CN101810779B - Combination drug containing Guadisu - Google Patents
Combination drug containing Guadisu Download PDFInfo
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- CN101810779B CN101810779B CN2010101492556A CN201010149255A CN101810779B CN 101810779 B CN101810779 B CN 101810779B CN 2010101492556 A CN2010101492556 A CN 2010101492556A CN 201010149255 A CN201010149255 A CN 201010149255A CN 101810779 B CN101810779 B CN 101810779B
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- chinese medicine
- grams
- hepatitis
- decocting liquid
- elaterin
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- 229940000425 combination drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 29
- 239000000203 mixture Substances 0.000 claims description 15
- NDYMQXYDSVBNLL-UHFFFAOYSA-N (9beta,10alpha,16alpha,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione Natural products CC12C(=O)CC3(C)C(C(C)(O)C(=O)C=CC(C)(C)OC(=O)C)C(O)CC3(C)C1CC=C1C2C=C(O)C(=O)C1(C)C NDYMQXYDSVBNLL-UHFFFAOYSA-N 0.000 claims description 13
- VVBWBGOEAVGFTN-SYJGCRHZSA-N Cucurbitacin P Chemical compound C([C@H]1[C@]2(C)C[C@@H](O)[C@@H]([C@]2(CC(=O)[C@]11C)C)[C@@](C)(O)C(=O)CCC(C)(O)C)C=C2[C@H]1C[C@@H](O)[C@@H](O)C2(C)C VVBWBGOEAVGFTN-SYJGCRHZSA-N 0.000 claims description 13
- VVBWBGOEAVGFTN-UHFFFAOYSA-N dihydrocucurbitacin F Natural products CC12C(=O)CC3(C)C(C(C)(O)C(=O)CCC(C)(O)C)C(O)CC3(C)C1CC=C1C2CC(O)C(O)C1(C)C VVBWBGOEAVGFTN-UHFFFAOYSA-N 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 244000050427 Melilotus officinalis subsp suaveolens Species 0.000 claims description 4
- 235000000839 Melilotus officinalis subsp suaveolens Nutrition 0.000 claims description 4
- 102000003929 Transaminases Human genes 0.000 claims description 4
- 108090000340 Transaminases Proteins 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 238000007654 immersion Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 2
- 208000006454 hepatitis Diseases 0.000 abstract description 16
- 231100000283 hepatitis Toxicity 0.000 abstract description 12
- 238000009098 adjuvant therapy Methods 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 description 7
- 206010067125 Liver injury Diseases 0.000 description 6
- 208000002672 hepatitis B Diseases 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000003390 Chinese drug Substances 0.000 description 4
- 206010008909 Chronic Hepatitis Diseases 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 206010019668 Hepatic fibrosis Diseases 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 231100000753 hepatic injury Toxicity 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 2
- 206010019799 Hepatitis viral Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 231100000012 chronic liver injury Toxicity 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 201000001862 viral hepatitis Diseases 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 208000005331 Hepatitis D Diseases 0.000 description 1
- 206010019754 Hepatitis cholestatic Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 231100000439 acute liver injury Toxicity 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 231100000838 cholestatic hepatitis Toxicity 0.000 description 1
- 230000002079 cooperative effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- SPPIIOPGDLITJE-VLQRKCJKSA-N diazanium;(2s,3s,4s,5r,6s)-6-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-5-[(2r,3r,4s,5s,6s)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-3,4-dihy Chemical compound N.N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O SPPIIOPGDLITJE-VLQRKCJKSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000036732 histological change Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 208000037890 multiple organ injury Diseases 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a cooperative medical combination containing Guadisu and traditional Chinese medicine derivatives, and the application of the combination in preparing medicaments for adjuvant treatment of hepatitis.
Description
Invention field
The present invention relates to the Pharmaceutical composition formed by Cucurbitacin P.E Elaterin and Chinese medicine extract, and the purposes of said composition in the medicine of preparation adjuvant treating hepatitis.
Background technology
Hepatitis has multiple sorting technique clinically, classifies as (1) nosetiology: viral hepatitis can be divided into five types is first, second, third, fourth, penta.(2) clinical classification can be divided into following a few type: 1. acute anicteric hepatitis, this is a modal type in the viral hepatitis, see with B-mode, third type, hepatitis D more, general this type of hepatitis clinical symptoms is less, and transaminase's elevated levels is lower, and Histological change is light, mortality rate is lower, but the course of disease can be delayed the long period, and " three is slow " characteristics are arranged, and morbidity is slow, recovery is slow, delay also slow (referring to the long meaning slowly); 2. acute icterohepatitis is less relatively compared with anicteric hepatitis, and the state of an illness is a self limiting often, and how good prognosis is, but minority can develop into hepatitis gravis; 3. chronic hepatitis: relevant experts in 1994 propose the name and the suggestion of chronic hepatitis again, with the cause of disease is the diagnosis name that chronic hepatitis is determined on the basis, simultaneously ordered grade scale, formulated standard by stages according to degree of hepatic fibrosis again according to the downright bad order of severity of hepatitis inflammation; 4. hepatitis gravis can be divided into acute heavy type, severe subacute and chronic heavy type again; 5. cholestatic hepatitis.
Wherein hepatitis B is caused by hepatitis B virus, serves as main a kind of infectious disease that also can cause multiple organ injury with the liver inflammatory lesion.China is the most popular country of hepatitis B, reaches more than 35% some local crowd infection rate, and be the most serious infectious disease of current harm people ' s health.According to investigations, China's hepatitis B patient is about 2,700 ten thousand, and annual New Development patient about 9,000,000.
The hepatitis B clinical manifestation is various, easily develops into chronic hepatitis and liver cirrhosis, and a few peoples finally develop into hepatocarcinoma.Hepatic fibrosis is the total pathological change of many chronic hepatopathy evolutions, and the damage of chronic, persistence is the prerequisite that hepatic fibrosis forms.Cause the factor of hepatic injury a lot,, hepatitis B, liver cirrhosis, take some drugs for a long time and can cause acute and chronic liver injury generally because of factors such as medicine, a large amount of ethanol, allergy cause acute liver damage.By reducing detrimental effect to liver function, can adjuvant treating hepatitis.
The medicine that is used for the treatment of the acute and chronic hepatic injury at present, commonly used have Cucurbitacin P.E Elaterin, a diammonium glycyrrhizinate etc.These chemicalses generally have certain side effect, and cause that therapeutic effect at a specified future date is poor, problem such as Strain produces after drug resistance phenomenon, the drug withdrawal relapse rate height.
The curative effect of Chinese medicine hepatitis B is proved by a large amount of clinical trials.Chinese medicine all can be brought into play curative effect preferably at aspects such as antiviral, adjusting immunity of organisms, protection hepatocyte.But Chinese medicine preparation ubiquity onset at present is slow, needs problems such as life-time service.
Therefore, Western medicine and Chinese Medicine and Clavicular need be got up, i.e. synergism is played in Chinese medicine and western medicine combination, solves the problem that above-mentioned Western medicine and Chinese medicine exist in auxiliary treatment all kinds hepatitis separately, produces synergistic therapeutic effect simultaneously.
Summary of the invention
One object of the present invention is to provide the Pharmaceutical composition of being made up of Cucurbitacin P.E Elaterin and a kind of Chinese medicine extract, wherein prepares on the method basis of the Chinese medicine extract of said composition according to embodiment 1 among the Chinese patent CN1049349C, and is as follows:
To get Melilotus suaveolens Ledeb. 9 gram, Herba Abri 9 grams, Herba Artemisiae Scopariae 9 grams, Herba Lysimachiae 6 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3 grams, earlier with Melilotus suaveolens Ledeb. with 10% alcohol water blend immersion 30 minutes, decoct twice then, the filtrate decocting liquid; Other four Chinese medicine mixing and water adding immersion after 30 minutes, is decocted twice, the filtrate decocting liquid; Merge above two decocting liquid, concentrating under reduced pressure, drying gets extract.
One object of the present invention is to provide the purposes of above-mentioned Pharmaceutical composition in preparation auxiliary treatment all kinds hepatitis medicament.
This Chinese medicine the water extracted immersing paste is called " the described Chinese medicine extract of this paper (or above) " hereinafter.
Above-mentioned composition and mixing acceptable accessories can be made acceptable forms clinically, as tablet, capsule, granule, oral liquid, subcutaneous administration preparation, suppository etc.
Pharmacological research
The main pharmacodynamics of Pharmaceutical composition of the present invention studies confirm that it has strong transaminase lowering effect, i.e. function for protecting liver and reducing enzyme activity.
Edit with reference to Zhang Juntian, " modern pharmacology test method " (volume two), combined publication society of China Concord Medical Science University of Beijing Medical University, the 1397-1398 page or leaf, disclosed method in " first segment chmice acute chemical liver injury model ", set up the acute chemical liver injury model of mouse carbon tetrachloride, carry out the pharmacodynamics test of Pharmaceutical composition anti-liver injury of the present invention.
The test grouping:
1, normal control group: animal does not do any processing, and normal physiological saline is irritated stomach;
2, model control group: after the animal model modeling success, normal physiological saline is irritated stomach;
3, pure Chinese drug-treated group: the water extracted immersing paste 0.9g/kg body weight as indicated above;
4, Cucurbitacin P.E Elaterin group: the 10mg/kg body weight is irritated stomach;
5, compositions group: 10mg/kg body weight Cucurbitacin P.E Elaterin+the water extracted immersing paste 0.9g/kg body weight mentioned above is irritated stomach.
Following table has shown the influence of each group to Mouse Liver function leading indicator GOT, GPT.
| Group | Number of animals | GOT (active unit) | GPT (active unit) |
| The normal control group | 10 | 20.78±17.75 | 48.31±17.87 |
| Model control group | 10 | 250.78±76.58 | 306.42±58.47 |
| Pure Chinese drug-treated group | 10 | 178.23±60.44 | 226.96±50.31 |
| The Cucurbitacin P.E Elaterin group | 10 | 105.57±36.16 | 203.71±32.43 |
| The compositions group | 10 | 78.41±22.74 | 100.67±41.23 |
This table shows that all there is significant difference (P＜0.05) in each group (pure Chinese drug-treated group, Cucurbitacin P.E Elaterin group, compositions group) of treatment with model control group, and all there are significant difference (P＜0.05) in compositions group and pure Chinese drug-treated group, compositions group and Cucurbitacin P.E Elaterin group.Show that there are cooperative effect in Cucurbitacin P.E Elaterin and described Chinese medicinal components in the compositions group.
The pharmaceutics test
Can produce the tablet that contains following component in a conventional manner:
Wherein compositions is made up of with weight ratio Cucurbitacin P.E Elaterin and Chinese medicine extract mentioned above at 1: 90.
Can produce the capsule that contains following component in a conventional manner:
Wherein compositions is made up of with weight ratio Cucurbitacin P.E Elaterin and Chinese medicine extract mentioned above at 1: 90.
Claims (2)
1. the Pharmaceutical composition of a transaminase lowering, it is made up of with weight ratio Cucurbitacin P.E Elaterin and Chinese medicine extract at 1: 90, and described Chinese medicine extract is by following method preparation:
To get Melilotus suaveolens Ledeb. 9 gram, Herba Abri 9 grams, Herba Artemisiae Scopariae 9 grams, Herba Lysimachiae 6 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3 grams, earlier with Melilotus suaveolens Ledeb. with 10% alcohol water blend immersion 30 minutes, decoct twice then, the filtrate decocting liquid; Other four Chinese medicine mixing and water adding immersion after 30 minutes, is decocted twice, the filtrate decocting liquid; Merge above two decocting liquid, concentrating under reduced pressure, drying gets extract.
2. the purposes of compositions as claimed in claim 1 in the medicine of preparation transaminase lowering.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101492556A CN101810779B (en) | 2010-04-15 | 2010-04-15 | Combination drug containing Guadisu |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101492556A CN101810779B (en) | 2010-04-15 | 2010-04-15 | Combination drug containing Guadisu |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101810779A CN101810779A (en) | 2010-08-25 |
| CN101810779B true CN101810779B (en) | 2011-09-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101492556A Expired - Fee Related CN101810779B (en) | 2010-04-15 | 2010-04-15 | Combination drug containing Guadisu |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101810779B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1108124A (en) * | 1994-12-02 | 1995-09-13 | 山东医科大学 | Chinese herb medicinal liquid for curing dropsy |
| CN1899522A (en) * | 2006-07-06 | 2007-01-24 | 张砚 | Synergistic medicinal composition for treating hepatitis |
| CN1907431A (en) * | 2006-08-17 | 2007-02-07 | 张娜 | Traditional Chinese medicine and western medicine compositions comprising biphenyldicarboxylate |
-
2010
- 2010-04-15 CN CN2010101492556A patent/CN101810779B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1108124A (en) * | 1994-12-02 | 1995-09-13 | 山东医科大学 | Chinese herb medicinal liquid for curing dropsy |
| CN1899522A (en) * | 2006-07-06 | 2007-01-24 | 张砚 | Synergistic medicinal composition for treating hepatitis |
| CN1907431A (en) * | 2006-08-17 | 2007-02-07 | 张娜 | Traditional Chinese medicine and western medicine compositions comprising biphenyldicarboxylate |
Non-Patent Citations (1)
| Title |
|---|
| 孟宪镛等.保护肝细胞辅助药.《实用消化病诊疗学》.上海世界图书出版公司,2006,第172-173页. * |
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| Publication number | Publication date |
|---|---|
| CN101810779A (en) | 2010-08-25 |
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