CN101795692B - 用于降低眼内压的治疗性取代环戊烷 - Google Patents

用于降低眼内压的治疗性取代环戊烷 Download PDF

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Publication number
CN101795692B
CN101795692B CN2008801052735A CN200880105273A CN101795692B CN 101795692 B CN101795692 B CN 101795692B CN 2008801052735 A CN2008801052735 A CN 2008801052735A CN 200880105273 A CN200880105273 A CN 200880105273A CN 101795692 B CN101795692 B CN 101795692B
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China
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chloro
carboxylic acid
thiophene
propyl
mmol
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Expired - Fee Related
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CN2008801052735A
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Chinese (zh)
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CN101795692A (zh
Inventor
D·W·奥尔德
V·X·恩戈
M·霍洛博斯基
M·F·波斯纳
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Allergan Inc
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Allergan Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47G—HOUSEHOLD OR TABLE EQUIPMENT
    • A47G19/00—Table service
    • A47G19/02—Plates, dishes or the like
    • A47G19/06—Plates with integral holders for spoons, glasses, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/559—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing hetero atoms other than oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • C07D333/10—Thiophene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D333/40—Thiophene-2-carboxylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CN2008801052735A 2007-07-03 2008-06-30 用于降低眼内压的治疗性取代环戊烷 Expired - Fee Related CN101795692B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94790407P 2007-07-03 2007-07-03
US60/947,904 2007-07-03
PCT/US2008/068716 WO2009006370A1 (en) 2007-07-03 2008-06-30 Therapeutic substituted cyclopentanes for reducing intraocular pressure

Publications (2)

Publication Number Publication Date
CN101795692A CN101795692A (zh) 2010-08-04
CN101795692B true CN101795692B (zh) 2013-06-12

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CN2008801052735A Expired - Fee Related CN101795692B (zh) 2007-07-03 2008-06-30 用于降低眼内压的治疗性取代环戊烷

Country Status (12)

Country Link
US (2) US9591935B2 (enExample)
EP (1) EP2170345B1 (enExample)
JP (1) JP5453254B2 (enExample)
KR (1) KR20100051803A (enExample)
CN (1) CN101795692B (enExample)
AU (2) AU2008269965A1 (enExample)
CA (1) CA2692572A1 (enExample)
DK (1) DK2170345T3 (enExample)
ES (1) ES2401920T3 (enExample)
NZ (1) NZ582705A (enExample)
RU (2) RU2010103149A (enExample)
WO (1) WO2009006370A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9636255B2 (en) 2009-02-13 2017-05-02 Dose Medical Corporation Uveoscleral drug delivery implant and methods for implanting the same
JP5937004B2 (ja) 2009-05-18 2016-06-22 ドーズ メディカル コーポレーションＤｏｓｅ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ 薬剤溶出眼内インプラント
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US8299068B2 (en) * 2010-01-29 2012-10-30 Allergan, Inc. Therapeutically active cyclopentanes
US9668915B2 (en) 2010-11-24 2017-06-06 Dose Medical Corporation Drug eluting ocular implant
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
JP6569661B2 (ja) * 2014-02-27 2019-09-04 小野薬品工業株式会社 選択的ｅｐ２アゴニスト活性を有する化合物
ES2837399T3 (es) * 2015-07-23 2021-06-30 Ono Pharmaceutical Co Derivados de ácido 2-(octahidrociclopenta(b)piran-2-il)1,3-tiazol-4-carboxílico y compuestos relacionados como agonistas de EP2 con actividad reductora de la presión intraocular
CA3083487A1 (en) 2017-12-01 2019-06-06 Lunella Biotech, Inc. Repurposcins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980700A (en) * 1971-10-07 1976-09-14 G. D. Searle & Co. Prostaglandin intermediates and optically active isomers thereof
US4149007A (en) * 1977-06-23 1979-04-10 Miles Laboratories, Inc. C14 Phenyl-substituted derivatives of prostaglandin analogues
WO1998058911A2 (en) * 1997-06-23 1998-12-30 Pfizer Inc. Prostaglandin agonists
WO2006076370A2 (en) * 2005-01-14 2006-07-20 Allergan, Inc. Substituted cyclopentanes or cyclopentanones for the treatment of ocular hypertensive conditions
WO2008008718A2 (en) * 2006-07-11 2008-01-17 Allergan, Inc. Cyclopentane derivatives as antiglaucoma agents

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2307882A (en) * 1939-12-04 1943-01-12 Freud Joseph Combined food and beverage server
US5390798A (en) * 1991-11-07 1995-02-21 G'-Ka International, Inc. Food and beverage support tray with beverage vessel cutout
US5323910A (en) * 1992-08-07 1994-06-28 Van De Graaf Jr Pieter A Party plate
US5688819A (en) * 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5536725A (en) 1993-08-25 1996-07-16 Fmc Corporation Insecticidal substituted-2,4-diamino-5,6,7,8-tetrahydroquinazolines
US5593062A (en) * 1995-10-10 1997-01-14 Martin; Melvin E. Social serving plate
US5727678A (en) * 1996-06-12 1998-03-17 Chen; Chin Chen Two-in-one paper dish and cup holder
US5950856A (en) * 1997-04-15 1999-09-14 Cinque; Richard Plate and cup holder
US6264026B1 (en) * 1997-04-15 2001-07-24 Vincent H. Bradley Food, beverage and utility tray
IL139941A0 (en) 1999-12-02 2002-02-10 Pfizer Prod Inc Use of prostaglandin agonists to treat erectile dysfunction or impotence
BR0211545A (pt) * 2001-07-31 2004-07-13 Sucampo Ag Método e composição para tratamento de hipertensão ocular e glaucoma
US6651836B1 (en) * 2002-07-03 2003-11-25 Leonard L. Hofheins Hand-held plate for holding a beverage container and food
JP2009541340A (ja) * 2006-06-20 2009-11-26 アラーガン インコーポレイテッド 治療用化合物
WO2008008701A2 (en) * 2006-07-10 2008-01-17 Allergan, Inc. Substituted cyclopentane derivatives as therapeutic agents
US20080015219A1 (en) * 2006-07-11 2008-01-17 Allergan, Inc. Therapeutic compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980700A (en) * 1971-10-07 1976-09-14 G. D. Searle & Co. Prostaglandin intermediates and optically active isomers thereof
US4149007A (en) * 1977-06-23 1979-04-10 Miles Laboratories, Inc. C14 Phenyl-substituted derivatives of prostaglandin analogues
WO1998058911A2 (en) * 1997-06-23 1998-12-30 Pfizer Inc. Prostaglandin agonists
WO2006076370A2 (en) * 2005-01-14 2006-07-20 Allergan, Inc. Substituted cyclopentanes or cyclopentanones for the treatment of ocular hypertensive conditions
WO2008008718A2 (en) * 2006-07-11 2008-01-17 Allergan, Inc. Cyclopentane derivatives as antiglaucoma agents

Also Published As

Publication number Publication date
CA2692572A1 (en) 2009-01-08
US20110062165A1 (en) 2011-03-17
EP2170345A1 (en) 2010-04-07
JP5453254B2 (ja) 2014-03-26
US9591935B2 (en) 2017-03-14
US20170144999A1 (en) 2017-05-25
WO2009006370A1 (en) 2009-01-08
DK2170345T3 (da) 2013-05-13
KR20100051803A (ko) 2010-05-18
JP2010532379A (ja) 2010-10-07
AU2014203599A1 (en) 2014-07-17
EP2170345B1 (en) 2013-03-06
RU2014105895A (ru) 2015-08-27
CN101795692A (zh) 2010-08-04
ES2401920T3 (es) 2013-04-25
US9765065B2 (en) 2017-09-19
NZ582705A (en) 2012-06-29
RU2010103149A (ru) 2011-08-10
AU2008269965A1 (en) 2009-01-08

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