CN101798588A - Method for testing bioactivities of GLP-1 receptor agonist - Google Patents
Method for testing bioactivities of GLP-1 receptor agonist Download PDFInfo
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- CN101798588A CN101798588A CN200910265928A CN200910265928A CN101798588A CN 101798588 A CN101798588 A CN 101798588A CN 200910265928 A CN200910265928 A CN 200910265928A CN 200910265928 A CN200910265928 A CN 200910265928A CN 101798588 A CN101798588 A CN 101798588A
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CN200910265928.1A CN101798588B (en) | 2009-12-21 | 2009-12-21 | GLP-1 receptor stimulant Determination of biological activity method |
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CN200910265928.1A CN101798588B (en) | 2009-12-21 | 2009-12-21 | GLP-1 receptor stimulant Determination of biological activity method |
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CN101798588A true CN101798588A (en) | 2010-08-11 |
CN101798588B CN101798588B (en) | 2015-09-09 |
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Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103267752A (en) * | 2013-05-31 | 2013-08-28 | 北京大学 | Method for determining proportion of number of A cells to number of B cells in pancreatic islets |
CN104870009A (en) * | 2012-12-21 | 2015-08-26 | 赛诺菲 | Functionalized exendin-4 derivatives |
US9694053B2 (en) | 2013-12-13 | 2017-07-04 | Sanofi | Dual GLP-1/glucagon receptor agonists |
US9751926B2 (en) | 2013-12-13 | 2017-09-05 | Sanofi | Dual GLP-1/GIP receptor agonists |
US9750788B2 (en) | 2013-12-13 | 2017-09-05 | Sanofi | Non-acylated exendin-4 peptide analogues |
US9758561B2 (en) | 2014-04-07 | 2017-09-12 | Sanofi | Dual GLP-1/glucagon receptor agonists derived from exendin-4 |
US9771406B2 (en) | 2014-04-07 | 2017-09-26 | Sanofi | Peptidic dual GLP-1/glucagon receptor agonists derived from exendin-4 |
US9775904B2 (en) | 2014-04-07 | 2017-10-03 | Sanofi | Exendin-4 derivatives as peptidic dual GLP-1/glucagon receptor agonists |
US9789165B2 (en) | 2013-12-13 | 2017-10-17 | Sanofi | Exendin-4 peptide analogues as dual GLP-1/GIP receptor agonists |
US9982029B2 (en) | 2015-07-10 | 2018-05-29 | Sanofi | Exendin-4 derivatives as selective peptidic dual GLP-1/glucagon receptor agonists |
US10758592B2 (en) | 2012-10-09 | 2020-09-01 | Sanofi | Exendin-4 derivatives as dual GLP1/glucagon agonists |
US10806797B2 (en) | 2015-06-05 | 2020-10-20 | Sanofi | Prodrugs comprising an GLP-1/glucagon dual agonist linker hyaluronic acid conjugate |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1099416A (en) * | 1993-08-21 | 1995-03-01 | 孙玉昆 | Process for gene engineering production of IL 28-GLP-I |
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2009
- 2009-12-21 CN CN200910265928.1A patent/CN101798588B/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1099416A (en) * | 1993-08-21 | 1995-03-01 | 孙玉昆 | Process for gene engineering production of IL 28-GLP-I |
Non-Patent Citations (2)
Title |
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刘素芳: ""GLP-1(7-36)NH2的促胰岛素分泌作用和胞内cAMP浓度改变与胰岛素mRNA表达", 《中国应用生理学杂志》 * |
李克坚: ""重组促胰岛素分泌素生物学活性测定方法的研究"", 《药物分析杂志》 * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10758592B2 (en) | 2012-10-09 | 2020-09-01 | Sanofi | Exendin-4 derivatives as dual GLP1/glucagon agonists |
CN104870009A (en) * | 2012-12-21 | 2015-08-26 | 赛诺菲 | Functionalized exendin-4 derivatives |
US9745360B2 (en) | 2012-12-21 | 2017-08-29 | Sanofi | Dual GLP1/GIP or trigonal GLP1/GIP/glucagon agonists |
US10253079B2 (en) | 2012-12-21 | 2019-04-09 | Sanofi | Functionalized Exendin-4 derivatives |
CN103267752A (en) * | 2013-05-31 | 2013-08-28 | 北京大学 | Method for determining proportion of number of A cells to number of B cells in pancreatic islets |
CN103267752B (en) * | 2013-05-31 | 2015-04-08 | 北京大学 | Method for determining proportion of number of A cells to number of B cells in pancreatic islets |
US9750788B2 (en) | 2013-12-13 | 2017-09-05 | Sanofi | Non-acylated exendin-4 peptide analogues |
US9789165B2 (en) | 2013-12-13 | 2017-10-17 | Sanofi | Exendin-4 peptide analogues as dual GLP-1/GIP receptor agonists |
US9751926B2 (en) | 2013-12-13 | 2017-09-05 | Sanofi | Dual GLP-1/GIP receptor agonists |
US9694053B2 (en) | 2013-12-13 | 2017-07-04 | Sanofi | Dual GLP-1/glucagon receptor agonists |
US9758561B2 (en) | 2014-04-07 | 2017-09-12 | Sanofi | Dual GLP-1/glucagon receptor agonists derived from exendin-4 |
US9771406B2 (en) | 2014-04-07 | 2017-09-26 | Sanofi | Peptidic dual GLP-1/glucagon receptor agonists derived from exendin-4 |
US9775904B2 (en) | 2014-04-07 | 2017-10-03 | Sanofi | Exendin-4 derivatives as peptidic dual GLP-1/glucagon receptor agonists |
US10806797B2 (en) | 2015-06-05 | 2020-10-20 | Sanofi | Prodrugs comprising an GLP-1/glucagon dual agonist linker hyaluronic acid conjugate |
US9982029B2 (en) | 2015-07-10 | 2018-05-29 | Sanofi | Exendin-4 derivatives as selective peptidic dual GLP-1/glucagon receptor agonists |
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Publication number | Publication date |
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CN101798588B (en) | 2015-09-09 |
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Effective date of registration: 20110516 Address after: 201321 Shanghai city Hongqiao Town Village 3 groups schleid Pudong New Area week Watergate Road No. 916 Applicant after: SHANGHAI HUAYI BIO-LAB Co.,Ltd. Co-applicant after: NATIONAL INSTITUTES FOR FOOD AND DRUG CONTROL Address before: 201321 Shanghai city Hongqiao Town Village 3 groups schleid Pudong New Area week Watergate Road No. 916 Applicant before: SHANGHAI HUAYI BIO-LAB Co.,Ltd. |
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Address after: 201321 Shanghai city Hongqiao Town Village 3 groups schleid Pudong New Area week Watergate Road No. 916 Applicant after: SHANGHAI BENEMAE PHARMACEUTICAL Corp. Applicant after: NATIONAL INSTITUTES FOR FOOD AND DRUG CONTROL Address before: 201321 Shanghai city Hongqiao Town Village 3 groups schleid Pudong New Area week Watergate Road No. 916 Applicant before: Shanghai Ren Hui Biological Pharmaceutical Co.,Ltd. Applicant before: NATIONAL INSTITUTES FOR FOOD AND DRUG CONTROL Address after: 201321 Shanghai city Hongqiao Town Village 3 groups schleid Pudong New Area week Watergate Road No. 916 Applicant after: Shanghai Ren Hui Biological Pharmaceutical Co.,Ltd. Applicant after: NATIONAL INSTITUTES FOR FOOD AND DRUG CONTROL Address before: 201321 Shanghai city Hongqiao Town Village 3 groups schleid Pudong New Area week Watergate Road No. 916 Applicant before: SHANGHAI HUAYI BIO-LAB Co.,Ltd. Applicant before: NATIONAL INSTITUTES FOR FOOD AND DRUG CONTROL |
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