CN101816431B - Precious peptide bone-strengthening capsules or tablets with function of improving osteoporosis and increasing bone mineral density and preparation method thereof - Google Patents
Precious peptide bone-strengthening capsules or tablets with function of improving osteoporosis and increasing bone mineral density and preparation method thereof Download PDFInfo
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- CN101816431B CN101816431B CN2010101622742A CN201010162274A CN101816431B CN 101816431 B CN101816431 B CN 101816431B CN 2010101622742 A CN2010101622742 A CN 2010101622742A CN 201010162274 A CN201010162274 A CN 201010162274A CN 101816431 B CN101816431 B CN 101816431B
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Abstract
The invention relates to a health food, in particular to precious peptide bone-strengthening capsules or tablets with the function of improving osteoporosis and increasing bone mineral density and a preparation method thereof. The product of the invention is prepared by mixing the following three raw materials: nanometer pearl powder, collagen peptide and kudzu-vine root extract (puerarin), wherein the pearl powder is prepared by the ultrafine grinding technology; collagen peptide uses the collagen extracted from the skins and bones of livestock or fish skin as raw material; the biological enzymolysis technology is used to degrade macromolecular collagen to micromolecular collagen, collagen peptide can be directly absorbed by the body; and the traditional Chinese medicine kudzu-vine root is extracted, separated and concentrated and performs spray drying so as to prepare the extract containing puerarin; the three raw materials are fully mixed in a certain formula ratio according to the demand quantity of human body, pelletized and filled or pressed into tablets to prepare the capsules or tablets. The product of the invention is primarily suitable for the middle-aged and elder people to take, in particular for middle-aged women and has the health function of improving osteoporosis and increasing bone mineral density after eaten for a long time.
Description
Technical field
The invention belongs to the Food Engineering Development field of functional food, particularly have and improve osteoporosis, the precious peptide capsule that increases the bone density function or tablet and preparation method thereof.
Background technology
Along with the society that gets into aging population; The aged constantly increases; Osteoporosis serious threat the elderly's health, and osteoporosis has the title of " noiseless killer ", and the WHO statistics shows: the patients with osteoporosis sum surpasses 200,000,000 people in the world wide at present; Only just there are more than 7,500 ten thousand people in the U.S., West Europe and Japanese developed country and area, every yearization in treatment and the expense on being in hospital up to 25,000,000,000 dollars.Promote " the osteoporosis China white paper 2008 " of foundation issue to show by China's Healthy; Survey estimates had 6,944 ten thousand people (man 1,534 ten thousand, woman 5,410 ten thousand) to suffer from osteoporosis in 2006 approximately among the crowd of the whole nation more than 50 years old; There is data to estimate; From 50 years futures counting now. have 75% hip fracture can appear at developing country, this and osteoporosis are closely related. and China is exactly the severely afflicated area.Osteoporosis is sent out well in postmenopausal women and elderly men, also has rejuvenation trend now.Therefore society, market demand have prevention of osteoporosis, increase the bone density health care foods.
Osteoporosis be since in the skeleton loss of calcium cause.Skeleton mainly is made up of calcium and collagen two parts, and wherein calcium salt accounts for 2/3. collagen and accounts for 1/3.Collagen is network structure in sclerotin. and the hardness of bone and toughness are strengthened.The relation of collagen and calcium is just as the relation of cement and sand, and is indispensable, has cement, sand just can be solidified as one; Otherwise will become a heap of a loose sand, behind the people to 30 year old, the ability of the synthetic collagen of body reduces; Loss is greater than synthetic, and the not enough calcium of collagen just can't be cemented in the bone, the bone calcium loss; Because ovarian function descends, estrogen secretion sharply reduces after menopause for just easy formation osteoporosis, particularly women; Body in-seam metabolic balance is destroyed, and the loss of collagen and calcium is faster, has quickened osteoporotic process.Therefore, scientific methods is replenishing collagen and an estrogen when replenishing the calcium, and calcium could be deposited in the bone under the bonding of collagen like this. the toughness of enhance bone, hardness.That is to say to have only picked-up enough collagen and complementing estrogen, human body can have normal absorption and utilization to calcium, and osteoporotic problem just can thoroughly solve.
Pearl is rich in several amino acids, calcium, B family vitamin and the various trace element that human body needs; Having profit face skin care and antidotal special efficacy, is traditional rare Chinese medicine, and the calcium content of pearl is more than 38%; Pearl often is processed to powder; Be referred to as pearl powder, be used to prevent and treat the disease that various calcium deficiency cause as calcium tonic, or as the raw material of the senior tonic article and the cosmetics of super quality.The pearl powder of domestic production at present is generally micron order, and particle diameter is in 3～10 μ m mostly.In order to improve the absorption rate of pearl powder, we prepare nano-glass pearl powder with superfine communication technique, make pearl powder average grain diameter＜100nm, have greatly improved fineness, and it is long-pending to increase particle surface, are prone to absorbed by body.
Collagen is the key of bone health; Collagen not only improves bone toughness and also plays the important function of sticking calcium; Relation between collagen and the calcium is just as the relation of cement and sand; When replenishing calcium, the participation of collagen must be arranged, not be solidified as one in the bone if there is the participation calcium of collagen just can't be cemented in.Behind the people to 30 year old, the ability of the synthetic collagen of body reduces, and runs off greater than synthetic.Collagen is not enough, and the bone calcium loss just is prone to form osteoporosis.Prevent and improve osteoporosis, scientific methods is to replenish calcium and collagen simultaneously.Like this, calcium could down be deposited on bone in the bonding of collagen, strengthens the toughness, hardness of bone, has also just played the effect that increases bone density.That is to say that human body has only the enough collagens of picked-up, calcium can be by effective absorption, and osteoporotic problem could really solve.Research according to the modern times shows that micromolecular protein peptides can directly be absorbed by enteron aisle; The bio-absorbable utilization rate of collagen peptide is more much higher than collagen; In order to improve the bioavilability of collagen, adopting biological enzymolysis technology is micromolecular collagen peptide with the big molecule enzymolysis of collagen, and its molecular weight ranges is 1000-3000 dalton; Be prone to sharp body and absorb, make it give full play to the efficacy effect of collagen.
Research shows that oestrogen deficiencies is the key factor that primary osteoporosis takes place, but estrogen prophylactic treatment osteoporosis.Puerarin (kudzuvine root isoflavone) is the main active ingredient of the Chinese medicine root of kudzu vine; As the osajin plant extracts that separation the earliest obtains, the similar estradiol of Puerarin structure, it has the chemical constitution similar with estrogen; Thereby performance estrogen-like action, Puerarin belong to a kind of phytoestrogen.Experimental study finds that Puerarin forms external bone has certain facilitation, and Puerarin causes that external and estrogenic effect characteristics conform to simultaneously.There are some researches show that all Puerarin can improve the bone mineral content of animal used as test, bone mineral density and bone biomechanical intensity both at home and abroad; The osteoporosis of treatment animal used as test; Adopt extraction process technology; Being the active ingredient in the solvent extraction root of kudzu vine with water, is that solvent further separates and concentrates Puerarin, the last spray-dried Powdered kudzu root extract that makes again with ethanol.
Replenish the calcium in the market, replenishing collagen, to replenish phytoestrogen (like isoflavones, Puerarin) product a feast for the eyes, not following hundred kinds of its kind quantity, its subjective wishes all is in order to improve osteoporosis, to increase bone density; But these products only consider and cause osteoporosis factor in a certain respect on prescription, or replenish the calcium or replenishing collagen or additional phytoestrogen, and the effect of its product is so not remarkable; Like many its mechanism of action of product of replenishing the calcium are simple replenishing the calcium; This series products exists some defective, and at first, the calcium that replenishes can not be absorbed and be deposited in the bone; Perhaps absorptivity is lower, and major part is lost in vain; Secondly the simple calcium that replenishes makes that the toughness of bone weakens, fragility increases, more be prone to cause fracture; Unabsorbed in addition calcium is as can not in time excreting. and accumulation is easy to cause diseases such as gall stone in vivo. influence healthy on the contrary.Modern study shows: the reason that causes osteoporosis is not due to the simple calcium deficiency, also reduces closely related with the estrogenic secretion of loss, the climacteric women of ossein.Therefore consider from above-mentioned three aspect combined factors; If work on the three areas simultaneously; Replenish calcium, collagen peptide, three kinds of compositions of plant hormone simultaneously; Make the collaborative each other absorption that just can greatly improve calcium of three, play the effect of prevention of osteoporosis, increase bone density, the present invention is based upon on the above-mentioned basis and studies.
Summary of the invention
The objective of the invention is to replenish simultaneously calcium, collagen peptide, three kinds of compositions of plant hormone, make the collaborative each other absorption that improves calcium widely of three, play the effect of prevention of osteoporosis, increase bone density.Selecting Nano pearl powder, collagen peptide, kudzu root extract (Puerarin) for use is primary raw material; From replenish the calcium, two approach of compensating collagen protein provide the synthetic required material of bone; Improve the metabolism of sclerotin through additional kudzu root extract (Puerarin, phytoestrogen); Promote bone to form, thereby reach prevention, improve osteoporosis, the purpose of increase bone density.Make the elderly, middle and aged women particularly, the long-term edible health care that improves osteoporosis, increases bone density that has.
The present invention is made up of Nano pearl powder, collagen peptide, three kinds of primary raw material prescriptions of kudzu root extract (Puerarin), and its pearl powder adopts the superfine technique preparation; Collagen peptide is a raw material with the collagen of skin, bone or the fish-skin extraction of domestic animal; Adopting biological enzymolysis technology is micromolecular collagen peptide with the collagen macromolecules degradation, and collagen peptide can directly be absorbed by body; The Chinese medicine root of kudzu vine through extraction to separate, concentrate, spray-drying makes the extract that contains Puerarin, three kinds of raw materials according to the requirement of human body by certain formula rate fully mix, granulation, can or compressing tablet, make capsule or tablet,
Product of the present invention is that the genesis mechanism according to osteoporosis designs prescription; Prescription has been selected Nano pearl powder, collagen peptide, three kinds of raw materials of kudzu root extract (Puerarin) for use; From replenishing the calcium, the replenishing collagen peptide, replenishing three approach of plant hormone and provide bone to synthesize required material; Regulate the bone metabolism, thereby increase bone density, reach the purpose of prevention of osteoporosis.
The used pearl powder of the present invention is a Nano pearl powder, through ultramicro grinding; Used collagen through biological enzymolysis, filtration, concentrate, PROCESS FOR TREATMENT such as spray-drying, be converted into collagen peptide; The root of kudzu vine is through extraction, separation, concentrated, drying process processing, and puerarin content is more than 30%.
The preparation of precious peptide capsule or tablet, the used raw material of filling a prescription is handled by following method:
(1) Nano pearl powder: earlier pearl powder is carried out coarse crushing with hammer crusher, carry out air-flow with airslide disintegrating mill then and pulverize, make pearl powder average grain diameter＜100 micron;
(2) collagen peptide: with pig, ox, mule, etc. the collagen protein powder of skin and fish-skin processing of the domestic animal water that adds 6～10 times of amounts put the dissolving of heating of enzymolysis pot; The compound protease (forming in proportion) of adding 0.1～0.5% by plant rennet and animal protease; Stir enzymolysis; 50～60 ℃ of temperature of control were held time 5～8 hours, were warming up to 85 ℃ of enzyme half an hour of going out after enzymolysis finishes; Make Powdered collagen peptide through concentrated, spray-drying, its molecular weight ranges is 1000～3000 dalton;
(3) kudzu root extract: the Chinese medicine root of kudzu vine is cleaned the water that adding 5-10 doubly measures, soak half an hour, heat to boil and keep 1 hour, isolated by filtration filtrating; Slag repeats to extract once, filters, and merges secondary filtrating and concentrates, and concentrate is with alcohol adjustment concentration of alcohol to 80%; Stir, leave standstill, cool overnight, centrifugal or separation of supernatant concentrates recovered alcohol, is concentrated into solid content and reaches 10% when above; Carry out spray-drying, make pulverous kudzu root extract, puerarin content is more than 30%.
Various raw material usage ratio prescriptions are: Nano pearl powder 40～60%; Collagen peptide 35～45%; Kudzu root extract 5～12%; Auxiliary material 1～2%;
The concrete preparation process of precious peptide capsule or tablet is following:
1) mixes: fully mix according to the required batching of prescription.
2) granulate: batch mixes evenly after, spray into 70% edible alcohol and continue again to mix, through the wobbler wet granulation until granulating;
3) oven dry: wet grain is through fluidized drying or microwave drying, and control moisture is below 4%.
4) whole grain: the particle of drying is carried out whole grain through pelletizing machine sieve, remove powder and thicker particle, make the granular size particle even.
5) dress capsule: select the appropriate size softgel shell to carry out can, packing, capsule product.
6) compressing tablet: if tablet then adds auxiliary material and particle mixing, select suitable punch die to carry out compressing tablet, through packing, tablet product according to required slice, thin piece shape.
7) check:
8) warehouse-in:
Concrete preparation method's step is following:
1. preparation Nano pearl powder: earlier pearl powder is carried out coarse crushing with hammer crusher, carry out air-flow with airslide disintegrating mill then and pulverize, make pearl powder average grain diameter＜100 micron.
Collagen peptide preparation: with pig, ox, mule, etc. the collagen protein powder of skin or fish-skin processing of the domestic animal water that adds 6～10 times of amounts put the jacketed pan dissolving of heating; The compound protease (forming in proportion) of adding 0.1～0.5% by plant rennet and animal protease; Stir enzymolysis; 50～60 ℃ of temperature of control were held time 5～8 hours, were warming up to 85 ℃ of enzyme half an hour of going out after enzymolysis finishes; Make Powdered collagen peptide through concentrated, spray-drying, its molecular weight ranges is 1000～3000 dalton.
3. the preparation of kudzu root extract: the Chinese medicine root of kudzu vine is cleaned input extract the water that adding 5-10 doubly measures in the pot pot, soak half an hour, heat to boil and keep 1 hour; Isolated by filtration filtrating, slag repeat to extract once, filter; Merge secondary filtrating and concentrate, concentrate stirs, leaves standstill, cools off with alcohol adjustment concentration of alcohol to 80%; Centrifugal or isolated by filtration supernatant concentrates recovered alcohol, is concentrated into solid content and reaches 10% when above; Carry out spray-drying, make pulverous kudzu root extract, puerarin content is more than 30%.
4. the preparation of the strong capsule of precious peptide (sheet):
4.1 prescription mixes: fully mix in mixer than the true Nano pearl powder, collagen peptide, three kinds of materials of kudzu root extract of taking by weighing of Liejing by prescription.
4.2 stir to granulate: dry powder blend evenly after, spray into 70% edible alcohol while stirring, make that material is moistening to have certain viscosity, through the oscillating granulator wet granulation.
4.3 fluidized drying: control fluidized drying under 70 ℃ of temperature conditions, moisture is controlled at below 4%.
4.4 whole grain: the particle of oven dry is sieved through vibratory sieve, remove the particle of powder and caking.
4.5 can or compressing tablet: as be capsule formulation, adopt the softgel shell of respective model to carry out can according to actual needs.As be tablet, add auxiliary material and particle mixing, select corresponding punch die to carry out compressing tablet according to the specification shape of required slice, thin piece.
4.6 packing:
4.7 check:
4.8 warehouse-in:
Description of drawings
Fig. 1 is the strong bone of precious peptide (capsule, a tablet) product processes flow chart.
The present invention has following technique effect:
It is primary raw material that the present invention selects Nano pearl powder, collagen peptide, kudzu root extract (Puerarin) for use; From replenish the calcium, two approach of compensating collagen protein provide the synthetic required material of bone; Improve the metabolism of sclerotin through additional kudzu root extract (Puerarin, phytoestrogen); Promote bone to form, thereby reach prevention, improve osteoporosis, the purpose of increase bone density.These article are applicable to that mainly the elderly takes, middle and aged women particularly, the long-term edible health care that improves osteoporosis, increases bone density that has.
The specific embodiment
Specify specific embodiment of the present invention below.
Embodiment 1
One. the strong capsule of precious peptide (sheet) pretreatment of raw material:
(1) preparation Nano pearl powder: earlier pearl powder is carried out coarse crushing with the hammering pulverizer, carry out air-flow with airslide disintegrating mill then and pulverize, make pearl powder average grain diameter＜100nm.
(2) preparation collagen peptide: with pig, ox, mule, etc. skin or the water that collagen protein powder that fish-skin is processed adds 6～10 times of amounts of domestic animal put the jacketed pan dissolving of heating; The compound protease (forming in proportion) of adding 0.1～0.5% by plant rennet and animal protease; Stir 50～60 ℃ of holding temperatures; 5～8 hours time was warming up to 85 ℃ of enzymes 15 minutes of going out after enzymolysis finishes, through concentrate, spray-drying makes Powdered collagen peptide.
(3) preparation kudzu root extract: the Chinese medicine root of kudzu vine is cleaned input extract pot, add the water that 5-10 doubly measures, soak half an hour, heat to boil and keep 1 hour; Isolated by filtration filtrating, slag repeat to extract once, filter, and merge secondary filtrating and concentrate; Concentrate is with alcohol adjustment concentration of alcohol to 80%, stirs, leaves standstill, cool overnight, centrifugation supernatant, recovered alcohol; Be concentrated into solid content and reach 10% when above, carry out spray-drying, make pulverous kudzu root extract.
Two. the strong capsule prescription of precious peptide:
Nano pearl powder 40～60%
Collagen peptide 35～45%
Kudzu root extract 5～10%
Three. the strong capsule production stage of precious peptide
1. raw material mixes: earlier the above-mentioned Nano pearl powder for preparing, collagen peptide and kudzu root extract are fully mixed by formula rate.
2. wet granulation: in the above-mentioned material that mixes, spray into the edible alcohol of dilution while stirring, continue to be stirred to suitable humidity, granulate through wobbler.
3. oven dry: the moist particle that will make is at 60 ℃～80 ℃ fluidized dryings, and moisture is controlled in 4%.
4. whole grain: the particle of drying is carried out whole grain through vibratory sieve sieve, remove the particle of powder and caking.
5. can:, select the softgel shell of suitable types to carry out can according to the loading amount specification requirement.
6. pack: plastic-aluminum pressing plate packing or bottled.
7. check:
8. put in storage.
Embodiment 2
One, the strong osteocomma prescription of precious peptide:
Nano pearl powder 40～50%
Collagen peptide 40～50%
Kudzu root extract 8～12%
Auxiliary material 1～2%
Two, the strong osteocomma production stage of precious peptide
1. raw material mixes: earlier the above-mentioned Nano pearl powder for preparing, collagen peptide and kudzu root extract are fully mixed by formula rate.
2. wet granulation: in the above-mentioned material that mixes, spray into the edible alcohol of dilution while stirring, continue to be stirred to suitable humidity, granulate through wobbler.
3. oven dry: the moist particle that will make is at 60 ℃～80 ℃ fluidized dryings, and moisture is controlled at below 4%.
4. whole grain: the particle of oven dry is passed through the whole grain of wobbler.
5. compressing tablet: the particle through whole grain is admixed auxiliary material, selects definite shape punch die compressing tablet.
6. pack: plastic-aluminum pressing plate blister package or bottled.
7. check:
8. put in storage.
Claims (2)
1. one kind has the strong osteocomma agent of precious peptide that improves osteoporosis, increases the bone density function, and the weight proportion that it is characterized in that raw material is a Nano pearl powder 40～50%, collagen peptide 40～50%, and kudzu root extract 8～12%, auxiliary material 1～2% prescription is formed; The used raw material of filling a prescription is handled by following method:
(1) Nano pearl powder: earlier pearl powder is carried out coarse crushing with hammer crusher, carry out air-flow with airslide disintegrating mill then and pulverize, make pearl powder average grain diameter＜100 nanometers;
(2) collagen peptide: the water that adds 6～10 times of amounts with the collagen protein powder of the skin of pig, ox, mule domestic animal and fish-skin processing is put the dissolving of heating of enzymolysis pot; The compound protease of adding 0.1～0.5%; Compound protease is made up of plant rennet and animal protease in proportion, stirs enzymolysis, 50～60 ℃ of control temperature; Held time 5～8 hours; Be warming up to 85 ℃ of enzyme half an hour of going out after enzymolysis finishes, through concentrate, spray-drying makes Powdered collagen peptide, its molecular weight ranges is 1000～3000 dalton;
(3) kudzu root extract: the Chinese medicine root of kudzu vine is cleaned the water that adding 5-10 doubly measures, soak half an hour, heat to boil and keep 1 hour, isolated by filtration filtrating; Slag repeats to extract once, filters, and merges secondary filtrating and concentrates, and concentrate is with alcohol adjustment concentration of alcohol to 80%; Stir, leave standstill, cool overnight, centrifugal or separation of supernatant concentrates recovered alcohol, is concentrated into solid content and reaches 10% when above; Carry out spray-drying, make pulverous kudzu root extract, puerarin content is more than 30%;
Concrete preparation method is following:
1) raw material mixes: the Nano pearl powder for preparing, collagen peptide and kudzu root extract are fully mixed by formula rate;
2) wet granulation: in the material that mixes, spray into the edible alcohol of dilution while stirring, continue to be stirred to suitable humidity, granulate through wobbler;
3) oven dry: the moist particle that will make is at 60 ℃～80 ℃ fluidized dryings, and moisture is controlled at below 4%;
4) whole grain: the particle of oven dry is passed through the whole grain of wobbler;
5) compressing tablet: the particle through whole grain is admixed auxiliary material, selects definite shape punch die compressing tablet;
6) packing: plastic-aluminum pressing plate blister package or bottled;
7) check;
8) warehouse-in.
2. the preparation method who improves osteoporosis, increases the strong osteocomma agent of precious peptide of bone density function according to claim 1 is characterized in that concrete preparation method is following:
1) raw material mixes: the Nano pearl powder for preparing, collagen peptide and kudzu root extract are fully mixed by formula rate;
2) wet granulation: in the material that mixes, spray into the edible alcohol of dilution while stirring, continue to be stirred to suitable humidity, granulate through wobbler;
3) oven dry: the moist particle that will make is at 60 ℃～80 ℃ fluidized dryings, and moisture is controlled at 4%
Below;
4) whole grain: the particle of oven dry is passed through the whole grain of wobbler;
5) compressing tablet: the particle through whole grain is admixed auxiliary material, selects definite shape punch die compressing tablet;
6) packing: plastic-aluminum pressing plate blister package or bottled;
7) check;
8) warehouse-in.
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| CN2010101622742A CN101816431B (en) | 2010-04-30 | 2010-04-30 | Precious peptide bone-strengthening capsules or tablets with function of improving osteoporosis and increasing bone mineral density and preparation method thereof |
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| CN103913045B (en) * | 2014-04-10 | 2016-02-24 | 广州康洛信生物科技有限公司 | A kind of collagen drying means of stability and high efficiency |
| CN104382033A (en) * | 2014-12-06 | 2015-03-04 | 黑龙江众生生物工程有限公司 | Compound protein tabletted candy and preparation method thereof |
| CN106853243A (en) * | 2015-12-08 | 2017-06-16 | 青岛举鑫海洋生物科技有限公司 | Improve osteoporosis and increase the marine peptide calcium activated and preparation technology of bone density |
| CN105854002A (en) * | 2016-01-15 | 2016-08-17 | 上海荣神生物化学有限公司 | Polypeptide powder composition and tablet and preparation method thereof |
| CN105982336A (en) * | 2016-05-13 | 2016-10-05 | 浙江省海洋开发研究院 | Tumor recovery type aquatic collagen peptide food |
| CN105982337A (en) * | 2016-05-13 | 2016-10-05 | 浙江省海洋开发研究院 | Aquatic collagen peptide food used for adjuvant therapy of osteoporosis and arthritis |
| CN105982331A (en) * | 2016-05-13 | 2016-10-05 | 浙江省海洋开发研究院 | Universal type aquatic collagen peptide food for wound healing |
| CN111265671B (en) * | 2020-01-21 | 2022-07-01 | 上海中医药大学 | Method for improving hot-melt wall adhesion of spray drying of traditional Chinese medicine or food raw materials |
| CN115211569A (en) * | 2022-08-01 | 2022-10-21 | 兆鑫堂(山东)生物科技有限公司 | Collagen peptide food with antioxidant function |
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