 connect 5V positive source, 7 foot ground connection, 8 feet and connect output regulating circuitry.
Output regulating circuitry is connected and composed by integrated circuit U11A, resistance R 10, capacitor C 15～capacitor C 19, potentiometer RC11, and the model of integrated circuit U11A is AD825.Inverting input 2 feet of integrated circuit U11A connect 8 feet of crystal oscillator Y1 and connect outfan, in-phase input end 3 feet through potentiometer RC11 through resistance R 10 and connect that power supply, 7 feet connect the 5V positive source, 4 feet connect the 5V power cathode; One termination 5V positive source of capacitor C 15, capacitor C 16～capacitor C 19, other end ground connection; One termination 5V power cathode of capacitor C 17, capacitor C 18, other end ground connection, outfan 8 feet of integrated circuit U11A connect amplifying circuit and computer system.
Amplifying circuit is connected and composed by integrated circuit U12A, resistance R 11, potentiometer RC12, and the model of integrated circuit U12A is AD825.Inverting input 2 feet of integrated circuit U12A connect outfan 8 feet of integrated circuit UU11A through resistance R 11 and connect through potentiometer RC12 that outfan, in-phase input end 1 foot ground connection, 7 feet connect the 5V positive source, 6 feet connect 5V power cathode, output termination voltage follower.
Voltage follower is connected and composed by integrated circuit U13, capacitor C 110, and the model of integrated circuit U13 is AD825B.Outfan 8 feet, inverting input 3 feet that in-phase input end 4 feet of integrated circuit U13 meet integrated circuit U12A connect that an end, power end 7 feet that outfan, 6 feet connect 5V power cathode and capacitor C 110 connect the 5V positive source, outfan 5 feet connect power amplification circuit, the other end ground connection of capacitor C 110.
Power amplification circuit is connected and composed by integrated circuit U14, resistance R 12～resistance R 18, capacitor C 11～capacitor C 14, capacitor C 111, capacitor C 112, excitation coil L11, and the model of integrated circuit U14 is PA19.Inverting input 5 feet of integrated circuit U14 connect capacitor C 112 an end and resistance R 18 an end and the termination 35V power cathode, 2 feet of an end and capacitor C 14 that connect outfan 5 feet, in-phase input end 4 foot ground connection, 6 feet and the capacitor C 13 of integrated circuit U13 through resistance R 12 connects through resistance R 13 that 35V positive source, 3 feet connect that 35V positive source, 7 feet connect through resistance R 14 that two ends, outfan 1 foot that 35V power cathode, 8 feet and outfan 1 foot connect capacitor C 111 connect the other end of capacitor C 112 through resistance R 17 and connect the end of excitation coil L11 through resistance R 15; One termination 35V positive source, the other end ground connection of capacitor C 11 and capacitor C 12; One termination 35V power cathode, the other end ground connection of capacitor C 13 and capacitor C 14, the other end of another termination excitation coil L11 of resistance R 18 is through resistance R 16 ground connection.
Sinusoidal excitation signal is produced by crystal oscillator Y11, capacitor C 15, capacitor C 16, and 8 feet of crystal oscillator Y11 output to inverting input 2 feet of integrated circuit U11A through resistance R 10, and integrated circuit U11A is to the sinusoidal excitation signal amplitude adjustment of input; Be input to integrated circuit U12 inverting input 2 feet through resistance R 11 and amplify, output to in-phase input end 4 feet of integrated circuit U13, the input and output impedance at integrated circuit U13 coupling two ends; Signal outputs to 5 feet of integrated circuit U14, and integrated circuit U14 carries out the electric current and voltage conversion to the sinusoidal excitation signal of input, outputs to excitation coil L11; During detection, excitation coil L11 band is at patient's head, and excitation coil L11 produces excitation field; Pass the intravital cerebral edema of human brain; Tissue fluid meeting eddy current in the cerebral edema, eddy current produces turbulent alternating magnetic field, outwards emission.
The components and parts of exciting circuit 2 and exciting circuit 3 and the annexation and the exciting circuit 1 of components and parts are identical, and the electronic circuit principle is identical.
In Fig. 4,7, the testing circuit 1 of present embodiment is connected and composed by pre-amplification circuit 1, active filter, and the outfan of pre-amplification circuit 1 is connected to source filter.
Active filter is connected and composed by integrated circuit U22, resistance R 28～resistance R 222, and the model of integrated circuit U22 is MAX275.The other end of one termination capacitor C26 of resistance R 28, the other end connect 8 feet of integrated circuit U22 through resistance R 29; 8 feet of integrated circuit U22 connect 4 feet, 4 feet through resistance R 213 and resistance R 212 and connect 6 feet and connect 14 feet, 7 feet through resistance R 210 and resistance R 211 through resistance R 214 and connect 2 feet, 19 feet through resistance R 215 and resistance R 216 and connect 15 feet, 16 feet through resistance R 221 and resistance R 222 and connect computer system, 14 feet through resistance R 219 and resistance R 220 and connect computer system, 18 feet through resistance R 217 and resistance R 218 and connect that computer system, 20 feet connect the 5V positive source, 11 feet connect the 5V power cathode, 5,9,10,12, the 17 foot ground connection of integrated circuit U22.
Coil L21 receives 5 feet input the carry out preposition amplification of the alternating magnetic field of cerebral edema generation from integrated circuit U21; 22 feet output by integrated circuit U21; Through capacitor C 26, resistance R 28, resistance R 29; By the 8 feet input of integrated circuit U22, integrated circuit U22 carries out filtering to the signal of input, and the signal of process filtering outputs to computer system by 18 feet of integrated circuit U22.
In Fig. 5,8, the testing circuit 2 of present embodiment is connected and composed by pre-amplification circuit 2, crystal filter 1, the output termination crystal filter 1 of pre-amplification circuit 2.
Coil L31 receives 5 feet input the carry out preposition amplification of the alternating magnetic field of cerebral edema generation from integrated circuit U31; 22 feet output by integrated circuit U31; Through the 1 foot input of capacitor C 37 by integrated circuit U32; Integrated circuit U32 carries out filtering to the signal of input, and the signal of process filtering outputs to computer system by 4 feet of integrated circuit U32.
In Fig. 6,9, the testing circuit 3 of present embodiment is connected and composed by pre-amplification circuit 3, second amplifying circuit, crystal filter 2, the output termination second amplifying circuit of pre-amplification circuit 3, the output termination crystal filter 2 of second amplifying circuit.Pre-amplification circuit 3 is connected and composed by integrated circuit U41, diode D41, diode D42, resistance R 41～resistance R 47, resistance R 411, resistance R 412, capacitor C 41～capacitor C 47, potentiometer resistance R41, coil L41, and the model of integrated circuit U21 is AD604.The components and parts of pre-amplification circuit 3 and the annexation of components and parts and preposition amplification electricity 1 are identical.5 feet of the termination integrated circuit U41 of coil L41 and the negative pole of diode D41 and the positive pole of diode D42, the other end ground connection of coil L41, coil L41 is arranged on the head of human body to be detected when detecting; During detection; Coil L41 is arranged on respect to the excitation coil opposite side, with the excitation coil symmetry, is used to receive the electromagnetic signal that the intracranial cerebral edema is sent; 22 feet of integrated circuit U41 connect an end of capacitor C 47, another termination second amplifying circuit of capacitor C 47.
Second amplifying circuit is connected and composed by integrated circuit U42, resistance R 48～resistance R 410, capacitor C 48, and the model of integrated circuit U42 is MAX436.2 feet of integrated circuit U42 connect capacitor C 47 the other end and through resistance R 48 ground connection, 1 foot connect 12 feet and 14 feet and capacitor C 48 an end and through resistance R 42 connect 5V positive source, 3 feet and 5 feet respectively two ends, the other end, 7 feet that 6 feet connect capacitor C 46 of connecting resistance R49 connect 8 feet and 10 feet and through resistance R 43 connect 5V power cathode, 10 feet and 11 feet respectively two ends, 11 feet and 14 feet of the connecting resistance R410 two ends, 13 feet that connect capacitor C 48 respectively connect crystal filter circuit 2.
Crystal filter circuit 2 is made up of integrated circuit U43, resistance R 413, and the model of integrated circuit U43 is LT2-1.1 foot of integrated circuit U43 connects 13 feet of integrated circuit U42 and connects computer system through R413 ground connection, 2 feet and 3 foot ground connection, outfan 4 feet.
Coil L41 receives 5 feet input the carry out preposition amplification of the alternating magnetic field of cerebral edema generation from integrated circuit U41; 22 feet output by integrated circuit U41; Through the 2 feet input of capacitor C 47 by integrated circuit U42, integrated circuit U42 amplifies the signal of input, outputs to 1 foot of integrated circuit U43 from 13 feet of integrated circuit U42 through amplifying signal; Integrated circuit U43 carries out filtering to the signal of input, and the signal of process filtering outputs to computer system by 4 feet of integrated circuit U43.
Figure 10 is the structural representation of computer system among Fig. 1.In Figure 10, the computer system of present embodiment by binding post insert 4, AD capture card 5, PC 6 connect and compose.Binding post inserts 4, AD capture card 5, the commodity of PC 6 for selling on the market, and PC 6 be a desk computer, and the model of binding post slotting 4 is that the model of NI-BNC-2110, AD capture card 5 is PCI-5115.Binding post is inserted 4 feet of integrated circuit U43 of 4 feet, the testing circuit 3 of the integrated circuit U32 of 18 feet that 3 input terminals of 4 meet the integrated circuit U22 of testing circuit 1 respectively, testing circuit 2; Other 3 input terminals of binding post are the outfan of outfan, exciting circuit 2 and exciting circuit 3 and exciting circuit 1 same circuits of the integrated circuit U11A of exciting circuit 1 respectively, and binding post is inserted 4 output termination AD capture card 5.AD capture card 5 is inserted in the pci expansion slot on PC 6 mainboards.PC 6 extracts the phase contrast between detection signal and the reference signal according to the LabVIEW software of prior input; Show phase change in real time; Judge in the cell and the bullate size of extracellular brain water, type and position; Distinguish in the cell and the bullate size of extracellular brain water, kind and position, demonstrate result of calculation.
Operation principle of the present invention is following:
The sinusoidal excitation signal that each exciting circuit produces passes the edema cerebral tissue through amplification, voltage to the excitation field that current conversion is applied to excitation coil L11 generation; Because biological tissue has electric conductivity; The excitation field of alternation can produce eddy current in biological tissue; Eddy current produces the disturbed magnetic field of alternation again, and excitation field is produced disturbance, and turbulent size reflects the variation of biological tissue's electrical conductivity.When the frequency of excitation field was hanged down, the eddy current of generation can not pass cell membrane, is merely able to pass from iuntercellular, and the eddy current that obtains is less, and the disturbed magnetic field of generation is less; When the frequency of excitation field was higher, the eddy current of generation can pass cell membrane, can pass from iuntercellular again, can obtain bigger eddy current, produced big disturbed magnetic field.Testing circuit 1, testing circuit 2, testing circuit 3 amplify the pulse signal that induction receives the size of disturbed magnetic field under the edema cerebral tissue different frequency, output to after the filtering AD capture card 5 of computer system; The reference signal of exciting circuit output outputs to the AD capture card 5 of computer system; Be input to PC 6 through AD capture card 5; PC 6 extracts the phase contrast between detection signal and the reference signal according to the LabVIEW software of prior input; Show phase change in real time, judge in the cell and the bullate size of extracellular brain water, type and position, demonstrate result of calculation.
Claims (2)
1. device for checking type of cerebral edema; Said device for checking type of cerebral edema comprises the computer system of the signal of being gathered being carried out date processing; Said device for checking type of cerebral edema comprises exciting circuit 1, exciting circuit 2, the exciting circuit 3 of the different frequency that is connected with computer system; Said device for checking type of cerebral edema also comprises testing circuit 1, testing circuit 2, testing circuit 3, the output termination computer system of testing circuit 1, testing circuit 2, testing circuit 3; It is characterized in that: the output termination testing circuit 1 of exciting circuit 1; The output termination testing circuit 2 of exciting circuit 2; The output termination testing circuit 3 of exciting circuit 3; Exciting circuit 1, testing circuit 1 connect and compose a cerebral edema detection system with computer system, and exciting circuit 2, testing circuit 2 connect and compose a cerebral edema detection system with computer system, and exciting circuit 3, testing circuit 3 connect and compose a cerebral edema detection system with computer system; Three separate cerebral edemas of carrying out of detection system detect, and the power of three detection systems is inequality; Described testing circuit 1 is connected and composed by pre-amplification circuit 1, active filter, and the outfan of pre-amplification circuit 1 is connected to source filter; Described testing circuit 2 is connected and composed by pre-amplification circuit 2, crystal filter 1, the output termination crystal filter 1 of pre-amplification circuit 2; Described testing circuit 3 is connected and composed by pre-amplification circuit 3, second amplifying circuit, crystal filter 2, the output termination second amplifying circuit of pre-amplification circuit 3, the output termination crystal filter 2 of second amplifying circuit.
2. according to the described device for checking type of cerebral edema of claim 1; It is characterized in that: described pre-amplification circuit 1 is: 5 feet of the termination integrated circuit U21 of coil L21 and the negative pole of diode D21 and the positive pole of diode D22; The minus earth of the other end of coil L21 and diode D21 positive pole and diode D22; 1 foot of integrated circuit U21 and 10 feet connect two ends that an end of the two ends of capacitor C 22, a end that 3 feet connect capacitor C 21 and capacitor C 23, the other end, 10 feet and 11 feet that 2 feet connect capacitor C 23 connect capacitor C 24 respectively, the other end that 12 feet connect capacitor C 21 and ground, 13 feet respectively and connect a end that 24 feet, 14 feet connect capacitor C 27, a end that 15 feet connect capacitor C 25,17 and 20 feet and connect 5V positive source, 18 and 19 feet through resistance R 224 and connect a end that 5V power cathode, 22 feet connect capacitor C 26,23 feet through resistance R 223 and connect the 5V positive source through resistance R 23 and resistance R 22 and connect an end and the adjustable end of potentiometer RC21 and connect 5V positive source, 6～8 feet and 16 feet and 21 foot ground connection through resistance R 26 through resistance R 23 and resistance R 24 ground connection and through resistance R 25 ground connection, 24 feet; The other end of potentiometer RC21 is through resistance R 27 ground connection, and the other end of capacitor C 26 is connected to source filter; The model of integrated circuit U21 is AD604; Described pre-amplification circuit 2 is identical with pre-amplification circuit 1 with pre-amplification circuit 3.
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| CN2010101906570A CN101849818B (en) | 2010-06-03 | 2010-06-03 | Device for checking type of cerebral edema |
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| CN102579009B (en) * | 2012-02-27 | 2013-10-23 | 重庆博恩富克医疗设备有限公司 | Electric signal processing unit for monitoring hydrocephalus and encephaledema |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1714746A (en) * | 2005-07-14 | 2006-01-04 | 中国人民解放军第四军医大学 | Non-contact magnetic inductive encephaledema monitoring method |
| CN201683898U (en) * | 2010-06-03 | 2010-12-29 | 中国人民解放军第三军医大学 | Hydrocephalus type examining device |
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| US20090312646A1 (en) * | 2007-09-13 | 2009-12-17 | The Regents Of The University Of California | Optical detection of seizure, a pre-seizure state, and cerebral edema and optical fiber detection of the same |
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| CN1714746A (en) * | 2005-07-14 | 2006-01-04 | 中国人民解放军第四军医大学 | Non-contact magnetic inductive encephaledema monitoring method |
| CN201683898U (en) * | 2010-06-03 | 2010-12-29 | 中国人民解放军第三军医大学 | Hydrocephalus type examining device |
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