CN101828960A - High-intensity focused ultrasound spherical phased array with array elements annually and intensively distributed - Google Patents

High-intensity focused ultrasound spherical phased array with array elements annually and intensively distributed Download PDF

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CN101828960A
CN101828960A CN 201010165879 CN201010165879A CN101828960A CN 101828960 A CN101828960 A CN 101828960A CN 201010165879 CN201010165879 CN 201010165879 CN 201010165879 A CN201010165879 A CN 201010165879A CN 101828960 A CN101828960 A CN 101828960A
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array
array element
crown body
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focused ultrasound
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陈亚珠
沈国峰
白景峰
吉翔
潘钢
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Shanghai Jiaotong University
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Abstract

The invention relates to a high-intensity focused ultrasound spherical phased array with array elements annually and intensively distributed, comprising a rigid spherical crown body and a plurality of array elements, wherein one array element is independently arranged in the center of the spherical crown body, and the other array elements are evenly and dispersedly distributed on a plurality of layers of concentric rings which take the center of the spherical crown body as an original point; the angular spacings among all ring layers are not equal, and the spacings among all ring layers and the spacing between adjacent array elements in the same ring are set according to an array element intensive distribution principle; the position of the original array element of each layer of concentric rings is randomly set, the other array elements are subsequently, intensively and evenly distributed on the concentric rings according to equiangular spacing, and each array element has independent electric excitation signal feeder lines which are respectively connected to a phased signal excitation system. The invention calculates the phase position and the voltage amplitude distribution of the array elements by adopting a focus model synthesis method based on a pseudo-inverse matrix theory, realizes acoustic beam electron focusing and scanning, generates required single-focus or multi-focus sound field control modes, and the like and is applied to heating and fusing target tumor focuses in the human body.

Description

Array element is the high-intensity focused ultrasound spherical phased array of dense distribution ringwise
Technical field
The present invention relates to a kind of ultrasonic phase array, relate in particular to a kind of array element high-intensity focused ultrasound spherical phased array of dense distribution ringwise, be applied to phase control-type high intensity focused ultrasound (P-HIFU) system of tumor treatment of NMR (Nuclear Magnetic Resonance)-imaging (MRI) guiding, belong to the biomedical engineering technology field.
Background technology
The high intensity focused ultrasound phased array is one of critical component of phase control-type high-intensity focus supersonic tumor therapy system.It is that Electronic Control focusing and focal length are variable, can produce multiple sound field control models such as single focus or a plurality of focuses.It is by regulating and control wherein the excitation phase and the amplitude of array element arbitrarily, just can realize that external supersonic converges at a bit in human body, this point (being focus) has the characteristic of maximum sound pressure amplitude in whole sound field distributes, so form the zone of a high sound intensity in the target area.The focus place deposits in a large number owing to ultrasonic energy, be positioned at the tissue temperature rapid rising of meeting (temperature can reach more than 65 ℃ in 2~10 seconds) wherein and then cause cell generation coagulation necrosis, and the normal structure outside the focus can not be subjected to obvious impairment because of only there being the temperature rise of less energy deposition very few.
Existing high intensity focused ultrasound phased array mainly contains: planar phased array and sphere phase array (or concave surface phased array).The shape of array element has forms such as circle, annular, rectangle, cylindricality and fan volute.
Planar phased array is meant that array element places formed phased array on the plane by definite shape, and it produces the secondary lobe that relative main lobe can't be ignored easily during focusing in the near field, and its electron scanning scope that realizes acoustic beam is less simultaneously, and operation flexibility is limited.And sphere phase array is meant that array element places formed phased array on the sphere by definite shape, because sphere self has geometrical focus, adopt such structure can either guarantee big sound intensity gain amplification, can in three dimensions, produce big focus scanning scope and multiple focus mode again, have good acoustical behavior.
Two kinds of image guidance modes of main employing in the high intensity focused ultrasound operation at present: a kind of is the B ultrasonic guiding, and another kind is NMR (Nuclear Magnetic Resonance)-imaging (MRI) guiding.In the phase control-type high intensity focused ultrasound system of B ultrasonic guiding, the B ultrasonic transducer is placed in the central openings of ultrasonic phase array usually, the transducer architecture of similar central openings will influence the sound field distribution character and the working method of this transducer, may restrict the performance of this class transducer, the MRI guiding then can not produce these problems.
Find through literature search prior art, China's utility model patent " the sectional polynary high-intensity focusing ultrasonic transducer of a kind of symmetry " (Granted publication number for CN2894640Y) has disclosed " the sectional polynary high-intensity focusing ultrasonic transducer of a kind of symmetry; it comprises: be fixed on the transducer sheet on the support; hemisphere face carriage; B ultrasonic transducer; O RunddichtringO; osculum, the O RunddichtringO is used for the sealing between high-intensity focusing ultrasonic transducer and the water pocket, the transducer sheet that is fixed on the support is divided into 4N subregion in 360 °, arrange and be fixed on the inner surface of hemisphere face carriage symmetrically, N is a natural number, 1~100 transducer sheet that is fixed on the support is placed in each zone, and transducer sheet diameter is 1~50MM; All subregions form the high-intensity focusing ultrasonic transducer chip arrays jointly, and each subregion is respectively by the control of power supply independently, the adjustment that power by adjusting driving power respectively and phase place realize burnt territory shape of focus supersonic and incident direction; The B ultrasonic transducer directly is embedded in hemisphere face carriage center; The transducer sheet battle array sealing and fixing that the use bonding agent can produce high intensity focused ultrasound is on the hemisphere face carriage, and the transducer chip arrays and the B ultrasonic transducer combinations that can produce high intensity focused ultrasound form high-intensity focusing ultrasonic transducer jointly." the obvious deficiency of this technology existence: because each subregion is respectively by independently power supply control; promptly all interior array elements of this subregion all will be energized the equal-wattage and the phase place of same driving power; so each subregion can be regarded as " greatly " array element equivalently; so this polynary high-intensity focusing ultrasonic transducer only is made up of individual " greatly " array element of 4N; equivalent array element quantity minimizing will limit the focus scanning scope of this transducer; simultaneously because the distance between adjacent " greatly " array element is more much bigger than original adjacent array element distance, promptly " greatly " array element spatial distribution is not compact, be easy to generate bigger secondary lobe when electron focusing and scanning, may cause outside the target area normal structure by superheated, the harm patient.
Chinese invention patent " wide focal domain phased array focusing ultrasonic transducer " (publication number is CN1775327) disclosed " wide focal domain phased array focusing ultrasonic transducer by a large aperture rigidity ball-crown body and several Discrete Distribution the ultrasonic transducer unit---array element is formed; the central circular hole of ball-crown body provides installing space for localization by ultrasonic Device Testing probe; it is on the several layers concentric ring of initial point that all array elements are distributed in the ball-crown body center discretely; the angular separation between each circular layer is equal; the initial element position of each layer concentric ring is decided at random; all the other array elements then in succession by etc. angular separation be evenly distributed on the concentric ring, each array element all has independently electric excitation signal feeder line, is connected to the phased signal excitation system respectively." there are following 2 deficiencies in this technology: first; because localization by ultrasonic Device Testing probe has been installed in the central circular hole of ball-crown body; the transducer architecture of this central openings can make the focus energy when focusing on beam axis not concentrate; can't bring into play the advantage of sphere phase array self geometric focusing; the distance (being the focus scanning scope) of the beam axis of focus point position skew simultaneously is restricted, and influences the therapeutic domain of this transducer; Second, " angular separation between each circular layer equates " makes that the adjacent array element ring spacing of inner circular layer is bigger than the adjacent array element ring spacing of outer circular layer, because the secondary lobe size that produces when interior adjacent array element distance of phased array and phase array focusing is directly proportional, it is big that the secondary lobe that produces when therefore array element is in this phase array focusing that non-dense set arranges is densely arranged phased array than array element under the same terms, and this will influence this phase array focusing effect.
Summary of the invention
The objective of the invention is to above-mentioned deficiency at prior art, design provides a kind of array element high-intensity focused ultrasound spherical phased array of dense distribution ringwise, the phase control-type high intensity focused ultrasound system that is used for the MRI guiding, electron focusing and scanning that it can realize acoustic beam by the phase place and the amplitude of each array element driving voltage of control, produce sound field control models such as required single focus or many focuses, and then make the formed burnt territory of focus cover the target area, guarantee the energy deposition of external supersonic target area tissue in human body, reach and make the target area tissue that the required temperature rise of coagulation necrosis take place, realize the heating ablation that adds human body internal object tumor focus.
For realizing such purpose, the present invention has adopted following design: whole array element ringwise dense distribution the high intensity focused ultrasound phased array by a rigidity ball-crown body and several Discrete Distribution the ultrasonic transducer unit---planar rondure array element is formed, central authorities at ball-crown body place an array element separately, it is on the several layers concentric ring of initial point that all the other array elements all are distributed in the ball-crown body center discretely, angular separation between each circular layer is all unequal, be according to array element between each circular layer of policy setting of dense distribution (being interval between the adjacent ring and as far as possible little) with the spacing of adjacent array element in the ring the interval and with the spacing of adjacent array element in the ring, the initial element position of each layer concentric ring is decided at random, all the other array elements then in succession by etc. angular separation closely be evenly distributed on the concentric ring.Each array element all has independently electric excitation signal feeder line, is connected to the phased signal excitation system respectively.
The frequency unanimity of each array element pumping signal, phase place and voltage amplitude have nothing in common with each other, by calculate the phase place and the voltage amplitude combination of array element based on the focus mode synthetic method of pseudo inverse matrix theory, realize the electron focusing and the scanning of acoustic beam, produce sound field control models such as required single focus or many focuses, and then make the formed burnt territory of focus cover the target area, guarantee the energy deposition of external supersonic target area tissue in human body, reach and make the target area tissue that the required temperature rise of coagulation necrosis take place, realize the heating ablation that adds human body internal object tumor focus.
Among the present invention, the radius of curvature R=L of described rigidity ball-crown body 1+ L 2, L wherein 1Be the focusing minimum-depth of this phased array, L 2Be the axial scan scope of this phased array, the f-number of rigidity ball-crown body satisfies 0.85≤f-number≤0.95, and wherein f-number is the radius of curvature R of rigidity ball-crown body and the ratio of outer dia D.
Array element of the present invention adopts circular, plane form, and the diameter of each array element, thickness are all identical, is made by the emissivity piezoelectric, and its outer surface gummed has matching layer.
The size of array element of the present invention, distribute spacing and quantity depend on a plurality of conditions such as the radius of curvature R of frequency, rigidity ball-crown body of sound field side lobe levels, pumping signal and outer dia D, determine through optimal design.Array element critically is embedded in respectively in the aperture of rigidity ball-crown body, is aided with the binding agent gummed simultaneously.Each array element all has independently electric excitation signal feeder line, is connected to the phased signal excitation system respectively.
The electric excitation signal of each array element of the present invention all is independent controlled, the frequency f unanimity of each array element pumping signal, phase place
Figure GDA0000021173740000041
With voltage amplitude μ iHave nothing in common with each other (wherein i represents the array element sequence number), so the phase place of each array element surface vibration velocity and amplitude also have nothing in common with each other, by calculate the phase place and the voltage amplitude combination of array element based on the focus mode synthetic method of pseudo inverse matrix theory
Figure GDA0000021173740000042
Array element is energized voltage signal
Figure GDA0000021173740000043
The stack in three dimensions of the radiating sound wave in back can make sound wave wave surface curvature and center change, thereby the electron focusing and the scanning of acoustic beam have been realized, produce multiple sound field control models such as required single focus or many focuses, and then make the formed burnt territory of focus cover the target area, and guarantee to be enough to make the target area tissue that the energy deposition of coagulation necrosis takes place.
The high intensity focused ultrasound phased array of dense distribution has sphere, rule, angular separation-varying concurrently to array element of the present invention simultaneously ringwise, the array element spatial distribution is compact and wait characteristics at random, therefore has concentrated focus Energy distribution, big three dimensions focus scanning scope, strong Sidelobe Suppression ability and high advantages such as sound intensity gain.The electron focusing and the scanning that can realize acoustic beam by the phase place and the amplitude of each array element pumping signal of control, produce multiple sound field control models such as required single focus or many focuses, and then make the formed burnt territory of focus cover the target area, guarantee the energy deposition of external supersonic target area tissue in human body, reach and make the target area tissue that the required temperature rise of coagulation necrosis take place, realize the heating ablation that adds human body internal object tumor focus.Novel structure compactness of the present invention, selection is common, and function admirable has broad application prospects.
Description of drawings
Fig. 1 is a structural representation of the present invention.
Among Fig. 1,1 is the rigidity ball-crown body, and 2 is array element.
The specific embodiment
In order to understand technical scheme of the present invention better, be described in further detail below in conjunction with accompanying drawing.The technical parameter that embodiment adopted does not constitute limitation of the invention.
Fig. 1 is a structural representation of the present invention.As shown in Figure 1, the high intensity focused ultrasound phased array of the present invention design by a rigidity ball-crown body 1 and N Discrete Distribution the ultrasonic transducer unit---circular flat array element 2 is formed, adopt sphere, rule, compactness, angular separation-varying ring battle array structure, the initial array element random position of every ring.
Radius of curvature R=the L of rigidity ball-crown body 1 1+ L 2, L wherein 1Be the focusing minimum-depth of this phased array, L 2Be the axial scan scope of this phased array, the f-number of rigidity ball-crown body satisfies 0.85≤f-number≤0.95, and wherein f-number is the radius of curvature R of rigidity ball-crown body and the ratio of outer dia D.
The distribution of array element 2 as shown in Figure 1, several circular apertures that distribute discretely on the rigidity ball-crown body 1 are inlayed a circular flat array element 2 in each aperture.The size of array element 2, distribute spacing and quantity depend on a plurality of conditions such as the radius of curvature R of frequency, rigidity ball-crown body of sound field side lobe levels, pumping signal and outer dia D, determine through optimal design.Array element critically is embedded in respectively in the aperture of rigidity ball-crown body, is aided with the binding agent gummed simultaneously.Each array element all has independently electric excitation signal feeder line, is connected to the phased signal excitation system respectively.
Array element 2 is multilamellar, dense distribution, angular separation-varying ring battle array, and promptly all array elements are distributed in A successively, B, and C, D ... on M circular layer, every layer element number of array difference, the element number of array sum of all layers is N.Wherein, only there is an array element A01 to be distributed on the A layer, array element A01 and Z axle are perpendicular to the ball-crown body center O, and the center of circle of array element A01 overlaps with the ball-crown body center O, it is on the M-1 layer concentric ring of initial point that all the other array elements are distributed in the ball-crown body center O discretely, angular separation between each circular layer is all unequal, that is, and and the array element center of circle on the A layer concentric ring and ball-crown body geometrical focus R oLine and the angle of Z axle be θ A, the array element center of circle on the B layer concentric ring and ball-crown body geometrical focus R oLine and the angle of Z axle be θ B, the array element center of circle on the C layer concentric ring and ball-crown body geometrical focus R oLine and the angle of Z axle be θ C, θ CB≠ θ BA, the rest may be inferred, be according to array element between each circular layer of policy setting of dense distribution (being interval between the adjacent ring and as far as possible little) with the spacing of adjacent array element in the ring the interval and with the spacing of adjacent array element in the ring.Because A layer array element only has one and fixed-site, therefore, first array element (B01 on beginning every layer from the B layer, C01 ...), decide at random its position, with the layer on all the other array elements then in succession by etc. angular separation closely be evenly distributed on the concentric ring, that is, lifting the B layer is example, the line of the center of circle of array element B01 and ball-crown body center O and the angle α of X-axis B01Numerical value generate at random, all the other array elements on the B layer then in succession by etc. angular separation closely be evenly distributed on the concentric ring i.e. α B03B02B02B01..., the rest may be inferred.All the rest may be inferred for all the other each layers.
In an embodiment of the present invention, the focusing minimum-depth L of this phased array 1=4cm, the axial scan range L 2=3.2cm, so the radius of curvature R=L of rigidity ball-crown body 1 1+ L 2=7.2cm, the f-number of rigidity ball-crown body 1 is taken as 0.9, its outer dia D=8cm.The diameter of array element 2 is 1.0cm, and thickness is 0.15cm.The material of array element 2 adopts the PZT-8 piezoelectric ceramics, and its outer surface gummed has matching layer.
In an embodiment of the present invention, concentric ring number of plies M=4, element number of array N=37, θ A=0.00 °, θ B=8.10 °, θ C=16.86 °, θ D=26.52 °, θ DC=9.66 ° ≠ θ CB=8.76 °.The element number of array N of A layer A=1, the element number of array N of B layer B=5, α B01=5 °, α B03B02B02B01=360 °/5=72 °, the element number of array N of C layer C=12, α C01=10 °, the angular separation of adjacent array element is 30 ° on its concentric ring, the element number of array N of D layer D=19, α D01=15 °, the angular separation of adjacent array element is 18.95 ° on its concentric ring.
The electric excitation signal of each array element 2 of the present invention all is independent controlled, the frequency f unanimity of each array element pumping signal, phase place
Figure GDA0000021173740000061
With voltage amplitude μ iHave nothing in common with each other (wherein i represents the array element sequence number), so the phase place of each array element surface vibration velocity and amplitude also have nothing in common with each other, by calculate the phase place and the voltage amplitude combination of array element based on the focus mode synthetic method of pseudo inverse matrix theory Array element is energized voltage signal
Figure GDA0000021173740000063
The stack in three dimensions of the radiating sound wave in back can make sound wave wave surface curvature and center change, thereby the electron focusing and the scanning of acoustic beam have been realized, produce multiple sound field control models such as required single focus or many focuses, and then make the formed burnt territory of focus cover the target area, and guarantee to be enough to make the target area tissue that the energy deposition of coagulation necrosis takes place.

Claims (4)

1. the array element high-intensity focused ultrasound spherical phased array of dense distribution ringwise, form by a rigidity ball-crown body (1) and several array element (2), it is characterized in that placing an array element (2) separately in the central authorities of ball-crown body (1), it is on the several layers concentric ring of initial point that all the other array elements (2) all are distributed in ball-crown body (1) center discretely, angular separation between each circular layer is all unequal, interval between each circular layer reaches with the spacing of encircling interior adjacent array element according to array element dense distribution policy setting, the initial element position of each layer concentric ring is decided at random, all the other array elements in succession by etc. angular separation closely be evenly distributed on the concentric ring, each array element (2) all has independently electric excitation signal feeder line, is connected to the phased signal excitation system respectively.
2. according to the array element of the claim 1 high-intensity focused ultrasound spherical phased array of dense distribution ringwise, it is characterized in that the radius of curvature R=L of described rigidity ball-crown body (1) 1+ L 2, L wherein 1Be the focusing minimum-depth of this phased array, L 2Be the axial scan scope of this phased array, the f-number of rigidity ball-crown body (1) satisfies 0.85≤f-number≤0.95, and wherein f-number is the radius of curvature R of rigidity ball-crown body (1) and the ratio of outer dia D.
3. according to the array element of claims 1 high-intensity focused ultrasound spherical phased array of dense distribution ringwise, it is characterized in that described array element (2) adopts circular, plane form, diameter, the thickness of each array element (2) are all identical, made by the emission type piezoelectric, its outer surface gummed has matching layer.
4. according to the array element of the claim 1 high-intensity focused ultrasound spherical phased array of dense distribution ringwise, the electric excitation signal that it is characterized in that described each array element (2) is independent controlled, the frequency unanimity of each array element pumping signal, phase place and voltage amplitude have nothing in common with each other, by calculate the phase place and the voltage amplitude combination of array element based on the focus mode synthetic method of pseudo inverse matrix theory, realize the electron focusing and the scanning of acoustic beam, produce required single focus or many focuses sound field control model.
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Cited By (8)

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CN101947129A (en) * 2010-10-12 2011-01-19 上海交通大学 Phase-control high-intensity focusing ultrasonic transducer and magnetic resonance breast coil integrating device
CN103341241A (en) * 2013-07-24 2013-10-09 苏州科技学院 High-strength focusing ultrasonic energy converter array
CN104271264A (en) * 2012-05-01 2015-01-07 富士胶片戴麦提克斯公司 Ultra wide bandwidth transducer with dual electrode
CN105911523A (en) * 2016-04-13 2016-08-31 东北石油大学 Point sound source positioning system intelligent detecting front-end based on semispherical microphone array
CN107121499A (en) * 2017-03-31 2017-09-01 中国航发北京航空材料研究院 A kind of single-chip and phased array supersonic coupling probe
CN107802969A (en) * 2017-11-13 2018-03-16 深圳市普罗医学股份有限公司 A kind of sphere self-focusing ultrasonic phased array transducers
CN111407313A (en) * 2020-04-03 2020-07-14 深圳先进技术研究院 Ultrasonic transducer and ultrasonic imaging device
CN113188646A (en) * 2021-03-19 2021-07-30 韶关东阳光自动化设备有限公司 Planar full-electronic focusing HIFU phased array and test system thereof

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Publication number Priority date Publication date Assignee Title
CN101947129A (en) * 2010-10-12 2011-01-19 上海交通大学 Phase-control high-intensity focusing ultrasonic transducer and magnetic resonance breast coil integrating device
CN101947129B (en) * 2010-10-12 2012-03-21 上海交通大学 Phase-control high-intensity focusing ultrasonic transducer and magnetic resonance breast coil integrating device
CN104271264A (en) * 2012-05-01 2015-01-07 富士胶片戴麦提克斯公司 Ultra wide bandwidth transducer with dual electrode
CN104271264B (en) * 2012-05-01 2017-07-21 富士胶片戴麦提克斯公司 Ultra wide band transducer with bipolar electrode
CN103341241A (en) * 2013-07-24 2013-10-09 苏州科技学院 High-strength focusing ultrasonic energy converter array
CN103341241B (en) * 2013-07-24 2016-01-20 苏州科技学院 A kind of high-intensity focusing ultrasonic transducer array
CN105911523A (en) * 2016-04-13 2016-08-31 东北石油大学 Point sound source positioning system intelligent detecting front-end based on semispherical microphone array
CN107121499A (en) * 2017-03-31 2017-09-01 中国航发北京航空材料研究院 A kind of single-chip and phased array supersonic coupling probe
CN107802969A (en) * 2017-11-13 2018-03-16 深圳市普罗医学股份有限公司 A kind of sphere self-focusing ultrasonic phased array transducers
CN111407313A (en) * 2020-04-03 2020-07-14 深圳先进技术研究院 Ultrasonic transducer and ultrasonic imaging device
CN113188646A (en) * 2021-03-19 2021-07-30 韶关东阳光自动化设备有限公司 Planar full-electronic focusing HIFU phased array and test system thereof

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