CN101810828B - 含替普瑞酮的组合药物 - Google Patents

含替普瑞酮的组合药物 Download PDF

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CN101810828B
CN101810828B CN2010101487581A CN201010148758A CN101810828B CN 101810828 B CN101810828 B CN 101810828B CN 2010101487581 A CN2010101487581 A CN 2010101487581A CN 201010148758 A CN201010148758 A CN 201010148758A CN 101810828 B CN101810828 B CN 101810828B
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chinese medicine
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CN101810828A (zh
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罗丹晓
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Linyi Enke Development And Construction Co ltd
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Abstract

本发明涉及一种含替普瑞酮的组合药物，该组合药物由中药提取物和替普瑞酮按照重量比58∶1组成，中西药结合，协同作用，以达到治疗胃溃疡的目的。

Description

含替普瑞酮的组合药物
本发明涉及一种治疗胃病的药物，系由中药材提取物和西药制成的组合物，特别适于用作治疗胃炎、消化性溃疡(含胃溃疡和十二指肠球部溃疡)等胃病的药物。
胃病，特别是胃炎(浅表和萎缩性)，消化性溃疡(含胃溃疡和十二指肠球部溃疡)是一种常见病、多发病。目前，治疗这些疾病的药物较多，各有不同程度的疗效，但一般而言，疗效不够理想，停药后复发率较高，就目前常用较好药物而言：其有效率在80％以下，其复发率在36％以上。
本发明的目的就在于：发明一种治疗胃病的由中药提取物和西药组成的组合物药物，以提高治疗疗效和降低复发率。
本发明是这样来实现其目的的：本发明组合物包含中药提取物和西药，其中中药提取物由下列方法制备：
中药药材组份及其配比量，以百分比％计为：
良姜4，木香3，乌贼骨3，莪术10，草蔻1，
甘松6，枯矾3，鸡内金3，黄连3，白芨10，
玄胡11，麦芽1，青藤香20，瓜萎仁2，象皮20。
其各组份的总和为100％。
先将中药材清选，按配比量计量，并对药村用常规炮制方法炮制，粉碎戍粉末，加水煎煮，过滤，浓缩滤液至稠膏，干燥。
另外本发明药物组合物中西药为替普瑞酮，并且中药提取物与西药的重量比为58∶1。
本发明的药物组合物中的中药提取物处方来自CN1055015C的实施例1。
本发明药物组合物可制成各种口服剂型，一日三次，每次2克，病重者每日四次，开水冲服。对于胃炎(浅表或萎缩性)，7日为一疗程，连服2-3个疗程，对于消化性溃疡(含胃溃疡和十二指肠球部溃汤)，一月为一疗程，连服2-3个疗程。禁忌：禁食燥辣、生冷硬等食物。
临床效果：
对消化性溃疡(含胃溃疡和十二指肠球部溃疡)42例，治疗5个疗程后。经医院纤维镜检和组织活检，其中痊愈19例，有效19例，无效4例。平均总有效率为90.5％，末发现有毒副作用反应。而用同等剂量的纯中药提取物或替普瑞酮，有效率分别为62％和81％。
治疗标准说明：痊愈指经2-3个疗程后，1临床症状消失。经纤维镜检和组织活检，病灶消失。有效指经2～8个疗程后，经纤维镜检和组织活检，临床症状消失，病灶组织范围缩小。无效指经2-3个疗程后，临床症状，经纤维镜检和组织活检与治疗前无明显变化。
药理及综合效果分析。本药物的莪术清热解毒，与黄连同用，增强清热解毒功效，象皮生肌良药，枯矾敛疮，重用白发，三味同用，生肌力宏，敛疮显著，有效地促进病灶组织修复，井能较好地止消化道出血；瓜萎仁宣脾，助甘松等行气导滞类药物功效更显著，有力地推动了胃动力功能的恢复，重用玄胡、青藤香，能快速有效地止痛。因此，综合配伍，该中成药能有效地清热解毒，而替普瑞酮能够有效的保护胃黏膜，强化黏膜防御能力。中西药结合能从根本上达到治疗目的。

Claims (2)

1.一种治疗胃溃疡的组合物，该组合物包含中药提取物和西药，其中中药提取物由下列方法制备：
中药药材组份及其配比量，以百分比％计为：
良姜4，木香3，乌贼骨3，莪术10，草蔻1，
甘松6，枯矾3，鸡内金3，黄连3，白芨10，
玄胡11，麦芽1，青藤香20，瓜萎仁2，象皮20，
其各组份的总和为100％，
先将中药材清选，按配比量计量，并对药材用常规炮制方法炮制，粉碎成粉末，加水煎煮，过滤，浓缩滤液至稠膏，干燥；
药物组合物中西药为替普瑞酮，并且中药提取物与西药的重量比为58∶1。
2.如权利要求1所述的组合物在制备治疗胃溃疡的药物中的用途。
CN2010101487581A 2010-04-15 2010-04-15 含替普瑞酮的组合药物 Expired - Fee Related CN101810828B (zh)

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Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1055015C (zh) * 1997-10-21 2000-08-02 肖启美 胃疾散
CN100515485C (zh) * 2007-06-05 2009-07-22 朱晓宝 治疗胃溃疡的药物组合物
CN100515484C (zh) * 2007-06-05 2009-07-22 陈旭龙 含有艾普拉唑的药物
CN101066418B (zh) * 2007-06-05 2010-09-01 李国� 含有胶体铋治疗胃溃疡的药物
CN100534516C (zh) * 2007-06-05 2009-09-02 徐雪娟 含有雷贝拉唑治疗胃溃疡的药物
CN101066434B (zh) * 2007-06-05 2010-06-16 李国� 含有奥美拉唑的药物
CN100574793C (zh) * 2008-04-29 2009-12-30 胡可丁 含有雷尼替丁的药物
CN100584371C (zh) * 2008-04-29 2010-01-27 胡可丁 含有硫糖铝治疗胃溃疡的中西药组合物

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