CN101810684B - 一种含有中药提取物的协同药用组合物 - Google Patents
一种含有中药提取物的协同药用组合物 Download PDFInfo
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- CN101810684B CN101810684B CN2010101586178A CN201010158617A CN101810684B CN 101810684 B CN101810684 B CN 101810684B CN 2010101586178 A CN2010101586178 A CN 2010101586178A CN 201010158617 A CN201010158617 A CN 201010158617A CN 101810684 B CN101810684 B CN 101810684B
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- chinese medicine
- ethanol
- cortex moutan
- medicine extract
- hepatitis
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- NDYMQXYDSVBNLL-UHFFFAOYSA-N (9beta,10alpha,16alpha,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione Natural products CC12C(=O)CC3(C)C(C(C)(O)C(=O)C=CC(C)(C)OC(=O)C)C(O)CC3(C)C1CC=C1C2C=C(O)C(=O)C1(C)C NDYMQXYDSVBNLL-UHFFFAOYSA-N 0.000 claims description 12
- VVBWBGOEAVGFTN-SYJGCRHZSA-N Cucurbitacin P Chemical compound C([C@H]1[C@]2(C)C[C@@H](O)[C@@H]([C@]2(CC(=O)[C@]11C)C)[C@@](C)(O)C(=O)CCC(C)(O)C)C=C2[C@H]1C[C@@H](O)[C@@H](O)C2(C)C VVBWBGOEAVGFTN-SYJGCRHZSA-N 0.000 claims description 12
- VVBWBGOEAVGFTN-UHFFFAOYSA-N dihydrocucurbitacin F Natural products CC12C(=O)CC3(C)C(C(C)(O)C(=O)CCC(C)(O)C)C(O)CC3(C)C1CC=C1C2CC(O)C(O)C1(C)C VVBWBGOEAVGFTN-UHFFFAOYSA-N 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- LJQKCYFTNDAAPC-UHFFFAOYSA-N ethanol;ethyl acetate Chemical compound CCO.CCOC(C)=O LJQKCYFTNDAAPC-UHFFFAOYSA-N 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 102000003929 Transaminases Human genes 0.000 claims description 4
- 108090000340 Transaminases Proteins 0.000 claims description 4
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- 238000000034 method Methods 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000019634 flavors Nutrition 0.000 claims description 2
- 229930182470 glycoside Natural products 0.000 claims description 2
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- 239000000843 powder Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
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- 208000006454 hepatitis Diseases 0.000 abstract description 16
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- 208000002672 hepatitis B Diseases 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000003390 Chinese drug Substances 0.000 description 4
- 206010008909 Chronic Hepatitis Diseases 0.000 description 4
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- 239000000243 solution Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 206010019799 Hepatitis viral Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 231100000012 chronic liver injury Toxicity 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 201000001862 viral hepatitis Diseases 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- 241000700721 Hepatitis B virus Species 0.000 description 1
- 208000005331 Hepatitis D Diseases 0.000 description 1
- 206010019754 Hepatitis cholestatic Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 231100000439 acute liver injury Toxicity 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 231100000838 cholestatic hepatitis Toxicity 0.000 description 1
- 230000002079 cooperative effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- SPPIIOPGDLITJE-VLQRKCJKSA-N diazanium;(2s,3s,4s,5r,6s)-6-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-5-[(2r,3r,4s,5s,6s)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-3,4-dihy Chemical compound N.N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O SPPIIOPGDLITJE-VLQRKCJKSA-N 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000036732 histological change Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
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- 239000007788 liquid Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 208000037890 multiple organ injury Diseases 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组别 | 动物数 | GOT(活性单位) | GPT(活性单位) |
正常对照组 | 10 | 20.38±16.76 | 48.31±17.35 |
模型对照组 | 10 | 250.76±76.58 | 306.25±57.47 |
纯中药组 | 10 | 176.96±61.65 | 226.74±51.42 |
瓜蒂素组 | 10 | 98.74±34.55 | 208.85±31.74 |
组合物组 | 10 | 87.85±28.74 | 109.15±45.90 |
Claims (2)
Priority Applications (1)
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CN2010101586178A CN101810684B (zh) | 2010-04-27 | 2010-04-27 | 一种含有中药提取物的协同药用组合物 |
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CN2010101586178A CN101810684B (zh) | 2010-04-27 | 2010-04-27 | 一种含有中药提取物的协同药用组合物 |
Publications (2)
Publication Number | Publication Date |
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CN101810684A CN101810684A (zh) | 2010-08-25 |
CN101810684B true CN101810684B (zh) | 2011-08-31 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN102335276B (zh) * | 2011-10-10 | 2014-06-04 | 杨永庆 | 一种牡丹提取物及其组合物的制备方法及其应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1418673A (zh) * | 2002-11-26 | 2003-05-21 | 安徽省天尊医药科技研究所 | 用于治疗肝炎类的牡丹皮总苷的提取方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN1141136C (zh) * | 2002-03-13 | 2004-03-10 | 张平 | 一种治疗急性脑出血的中药注射液及其制法 |
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- 2010-04-27 CN CN2010101586178A patent/CN101810684B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1418673A (zh) * | 2002-11-26 | 2003-05-21 | 安徽省天尊医药科技研究所 | 用于治疗肝炎类的牡丹皮总苷的提取方法 |
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CN101810684A (zh) | 2010-08-25 |
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Owner name: LI GUO Free format text: FORMER OWNER: ZHANG DAYU Effective date: 20110524 |
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Inventor after: Li Guo Inventor after: Zhang Dayu Inventor before: Zhang Dayu |
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Free format text: CORRECT: INVENTOR; FROM: ZHANG DAYU TO: LI GUO ZHANG DAYU Free format text: CORRECT: ADDRESS; FROM: 100070 BUILDING 18, AREA 8, HEADQUARTER BASE, NO. 188, SOUTH 4TH RING ROAD WEST, FENGTAI DISTRICT, BEIJING TO: 315135 YUNLONG JIAYUAN RESIDENTIAL QUARTER, YUNLONG TOWN, YINZHOU DISTRICT, NINGBO CITY, ZHEJIANG PROVINCE |
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Effective date of registration: 20130110 Address after: 226600 No. 8 Yingbin Road, Chengdong Town, Haian County, Nantong, Jiangsu Patentee after: Nantong Huake Intellectual Property Service Co.,Ltd. Address before: 315135 Yunlong District, Yunlong Town, Ningbo, Zhejiang, Yinzhou District Patentee before: Li Guo |
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Owner name: HAIAN CHANGDA TECHNOLOGY TRANSFER CENTER CO., LTD. Free format text: FORMER OWNER: NANTONG HUAKE INTELLECTUAL PROPERTY SERVICE CO., LTD. Effective date: 20140514 |
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Effective date of registration: 20230519 Address after: Room 238, 2nd Floor, Building 6, No. 2 East Binhe Road, Youanmenwai, Fengtai District, Beijing, 100071 Patentee after: Beijing Institute of Traditional Chinese Medicine Address before: 413, Floor 4, Building B, Innovation Building, Linyi Hi tech Industrial Development Zone, Shandong Province, 276000 Patentee before: Linyi High tech Zone Jinlanling Labor Service Co.,Ltd. |
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