CN101843931A - Blood cell apoptosis inducing method - Google Patents
Blood cell apoptosis inducing method Download PDFInfo
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- CN101843931A CN101843931A CN 201010175979 CN201010175979A CN101843931A CN 101843931 A CN101843931 A CN 101843931A CN 201010175979 CN201010175979 CN 201010175979 CN 201010175979 A CN201010175979 A CN 201010175979A CN 101843931 A CN101843931 A CN 101843931A
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- blood cell
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- cell apoptosis
- apoptosis inducing
- inducing method
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Abstract
The invention discloses a blood cell apoptosis inducing method, and relates to the technical field of medical treatment, in particular to the technical field of apoptosis induction of in-vitro blood cells. The technical scheme of the invention is that fresh blood cells are apoptotic under the induction of temperature, ozone and ultraviolet irradiation. Under the irradiation of ultraviolet with the wavelength of 253.7nm, a container which is filled with fresh blood is placed in a water bath at the temperature of 42.5+/-0.1 DEG C, and the gaseous ozone acts on the blood surface for 20 minutes. After the treatment of the method, the blood cell apoptosis incidence reaches 80 percent, the treatment process is simple and scientific, and the stability is high.
Description
Technical field
The present invention relates to field of medical technology, is the technical field of in-vitro blood cells being carried out apoptosis induction.
Background technology
Heart failure has sickness rate height, disability rate height and the high characteristics of fatality rate, is called as last fort of not captured of cardiovascular disease prevention and control field.The various Therapeutic Method in the comprehensive present age, its 5 annual death rate still may surpass 50% (male) or 30% (women).In recent years, in the research to heart failure generation development mechanism, recognize progressively that inflammatory factor and immune activation state are the important mechanisms that heart failure runs down.Different researchers has successively been attempted multiple different medicine and biological method, and patients with heart failure is carried out immunologic intervention, but does not all obtain positive effect.
Over year, the research data of different researchers shows that the hemocyte of apoptosis has immunoregulation effect, may have therapeutical effect to the panimmunity disease surplus in the of nearly ten.And then certain company of Canada is name with Celacade, has set up the equipment of inducing blood cell apoptosis by comprehensive physical stimulation, through this processing, can make the hemocyte generation apoptosis more than 80%.They are applied to panimmunity abnormity disease treatment research field with this method, wherein, have showed good prospect for the treatment of heart failure.But up to now, China is still for setting up the method for inducing blood cell apoptosis of stability and high efficiency.
Summary of the invention
The object of the invention is to set up a kind of stable method of inducing blood cell apoptosis, uses for Related Research Domain and exploitation clinical treatment method.
Technical scheme of the present invention is: serviceability temperature, ozone and ultraviolet radiation are induced simultaneously, make fresh blood cell generation apoptosis.
That is, be under the irradiation under ultraviolet ray of 253.7nm at wavelength, the container that is marked with fresh blood is placed in the water-bath of 42.5 ± 0.1 ℃ of temperature, ozone gas is acted on blood surface 20 minutes.
After the inventive method processing, can make the blood cell apoptosis incidence rate reach 80%, and the invention processing procedure is simple, science, good stability.
The specific embodiment
On operating table surface, fixedly install thermostatic water bath, the quartz burner of band ultraviolet protection cover is set in the tank top, the container of making by support fixed placement quartz glass in tank, the both sides on container top connect ozone gas input channel and output channel respectively.
The blood cell apoptosis processing procedure: the water in the control tank is warming up to 42.5 ± 0.1 ℃, the container that fresh blood is housed is placed on the support, and makes blood be immersed in below the water level of tank 3/4 of the about container of the degree of depth; Open ozone gas generation equipment and produce ozone gas, open the valve of ozone gas input channel and output channel, carry out the ultraviolet radiation that wavelength is 253.7nm simultaneously.Keep above conditional stability constant, continue 20 minutes, can effectively stably induce the blood cell apoptosis.
To re-enter in patient's body through the blood (10ml, wherein apoptosis has taken place 80% hemocyte) of above-mentioned processing, can play immunoregulation effect, be applied to chronic inflammatory reaction treatment of diseases such as chronic heart failure.We will at first be applied to this method the treatment of heart failure.
Apoptotic blood will take place re-enter in patient's body, it is nearly 30% that 2 years admission rates of light, moderate patients with heart failure and mortality rate are reduced, for new prospect has been showed in the treatment of heart failure.First clinical practice target of the present invention is to invent new Therapeutic Method, the therapeutic effect of raising China heart failure patient.
Claims (2)
1. blood cell apoptosis inducing method is characterized in that: serviceability temperature, ozone and ultraviolet radiation are induced simultaneously, make fresh blood cell generation apoptosis.
2. according to claim 1 blood cell apoptosis inducing method, it is characterized in that: be under the irradiation under ultraviolet ray of 253.7nm at wavelength, the container that is marked with fresh blood placed in the water-bath of 42.5 ± 0.1 ℃ of temperature, ozone gas is acted on blood surface 20 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010175979 CN101843931A (en) | 2010-05-19 | 2010-05-19 | Blood cell apoptosis inducing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010175979 CN101843931A (en) | 2010-05-19 | 2010-05-19 | Blood cell apoptosis inducing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101843931A true CN101843931A (en) | 2010-09-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN 201010175979 Pending CN101843931A (en) | 2010-05-19 | 2010-05-19 | Blood cell apoptosis inducing method |
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| CN (1) | CN101843931A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968483A (en) * | 1987-01-15 | 1990-11-06 | Quarzlampenfabrik Dr.-Ing. Felix W. Muller Gmbh & Co. Kg | Apparatus for the production of oxygenated blood |
| US5591457A (en) * | 1992-02-07 | 1997-01-07 | Vasogen Inc | Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human |
| CN1400906A (en) * | 2000-01-18 | 2003-03-05 | 瓦索根爱尔兰有限公司 | Treatment of congestive heart failure by pretreated autologous blood |
| CN101829372A (en) * | 2010-05-11 | 2010-09-15 | 江苏中惠医疗科技股份有限公司 | Blood cell apoptosis inducible system |
| CN201676334U (en) * | 2010-05-11 | 2010-12-22 | 江苏中惠医疗科技股份有限公司 | Blood cell apoptosis induction system |
-
2010
- 2010-05-19 CN CN 201010175979 patent/CN101843931A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968483A (en) * | 1987-01-15 | 1990-11-06 | Quarzlampenfabrik Dr.-Ing. Felix W. Muller Gmbh & Co. Kg | Apparatus for the production of oxygenated blood |
| US5591457A (en) * | 1992-02-07 | 1997-01-07 | Vasogen Inc | Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human |
| CN1400906A (en) * | 2000-01-18 | 2003-03-05 | 瓦索根爱尔兰有限公司 | Treatment of congestive heart failure by pretreated autologous blood |
| CN101829372A (en) * | 2010-05-11 | 2010-09-15 | 江苏中惠医疗科技股份有限公司 | Blood cell apoptosis inducible system |
| CN201676334U (en) * | 2010-05-11 | 2010-12-22 | 江苏中惠医疗科技股份有限公司 | Blood cell apoptosis induction system |
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| PB01 | Publication | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20100929 |