CN101785714A - Electric spinning device for preparing artificial blood vessel - Google Patents
Electric spinning device for preparing artificial blood vessel Download PDFInfo
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- CN101785714A CN101785714A CN201010117509A CN201010117509A CN101785714A CN 101785714 A CN101785714 A CN 101785714A CN 201010117509 A CN201010117509 A CN 201010117509A CN 201010117509 A CN201010117509 A CN 201010117509A CN 101785714 A CN101785714 A CN 101785714A
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- blood vessel
- artificial blood
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- electric spinning
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Abstract
The invention discloses an electric spinning device for preparing an artificial blood vessel, which comprises a solution storage device, a spraying device, a collecting device and a high-voltage static generator used for providing a strong electric field between the spraying device and the collecting device. The collecting device comprises a translating table, a rotating table and a receiving rod. The receiving rod is fixed on the rotating table which is fixed on the translating table. The electric spinning device is convenient for industrialization and scale production of preparing the artificial blood vessel by the electric spinning technology.
Description
Technical field
The present invention relates to electric spinning device, relate in particular to a kind of artificial blood vessel's of preparation electric spinning device.
Background technology
Blood vessel is the pipeline of transportation blood, sends to nutrition and oxygen for the histoorgan of whole body, takes away metabolic waste.Often jeopardize human life safety with the blood vessel diseases associated, as the vasodilation that aortic aneurysm causes, stricture of artery that atherosclerosis causes even obturation, the heart disease that the arteria coronaria sclerosis causes etc.Therefore when the blood vessel of human body part can not guarantee the normal blood supply of histoorgan owing to reasons such as arteriosclerosis, aging or breakages, need the employing artificial blood vessel to replace, put up a bridge or surgical operation therapy such as intervention.
The existing so far nearly 60 years history of the exploitation of artificial blood vessel and development, in clinical practice at present, artificial blood vessel has been obtained satisfied effect aspect the large artery trunks substituting, but (research of internal diameter≤6mm) also has big distance because key problems such as biocompatibility and compliance, patency rate are still unresolved from practical application to small-bore artificial blood vessel.
Electrospinning claims " electrospinning silk " again, is that a kind of polymer solution or melt of utilizing forms the technology that injection stream is carried out spinning processing under the highfield effect.In recent years, but electrospinning causes people's extensive concern as a kind of effective way of continuous production nanofiber, and the polymer that successfully carries out electrospinning processing at present in the world is above 30 kinds.The fiber diameter range that electrospinning makes is generally at 3nm～5um, than the little several magnitude of the fibre diameter that makes with conventional method.By the artificial blood vessel that electricity spinning fibre makes, has the porosity height, advantage such as specific surface area is big, fiber fine degree and homogeneity height, draw ratio are big.These with traditional method the good characteristic that can't obtain, given the electricity spinning fibre application prospects.In addition, electrospinning silk technology also has fast, efficient, advantages such as equipment is simple, easy operating, can be used for preparation complicated, exempt to sew up support, be control high-molecular biologic goods pattern, porosity and the effective way of regulating component.
Existing electric spinning device mainly is made up of following 4 parts:
HV generator: the highfield between injection apparatus and gathering-device is provided, and generally adopting maximum output voltage is the high direct voltage electrostatic generator of 30～100KV.
Solution storage device: can use syringe or liquid storage pipe etc., wherein fill polymer solution.
Injection apparatus: injection apparatus is capillary tube or the syringe needle of internal diameter 0.5～2mm.Can regulate hydrostatic pressure by air pump is installed in the solution storage device, or make polymer solution form drop at spinning nozzle with the method for the slow pushing syringe of numerical controlled machinery device.
Gathering-device: can select metal plate, grid or cylinder, rod iron according to the requirement of experimental result.Utilize difform gathering-device, can make the non-woven fabrics product of various character.Gathering-device ground connection is like this because the potential difference between nozzle and gathering-device forms high electric field between the two.Electric field intensity can be by the output valve of HV generator and the distance control between injection apparatus and gathering-device.
But still there is not directly to prepare at present artificial blood vessel's electric spinning device.
Summary of the invention
At the deficiencies in the prior art, the purpose of this invention is to provide a kind of electric spinning device that is used to prepare the artificial blood vessel, be convenient to industrialization, scale that electrospinning silk technology prepares the artificial blood vessel.
To achieve these goals, technical scheme of the present invention is: a kind of electric spinning device that is used to prepare the artificial blood vessel, it comprises solution storage device, injection apparatus, gathering-device and the HV generator that is used to provide the highfield between injection apparatus and gathering-device, described gathering-device comprises translation stage, turntable, reception rod, receive rod and be fixed on the turntable, turntable is fixed on the translation stage.
Described turntable is a high-speed rotary motor, and described reception rod is fixedly connected by fixture and high speed shaft coupling in the rotating shaft with high-speed rotary motor.
Beneficial effect of the present invention is: 1. fill the domestic gaps; 2. drive the reception rod and carry out high speed rotary motion, can regulate rotating speed according to the needs of different polymer solutions and make the electrospinning silk on receiving system, be orientated deposition; 3. drive the reception rod and carry out horizontal reciprocating movement, guarantee that electrospinning silk uniform deposition is in gathering-device; 4. can select the artificial blood vessel of the various internal diameters of reception rod preparation of different-diameter according to actual needs; 5. the electrospinning receiving efficiency be can improve, industrialization and popularization that the electrospinning silk prepares artificial blood vessel's technology helped; 6. can the uniform nanofiber nonwoven of one-shot forming manufacturing artificial blood vessel.
Description of drawings
The present invention is described in further detail below in conjunction with accompanying drawing.
Fig. 1 is a composition sketch map of the present invention.
Fig. 2 is the positive overall structure sketch map of gathering-device of the present invention.
Fig. 3 is a gathering-device of the present invention side overall structure sketch map.
The specific embodiment
See also Fig. 1, the electric spinning device that being used to of present embodiment prepares the artificial blood vessel comprises solution storage device 5, injection apparatus 6, gathering-device 7 and is used to provide injection apparatus 6 and the HV generator 8 of the highfield of 7 of gathering-devices.See also Fig. 2 and Fig. 3, gathering-device 7 comprises reception rod 1, high speed shaft coupling 2, turntable 3, translation stage 4, receiving rod 1 is fixedly connected on turntable 3 by fixture and high speed shaft coupling 2, this turntable 3 is a high-speed rotary motor, drive reception rod 1 by it and carry out high speed rotary motion, this turntable 3 is fixed on the translation stage 4 simultaneously, can carry out horizontal reciprocating movement thereby receive rod 1 in high speed rotating.Translation stage can carry out horizontal reciprocating movement, reciprocal distance＜100mm, the speed of service is 0.1～5mm/S, its reciprocal distance of scalable and the speed of service, turntable can carry out high speed rotating, rotating speed is 100～3000r/min, can regulate rotating speed according to the requirement of different polymer solutions and make the electrospinning silk be orientated deposition on receiving system, receives bar fixing device and is used for fixing the reception rod.Can select the reception rod of different-diameter according to preparation different inner diameters artificial blood vessel's needs, be connected on the high speed shaft coupling by fixation workpiece.
During use, at first in device for storing liquid, fill with the electrospinning solution for preparing, under the self gravitation effect or regulate flow velocity by electronic syringe pump and make drop be full of injection apparatus but do not drip.Select the reception rod of different-diameter to be fixed on the turntable on demand, adjust the reciprocating distance and the speed of the rotating speed and the adjustment translation stage of turntable after the energized.Start HV generator, after the energising, because injection apparatus (spinning head) has positive electricity, and gathering-device ground connection is no-voltage, and under the electric field force effect, spinning liquid is drawn out from spinning head, form high velocity jet, and be received the rod collection rapidly, the solvent in the spinning liquid volatilizees rapidly simultaneously.Behind the deenergization, unload and receive rod, take off electrospinning silk product (artificial blood vessel).
The present invention is rational in infrastructure, easy to operate, and electrospinning silk collection efficiency height can form the artificial blood vessel that is evenly distributed, and helps industrialization and development that electrospinning silk technology prepares the artificial blood vessel technology, thereby is worthy of popularization.
Claims (2)
1. electric spinning device that is used to prepare the artificial blood vessel, it comprises solution storage device, injection apparatus, gathering-device and the HV generator that is used to provide the highfield between injection apparatus and gathering-device, it is characterized in that, described gathering-device comprises translation stage, turntable, reception rod, receive rod and be fixed on the turntable, turntable is fixed on the translation stage.
2. the electric spinning device that is used to prepare the artificial blood vessel according to claim 1 is characterized in that, described turntable is a high-speed rotary motor, and described reception rod is fixedly connected by fixture and high speed shaft coupling in the rotating shaft with high-speed rotary motor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010117509A CN101785714A (en) | 2010-02-25 | 2010-02-25 | Electric spinning device for preparing artificial blood vessel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010117509A CN101785714A (en) | 2010-02-25 | 2010-02-25 | Electric spinning device for preparing artificial blood vessel |
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| CN101785714A true CN101785714A (en) | 2010-07-28 |
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| CN201010117509A Pending CN101785714A (en) | 2010-02-25 | 2010-02-25 | Electric spinning device for preparing artificial blood vessel |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103334167A (en) * | 2013-07-11 | 2013-10-02 | 厦门大学 | Microfiber coil electrospinning direct-writing device |
| CN105671657A (en) * | 2016-04-01 | 2016-06-15 | 重庆大学 | Small-aperture artificial blood vessel preparation device based on electrostatic spinning |
| CN105755554A (en) * | 2016-04-01 | 2016-07-13 | 重庆大学 | Small-diameter artificial vascular graft preparation method based on electrostatic spinning |
| CN106012052A (en) * | 2016-08-03 | 2016-10-12 | 苏州大学附属第二医院 | Device for manufacturing artificial blood vessel through combination of bio-printing and electro-spinning technologies |
| CN108525015A (en) * | 2017-03-13 | 2018-09-14 | 南开大学 | It is engineered arterial vascular method by structure in skeleton body of melt-spinning fiber |
| CN110481019A (en) * | 2019-08-20 | 2019-11-22 | 广州帷幄生物科技有限公司 | A kind of artificial blood vessel printing device |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2004074559A1 (en) * | 2003-02-24 | 2004-09-02 | Hag-Yong Kim | A process of preparing continuous filament composed of nano fiber |
| CN101214393A (en) * | 2007-12-28 | 2008-07-09 | 苏州大学 | Nano fibrous tissue engineering blood vessel and preparation thereof |
| CN201343585Y (en) * | 2008-12-19 | 2009-11-11 | 青岛大学 | Electrostatic spinning device for producing nanofiber |
| CN201670897U (en) * | 2010-02-25 | 2010-12-15 | 王深明 | Electrospinning device for producing artificial blood vessels |
-
2010
- 2010-02-25 CN CN201010117509A patent/CN101785714A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004074559A1 (en) * | 2003-02-24 | 2004-09-02 | Hag-Yong Kim | A process of preparing continuous filament composed of nano fiber |
| CN101214393A (en) * | 2007-12-28 | 2008-07-09 | 苏州大学 | Nano fibrous tissue engineering blood vessel and preparation thereof |
| CN201343585Y (en) * | 2008-12-19 | 2009-11-11 | 青岛大学 | Electrostatic spinning device for producing nanofiber |
| CN201670897U (en) * | 2010-02-25 | 2010-12-15 | 王深明 | Electrospinning device for producing artificial blood vessels |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103334167A (en) * | 2013-07-11 | 2013-10-02 | 厦门大学 | Microfiber coil electrospinning direct-writing device |
| CN105671657A (en) * | 2016-04-01 | 2016-06-15 | 重庆大学 | Small-aperture artificial blood vessel preparation device based on electrostatic spinning |
| CN105755554A (en) * | 2016-04-01 | 2016-07-13 | 重庆大学 | Small-diameter artificial vascular graft preparation method based on electrostatic spinning |
| CN106012052A (en) * | 2016-08-03 | 2016-10-12 | 苏州大学附属第二医院 | Device for manufacturing artificial blood vessel through combination of bio-printing and electro-spinning technologies |
| CN108525015A (en) * | 2017-03-13 | 2018-09-14 | 南开大学 | It is engineered arterial vascular method by structure in skeleton body of melt-spinning fiber |
| CN110481019A (en) * | 2019-08-20 | 2019-11-22 | 广州帷幄生物科技有限公司 | A kind of artificial blood vessel printing device |
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Application publication date: 20100728 |