CN101843625A - Compound ofloxacin injection for livestock and preparation method thereof - Google Patents
Compound ofloxacin injection for livestock and preparation method thereof Download PDFInfo
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- CN101843625A CN101843625A CN 201010136351 CN201010136351A CN101843625A CN 101843625 A CN101843625 A CN 101843625A CN 201010136351 CN201010136351 CN 201010136351 CN 201010136351 A CN201010136351 A CN 201010136351A CN 101843625 A CN101843625 A CN 101843625A
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Abstract
The invention discloses a compound ofloxacin injection for livestock and a preparation method thereof. Each 100mL of injection comprises the following components: 1-4g of ofloxacin, 0.5-2g of acetylcysteine, 3g of polyethylene glycol 10000, 0.05-0.1g of dexamethasone sodium phosphate, and the balance of water for injection, wherein, the mass ratio of ofloxacin to acetylcysteine is 2:1. The preparation method comprises the following steps: dissolving acetylcysteine into part of water for injection, adding ofloxacin, stirring for dissolving to obtain solution A; dissolving 10000g of polyethylene glycol into part of water for injection; adding dexamethasone sodium phosphate, and stirring for dissolving to obtain solution B; mixing the solution A and the solution B; adding 100mL of water for injection; evenly mixing, filtering, encapsulating, and sterilizing to obtain the compound ofloxacin injection. The injection of the invention has the characteristics of high efficiency and long effect, simple preparation method and good product stability, and is especially suitable for livestock bacteria and mycoplasma severe infection.
Description
Technical field
The present invention relates to a kind of veterinary medicine, particularly a kind of compound ofloxacin injection for animals also relates to the preparation method of this injection.
Background technology
Ofloxacin is the high-efficiency broad spectrum antimicrobial drug, by acting on the A subunit of DNA of bacteria helicase, suppresses the synthetic of DNA and duplicates and cause antibacterial death.At present, digestive tract disease, respiratory tract disease and reproductive system disease etc. that the widely-used ofloxacin injection treatment of veterinary clinic poultry antibacterial, mycoplasma infection cause have good result.But still there are some problems in actual applications in it: 1. the water solublity of ofloxacin is relatively poor, when preparing ofloxacin injection, mainly adopt the method for solubilizing agent regulator solution pH value such as adding hydrochloric acid, acetic acid to increase the dissolubility of ofloxacin in water in the prior art, but this method is because acidity easy-regulating not, product stability is poor, and very easily variable color was lost efficacy under illumination; 2. folk prescription ofloxacin injection antiallergic and antiphlogistic effects when treatment poultry antibacterial, mycoplasma severe infections is not satisfactory, and use in conjunction antiallergic and anti-inflammatory drug have increased the treatment cost again.
Summary of the invention
In view of this, one of purpose of the present invention is to provide a kind of compound ofloxacin injection for animals, not only can solve the difficult problem of ofloxacin poorly water-soluble and injection poor stability thereof, and can improve antibacterial effect, prolongs drug effect; Simultaneously,, can also strengthen antiallergic and antiphlogistic effects, and reduce chemical sproof generation by reasonable compatibility antiallergic and anti-inflammatory drug; Two of purpose is to provide a kind of preparation method of described compound ofloxacin injection for animals, and is easy and simple to handle, and product stability is good, and cost is low, is suitable for large-scale industrialization production.
For achieving the above object, the present invention adopts following technical scheme:
1, compound ofloxacin injection for animals, every 100mL injection is made up of the component of following proportioning: ofloxacin 1～4g, acetylcysteine 0.5～2g, cetomacrogol 1000 03g, dexamethasone sodium phosphate 0.05～0.1g, surplus is a water for injection; Wherein, the mass ratio of ofloxacin and acetylcysteine is 2: 1.
Further, the pH value of described injection is 4.0～4.5.
2, the preparation method of described compound ofloxacin injection for animals may further comprise the steps:
A, the acetylcysteine of formula ratio is dissolved in the part water for injection, adds the ofloxacin of formula ratio again, stir and make dissolving fully, solution A;
B, the cetomacrogol 1000 0 of formula ratio is dissolved in the part water for injection, adds the dexamethasone sodium phosphate of formula ratio again, stir and make dissolving fully, solution B;
C, step a gained solution A and step b gained solution B are mixed, add water for injection to 100mL, mixing filters, embedding, and sterilization promptly gets compound ofloxacin injection for animals.
In injection of the present invention, acetylcysteine is mainly as the solubilizing agent of ofloxacin.Compare with solubilizing agents such as available technology adopting hydrochloric acid, acetic acid, acetylcysteine have acidity easily controls, stable, advantage such as lyotropy is good.In addition, the sputum that also respiratory tract infection caused of bibliographical information acetylcysteine increases good resolve phlegm effect.
In injection of the present invention, cetomacrogol 1000 0 is mainly as the stabilizing agent and the synergist of ofloxacin.Cetomacrogol 1000 0 is the flexible macromolecule chemical compound, ofloxacin and antibacterial all can be adsorbed on the macromolecular chain, reduces on the one hand contacting of ofloxacin and unstable factors such as metal ion, illumination, thus the stability of increase ofloxacin; Increase contacting of ofloxacin and antibacterial on the other hand, thereby increase the antibacterial effect of ofloxacin.Simultaneously, cetomacrogol 1000 0 can increase the denseness of injection, and prolong drug is in the time of staying of injection site, thereby helps drug absorption and prolong drug effect.In addition, bibliographical information cetomacrogol 1000 0 can also suppress colibacillary growth, and the antagonism bacterial endotoxin is to the murder by poisoning of animal, the shock that animal is caused because of severe infections and hemorrhage good effect arranged also.
In injection of the present invention, dexamethasone sodium phosphate is as antiallergic and anti-inflammatory drug and ofloxacin compatibility.Dexamethasone sodium phosphate is an Aeroseb-Dex, have effects such as antiinflammatory, antiallergic, antiendotoxin, its mechanism of action is: 1. antiinflammatory action: can suppress neutrophil cell gathering to inflammation part, stablize lysosome membrane, vasoconstrictive, reduce vascular permeability, stop the synthetic and release of lysosomal enzyme and inflammation chemistry intermediary material, strengthen the resistance of cellular matrix, suppress the fibroblast proliferation of connective tissue and the fibrocyte antiinflammatory action that reaches such as synthetic mucopolysaccharide acid enzyme.2. anti-allergic effects: can reduce sanguimotor T lymphocyte, mononuclear cell, oxyphil cell, suppress macrophage to antigenic picked-up and processing, impel the protein alienation, Profilin matter is synthetic, influence the synthetic grade of antibody and reaches anti-allergic effects.3. anti-endotoxin effect: can keep the integrity of cell membrane and reduce the permeability of cell membrane, thereby make bacterial endotoxin be difficult for penetrating in the cell.
The present invention considers that the adaptability of animal body and ofloxacin produce the optimum condition of bactericidal action, and control injection pH value is 4.0～4.5, and has determined the proportioning of each component of injection thus.Than the injection that makes, its pH value is 4.0～4.5 by set of dispense of the present invention, does not generally need to add in addition the pH regulator agent.
Beneficial effect of the present invention is: the present invention adopts acetylcysteine to increase the dissolubility of ofloxacin, under cetomacrogol 1000 0 collaborative, make stable, efficient, long lasting ofloxacin injection, not only solved the difficult problem of ofloxacin poorly water-soluble and injection poor stability thereof, and improved antibacterial effect, prolonged drug effect; Simultaneously, reasonable compatibility has the dexamethasone sodium phosphate of antiallergic and antiinflammatory action in injection, the antiallergic and the antiphlogistic effects of injection have been strengthened again, and can reduce the chemical sproof generation of ofloxacin, the gained injection is specially adapted to poultry antibacterial, mycoplasma severe infections such as piglet malignant dysentery, porcine nameless high-fever, mammitis of cow, Pullorum Disease etc., has characteristics such as efficient, long-acting, short treating period, treating both the principal and secondary aspects of a disease.The preparation method of injection of the present invention is easy, and product stability is good, and cost is low, is suitable for large-scale industrialization production.
Description of drawings
Accompanying drawing is the drug sensitive test result of compound ofloxacin injection for animals, and wherein, " 104-A " is matched group, and " 104-B " is experimental group, " 1 " expression original content medicinal liquid, and 10 times of dilute liquid medicines of " 10 " expression, " 100 " are expressed as 100 times of dilute liquid medicines.
The specific embodiment
In order to make the purpose, technical solutions and advantages of the present invention clearer, the preferred embodiments of the present invention are described in detail below in conjunction with accompanying drawing.
The ofloxacin that uses among the embodiment (is 99.7% in dry product content) closes mesophytization medical material factory available from city far away, Wuhan, acetylcysteine (is 99.5% in dry product content) is available from Wuhan University Hoyo Pharmaceutical Co., Ltd., cetomacrogol 1000 0 (chemical pure) is available from the grand industry and trade Co., Ltd of the prosperous perseverance in Wuhan, and dexamethasone sodium phosphate (is 99.7% in dry product content) is available from city far away, Wuchang, Wuhan Science and Technology Ltd..
Embodiment 1,1% (g/mL) compound ofloxacin injection for animals
Prescription: ofloxacin 1.0g, acetylcysteine 0.5g, cetomacrogol 1000 03.0g, dexamethasone sodium phosphate 0.05g, water for injection adds to 100mL.
Method for making: may further comprise the steps:
A, the acetylcysteine of formula ratio is dissolved among the water for injection 10mL, adds the ofloxacin of formula ratio again, stir and make dissolving fully, solution A;
B, the cetomacrogol 1000 0 of formula ratio is dissolved among the water for injection 40mL, adds the dexamethasone sodium phosphate of formula ratio again, stir and make dissolving fully, solution B;
C, step a gained solution A and step b gained solution B are mixed, add water for injection to 100mL, mix homogeneously is that the microporous filter membrane of 0.45 μ m filters with the aperture, and embedding is that 120 ℃, pressure are that the circulation steam of 0.15MPa was sterilized in 25 minutes with temperature, promptly.
Embodiment 2,2% (g/mL) compound ofloxacin injection for animals
Prescription: ofloxacin 2.0g, acetylcysteine 1.0g, cetomacrogol 1000 03.0g, dexamethasone sodium phosphate 0.075g, water for injection adds to 100mL.
Method for making: identical with embodiment 1 described method for making.
Embodiment 3,3% (g/mL) compound ofloxacin injection for animals
Prescription: ofloxacin 3.0g, acetylcysteine 1.5g, cetomacrogol 1000 03.0g, dexamethasone sodium phosphate 0.1g, water for injection adds to 100mL.
Method for making: identical with embodiment 1 described method for making.
Embodiment 4,4% (g/mL) compound ofloxacin injection for animals
Prescription: ofloxacin 4.0g, acetylcysteine 2.0g, cetomacrogol 1000 03.0g, dexamethasone sodium phosphate 0.1g, water for injection adds to 100mL.
Method for making: identical with embodiment 1 described method for making.
Embodiment 5, contrast folk prescription ofloxacin injection
Prescription: ofloxacin 4.0g, acetylcysteine 2.0g, water for injection adds to 100mL.
Method for making: the acetylcysteine of formula ratio is dissolved among the water for injection 10mL, the ofloxacin that adds formula ratio again, stirring makes dissolving fully, add water for injection to 100mL, mix homogeneously is the microporous filter membrane filtration of 0.45 μ m with the aperture, embedding, with temperature is that 120 ℃, pressure are the circulation steam sterilization in 25 minutes of 0.15MPa, promptly.
The stability test of test example 1, compound ofloxacin injection for animals
Method: get the compound ofloxacin injection for animals of embodiment 1～4 and the contrast folk prescription ofloxacin injection of embodiment 5, carry out accelerated test according to an appendix veterinary drug of Chinese veterinary drug allusion quotation version in 2005 stability test guideline, press commercially available back, in temperature is that 40 ± 2 ℃, relative humidity are that 75+5%, illumination are to place 6 months under the condition of 4500+500LX, take a sample respectively once the 1st, 2,3,6 the end of month at duration of test, appearance luster, pH value and the content of injection (by indicating percentage composition) are detected.
Result: see Table 1.As shown in Table 1, through after 6 months accelerated tests, the appearance luster of compound ofloxacin injection for animals of the present invention, pH value, ofloxacin content and content determination of Dexamethasone Sodium have no significant change, and having good stability of injection of the present invention is described.
The stability test result of table 1 compound ofloxacin injection for animals
The clinical trial of test example 2, compound ofloxacin injection for animals
Method: choose infected animal, be divided into experimental group, matched group and blank group at random, experimental group apparent motion species and body weight give the compound ofloxacin injection for animals of embodiment 1,2,3 or 4, and matched group gives the contrast folk prescription ofloxacin injection of embodiment 5, and blank group gives normal saline; Wherein, 1. piglet malignant dysentery experimental group gives the compound ofloxacin injection for animals of embodiment 1 or 2, and dosage is per kilogram of body weight 5mg (in an ofloxacin), administration every day 2 times, and successive administration 2～3 days, administering mode are intramuscular injection; 2. the porcine nameless high-fever experimental group gives the compound ofloxacin injection for animals of embodiment 3 or 4, and dosage is per kilogram of body weight 5mg (in an ofloxacin), administration every day 2 times, and successive administration 2～3 days, administering mode are intramuscular injection; 3. the mammitis of cow experimental group gives the compound ofloxacin injection for animals of embodiment 4, and dosage is each newborn chamber 10mg (in ofloxacin), administration every day 1 time, and successive administration 2～3 days, administering mode is perfusion; 4. the Pullorum Disease experimental group is thin up after for sick chicken cut off the water 3 hour after freely to drink every day administration 1～2 time, successive administration 2～3 day at 1: 1000 with the compound ofloxacin injection for animals of embodiment 4 by volume; Matched group is identical with the experimental group of corresponding disease with administering mode with the dosage of blank group; After the treatment beginning, write down infected animal health situation of change every day, treat and add up therapeutic outcome after 2 days.
Result: see Table 2.As shown in Table 2, compound ofloxacin injection for animals of the present invention all has good efficacy to piglet malignant dysentery, porcine nameless high-fever, mammitis of cow and Pullorum Disease.
The clinical test results of table 2 compound ofloxacin injection for animals
The long-lasting test of test example 3, compound ofloxacin injection for animals
Method: with body weight is that the healthy rabbits of 2+0.5kg is divided into two groups at random: experimental group and matched group, every group 6, male and female half and half, experimental group give the compound ofloxacin injection for animals of embodiment 4, and matched group gives the contrast folk prescription ofloxacin injection of embodiment 5; Two groups all by the dosage administered intramuscular of per kilogram of body weight 5mg (in ofloxacin), respectively at after the administration 0.5,1,2,4,6,9,12 hour through ear vein blood sampling 1mL, handle removal albumen with trichloroacetic acid, the reuse aperture is the filtering with microporous membrane of 0.45 μ m, filtrate is with the content of high effective liquid chromatography for measuring ofloxacin, with MCPKP computed in software blood drug level and pharmacokinetic parameter.
Result: see Table 3, as shown in Table 3, the blood drug level and the pharmacokinetic parameter of experimental group and matched group have significant difference, illustrate that compound ofloxacin injection for animals of the present invention has to prolong ofloxacin and absorb, increase its body internal diffusion, postpone the effect of its elimination.
The long-lasting result of the test of table 3 compound ofloxacin injection for animals
| Blood drug level and pharmacokinetic parameter | Experimental group | Matched group |
| Peak time (h) | ??1.98 | ??0.73 |
| Maximum plasma concentration (mgL -1) | ??9.321±0.27 | ??4.763±0.32 |
| Distribution half-life (h) | ??29.131±33.217 | ??17.675±14.813 |
| Area under the drug-time curve (mgLh -1) | ??46.276±4.758 | ??32.732±2.365 |
| Apparent volume of distribution (Lkg -1) | ??2.779 | ??1.423 |
The drug sensitive test of test example 4, compound ofloxacin injection for animals
Method: the picking enterotoxigenic Escherichia coli is (from the sick pig in pig farm and chicken farm, sick chicken goes up gathers typical pathological material of disease, get through the pathogen separation evaluation) culture, streak inoculation is on the maconkey agar flat board, circular rustless steel tubule (internal diameter 6nm with sterilization, external diameter 8nm, high 10nm) is positioned on the flat board, pressurization gently, make itself and the dull and stereotyped tight that contacts, each dull and stereotyped going up is placed 6 tubules, in tubule, drip original content medicinal liquid (is 5mg/mL in ofloxacin concentration) respectively, 10 times of dilute liquid medicines and 100 times of dilute liquid medicines, each concentration liquid respectively adds two tubules, notice that the messenger drug hydrorrhea does not go out tubule, wherein the used medicinal liquid of experimental group is the compound ofloxacin injection for animals of embodiment 1, the used medicinal liquid of matched group is the contrast folk prescription ofloxacin injection of embodiment 5, cultivated 8～18 hours, and observed the antibacterial circle diameter size for the most rearmounted 37 ℃.
Result: see accompanying drawing, by accompanying drawing as can be known, compare that compound ofloxacin injection for animals of the present invention has stronger sensitivity to enterotoxigenic Escherichia coli with contrast folk prescription ofloxacin injection.
Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although by invention has been described with reference to the preferred embodiments of the present invention, but those of ordinary skill in the art is to be understood that, can make various changes to it in the form and details, and the spirit and scope of the present invention that do not depart from appended claims and limited.
Claims (3)
1. compound ofloxacin injection for animals, it is characterized in that: every 100mL injection is made up of the component of following proportioning: ofloxacin 1～4g, acetylcysteine 0.5～2g, cetomacrogol 1000 0 3g, dexamethasone sodium phosphate 0.05～0.1g, and surplus is a water for injection; Wherein, the mass ratio of ofloxacin and acetylcysteine is 2: 1.
2. according to the described compound ofloxacin injection for animals of claim 1, it is characterized in that: the pH value of described injection is 4.0～4.5.
3. the preparation method of the described compound ofloxacin injection for animals of claim 1 is characterized in that: may further comprise the steps:
A, the acetylcysteine of formula ratio is dissolved in the part water for injection, adds the ofloxacin of formula ratio again, stir and make dissolving fully, solution A;
B, the cetomacrogol 1000 0 of formula ratio is dissolved in the part water for injection, adds the dexamethasone sodium phosphate of formula ratio again, stir and make dissolving fully, solution B;
C, step a gained solution A and step b gained solution B are mixed, add water for injection to 100mL, mixing filters, embedding, and sterilization promptly gets compound ofloxacin injection for animals.
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| CN2010101363517A CN101843625B (en) | 2010-03-30 | 2010-03-30 | Compound ofloxacin injection for livestock and preparation method thereof |
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| CN101676290A (en) * | 2008-09-16 | 2010-03-24 | 沈阳华泰药物研究有限公司 | Levofloxacin salt, and preparation method thereof and medicament composition |
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2010
- 2010-03-30 CN CN2010101363517A patent/CN101843625B/en not_active Expired - Fee Related
Patent Citations (7)
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| CN1522704A (en) * | 2003-02-19 | 2004-08-25 | 王玉万 | Parasite resistant slow release injection formulation for animals |
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| 《中国实用内科杂志》 20071231 谢伟等 N－乙酰半胱氨酸对铜绿假单胞菌生物被膜影响的实验研究 第1952-1954 1-2 第27卷, 第24期 2 * |
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Owner name: SICHUAN SANMING PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: CHONGQING BASHIDI ANIMAL MEDICINE CO., LTD. Effective date: 20120828 |
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