CN101829264A - Medicine composition for treating hyperuricemia and related diseases and preparation method and application thereof - Google Patents

Medicine composition for treating hyperuricemia and related diseases and preparation method and application thereof Download PDF

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Publication number
CN101829264A
CN101829264A CN200910025326A CN200910025326A CN101829264A CN 101829264 A CN101829264 A CN 101829264A CN 200910025326 A CN200910025326 A CN 200910025326A CN 200910025326 A CN200910025326 A CN 200910025326A CN 101829264 A CN101829264 A CN 101829264A
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alcohol
concentrated solution
water
bulbus fritillariae
alcohol extraction
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CN101829264B (en
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萧伟
丁岗
曹亮
崔瑛
杨保林
李明慧
陈俊
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Jiangsu Kanion Pharmaceutical Co Ltd
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Jiangsu Zeukov Pharmaceutical S & T Inc
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Abstract

The invention relates to a medicine composition for treating hyperuricemia and hyperuricemia related diseases (such as gout, urate nephropathy). The medicine composition is characterized by being prepared by adopting the following traditional Chinese medicine raw material according to the weight proportion: 0.1-15g of artemisia anomala, 0.1-15g of the bark of ash, 0.1-15g of thunberg fritillary bulb, 0.1-30g of wild chrysanthemum flower, 0-30g of astragalus root, 0-15g of cassia twig, 0-15g of kadsura pepper stem, 0-15g of herba lycopi and 0-15g of baical skullcap root. The invention discloses a preparation method, a preparation and application of the medicine composition. The invention has better safety, can effectively lower the concentration of uric acid and remarkably improve the symptoms of all stages of gout, and is suitable for treatment of hyperuricemia related diseases (such as gout, urate nephropathy), especially treatment of gout incubation (hyperuricemia) and diapause.

Description

Pharmaceutical composition and the method for making and the purposes of treatment hyperuricemia and relevant disease
Technical field
The present invention relates to a kind of is the pharmaceutical composition of raw material with Chinese medicine, and particularly a kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy); The invention still further relates to this preparation of drug combination method, preparation and purposes.
Background technology
Gout (gout) is because purine metabolic disturbance, and uric acid produces too much and/or urate excretion reduces, and serum uric acid level continues to increase and causes urate crystal to be deposited on one group of metabolic disease due to joint and the soft tissue.
The gout clinical manifestation can be divided into 4 stages: incubation period (hyperuricemia phase), acute stage, intermission, chronic phase.Asymptomatic stage only shows as hyperuricemia and does not have any symptom, be developed to gout by asymptomatic hyperuricemia and generally experience the several years to many decades, gout does not take place throughout one's life but have yet, hyperuricemia (hyperuricemia) is the important biochemical basis of gout, but also involves kidney and cardiovascular system easily.Gout is sent out the author repeatedly and is made progress gradually and be the chronic arthritis phase, is more common in untreated or the not good patient of treatment, prevents that in early days the patient of hyperuricemia from can not have this phase.Later stage can also cause nephropathy, shows as urate nephropathy, kidney urate calculus and acute renal failure.
Diseases such as hyperuricemia and primary gout and obesity, hyperlipemia, hypertension, diabetes, atherosclerosis are remarkable positive correlation, 60% the concurrent hypertension of patient with gout, coronary heart disease and hyperlipemia are arranged, the concurrent renal dysfunction of 30% patient.Therefore, gout is the same with diabetes, is a kind of serious metabolic disease of harm humans health.Seek the research determined curative effect, few or light medical treatment hyperuricemia and the gouty arthritis of untoward reaction has great importance.
Present China hyperuricemia sickness rate 10%, about 1.2 hundred million people.Gout sickness rate 1%, the patient about 1,200 ten thousand.Modern medicine still is in the symptomatic treatment stage to the treatment of gout, and according to the drug effect mode, chemical medicine can be divided into five classes: (1) suppresses granulocyte and soaks into medicine, as colchicine; (2) suppress the uricopoiesis medicine, as the xanthine oxidase inhibitor allopurinol; (3) uricosureic agent is as probenecid, sulphinpyrazone, benzbromarone; (4) on-steroidal AID is as naproxen, indomethacin, Phenylbutazone or crovaril, piroxicam; (5) glucocorticoid is as prednisone.Wherein many kinds are the old medicine of last century five, sixties exploitation, and side effect is bigger, and as medicine irritation, anaphylaxis, Liver and kidney toxicity, bone marrow depression etc., the patient is difficult to continue to use.Therefore the anti-gout drugs of seeking high-efficiency low-toxicity from Chinese medicine is the focus of research always.
The traditional Chinese medical science is thought, gout mainly is because surfeit Sorghum vulgare Pers. savoury usually, accumulate in the turbid damp poison heresy, affection of exogenous wind-cold, QI and blood is not smooth, spleen kidney imbalance in addition, wet, expectorant, the stasis of blood, the all evil numbness resistance passages through which vital energy circulates of heat form, therefore, the heat-clearing and toxic substances removing that adopt more, dampness removing is let out turbid, the dispelling wind collateral dredging, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, the rule of treatment method of treatment of strengthening spleen, tonifying kidney, the Chinese patent medicine of treatment gout is still few at present, mainly contain numbness Medicine wine for activating the channels clearly, compound recipe is stretched the muscle capsule, the gout stator, gout relieving capsule and granule, the TONGFENGDING capsule, Bin leaves of pulse plants gout mixture etc., still can not satisfy the demand that sharply rises to the gout Chinese patent medicine that can effectively reduce blood uric acid in market, gout is that the medicine of hyperuricemia still belongs to blank incubation period.
Summary of the invention
Technical problem to be solved by this invention provides a kind of treatment hyperuricemia new, that compatibility is reasonable, curative effect is better and the pharmaceutical composition of associated disease.
Another technical problem to be solved by this invention has provided the preparation of drug combination method of aforesaid multiple treatment hyperuricemia and associated disease.
Another technical problem to be solved by this invention has provided the pharmaceutical composition of aforesaid treatment hyperuricemia and associated disease or the pharmaceutical preparation that aforesaid preparation method is made.
Pharmaceutical composition of the present invention is applicable to hyperuricemia, and with the hyperuricemia diseases associated, as goat, urate nephropathy, be specially adapted to treat gout and hyperuricemia (gout incubation period, intermission).
Technical problem to be solved by this invention is to realize by following technical scheme.The present invention is a kind of pharmaceutical composition for the treatment of hyperuricemia and associated disease, is characterized in, it is to be made by following Chinese medicine raw materials by weight proportion,
Herba Artemisiae Anomalae 0.1～15; Cortex Fraxini 0.1～15; Bulbus Fritillariae Thunbergii 0.1～15; Flos Chrysanthemi Indici 0.1～30;
The Radix Astragali 0～30; Ramulus Cinnamomi 0～15; Caulis Piperis Kadsurae 0～15; The Herba Lycopi 0～15;
Radix Scutellariae 0～15.
In drug regimen composition formula of the present invention, Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii and Flos Chrysanthemi Indici 4 flavor raw materials are formed square substantially; The Radix Astragali, Ramulus Cinnamomi, Caulis Piperis Kadsurae, Herba Lycopi and Radix Scutellariae 5 flavor raw materials are optional raw materials; 5 flavors any in the optional raw material or multiplely can carry out prescription with the basic side of above-mentioned 4 flavors; When the weight proportion of the optional raw material of 5 flavors is selected " 0 ", represent and do not contain this raw material in the prescription.
In above-described pharmaceutical composition, the preferred weight proportioning of each raw material is:
Herba Artemisiae Anomalae 6～9; Cortex Fraxini 6～9; Bulbus Fritillariae Thunbergii 3～9; Flos Chrysanthemi Indici 6～9;
The Radix Astragali 0～18; Ramulus Cinnamomi 0～9; Caulis Piperis Kadsurae 0～9; The Herba Lycopi 0～9;
Radix Scutellariae 0～9.
In above-described pharmaceutical composition, when the basic side of any or multiple and above-mentioned 4 flavors in the Radix Astragali, Ramulus Cinnamomi, Caulis Piperis Kadsurae, Herba Lycopi and the optional raw material of Radix Scutellariae 5 flavors carried out prescription, its weight proportion was preferably respectively; The Radix Astragali 0.1～30; Ramulus Cinnamomi 0.1～15; Caulis Piperis Kadsurae 0.1～15;
The Herba Lycopi 0.1～15; Radix Scutellariae 0.1～15;
The further preferred weight proportion of the optional raw material of 5 flavors is respectively:
The Radix Astragali 3～18; Ramulus Cinnamomi 0.1～6; Caulis Piperis Kadsurae 3～9;
The Herba Lycopi 3～9; Radix Scutellariae 3～9.
In aforementioned pharmaceutical compositions, the preferred Artemisia anomah S. Moore of described Herba Artemisiae Anomalae (Artemisia anomala) also can be siphonostegia chinensis (Siphonostegia chinensis).
Pharmaceutical composition of the present invention can be prepared according to conventional method of the prior art, extracts the active ingredient of each raw material of Chinese medicine, adds needed pharmaceutic adjuvant, makes the medicine of clinical any oral or exterior-applied formulation applicatory.Pharmaceutical composition of the present invention preferably is prepared by the method for the following stated.Drug combination preparation of the present invention or can be the medicament of acceptable clinically any oral or exterior-applied formulation by the preparation that the inventive method makes, its dosage form includes but not limited to capsule, soft capsule, tablet, pill, drop pill, granule, powder, patch, unguentum, gel, liquid preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can prepare by the following method, and its step is as follows,
(1) get whole raw material of Chinese medicine by weight ratio and carry out decocting and get the water extract, concentrate water extracting liquid; Perhaps, the water extracting liquid precipitate with ethanol, the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution;
(2) get water extracting liquid or water extract-alcohol precipitation concentrated solution, make oral or external preparation; Perhaps, with water extracting liquid or water extract-alcohol precipitation concentrated solution drying, make oral or external preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is as follows,
(1) gets Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavor extraction volatile oil by weight ratio;
(2) medicinal residues merge decocting with the residue raw material of Chinese medicine and get the water extract, concentrate water extracting liquid; Perhaps, the water extract concentrates the back precipitate with ethanol, and the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution;
(3) get water extracting liquid or water extract-alcohol precipitation concentrated solution, add volatile oil, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation water extracting liquid or water extract-alcohol precipitation concentrated solution drying.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, its step is as follows, get whole raw material of Chinese medicine by weight ratio and carry out alcohol extraction, alcohol extract is made mixture or oral liquid after concentrating, and perhaps concentrates the back drying and makes oral or external preparation; Perhaps, get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, and alcohol extract concentrates, and the alcohol extraction concentrated solution is merged, and makes mixture or oral liquid, and perhaps drying is made oral or external preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is as follows,
(1) get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates;
(2) get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates;
(3) the alcohol extraction concentrated solution is merged, add volatile oil, make oral or external preparation; Or, add behind the enclose or the volatile oil of enclose not with alcohol extraction concentrated solution drying, make oral or external preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is as follows,
(1) gets Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio;
(2) medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates, and adds volatile oil, makes oral or external preparation; Or, add behind the enclose or the volatile oil of enclose not with alcohol extraction concentrated solution drying, make oral or external preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is as follows, gets whole raw material of Chinese medicine by weight ratio and carries out alcohol extraction, and alcohol extract concentrates; The medicinal residues decocting, the water extract concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation; Perhaps, with alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is as follows,
(1) gets Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio;
(2) medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, gets alcohol extract;
(3) medicinal residues decocting, the water extract concentrates, and merges with alcohol extract, adds volatile oil, makes oral or external preparation; Perhaps the water extract is concentrated, merge with alcohol extract, drying adds behind the enclose or the volatile oil of enclose not, makes oral or external preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is as follows,
(1) get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates;
(2) residue raw material of Chinese medicine alcohol extraction together, alcohol extract concentrates;
(3) medicinal residues after the above-mentioned alcohol extraction are merged water and carry, the water extract concentrates;
(4) alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation; Perhaps, with alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is as follows,
(1) get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates;
(2) get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates;
(3) medicinal residues after the above-mentioned alcohol extraction are merged water and carry, the water extract concentrates;
(4) alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation alcohol extraction concentrated solution, water extracting liquid drying.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is as follows,
(1) get by weight ratio Radix Astragali water carry the water extract, concentrate water extracting liquid; Perhaps, get the water extracting liquid precipitate with ethanol, the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution;
(2) get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates;
(3) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is as follows,
(1) get Radix Astragali water by weight ratio and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution;
(2) get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates;
(3) get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates;
(4) above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is as follows,
(1) get Radix Astragali water by weight ratio and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution;
(2) residue raw material of Chinese medicine alcohol extraction, alcohol extract concentrates;
(3) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Perhaps, with water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying, make oral or external preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is as follows,
(1) get Radix Astragali water by weight ratio and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution;
(2) get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates;
(3) the residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract concentrates;
(4) above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Perhaps, with water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying, make oral or external preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, gets whole raw material of Chinese medicine by weight ratio and pulverizes, and makes oral or external preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is as follows,
(1) gets Bulbus Fritillariae Thunbergii 1 flavor or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 flavors by weight ratio;
(2) residue raw material of Chinese medicine alcohol extraction together, concentrated back of alcohol extract and Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying is made oral or external preparation; Perhaps, get residue Bulbus Fritillariae Thunbergii alcohol extraction, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, and alcohol extract concentrates, and the alcohol extraction concentrated solution is merged, and with Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying is made oral or external preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is as follows,
(1) gets Bulbus Fritillariae Thunbergii 1 flavor or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 flavors by weight ratio; The residue raw material of Chinese medicine carries out decocting and gets the water extract; The extract of perhaps fetching water concentrates the back precipitate with ethanol, gets the precipitate with ethanol supernatant;
(2) after water extract or the precipitate with ethanol supernatant concentration with Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying is made oral or external preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is following (in this technical scheme, when the raw material Bulbus Fritillariae Thunbergii is all beaten powder, then to need not to carry out the operation of step (3); When the raw material Radix Astragali is all beaten powder, when perhaps not having the Radix Astragali in the raw material, then need not to carry out the operation of step (2); Just do not add extract correspondingly in the last preparation step (5) yet),
(1) gets Bulbus Fritillariae Thunbergii 1 flavor or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 flavors by weight ratio;
(2) get residue Radix Astragali water and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution;
(3) get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates;
(4) get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates;
(5) with water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
The pharmaceutical composition of treatment hyperuricemia of the present invention and associated disease can also prepare by the following method, and its step is following (in this technical scheme, when the raw material Bulbus Fritillariae Thunbergii is all beaten powder, then to need not to carry out the operation of step (2); Just do not add extract correspondingly in the last preparation step (4) yet),
(1) gets Bulbus Fritillariae Thunbergii 1 flavor or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 flavors by weight ratio;
(2) get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates;
(3) get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates;
(4) with above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
It below is the drug action experiment that the inventor did.
One, experiment medicine:
1, G1: prescription is that Herba Artemisiae Anomalae, Cortex Fraxini, Flos Chrysanthemi Indici, Bulbus Fritillariae Thunbergii, weight proportion are 1: 1: 1: 1;
2, G2: prescription is that Herba Artemisiae Anomalae, Cortex Fraxini, Flos Chrysanthemi Indici, Bulbus Fritillariae Thunbergii, the Radix Astragali, weight proportion are 1: 1: 1: 1: 2;
3, G3: prescription is that Herba Artemisiae Anomalae, Cortex Fraxini, Flos Chrysanthemi Indici, Bulbus Fritillariae Thunbergii, the Radix Astragali, Ramulus Cinnamomi, weight proportion are 9: 9: 15: 3: 15: 1;
4, G4: prescription is, Herba Artemisiae Anomalae, Cortex Fraxini, Flos Chrysanthemi Indici, Bulbus Fritillariae Thunbergii, the Radix Astragali, Ramulus Cinnamomi, Caulis Piperis Kadsurae, Radix Scutellariae, Herba Lycopi, and weight proportion is 9: 9: 15: 3: 15: 1: 6: 3: 6.
Two, experimentation and result.
1, the effect of G1 gout hyperuricemia research.
1.1G1 hypoxanthine is caused the influence of mice hyperuricemia model.
Get 60 of ICR mices, female half and half, body weight 18～22g.Mice is divided equally the cage raising, freely drinks water, and raises with the laboratory animal mixed feed, keeps 20～25 ℃ of room temperatures, humidity 40～70%.
Get the ICR mice, be divided into 6 groups at random, 10 every group.Be respectively: blank group, model control group, the large, medium and small dosage group of G1 and positive controls.Wherein G1 little, in, heavy dose of group irritate respectively stomach give (4,8, the medicine normal saline suspension of 16g crude drug/kg), positive controls gives the allopurinol physiological salt liquid of 39mg/kg, and blank group and model control group give isometric normal saline.Once a day, be total to administration 5 days.1h after the last administration respectively organizes mouse peritoneal injection hypoxanthine 1g/kg except that the blank group, blank group injection equal solvent normal saline.1h behind the injection hypoxanthine, each is organized mouse orbit and gets blood, and conventional separation of serum is measured uric acid level in the serum, and the result adopts the one factor analysis of variance of SPSS 13.0 to add up.The results are shown in Table 1.
Table 1G1 causes the influence of mice hyperuricemia model to hypoxanthine
Figure B2009100253269D0000091
Figure B2009100253269D0000092
*Expression is compared P＜0.01 with the blank group, △ △P＜0.01 is compared in expression with model group
The result shows: compare with the blank group, model group mice serum uric acid content obviously raises (P＜0.01), and the modeling success is described.And G1 is large, medium and small to compare the reduction (P＜0.01) that all has in various degree with positive controls mice serum uric acid content in model group, and along with the increase of dosage, presents certain dose-effect relationship.Showing that G1 has can reduce the effect that hypoxanthine induced mice uric acid increases.
1.2G1 Oteracil Potassium is caused the influence of mice metabolic arthritis model.
Get 60 of ICR mices, female half and half, mice is divided equally cage and raises, and freely drinks water, and raises with the laboratory animal mixed feed 20～25 ℃ of maintenance room temperatures, humidity 40～70%.
Get the ICR mice and be divided into 6 groups at random, be respectively: blank group, model control group, the large, medium and small dosage group of G1 and positive controls.Wherein G1 little, in, heavy dose of group irritate respectively stomach give (4,8, the medicine normal saline suspension of 16g crude drug/kg), positive controls gives the benzene of 6.5mg/kg and smells the grand physiological salt liquid of agate, and blank group and model control group give isometric normal saline.Once a day, be total to administration 5 days.1h after the last administration respectively organizes mouse peritoneal injection Oteracil Potassium 300mg/kg except that the blank group, the blank group is injected isometric normal saline.1h behind the injection Oteracil Potassium, each is organized mouse orbit and gets blood, and conventional separation of serum is measured uric acid level in the serum, relatively each group difference.Continuous data all adopts the one factor analysis of variance of SPSS 13.0.The results are shown in Table 2.
Table 2G1 causes the influence of mice hyperuricemia model to Oteracil Potassium
Figure B2009100253269D0000101
Figure B2009100253269D0000102
*Expression is compared P＜0.01 with the blank group, and △ represents to compare with model group P＜0.05, and △ △ represents to compare with model group P＜0.01
The result shows: compare with the blank group, model group mice serum uric acid content significantly raises (P＜0.01), shows the modeling success.Compare with model group, positive controls and G1 group mice serum uric acid content significantly reduces (P＜0.01), G1 is little, in, heavy dose of group serum uric acid content has and extremely significantly reduces (P＜0.01).Showing that G1 has can suppress Oteracil Potassium and cause the effect that the mice uric acid increases.
2, the effect of G1～G4 gout hyperuricemia research.
2.1G1～G4 causes the influence of mice hyperuricemia model to hypoxanthine.
Get 70 of ICR mices, female half and half, body weight 18～22g.Mice is divided equally the cage raising, freely drinks water, and raises with the laboratory animal mixed feed, keeps 20～25 ℃ of room temperatures, humidity 40～70%.
Get the ICR mice, be divided into 7 groups at random, male and female half and half, 10 every group.Be respectively: blank group, model control group, G1 group, G2 group, G3 group, G4 group and positive controls.Wherein G1～4 group irritate respectively stomach give (8,12,13.2, the medicine normal saline suspension of 16.8g crude drug/kg), positive controls gives the allopurinol physiological salt liquid of 39mg/kg, model control group gives isometric normal saline.Once a day, be total to administration 5 days.1h after the last administration respectively organizes mouse peritoneal injection hypoxanthine 1g/kg except that the blank group, blank group mouse peritoneal is injected isometric normal saline.1h behind the injection hypoxanthine, each is organized mouse orbit and gets blood, and conventional separation of serum is measured uric acid level in the serum, and the result adopts the one factor analysis of variance of SPSS 13.0 to add up.The results are shown in Table 3.
Table 3G1～G4 causes the influence of mice hyperuricemia model to hypoxanthine
Figure B2009100253269D0000111
Figure B2009100253269D0000112
*Expression is compared P＜0.01 with the blank group, and △ △ represents to compare with model group P＜0.01
The result shows: compare with the blank group, model group mice serum uric acid content obviously raises (P＜0.01), and the modeling success is described.Comparing positive controls and each treatment group mice serum uric acid content with model group all has extremely significantly reduction (P＜0.01), and reduces the most obvious with the G4 group.Illustrate that medicine G1～G4 group all has the hypoxanthine of inhibition and causes the effect that the mice uric acid increases.
2.2G1～G4 causes the influence of mice metabolic arthritis model to Oteracil Potassium.
Get 60 of ICR mices, female half and half, body weight 18～22g.Mice is divided equally the cage raising, freely drinks water, and raises with the laboratory animal mixed feed, keeps 20～25 ℃ of room temperatures, humidity 40～70%.
Get the ICR mice, be divided into 7 groups at random, male and female half and half, 10 every group.Be respectively: blank group, model control group, G1 group, G2 group, G3 group, G4 group and positive controls.Wherein G1～G4 group irritate respectively stomach give (the medicine normal saline suspension of 8g, 12,13.2,16.8g crude drug/kg), positive controls gives the benzbromarone physiological salt liquid of 6.5mg/kg, model control group gives isometric normal saline.Once a day, be total to administration 5 days.1h after the last administration, each organizes mouse peritoneal injection Oteracil Potassium 300mg/kg, 1h behind the injection Oteracil Potassium, each is organized mouse orbit and gets blood, and conventional separation of serum is measured uric acid level in the serum, and data all adopt the one factor analysis of variance of SPSS 13.0 to add up.The results are shown in Table 4.
Table 4 G1～G4 causes the influence of mice hyperuricemia model to Oteracil Potassium
Figure B2009100253269D0000121
Figure B2009100253269D0000122
*Expression is compared P＜0.01 with the blank group, and △ △ represents to compare with model group P＜0.01
The result shows: compare with the blank group, model group mice serum uric acid content obviously raises (P＜0.01), and the modeling success is described.Compare positive controls and each treatment group mice serum uric acid content with model group extremely significantly reduction (P＜0.01) is all arranged.Illustrate that medicine G1～G4 group all has inhibition time Oteracil Potassium and causes the effect that the mice uric acid increases.
2.3G1～G4 is to the influence of rat hyperuricemia model.
Get 70 of Wistar rats, female half and half, body weight 180～220g.Rat is divided equally the cage raising, freely drinks water, and raises with the laboratory animal mixed feed, keeps 20～25 ℃ of room temperatures, humidity 40～70%.
Get the Wistar rat, be divided into 7 groups at random, male and female half and half, 10 every group.Be respectively: blank group, model control group, G1 group, G2 group, G3 group, G4 group and positive controls.Except that the blank group, every group of equal lumbar injection of rat, wherein contains oxonic acid 2g/100ml, contains pyrazinamide 1g/100ml than carboxamide dihydrochloride suspension with the oxonic acid+mouth of aquesterilisa preparation.Injected dose is the 1.5ml/100g body weight, administration every day 2 times.The blank group is injected isometric normal saline.All the other 5 groups give respectively G1, G2, G3, G4 (4.0,6.0,6.6,8.4g crude drug/kg) and positive control drug allopurinol 19.5mg/kg body weight, every day gastric infusion once, in the last administration after one hour every group every rat eye socket get blood, conventional separation of serum, measure uric acid (UA) and xanthine oxidase (XOD) content in the serum, the one factor analysis of variance of The data SPSS13.0 is added up.The results are shown in Table 5.
Table 5 G1～G4 is to the influence of rat hyperuricemia model serum UA content and XOD level
Figure B2009100253269D0000132
*Expression is compared P＜0.01 with the blank group, and △ represents to compare with model group P＜0.05, and △ △ represents to compare with model group P＜0.01
The result shows: model group rat blood serum UA compares with the blank group with XOD all has utmost point significant difference (P＜0.01), and the modeling success is described.For serum UA, compare each treatment group with model group and all can reduce its content in various degree, wherein positive controls and each administration group have significant difference (P＜0.01).Illustrate that medicine G1～G4 has the effect that this rat of inhibition metabolic arthritis model serum uric acid increases, the mechanism that medicine plays a role may be to realize by the activity that reduces XOD.
3, G1～G4 antiinflammatory action research.
3.1G1～G4 Dichlorodiphenyl Acetate causes the influence that the mouse peritoneal capillary permeability increases.
Get 60 of ICR mices, male, body weight 18～22g.Mice is divided equally the cage raising, freely drinks water, and raises with the laboratory animal mixed feed, keeps 20～25 ℃ of room temperatures, humidity 40～70%.
Get the ICR mice, adaptability is fed and is begun test after three days.Be divided into 6 groups at random, 10 every group.Be respectively: model control group, G1～G4 group and positive controls.Wherein G1 group, G2 group, G3 group, G4 group are irritated stomach respectively and are given four kinds of medicines (normal saline suspension of 8g, 12,13.2,16.8g crude drug/kg), positive controls is irritated stomach and is given acetysalicylic physiological salt liquid 0.4g/kg, and model control group gives isometric normal saline.Administration every day 1 time, successive administration 5 days.30min after the last administration, each organizes mouse mainline 0.5% azovan blue normal saline solution 0.1ml/10g, lumbar injection 0.6% acetic acid 0.2ml/ only immediately, put to death behind the 20min, wash the abdominal cavity with the 5ml normal saline immediately, the sucking-off cleaning mixture, 3000 leave heart 15min, get one times of supernatant dilution, in each sample cell absorbance of 590nm colorimetric determination.The result adopts the one factor analysis of variance of SPSS13.0 to add up.The results are shown in Table 6.
The property influence that table 6 G1～G4 is penetrating to the mouse peritoneal blood capillary
Figure B2009100253269D0000141
Figure B2009100253269D0000142
△ represents to compare with model group P＜0.05, and △ △ represents to compare with model group P＜0.01
The result shows that each treatment group is compared the OD value and all decreased with model group, and wherein G2, G3, G4 and positive controls reduce significantly (P＜0.01), and the G1 group has significant difference (P＜0.05) equally.Illustrate that G1～G4 all has antiinflammatory action preferably.
3.2G1～G4 xylol causes the influence of mice auricle swelling
Get 60 of ICR mices, male, body weight 18～22g.Mice is divided equally the cage raising, freely drinks water, and raises with the laboratory animal mixed feed, keeps 20～25 ℃ of room temperatures, humidity 40～70%.
Get the ICR mice, adaptability is fed and is begun test after three days.Be divided into 6 groups at random, 10 every group.Be respectively: model control group, G1 group, G2 group, G3 group, G4 group and positive controls.Wherein G1 group, G2 group, G3 group, G4 group are irritated stomach respectively and are given four kinds of medicines (normal saline suspension of 8.0g, 12.0,13.2,16.8g crude drug/kg), positive controls is irritated stomach and is given acetysalicylic physiological salt liquid 0.4g/kg, and model control group gives isometric normal saline.Administration every day 1 time, successive administration 3 days.The last administration is every group of caused by dimethylbenzene xylene inflammation that 0.04ml is evenly smeared in mouse right ear exterior feature front and back after one hour, put to death mice after causing scorching 45min, two ears about cutting along the auricle baseline, (diameter 9mm) takes off round auricle at same position respectively with card punch, scales/electronic balance weighing, as auricle swelling degree, and calculate the swelling percentage rate with the difference of mice left and right sides auricle weight.Carry out statistical analysis according to result of the test, measurement data is added up with the one factor analysis of variance of SPSS13.0.The results are shown in Table 7.
Figure B2009100253269D0000143
Table 7 G1～G4 xylol causes the influence of mice auricle swelling
Figure B2009100253269D0000152
* represent to compare P＜0.05 with model control group, *P＜0.01 is compared in expression with model control group
The result shows: each administration group mice causes scorching back ear swelling rate all in various degree reduction, and G3, G4 group and positive controls are compared with model group has utmost point significant difference (P＜0.01), and G1, G2 group is compared with model group also has significant difference (P＜0.05).Illustrate that G1～G4 all has antiinflammatory action preferably.
The inventor is by going deep into systematic study, and having filtered out can antalgic and inflammation relieving, can reduce the Chinese medicine basic recipe of blood uric acid again, promptly forms square substantially by Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii and Flos Chrysanthemi Indici 4 flavor raw materials; One or more raw materials that also can select to add in the Radix Astragali, Ramulus Cinnamomi, Caulis Piperis Kadsurae, Herba Lycopi and the Radix Scutellariae 5 flavor raw materials carry out prescription.Compared with prior art, pharmaceutical composition of the present invention has good safety, can effectively reduce the concentration of blood uric acid, obviously alleviates each phase symptom of gout, be particularly useful for treating gout incubation period (hyperuricemia), intermission, filled up the blank of gout clinical medicine incubation period.
The specific embodiment
Below further describe concrete technical scheme of the present invention,, and do not constitute restriction its right so that those skilled in the art understands the present invention further.
Embodiment 1.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 30.Its method for making is: technology extracts each materials of effective ingredients routinely, adds conventional adjuvant, makes oral or external preparation.
Embodiment 2.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 0.1; Cortex Fraxini 0.1; Bulbus Fritillariae Thunbergii 0.1; Flos Chrysanthemi Indici 0.1.Its method for making is: get whole raw material of Chinese medicine by weight ratio and carry out decocting and get the water extract; The water extract is made mixture or oral liquid after concentrating.
Embodiment 3.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 9; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 15.Its method for making is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio; Medicinal residues merge decocting with the residue raw material of Chinese medicine, get the water extract; The water extract concentrates the back and adds volatile oil, makes mixture or oral liquid.
Embodiment 4.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 12.Its method for making is: get whole raw material of Chinese medicine by weight ratio and carry out alcohol extraction, alcohol extract is made mixture or oral liquid after concentrating.
Embodiment 5.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 15.Its method for making is: get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; The alcohol extraction concentrated solution is merged, add volatile oil, make tablet.
Embodiment 6.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 5; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 10.Its method for making is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio; Medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates, and adds volatile oil, makes capsule.
Embodiment 7.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 12; Cortex Fraxini 12; Bulbus Fritillariae Thunbergii 12; Flos Chrysanthemi Indici 5.Its method for making is: get whole raw material of Chinese medicine by weight ratio and carry out alcohol extraction, alcohol extract concentrates; The medicinal residues decocting, the water extract concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation; Perhaps, with alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
Embodiment 8.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 14; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 18.Its method for making is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio; Medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, gets alcohol extract; The medicinal residues decocting, the water extract concentrates, and merges with alcohol extract, adds volatile oil, makes oral or external preparation.
Embodiment 9.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 12; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 12; Flos Chrysanthemi Indici 23.Its method for making is: get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; Medicinal residues after the above-mentioned alcohol extraction are merged water carry, the water extract concentrates; Alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation alcohol extraction concentrated solution, water extracting liquid drying.
Embodiment 10.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 15.Its method for making is: get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates; Medicinal residues after the above-mentioned alcohol extraction are merged water carry, the water extract concentrates; Alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation; Perhaps, with alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
Embodiment 11.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 8; Cortex Fraxini 7; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 10.Its method for making is: get whole raw material of Chinese medicine by weight ratio and pulverize, make oral or external preparation.
Embodiment 12.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 1; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 30.Its recipe step is as follows: get all or part of powder of beating of Bulbus Fritillariae Thunbergii by weight ratio; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates back and Bulbus Fritillariae Thunbergii powder mixing, and drying is made oral or external preparation; Perhaps, get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, and alcohol extract concentrates, and the alcohol extraction concentrated solution is merged, and with Bulbus Fritillariae Thunbergii powder mixing, drying is made oral or external preparation.
Embodiment 13.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 1.Its recipe step is as follows: get all or part of powder of beating of Bulbus Fritillariae Thunbergii by weight ratio; The residue raw material of Chinese medicine carries out decocting and gets the water extract; The extract of perhaps fetching water concentrates the back precipitate with ethanol, gets the precipitate with ethanol supernatant; With Bulbus Fritillariae Thunbergii powder mixing, drying is made oral or external preparation after water extract or the precipitate with ethanol supernatant concentration.
Embodiment 14.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 12; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 25.Its recipe step is as follows: get Bulbus Fritillariae Thunbergii by weight ratio and partly beat powder; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make patch.
Embodiment 15.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 10.Its recipe step is as follows: get Bulbus Fritillariae Thunbergii by weight ratio and all beat powder; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make powder.
Embodiment 16.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 1; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 1; The Radix Astragali 2.Its recipe step is as follows: get by weight ratio Radix Astragali water carry the water extract, the water extract concentrates, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution; Get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; The residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract concentrates; With water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying, make oral or external preparation.
Embodiment 17.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 30; The Radix Astragali 30.Its recipe step is as follows: get by weight ratio Radix Astragali water carry the water extract, concentrate water extracting liquid; Perhaps, get the water extracting liquid precipitate with ethanol, the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; Water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying.
Embodiment 18.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 9; The Radix Astragali 20.Its recipe step is as follows: get Radix Astragali water by weight ratio and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution; Get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; Above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying.
Embodiment 19.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 12; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 15; The Radix Astragali 10.Its recipe step is as follows: get Radix Astragali water by weight ratio and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution; The alcohol extraction of residue raw material of Chinese medicine, alcohol extract concentrates; Water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Perhaps, with water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying, make gel.
Embodiment 20.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 14; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 28; The Radix Astragali 0.1.Its recipe step is as follows: get Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 flavors by weight ratio; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrate back and Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, and drying is made oral or external preparation; Perhaps, get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, and alcohol extract concentrates, and the alcohol extraction concentrated solution is merged, and with Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying is made oral or external preparation.
Embodiment 21.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 7; Cortex Fraxini 11; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 23; The Radix Astragali 25.Its recipe step is as follows: get Bulbus Fritillariae Thunbergii, the whole powder of beating of the Radix Astragali 2 flavors by weight ratio; The residue raw material of Chinese medicine carries out decocting and gets the water extract; The extract of perhaps fetching water concentrates the back precipitate with ethanol, gets the precipitate with ethanol supernatant; With Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying is made granule after water extract or the precipitate with ethanol supernatant concentration.
Embodiment 22.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 5; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 7; Flos Chrysanthemi Indici 10; Ramulus Cinnamomi 6.Its method for making is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio; Medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, gets alcohol extract; Medicinal residues decocting, water extract concentrate, and merge with alcohol extract, and drying adds behind the enclose or the volatile oil of enclose not, makes oral or external preparation.
Embodiment 23.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 12; Cortex Fraxini 8; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 20; Ramulus Cinnamomi 15.Its method for making is: get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates; Medicinal residues after the above-mentioned alcohol extraction are merged water carry, the water extract concentrates; Alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation.
Embodiment 24.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 10; Flos Chrysanthemi Indici 15; Caulis Piperis Kadsurae 6.Its method for making is: get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; Medicinal residues after the above-mentioned alcohol extraction are merged water carry, the water extract concentrates; Alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral or external preparation.
Embodiment 25.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 25; Caulis Piperis Kadsurae 15.Its method for making is: get whole raw material of Chinese medicine by weight ratio and carry out alcohol extraction, alcohol extract concentrates; The medicinal residues decocting, the water extract concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation; Perhaps, with alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
Embodiment 26.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 3; The Herba Lycopi 6.Its method for making is: get whole raw material of Chinese medicine by weight ratio and carry out decocting and get the water extract, concentrate water extracting liquid; Get water extracting liquid, make oral or external preparation; Perhaps, with the water extracting liquid drying, make oral or external preparation.
Embodiment 27.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 10; Flos Chrysanthemi Indici 15; The Herba Lycopi 12.Its method for making is: get whole raw material of Chinese medicine by weight ratio and carry out decocting and get the water extract, concentrate water extracting liquid; The water extracting liquid precipitate with ethanol, the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution; The precipitate with ethanol concentrated solution is carried in water intaking, makes oral or external preparation; Perhaps, with water extract-alcohol precipitation concentrated solution drying, make oral or external preparation.
Embodiment 28.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 8; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 18; Radix Scutellariae 9.Its method for making is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio; Medicinal residues merge decocting with the residue raw material of Chinese medicine and get the water extract, concentrate water extracting liquid; Get water extracting liquid, add volatile oil, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make unguentum the water extracting liquid drying.
Embodiment 29.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 14; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 8; Radix Scutellariae 5.Its method for making is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio; Medicinal residues merge decocting with the residue raw material of Chinese medicine and get the water extract, concentrate water extracting liquid; The water extracting liquid precipitate with ethanol, the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution; The precipitate with ethanol concentrated solution is carried in water intaking, adds volatile oil, makes oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation water extract-alcohol precipitation concentrated solution drying.
Embodiment 30.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 7; Cortex Fraxini 7; Bulbus Fritillariae Thunbergii 7; Flos Chrysanthemi Indici 7; The Radix Astragali 7; Ramulus Cinnamomi 7.Its method for making is: get whole raw material of Chinese medicine by weight ratio and carry out decocting and get the water extract, the water extract concentrates the back precipitate with ethanol, and the precipitate with ethanol supernatant is made mixture or oral liquid through concentrating.
Embodiment 31.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 9; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 15; The Radix Astragali 15; Ramulus Cinnamomi 0.1.Its method for making is: get Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 flavors by weight ratio; The residue raw material of Chinese medicine carries out decocting and gets the water extract; The extract of perhaps fetching water concentrates the back precipitate with ethanol, gets the precipitate with ethanol supernatant; With Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying is made oral or external preparation after water extract or the precipitate with ethanol supernatant concentration.
Embodiment 32.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 7; Cortex Fraxini 7; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 8; The Radix Astragali 20; Ramulus Cinnamomi 1.Its method for making is: get Bulbus Fritillariae Thunbergii, the whole powder of beating of the Radix Astragali 2 flavors by weight ratio; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
Embodiment 33.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 7; Cortex Fraxini 7; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 17; The Radix Astragali 5; Caulis Piperis Kadsurae 0.1.Its method for making is: its method for making is: get Bulbus Fritillariae Thunbergii, the Radix Astragali 2 flavor parts by weight ratio and beat powder; Get residue Radix Astragali water and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
Embodiment 34.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 11; Cortex Fraxini 11; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 13; The Radix Astragali 25; Radix Scutellariae 3; Its method for making is: get Bulbus Fritillariae Thunbergii 1 flavor or Bulbus Fritillariae Thunbergii, the whole powder of beating of the Radix Astragali 2 flavors by weight ratio; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
Embodiment 35.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 20; The Radix Astragali 20; The Herba Lycopi 6.Its method for making is: its method for making is: get Bulbus Fritillariae Thunbergii, the Radix Astragali 2 flavor parts by weight ratio and beat powder; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
Embodiment 36.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 10; Ramulus Cinnamomi 1; Caulis Piperis Kadsurae 15; Its method for making is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio; Medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates, and adds volatile oil, makes oral or external preparation.
Embodiment 37.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 5; Cortex Fraxini 3; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 15; Ramulus Cinnamomi 8; The Herba Lycopi 0.1; Its method for making is: get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates; Medicinal residues after the above-mentioned alcohol extraction are merged water carry, the water extract concentrates; With alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
Embodiment 38.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 7; Flos Chrysanthemi Indici 10; Ramulus Cinnamomi 5; Radix Scutellariae 1; Its method for making is: get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; Medicinal residues after the above-mentioned alcohol extraction are merged water carry, the water extract concentrates; With alcohol extraction concentrated solution, water extracting liquid drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
Embodiment 39.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 8; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 10; Caulis Piperis Kadsurae 10; The Herba Lycopi 10; Its method for making is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio; Medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, gets alcohol extract; The medicinal residues decocting, the water extract concentrates, and merges with alcohol extract, adds volatile oil, makes oral or external preparation.
Embodiment 40.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 10; Caulis Piperis Kadsurae 8; Radix Scutellariae 6; Its method for making is: get Bulbus Fritillariae Thunbergii by weight ratio and all beat powder; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
Embodiment 41.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 20; The Herba Lycopi 4; Radix Scutellariae 15; Get Bulbus Fritillariae Thunbergii by weight ratio and partly beat powder; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
Embodiment 42.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 15; The Radix Astragali 20; Ramulus Cinnamomi 5; Caulis Piperis Kadsurae 6; Its method for making is: get Radix Astragali water by weight ratio and carry, the water extract concentrates; The water extract concentrates, precipitate with ethanol, and the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution; The alcohol extraction of residue raw material of Chinese medicine, alcohol extract concentrates; Water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Perhaps, with water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying, make oral or external preparation.
Embodiment 43.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 9; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 30; The Radix Astragali 30; Ramulus Cinnamomi 3; Radix Scutellariae 0.1; Its method for making is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio; Medicinal residues merge decocting with the residue raw material of Chinese medicine, get the water extract; The water extract concentrates the back precipitate with ethanol, with precipitate with ethanol supernatant concentration, drying, adds behind the enclose or the volatile oil of enclose not, makes oral solid formulation.
Embodiment 44.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 12; Flos Chrysanthemi Indici 12; The Radix Astragali 15; Ramulus Cinnamomi 1; The Herba Lycopi 6.Its method for making is: get Bulbus Fritillariae Thunbergii, the Radix Astragali 2 flavor parts by weight ratio and beat powder; Get residue Radix Astragali water and carry, the water extract concentrates, precipitate with ethanol, and the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
Embodiment 45.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 12; Cortex Fraxini 12; Bulbus Fritillariae Thunbergii 12; Flos Chrysanthemi Indici 12; Ramulus Cinnamomi 12; Caulis Piperis Kadsurae 12; Radix Scutellariae 12; Its method for making is: get Bulbus Fritillariae Thunbergii by weight ratio and all beat powder; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
Embodiment 46.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 14; Ramulus Cinnamomi 8; Caulis Piperis Kadsurae 10; The Herba Lycopi 10.Its method for making is: get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; The alcohol extraction concentrated solution is merged, add volatile oil, make oral or external preparation; Or, add behind the enclose or the volatile oil of enclose not with alcohol extraction concentrated solution drying, make oral or external preparation.
Embodiment 47.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 14; Caulis Piperis Kadsurae 10; The Herba Lycopi 10; Radix Scutellariae 8; Its method for making is: get Bulbus Fritillariae Thunbergii by weight ratio and partly beat powder; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.。
Embodiment 48.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 30; Caulis Piperis Kadsurae 15; The Herba Lycopi 15; The Radix Astragali 30; Its method for making is: get Radix Astragali water by weight ratio and carry, the water extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; Water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation.
Embodiment 49.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 14; Caulis Piperis Kadsurae 10; The Radix Astragali 10; Radix Scutellariae 8; Its method for making is: get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates; Medicinal residues after the above-mentioned alcohol extraction are merged water carry, the water extract concentrates; Alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation.
Embodiment 50.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 14; Ramulus Cinnamomi 10; The Herba Lycopi 10; Radix Scutellariae 8; Its method for making is: get whole raw material of Chinese medicine by weight ratio and pulverize, make oral or external preparation.
Embodiment 51.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 12; Cortex Fraxini 12; Bulbus Fritillariae Thunbergii 4; Flos Chrysanthemi Indici 20; The Radix Astragali 15; Ramulus Cinnamomi 15; Caulis Piperis Kadsurae 15; Radix Scutellariae 9; Its method for making is: get Radix Astragali water by weight ratio and carry, the water extract concentrates; Get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With water extracting liquid, alcohol extraction concentrated solution drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
Embodiment 52.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 9; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 16; The Radix Astragali 16; Ramulus Cinnamomi 2; Caulis Piperis Kadsurae 9; The Herba Lycopi 9.Its method for making is: get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; Medicinal residues after the above-mentioned alcohol extraction are merged water carry, the water extract concentrates; Alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation alcohol extraction concentrated solution, water extracting liquid drying.
Embodiment 53.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 8; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 18; The Radix Astragali 10; Ramulus Cinnamomi 5; Radix Scutellariae 6; The Herba Lycopi 6.Its method for making is: get Radix Astragali water by weight ratio and carry, the water extract concentrates; Get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; The residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract concentrates; Above-mentioned water extracting liquid, alcohol extraction concentrated solution are merged, make oral or external preparation.
Embodiment 54.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 8; Bulbus Fritillariae Thunbergii 10; Flos Chrysanthemi Indici 6; The Radix Astragali 15; Caulis Piperis Kadsurae 6; Radix Scutellariae 6; The Herba Lycopi 10.Its method for making is: get Radix Astragali water by weight ratio and carry, the water extract concentrates; The water extract concentrates, precipitate with ethanol, and the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution; Get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; The residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract concentrates; Above-mentioned water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Perhaps, with water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying, make oral or external preparation.
Embodiment 55.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 8; Bulbus Fritillariae Thunbergii 10; Flos Chrysanthemi Indici 6; Ramulus Cinnamomi 15; Caulis Piperis Kadsurae 6; Radix Scutellariae 6; The Herba Lycopi 10.Its method for making is: get Radix Astragali water by weight ratio and carry, the water extract concentrates; The water extract concentrates, precipitate with ethanol, and the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution; Get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
Embodiment 56.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 1; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 1; The Radix Astragali 2; Ramulus Cinnamomi 1; Caulis Piperis Kadsurae 1; Radix Scutellariae 1; The Herba Lycopi 1.Its method for making is: get Radix Astragali water by weight ratio and carry, the water extract concentrates; The water extracting liquid precipitate with ethanol, the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
Embodiment 57.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 0.5; Bulbus Fritillariae Thunbergii 0.5; Flos Chrysanthemi Indici 0.5; The Radix Astragali 0.5; Ramulus Cinnamomi 0.5; Caulis Piperis Kadsurae 0.5; Radix Scutellariae 15; The Herba Lycopi 15.Its method for making is: get Radix Astragali water by weight ratio and carry, the water extract concentrates; Get Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; Water extracting liquid, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation.
Embodiment 58.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 15; The Radix Astragali 15; Ramulus Cinnamomi 6; Caulis Piperis Kadsurae 9; Radix Scutellariae 9; The Herba Lycopi 9.Its method for making is: get Radix Astragali water by weight ratio and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution; Get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; The residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract concentrates; Above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Perhaps, with water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying, make oral or external preparation.
Embodiment 59.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 9; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 20; The Radix Astragali 20; Ramulus Cinnamomi 9; Caulis Piperis Kadsurae 6; Radix Scutellariae 6; The Herba Lycopi 6.Its method for making is: get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; Medicinal residues after the above-mentioned alcohol extraction are merged water carry, the water extract concentrates; Alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation alcohol extraction concentrated solution, water extracting liquid drying.
Embodiment 60.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 10; Cortex Fraxini 8; Bulbus Fritillariae Thunbergii 10; Flos Chrysanthemi Indici 25; The Radix Astragali 30; Ramulus Cinnamomi 8; Caulis Piperis Kadsurae 10; Radix Scutellariae 10; The Herba Lycopi 10.Its method for making is: get Radix Astragali water by weight ratio and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution; Get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; Above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying.
Embodiment 61.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 4; Flos Chrysanthemi Indici 10; The Radix Astragali 10; Ramulus Cinnamomi 5; Caulis Piperis Kadsurae 4; Radix Scutellariae 2; The Herba Lycopi 5.Its method for making is, gets whole raw material of Chinese medicine by weight ratio and pulverizes, and makes oral or external preparation.
Embodiment 62.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 8; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 9; The Radix Astragali 18; Ramulus Cinnamomi 7; Caulis Piperis Kadsurae 6; Radix Scutellariae 5; The Herba Lycopi 6.Its method for making is to get Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 flavors by weight ratio; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrate back and Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, and drying is made oral or external preparation; Perhaps, get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, and alcohol extract concentrates, and the alcohol extraction concentrated solution is merged, and with Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying is made oral or external preparation.
Embodiment 63.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 15; The Radix Astragali 6; Ramulus Cinnamomi 9; Caulis Piperis Kadsurae 5; Radix Scutellariae 9; The Herba Lycopi 7.Its method for making is to get Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 flavors by weight ratio; The residue raw material of Chinese medicine carries out decocting and gets the water extract; The extract of perhaps fetching water concentrates the back precipitate with ethanol, gets the precipitate with ethanol supernatant; With Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying is made oral or external preparation after water extract or the precipitate with ethanol supernatant concentration.
Embodiment 64.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 7; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 9; Flos Chrysanthemi Indici 12; The Radix Astragali 9; Ramulus Cinnamomi 8; Caulis Piperis Kadsurae 7; Radix Scutellariae 8; The Herba Lycopi 9.Its method for making is, gets Bulbus Fritillariae Thunbergii by weight ratio, the Radix Astragali 2 flavor parts are beaten powder; Get residue Radix Astragali water and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
Embodiment 65.A kind of treatment hyperuricemia reaches the pharmaceutical composition with hyperuricemia diseases related (as gout, urate nephropathy), and it is to be made by following Chinese medicine raw materials by weight proportion, Herba Artemisiae Anomalae 7.5; Cortex Fraxini 7.5; Bulbus Fritillariae Thunbergii 7.5; Flos Chrysanthemi Indici 7.5; The Radix Astragali 9; Ramulus Cinnamomi 7.5; Caulis Piperis Kadsurae 7.5; Radix Scutellariae 7.5; The Herba Lycopi 7.5.Its method for making is, gets Bulbus Fritillariae Thunbergii by weight ratio, the Radix Astragali 2 flavor parts are beaten powder; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates; With above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.

Claims (21)

1. a pharmaceutical composition for the treatment of hyperuricemia and associated disease is characterized in that, it is to be made by following Chinese medicine raw materials by weight proportion,
Herba Artemisiae Anomalae 0.1～15; Cortex Fraxini 0.1～15; Bulbus Fritillariae Thunbergii 0.1～15; Flos Chrysanthemi Indici 0.1～30;
The Radix Astragali 0～30; Ramulus Cinnamomi 0～15; Caulis Piperis Kadsurae 0～15; The Herba Lycopi 0～15;
Radix Scutellariae 0～15.
2. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease is characterized in that, its step is as follows,
(1) get whole raw material of Chinese medicine by weight ratio and carry out decocting and get the water extract, concentrate water extracting liquid; Perhaps, the water extracting liquid precipitate with ethanol, the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution;
(2) get water extracting liquid or water extract-alcohol precipitation concentrated solution, make oral or external preparation; Perhaps, with water extracting liquid or water extract-alcohol precipitation concentrated solution drying, make oral or external preparation.
3. a treatment hyperuricemia as claimed in claim 1 and associated disease medicament preparation of compositions method is characterized in that its step is as follows:
(1) gets Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavor extraction volatile oil by weight ratio;
(2) medicinal residues merge decocting with the residue raw material of Chinese medicine and get the water extract, concentrate water extracting liquid; Perhaps, the water extract concentrates the back precipitate with ethanol, and the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution;
(3) get water extracting liquid or water extract-alcohol precipitation concentrated solution, add volatile oil, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation water extracting liquid or water extract-alcohol precipitation concentrated solution drying.
4. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease, it is characterized in that, get whole raw material of Chinese medicine by weight ratio and carry out alcohol extraction, alcohol extract is made mixture or oral liquid after concentrating, and perhaps concentrates the back drying and makes oral or external preparation;
Perhaps, get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, and alcohol extract concentrates, and the alcohol extraction concentrated solution is merged, and makes mixture or oral liquid, and perhaps drying is made oral or external preparation.
5. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease is characterized in that, its step is as follows:
(1) get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates;
(2) get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates;
(3) the alcohol extraction concentrated solution is merged, add volatile oil, make oral or external preparation; Or, add behind the enclose or the volatile oil of enclose not with alcohol extraction concentrated solution drying, make oral or external preparation.
6. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease is characterized in that, its step is as follows:
(1) gets Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio;
(2) medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates, and adds volatile oil, makes oral or external preparation; Or, add behind the enclose or the volatile oil of enclose not with alcohol extraction concentrated solution drying, make oral or external preparation.
7. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease is characterized in that, gets whole raw material of Chinese medicine by weight ratio and carries out alcohol extraction, and alcohol extract concentrates; The medicinal residues decocting, the water extract concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation; Perhaps, with alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
8. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease is characterized in that, its step is as follows:
(1) gets Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio;
(2) medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, gets alcohol extract;
(3) medicinal residues decocting, the water extract concentrates, and merges with alcohol extract, adds volatile oil, makes oral or external preparation; Perhaps the water extract is concentrated, merge with alcohol extract, drying adds behind the enclose or the volatile oil of enclose not, makes oral or external preparation.
9. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease is characterized in that, its step is as follows:
(1) get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates;
(2) residue raw material of Chinese medicine alcohol extraction together, alcohol extract concentrates;
(3) medicinal residues after the above-mentioned alcohol extraction are merged water and carry, the water extract concentrates;
(4) alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation; Perhaps, with alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
10. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease is characterized in that, its step is as follows:
(1) get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates;
(2) get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates;
(3) medicinal residues after the above-mentioned alcohol extraction are merged water and carry, the water extract concentrates;
(4) alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation alcohol extraction concentrated solution, water extracting liquid drying.
11. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease is characterized in that, its step is as follows:
(1) get by weight ratio Radix Astragali water carry the water extract, concentrate water extracting liquid; Perhaps, get the water extracting liquid precipitate with ethanol, the precipitate with ethanol supernatant concentration gets the water extract-alcohol precipitation concentrated solution;
(2) get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates;
(3) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying.
12. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease is characterized in that, its step is as follows:
(1) get Radix Astragali water by weight ratio and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution;
(2) get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates;
(3) get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates;
(4) above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Perhaps,, add behind the enclose or the volatile oil of enclose not, make oral or external preparation water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying.
13. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease is characterized in that, its step is as follows:
(1) get Radix Astragali water by weight ratio and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution;
(2) residue raw material of Chinese medicine alcohol extraction, alcohol extract concentrates;
(3) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Perhaps, with water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying, make oral or external preparation.
14. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease is characterized in that, its step is as follows:
(1) get Radix Astragali water by weight ratio and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution;
(2) get the independent alcohol extraction of Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates;
(3) the residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract concentrates;
(4) above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Perhaps, with water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution drying, make oral or external preparation.
15. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease is characterized in that, gets whole raw material of Chinese medicine by weight ratio and pulverizes, and makes oral or external preparation.
16. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease, its step is as follows:
(1) gets Bulbus Fritillariae Thunbergii 1 flavor or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 flavors by weight ratio;
(2) residue raw material of Chinese medicine alcohol extraction together, concentrated back of alcohol extract and Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying is made oral or external preparation; Perhaps, get residue Bulbus Fritillariae Thunbergii alcohol extraction, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, and alcohol extract concentrates, and the alcohol extraction concentrated solution is merged, and with Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying is made oral or external preparation.
17. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease, its step is as follows:
(1) gets Bulbus Fritillariae Thunbergii 1 flavor or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 flavors by weight ratio; The residue raw material of Chinese medicine carries out decocting and gets the water extract; The extract of perhaps fetching water concentrates the back precipitate with ethanol, gets the precipitate with ethanol supernatant;
(2) after water extract or the precipitate with ethanol supernatant concentration with Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying is made oral or external preparation.
18. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease, its step is as follows:
(1) gets Bulbus Fritillariae Thunbergii 1 flavor or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 flavors by weight ratio;
(2) get residue Radix Astragali water and carry, the water extract concentrates; Perhaps the water extract concentrate, precipitate with ethanol, the precipitate with ethanol supernatant concentration, the water extract-alcohol precipitation concentrated solution;
(3) get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates;
(4) get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates;
(5) with water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
19. the preparation of drug combination method of a treatment hyperuricemia as claimed in claim 1 and associated disease, its step is as follows:
(1) gets Bulbus Fritillariae Thunbergii 1 flavor or Bulbus Fritillariae Thunbergii, all or part of powder of beating of the Radix Astragali 2 flavors by weight ratio;
(2) get the alcohol extraction of residue Bulbus Fritillariae Thunbergii, alcohol extract concentrates;
(3) get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 flavors or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 5 flavors or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi, Herba Lycopi's 4 flavor extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with the residue raw material of Chinese medicine, and alcohol extract concentrates;
(4) with above-mentioned alcohol extraction concentrated solution, Bulbus Fritillariae Thunbergii powder or Bulbus Fritillariae Thunbergii, astragalus membranaceus powder mixing, drying, add behind the enclose or the volatile oil of enclose not, make oral or external preparation.
20. one kind described in claim 1 pharmaceutical composition or as preparation method makes as described in any one in the claim 21 preparation, it is characterized in that, described preparation is the medicament of acceptable clinically any oral or exterior-applied formulation, comprises capsule, soft capsule, tablet, pill, drop pill, granule, powder, patch, unguentum, gel, liquid preparation.
21. a pharmaceutical composition as claimed in claim 1 is as the purposes of active ingredient in treatment hyperuricemia or gout or urate nephropathy.
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Publication number Priority date Publication date Assignee Title
CN103893512A (en) * 2012-12-25 2014-07-02 江苏康缘药业股份有限公司 Traditional Chinese medicinal composition for treating gouty arthritis
CN103893512B (en) * 2012-12-25 2018-11-06 江苏康缘药业股份有限公司 A kind of Chinese medicine composition for treating urarthritis
EP3238732A4 (en) * 2014-12-23 2018-07-18 Korea Institute of Oriental Medicine Anti-gout composition containing mixture extract of chrysanthemum indicum and cinnamomum cassia as active ingredient
US10098921B2 (en) 2014-12-23 2018-10-16 Korea Institute Of Oriental Medicine Method for treating gout and gout-induced arthritis using composition containing mixed extract of Chrysanthemum indicum and Cinnamomum cassia
CN107753724A (en) * 2016-08-17 2018-03-06 江苏康缘药业股份有限公司 A kind of preparation method and detection method of the tablet for treating urarthritis

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