CN101810684B - 一种含有中药提取物的协同药用组合物 - Google Patents

一种含有中药提取物的协同药用组合物 Download PDF

Info

Publication number
CN101810684B
CN101810684B CN2010101586178A CN201010158617A CN101810684B CN 101810684 B CN101810684 B CN 101810684B CN 2010101586178 A CN2010101586178 A CN 2010101586178A CN 201010158617 A CN201010158617 A CN 201010158617A CN 101810684 B CN101810684 B CN 101810684B
Authority
CN
China
Prior art keywords
chinese medicine
ethanol
cortex moutan
medicine extract
hepatitis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2010101586178A
Other languages
English (en)
Other versions
CN101810684A (zh
Inventor
李国�
张大宇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BEIJING INSTITUTE OF TRADITIONAL CHINESE MEDICINE
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN2010101586178A priority Critical patent/CN101810684B/zh
Publication of CN101810684A publication Critical patent/CN101810684A/zh
Application granted granted Critical
Publication of CN101810684B publication Critical patent/CN101810684B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

公开了含有瓜蒂素和中药提取物的协同药用组合物,以及该组合物在制备辅助治疗肝炎的药物中的应用。

Description

一种含有中药提取物的协同药用组合物
发明领域
本发明涉及由瓜蒂素和中药提取物组成的药用组合物,以及该组合物在制备辅助治疗肝炎的药物中的用途。
背景技术
肝炎在临床上有多种分类方法,如(1)病原学分类:可将病毒性肝炎分为五型即甲、乙、丙、丁、戊。(2)临床分类可分为以下几型:①急性无黄疸型肝炎,这是病毒性肝炎中最常见的类型,以乙型、丙型、丁型肝炎多见,一般此类肝炎临床症状较少,转氨酶升高水平较低,组织学改变轻,死亡率较低,但病程可迁延较长时间,有“三慢”特点,发病慢、恢复慢、迁延也慢(慢指长的意思);②急性黄疸型肝炎,比起无黄疸型肝炎来说相对较少,病情常为自限性,预后多良好,但少数可发展成重型肝炎;③慢性肝炎:1994年有关专家又提出慢性肝炎的命名与建议,以病原为基础确定慢性肝炎的诊断命名,同时根据肝炎炎症的坏死严重程度订了分级标准,又根据肝纤维化程度制定了分期标准;④重型肝炎,又可分为急性重型、亚急性重型和慢性重型;⑤淤胆型肝炎。
其中乙型肝炎是由乙型肝炎病毒引起的,以肝脏炎性病变为主并可引起多器官损害的一种传染病。中国是乙型肝炎最流行的国家,在某些地方人群感染率达到35%以上,是当前危害人民健康的最严重传染病。据调查,我国乙肝患者约2700万,每年新发病人约900万。
乙肝临床表现多样,易发展为慢性肝炎和肝硬化,少数人最终发展为肝癌。肝纤维化是诸多慢性肝病发展过程的共有病理变化,而慢性、持续性损伤是肝纤维化形成的前提。造成肝损伤的因素很多,一般因药物、大量酒精、过敏等因素造成急性肝损伤,乙肝、肝硬化、长期服用某些药物可引起急慢性肝损伤。通过降低对肝功能的损害作用,可以辅助治疗肝炎。
目前用于治疗急慢性肝损害的药物,较常用的有瓜蒂素、甘草酸二铵等。这些化学药物普遍有一定的副作用,并导致远期治疗效果差、病毒株产生耐药现象、停药后复发率高等问题。
中医药治疗乙肝的疗效已被大量的临床试验所证明。中药在抗病毒、调节机体免疫力、保护肝细胞等方面都可发挥较好的疗效。但是目前中药制剂普遍存在起效缓慢,需要长期使用等问题。
因此,需要将西药与中药结合起来,即中西药结合,起到协同作用,来解决上述西药和中药在辅助治疗各种类型肝炎中各自存在的问题,同时产生协同治疗效果。
发明内容
本发明的一个目的在于提供由瓜蒂素和一种中药提取物组成的药用组合物,其中该组合物的中药提取物按照中国专利CN1187069C中实施例的方法制备,如下:
取干燥的100kg牡月皮打成粗粉,用400kg的浓度为30-70%的乙醇浸泡24小时后渗漉,接取渗漉液;将得到的渗漉液,用减压蒸馏法回收乙醇试剂,其中减压到400mmHg,在水浴锅中加热,直到回收的溶剂中无乙醇味,此时得到牡丹皮浸膏;
取牡丹皮漫膏,按容积1∶1比例加入乙酸乙酯-乙醇混合液进行萃取,乙酸乙酯-乙醇混合液的比例为2∶1,在溶液分层后取上层的溶液;
将职出的上层溶液用减压蒸馏法回收乙酸乙酯-乙醇试剂,其中减压到400mmHg在水浴锅中加热,直到浓缩成稠膏;
在740mmHg下,温度为50-60℃时,进行真空干燥,得牡丹皮总苷膏。
本发明的一个目的在于提供上述药用组合物在制备辅助治疗各种类型肝炎药物中的用途。
该中药水提浸膏在下文中称作“本文(或上文)所述的中药提取物”。
可将上述组合物与药学上可接受的辅料混合制成临床上可接受的剂型,如片剂、胶囊、颗粒剂、口服液体制剂、皮下给药制剂、栓剂等。
药理作用研究
本发明药用组合物的主要药效学研究证实了其具有较强降低转氨酶作用,即保肝降酶作用。
参照张均田主编,《现代药理试验方法》(下册),北京医科大学中国协和医科大学联合出版社,第1397-1398页,“第一节小鼠急性化学性肝损伤模型”中公开的方法,建立小鼠四氯化碳急性化学肝损伤模型,进行本发明的药用组合物抗肝损伤的药效学试验。
试验分组:
1、正常对照组:动物未作任何处理,正常生理盐水灌胃;
2、模型对照组:动物模型造模成功后,正常生理盐水灌胃;
3、纯中药组:如上文所述的水提浸膏1.01g/kg体重
4、瓜蒂素组:10mg/kg体重灌胃
5、组合物组:10mg/kg体重瓜蒂素+上文所述的水提浸膏1.01g/kg体重灌胃。
下表显示了各组对小鼠肝功能主要指标GOT、GPT的影响。
  组别   动物数   GOT(活性单位)   GPT(活性单位)
  正常对照组   10   20.38±16.76   48.31±17.35
  模型对照组   10   250.76±76.58   306.25±57.47
  纯中药组   10   176.96±61.65   226.74±51.42
  瓜蒂素组   10   98.74±34.55   208.85±31.74
  组合物组   10   87.85±28.74   109.15±45.90
该表显示治疗各组(纯中药组、瓜蒂素组、组合物组)均与模型对照组存在显著性差异(P<0.05),而组合物组与纯中药组、组合物组与瓜蒂素组均存在显著性差异(P<0.05)。显示组合物组中的瓜蒂素与所述的中药组分存在协同效应。
药剂学试验
可按照常规方式生产含有下列组分的片剂:
组分                Mg/片
本发明药用组合物    200-1000
玉米淀粉            125.0
滑石粉              75.0
硬脂酸镁            1.0
其中组合物由瓜蒂素和上文所述中药提取物以重量比1∶101组成。
可按照常规方式生产含有下列组分的胶囊:
组分                Mg/片
本发明药用组合物    200-1000
乳糖                10.0
玉米淀粉            20.0
滑石                5.0
其中组合物由瓜蒂素和上文所述中药提取物以重量比1∶101组成。

Claims (2)

1.一种降低转氨酶的药用组合物,其由瓜蒂素和中药提取物以重量比1∶101组成,所述的中药提取物按下列方法制备:
取干燥的100kg牡丹皮打成粗粉,用400kg的浓度为30-70%的乙醇浸泡24小时后渗漉,接取渗漉液;将得到的渗漉液,用减压蒸馏法回收乙醇试剂,其中减压到400mmHg,在水浴锅中加热,直到回收的溶剂中无乙醇味,此时得到牡丹皮浸膏;取牡丹皮漫膏,按容积1∶1比例加入乙酸乙酯-乙醇混合液进行萃取,乙酸乙酯-乙醇混合液的比例为2∶1,在溶液分层后取上层的溶液;将职出的上层溶液用减压蒸馏法回收乙酸乙酯-乙醇试剂,其中减压到400mmHg在水浴锅中加热,直到浓缩成稠膏;在740mmHg下,温度为50-60℃时,进行真空干燥,得牡丹皮总苷膏。
2.如权利要求1所述的组合物在制备降低转氨酶的药物中的用途。
CN2010101586178A 2010-04-27 2010-04-27 一种含有中药提取物的协同药用组合物 Active CN101810684B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2010101586178A CN101810684B (zh) 2010-04-27 2010-04-27 一种含有中药提取物的协同药用组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2010101586178A CN101810684B (zh) 2010-04-27 2010-04-27 一种含有中药提取物的协同药用组合物

Publications (2)

Publication Number Publication Date
CN101810684A CN101810684A (zh) 2010-08-25
CN101810684B true CN101810684B (zh) 2011-08-31

Family

ID=42618144

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010101586178A Active CN101810684B (zh) 2010-04-27 2010-04-27 一种含有中药提取物的协同药用组合物

Country Status (1)

Country Link
CN (1) CN101810684B (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102335276B (zh) * 2011-10-10 2014-06-04 杨永庆 一种牡丹提取物及其组合物的制备方法及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1418673A (zh) * 2002-11-26 2003-05-21 安徽省天尊医药科技研究所 用于治疗肝炎类的牡丹皮总苷的提取方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1141136C (zh) * 2002-03-13 2004-03-10 张平 一种治疗急性脑出血的中药注射液及其制法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1418673A (zh) * 2002-11-26 2003-05-21 安徽省天尊医药科技研究所 用于治疗肝炎类的牡丹皮总苷的提取方法

Also Published As

Publication number Publication date
CN101810684A (zh) 2010-08-25

Similar Documents

Publication Publication Date Title
CN100444857C (zh) 辅助治疗肝炎的药物
CN101810684B (zh) 一种含有中药提取物的协同药用组合物
CN100367986C (zh) 含有联苯双酯的协同药物
CN100421688C (zh) 含有硫普罗宁和中药提取物的协同药用组合物
CN101502551B (zh) 含联苯双酯的协同组合物
CN101502572B (zh) 辅助治疗肝炎的中西药组合物
CN100448462C (zh) 含有甘草酸二铵和中药的协同药用组合物
CN100367978C (zh) 协同药用组合物
CN101708227B (zh) 含有葡醛内酯的协同药用组合物
CN101837036B (zh) 一种协同药用组合物
CN100450498C (zh) 辅助治疗肝炎药用组合物
CN100356962C (zh) 一种含有含联苯双酯的中西药组合物
CN100356961C (zh) 治疗肝炎的协同药用组合物
CN100393337C (zh) 协同药用组合物
CN100450508C (zh) 一种含有联苯双酯的药用组合物
CN100363045C (zh) 含联苯双酯的辅助治疗肝炎中西药组合物
CN101797339B (zh) 含有齐墩果酸的协同药用组合物
CN101716239B (zh) 含齐墩果酸的药用组合物
CN100421686C (zh) 治疗肝炎的中西药结合药用组合物
CN101721451B (zh) 一种协同药用组合物
CN100367980C (zh) 含联苯双酯的协同组合物
CN101856402B (zh) 辅助治疗肝炎的药物组合物
CN100363042C (zh) 一种含联苯双酯的组合物
CN101810779B (zh) 含有瓜蒂素的组合药物
CN100421692C (zh) 含联苯双酯的中西药组合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: LI GUO

Free format text: FORMER OWNER: ZHANG DAYU

Effective date: 20110524

C41 Transfer of patent application or patent right or utility model
C53 Correction of patent of invention or patent application
CB03 Change of inventor or designer information

Inventor after: Li Guo

Inventor after: Zhang Dayu

Inventor before: Zhang Dayu

COR Change of bibliographic data

Free format text: CORRECT: INVENTOR; FROM: ZHANG DAYU TO: LI GUO ZHANG DAYU

Free format text: CORRECT: ADDRESS; FROM: 100070 BUILDING 18, AREA 8, HEADQUARTER BASE, NO. 188, SOUTH 4TH RING ROAD WEST, FENGTAI DISTRICT, BEIJING TO: 315135 YUNLONG JIAYUAN RESIDENTIAL QUARTER, YUNLONG TOWN, YINZHOU DISTRICT, NINGBO CITY, ZHEJIANG PROVINCE

TA01 Transfer of patent application right

Effective date of registration: 20110524

Address after: 315135 Yunlong District, Yunlong Town, Ningbo, Zhejiang, Yinzhou District

Applicant after: Li Guo

Address before: 100070, No. 18, building eight, 188, base station, South Fourth Ring Road West, Beijing, Fengtai District

Applicant before: Zhang Dayu

C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: NANTONG HUAKE INTELLECTUAL PROPERTY SERVICE CO., L

Free format text: FORMER OWNER: LI GUO

Effective date: 20130110

C41 Transfer of patent application or patent right or utility model
COR Change of bibliographic data

Free format text: CORRECT: ADDRESS; FROM: 315135 NINGBO, ZHEJIANG PROVINCE TO: 226600 NANTONG, JIANGSU PROVINCE

TR01 Transfer of patent right

Effective date of registration: 20130110

Address after: 226600 No. 8 Yingbin Road, Chengdong Town, Haian County, Nantong, Jiangsu

Patentee after: Nantong Huake Intellectual Property Service Co.,Ltd.

Address before: 315135 Yunlong District, Yunlong Town, Ningbo, Zhejiang, Yinzhou District

Patentee before: Li Guo

ASS Succession or assignment of patent right

Owner name: HAIAN CHANGDA TECHNOLOGY TRANSFER CENTER CO., LTD.

Free format text: FORMER OWNER: NANTONG HUAKE INTELLECTUAL PROPERTY SERVICE CO., LTD.

Effective date: 20140514

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20140514

Address after: 226600 No. 8 Yingbin Road, Haian County, Nantong, Jiangsu

Patentee after: HAIAN CHANGZHOU UNIVERSITY TECHNOLOGY TRANSFER CENTER Co.,Ltd.

Address before: 226600 No. 8 Yingbin Road, Chengdong Town, Haian County, Nantong, Jiangsu

Patentee before: Nantong Huake Intellectual Property Service Co.,Ltd.

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20221230

Address after: 413, Floor 4, Building B, Innovation Building, Linyi Hi tech Industrial Development Zone, Shandong Province, 276000

Patentee after: Linyi High tech Zone Jinlanling Labor Service Co.,Ltd.

Address before: 226600 No.8 Yingbin Road, Hai'an County, Nantong City, Jiangsu Province

Patentee before: HAIAN CHANGZHOU UNIVERSITY TECHNOLOGY TRANSFER CENTER Co.,Ltd.

TR01 Transfer of patent right

Effective date of registration: 20230519

Address after: Room 238, 2nd Floor, Building 6, No. 2 East Binhe Road, Youanmenwai, Fengtai District, Beijing, 100071

Patentee after: Beijing Institute of Traditional Chinese Medicine

Address before: 413, Floor 4, Building B, Innovation Building, Linyi Hi tech Industrial Development Zone, Shandong Province, 276000

Patentee before: Linyi High tech Zone Jinlanling Labor Service Co.,Ltd.

TR01 Transfer of patent right