CN101797339B - Synergistic medicinal composition containing oleanolic acid - Google Patents
Synergistic medicinal composition containing oleanolic acid Download PDFInfo
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- CN101797339B CN101797339B CN2009102653745A CN200910265374A CN101797339B CN 101797339 B CN101797339 B CN 101797339B CN 2009102653745 A CN2009102653745 A CN 2009102653745A CN 200910265374 A CN200910265374 A CN 200910265374A CN 101797339 B CN101797339 B CN 101797339B
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- oleanolic acid
- hepatitis
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Abstract
The invention discloses a synergistic medicinal composition containing oleanolic acid and traditional Chinese medicinal extractives, as well as an application of the composition in the preparation of medicaments for the adjuvant therapy of hepatitis.
Description
Invention field
The present invention relates to the Pharmaceutical composition formed by oleanolic acid and Chinese medicine extract, and the purposes of said composition in the medicine of preparation adjuvant treating hepatitis.
Background technology
Hepatitis has multiple sorting technique clinically, classifies as (1) nosetiology: viral hepatitis can be divided into five types is first, second, third, fourth, penta.(2) clinical classification can be divided into following a few type: 1. acute anicteric hepatitis, this is a modal type in the viral hepatitis, see with B-mode, third type, hepatitis D more, general this type of hepatitis clinical symptoms is less, and transaminase's elevated levels is lower, and Histological change is light, mortality rate is lower, but the course of disease can be delayed the long period, and " three is slow " characteristics are arranged, and morbidity is slow, recovery is slow, delay also slow (referring to the long meaning slowly); 2. acute icterohepatitis is less relatively compared with anicteric hepatitis, and the state of an illness is a self limiting often, and how good prognosis is, but minority can develop into hepatitis gravis; 3. chronic hepatitis: relevant experts in 1994 propose the name and the suggestion of chronic hepatitis again, with the cause of disease is the diagnosis name that chronic hepatitis is determined on the basis, simultaneously ordered grade scale, formulated standard by stages according to degree of hepatic fibrosis again according to the downright bad order of severity of hepatitis inflammation; 4. hepatitis gravis can be divided into acute heavy type, severe subacute and chronic heavy type again; 5. cholestatic hepatitis.
Wherein hepatitis B is caused by hepatitis B virus, serves as main a kind of infectious disease that also can cause multiple organ injury with the liver inflammatory lesion.China is the most popular country of hepatitis B, reaches more than 35% some local crowd infection rate, and be the most serious infectious disease of current harm people ' s health.According to investigations, China's hepatitis B patient is about 2,700 ten thousand, and annual New Development patient about 9,000,000.
The hepatitis B clinical manifestation is various, easily develops into chronic hepatitis and liver cirrhosis, and a few peoples finally develop into hepatocarcinoma.Hepatic fibrosis is the total pathological change of many chronic hepatopathy evolutions, and the damage of chronic, persistence is the prerequisite that hepatic fibrosis forms.Cause the factor of hepatic injury a lot,, hepatitis B, liver cirrhosis, take some drugs for a long time and can cause acute and chronic liver injury generally because of factors such as medicine, a large amount of ethanol, allergy cause acute liver damage.By reducing detrimental effect to liver function, can adjuvant treating hepatitis.
The medicine that is used for the treatment of the acute and chronic hepatic injury at present, commonly used have oleanolic acid, a diammonium glycyrrhizinate etc.These chemicalses generally have certain side effect, and cause that therapeutic effect at a specified future date is poor, problem such as Strain produces after drug resistance phenomenon, the drug withdrawal relapse rate height.
The curative effect of Chinese medicine hepatitis B is proved by a large amount of clinical trials.Chinese medicine all can be brought into play curative effect preferably at aspects such as antiviral, adjusting immunity of organisms, protection hepatocyte.But Chinese medicine preparation ubiquity onset at present is slow, needs problems such as life-time service.
Therefore, Western medicine and Chinese Medicine and Clavicular need be got up, i.e. synergism is played in Chinese medicine and western medicine combination, solves the problem that above-mentioned Western medicine and Chinese medicine exist in auxiliary treatment all kinds hepatitis separately, produces synergistic therapeutic effect simultaneously.
Summary of the invention
One object of the present invention is to provide the Pharmaceutical composition of being made up of oleanolic acid and a kind of Chinese medicine extract, wherein prepares on the method basis of the Chinese medicine extract of said composition according to embodiment 1 among the Chinese patent CN1049349C, and is as follows:
To get Melilotus suaveolens Ledeb. 9 gram, Herba Abri 9 grams, Herba Artemisiae Scopariae 9 grams, Herba Lysimachiae 6 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3 grams, earlier with Melilotus suaveolens Ledeb. with 10% alcohol water blend immersion 30 minutes, decoct twice then, the filtrate decocting liquid; Other four Chinese medicine mixing and water adding immersion after 30 minutes, is decocted twice, the filtrate decocting liquid; Merge above two decocting liquid, concentrating under reduced pressure, drying gets extract.
One object of the present invention is to provide the purposes of above-mentioned Pharmaceutical composition in preparation auxiliary treatment all kinds hepatitis medicament.
This Chinese medicine the water extracted immersing paste is called " the described Chinese medicine extract of this paper (or above) " hereinafter.
Above-mentioned composition and mixing acceptable accessories can be made acceptable forms clinically, as tablet, capsule, granule, oral liquid, subcutaneous administration preparation, suppository etc.
Pharmacological research
The main pharmacodynamics of Pharmaceutical composition of the present invention studies confirm that it has strong transaminase lowering effect, i.e. function for protecting liver and reducing enzyme activity.
Edit with reference to Zhang Juntian, " modern pharmacology test method " (volume two), combined publication society of China Concord Medical Science University of Beijing Medical University, the 1397-1398 page or leaf, disclosed method in " first segment chmice acute chemical liver injury model ", set up the acute chemical liver injury model of mouse carbon tetrachloride, carry out the pharmacodynamics test of Pharmaceutical composition anti-liver injury of the present invention.
The test grouping:
1 normal control group: animal does not do any processing, and normal physiological saline is irritated stomach;
2 model control group: after the animal model modeling success, normal physiological saline is irritated stomach;
2 pure Chinese drug-treated group: the water extracted immersing paste 1.04g/kg body weight as indicated above
3 oleanolic acid groups: the 10mg/kg body weight is irritated stomach
4 compositions groups: 10mg/kg body weight oleanolic acid+the water extracted immersing paste 1.04g/kg body weight mentioned above is irritated stomach.
Following table has shown the influence of each group to Mouse Liver function leading indicator GOT, GPT.
| Group | Number of animals | GOT (active unit) | GPT (active unit) |
| The normal control group | 10 | 20.78±16.75 | 48.31±17.35 |
| Model control group | 10 | 250.76±76.58 | 306.25±59.47 |
| Pure Chinese drug-treated group | 10 | 178.22±60.12 | 226.99±50.25 |
| The oleanolic acid group | 10 | 105.74±36.56 | 203.71±32.56 |
| The compositions group | 10 | 78.41±22.74 | 100.55±41.68 |
This table shows that all there is significant difference (P＜0.05) in each group (pure Chinese drug-treated group, oleanolic acid group, compositions group) of treatment with model control group, and all there are significant difference (P＜0.05) in compositions group and pure Chinese drug-treated group, compositions group and oleanolic acid group.Show that there are cooperative effect in oleanolic acid and described Chinese medicinal components in the compositions group.
The pharmaceutics test
Can produce the tablet that contains following component in a conventional manner:
Component
The Mg/ sheet
Pharmaceutical composition 200-1000 of the present invention
Corn starch 125.0
Pulvis Talci 75.0
Magnesium stearate 1.0
Wherein compositions is made up of with weight ratio oleanolic acid and Chinese medicine extract mentioned above at 1: 104.
Can produce the capsule that contains following component in a conventional manner:
Component
The Mg/ sheet
Pharmaceutical composition 200-1000 of the present invention
Lactose 10.0
Corn starch 20.0
Talcum 5.0
Wherein compositions is made up of with weight ratio oleanolic acid and Chinese medicine extract mentioned above at 1: 104.
Claims (2)
1. the Pharmaceutical composition of a transaminase lowering, it is made up of with weight ratio oleanolic acid and Chinese medicine extract at 1: 104, and described Chinese medicine extract is by following method preparation:
To get Melilotus suaveolens Ledeb. 9 gram, Herba Abri 9 grams, Herba Artemisiae Scopariae 9 grams, Herba Lysimachiae 6 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3 grams, earlier with Melilotus suaveolens Ledeb. with 10% alcohol water blend immersion 30 minutes, decoct twice then, the filtrate decocting liquid; Other four Chinese medicine mixing and water adding immersion after 30 minutes, is decocted twice, the filtrate decocting liquid; Merge above two decocting liquid, concentrating under reduced pressure, drying gets extract.
2. the purposes of compositions as claimed in claim 1 in the medicine of preparation transaminase lowering.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102653745A CN101797339B (en) | 2009-12-30 | 2009-12-30 | Synergistic medicinal composition containing oleanolic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102653745A CN101797339B (en) | 2009-12-30 | 2009-12-30 | Synergistic medicinal composition containing oleanolic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101797339A CN101797339A (en) | 2010-08-11 |
| CN101797339B true CN101797339B (en) | 2011-12-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102653745A Expired - Fee Related CN101797339B (en) | 2009-12-30 | 2009-12-30 | Synergistic medicinal composition containing oleanolic acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101797339B (en) |
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2009
- 2009-12-30 CN CN2009102653745A patent/CN101797339B/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN101797339A (en) | 2010-08-11 |
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Owner name: NINGBO YINZHOU FURUIDA BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: QIAN XIN Effective date: 20111025 |
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Inventor after: Li Gang Inventor after: Qian Xin Inventor before: Qian Xin |
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Free format text: CORRECT: ADDRESS; FROM: 311203 HANGZHOU, ZHEJIANG PROVINCE TO: 315100 NINGBO, ZHEJIANG PROVINCE Free format text: CORRECT: INVENTOR; FROM: QIAN XIN TO: LI GANG QIAN XIN |
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Effective date of registration: 20111025 Address after: 315100 Zhejiang city of Ningbo province Yinzhou District Zhonggongmiao Street Tiantong Road No. 1388 room 3624 Applicant after: Ningbo Yinzhou Furuida Biotechnology Co., Ltd. Address before: 311203, Hangzhou District, Zhejiang City, Xiaoshan Province South Gate residential area Applicant before: Qian Xin |
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