CN101780211A

CN101780211A - Traditional Chinese medicine for treating infantile chronic cough and asthma

Info

Publication number: CN101780211A
Application number: CN 201010130753
Authority: CN
Inventors: 李有田; 李洋
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-03-24
Filing date: 2010-03-24
Publication date: 2010-07-21
Anticipated expiration: 2030-03-24
Also published as: CN101780211B

Abstract

The invention relates to a traditional Chinese medicine for treating infantile chronic cough and asthma, and belongs to the field of traditional Chinese medicines. The invention aims to adopt the traditional Chinese medicine theory to prepare the traditional Chinese medicine for treating infantile chronic cough and asthma, which can clear away lung-heat and detoxicate, eliminate phlegm and stop cough, purge lung and stop asthma. The active components of the invention comprise the following raw material by weight part: red tangerine peel, hogfennel root, ginkgo seed, pumice, baical skullcap root, apricot seed, bulbus fritilariae, liquorice root, heartleaf houttuynia herb, snakegourd fruit, perilla fruit, pinellia tuber and Poria. The invention has simple preparation, low cost, reliable curative effect, short time of treatment, no relapse, no toxic side effects like western medicines (antifungal agents), and good social and economic benefits, and is particularly important for some children which have allergic history for various antibiotics.

Description

A kind of Chinese medicine for the treatment of infantile chronic cough and asthma

Technical field:

The invention belongs to the field of Chinese medicines.

Background technology:

Infantile chronic cough and asthma is the clinical common frdquently encountered disease of department of pediatrics, and the disease of easy recurrence, brings great misery and worry for the infant and the head of a family.Also influence growth, the growth of infant.Comprise pediatric infantile acute bronchitis, bronchitis, children asthmatic brouchitis, children's bronchopneumonia, acute infantile pneumonia diseases such as (convalescent periods).The disease of infantile chronic cough and asthma accounts for first of the pediatric disease, physical weakness child at ordinary times particularly, and common morbidity repeatedly has a strong impact on children's's growth promoter and healthy living.Particularly the part children's all has allergies to various antibiotics, and is particularly important.

Summary of the invention:

The objective of the invention is to adopt theory of Chinese medical science, with clearing away lung-heat detoxifcation, preventing phlegm from forming and stopping coughing, the Chinese medicine of the treatment infantile chronic cough and asthma of eliminating the pathogens from the lung Dingchuan.

The present invention makes the raw materials of effective components weight portion and consists of:

Tangerine 3～15 Radix Peucedanis, 5～15 Semen Ginkgoes, 3～15 Pumexs 5～15

Radix Scutellariae 5～15 Semen Armeniacae Amarums 3～5 Bulbus Fritillariae Cirrhosae 3～8 Radix Glycyrrhizaes 3～5

Herba Houttuyniae 5～15 Fructus Trichosanthis 5～15 Fructus Perillaes 3～5 Rhizoma Pinelliaes 3～5

Poria 5～15

The present invention makes raw materials of effective components optimum weight part and consists of:

Tangerine 10 Radix Peucedanis, 5 Semen Ginkgoes, 5 Pumexs 10

Radix Scutellariae 10 Semen Armeniacae Amarums 3 Bulbus Fritillariae Cirrhosae 5 Radix Glycyrrhizaes 5

Herba Houttuyniae 15 Fructus Trichosanthis 10 Fructus Perillaes 5 Rhizoma Pinelliaes 5

Poria 10

The present invention prepares simply, and cheap, curative effect is reliable, and treatment time is short, should not recur, and does not more have the toxic and side effects that resembles Western medicine (bacteriums disappears).Social benefit is good, and economic benefit is splendid.Particularly the part children's all has allergies particularly important to various antibiotics.

The specific embodiment:

Tangerine 3～15 Radix Peucedanis, 5～15 Semen Ginkgoes, 3～15 Pumexs 5～15

Poria 5～15

Tangerine 10 Radix Peucedanis, 5 Semen Ginkgoes, 5 Pumexs 10

Poria 10

Preparation method of the present invention:

At first, soaked 30 minutes, after the reuse big fire is boiled 30 minutes the above-mentioned medicinal cold water 1000ml that respectively distinguishes the flavor of, using slow fire (little fire) instead decocts, decoct medicinal herbs liquid is surplus to be 100ml, with health gauze (three layers) filtering liquid medicine, and then adopts said method to repeat once, to obtain herb liquid is placed on for twice in one glass, divide two parts, every part of 100ml, every day secondary, each 50ml, one after each meal.(heating back)

Embodiment 1:

Tangerine 3 Radix Peucedanis, 5 Semen Ginkgoes, 3 Pumexs 5

Radix Scutellariae 5 Semen Armeniacae Amarums 3 Bulbus Fritillariae Cirrhosae 3 Radix Glycyrrhizaes 3

Herba Houttuyniae 5 Fructus Trichosanthis 5 Fructus Perillaes 3～5 Rhizoma Pinelliaes 3

Poria 5

Preparation method:

At first, soaked 30 minutes, after the reuse big fire is boiled 30 minutes the above-mentioned medicinal cold water 1000ml that respectively distinguishes the flavor of, use slow fire (little fire) instead and decoct, decoct medicinal herbs liquid is surplus to be 100ml, with health gauze (three layers) filtering liquid medicine, and then adopt said method to repeat once, will obtain herb liquid and mix.

Embodiment 2:

Tangerine 9 Radix Peucedanis, 10 Semen Ginkgoes, 9 Pumexs 10

Radix Scutellariae 10 Semen Armeniacae Amarums 4 Bulbus Fritillariae Cirrhosae 5.5 Radix Glycyrrhizaes 4

Herba Houttuyniae 10 Fructus Trichosanthis 10 Fructus Perillaes 4 Rhizoma Pinelliaes 4

Poria 10

Preparation method is with embodiment 1.

Embodiment 3:

Tangerine 15 Radix Peucedanis, 15 Semen Ginkgoes, 15 Pumexs 15

Radix Scutellariae 15 Semen Armeniacae Amarums 5 Bulbus Fritillariae Cirrhosae 8 Radix Glycyrrhizaes 5

Herba Houttuyniae 15 Fructus Trichosanthis 15 Fructus Perillaes 5 Rhizoma Pinelliaes 5

Poria 15

Preparation method is with embodiment 1:

Most preferred embodiment of the present invention is:

Tangerine 10 Radix Peucedanis, 5 Semen Ginkgoes, 5 Pumexs 10

Poria 10

Preparation method is with embodiment 1.

Radix Peucedani is gone into lung meridian in the present invention's prescription, the energy lowering the adverse-rising QI to resolve phlegm, and wind and heat dispersing can increase the respiratory tract secretion, phlegm-dispelling functions is arranged, and action time is longer, simultaneously influenza virus is had inhibitory action, has antibiotic and antifungic action.The bitter temperature of Semen Armeniacae Amarum, sweet in the mouth is gone into lung and large intestine channel, and the merit (theory of Chinese medical science has the lung and the large intestine being interior-exteriorly related) of relieving cough and relieving asthma loosening bowel to relieve constipation is arranged.Cure mainly the cough with dyspnea dyspnea with rapid and short breath, accumulation and obstruction of sputum.Two medicine compatibilities more can increase the merit of eliminating phlegm to relieve asthma antitussive, and antibiotic effect is also arranged.Radix Scutellariae in the side is cold in nature, bitter in the mouth, and lung moistening, large intestine channel has heat clearing and damp drying, the effect of eliminating fire and detoxication, the Radix Scutellariae decoct has a wider antimicrobial spectrum external, and it all has inhibitory action to staphylococcus, streptococcus, bordetella pertussis, Diplococcus pneumoniae etc.Semen Ginkgo property in the side is flat, sweet in the mouth, and is bitter, puckery, has the merit of astringing lung QI for relieving asthma.The present invention contains multiple alkaloid, as fritimine etc., has antitussive, phlegm-dispelling functions, in addition bronchial smooth muscle is had the spasmolytic anti-asthmatic action.Herba Houttuyniae cold nature in the side, the flavor raw meat, return lung meridian, have heat-clearing and toxic substances removing, the merit of the pain evacuation of pus that disappears, the present invention contains houttuynine sodium bisulfite, volatilization wet goods, Herba Houttuyniae all has in various degree inhibitory action to the blue formula positive of multiple leather such as staphylococcus aureus, Diplococcus pneumoniae, influenza liver bacterium and knot bacillus and negative bacteria, can strengthen the leukocytes phagocytic ability, human body immunity improving power, and antiinflammatory, antitussive effect are arranged.The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, full side is a heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing, the merit of eliminating the pathogens from the lung Dingchuan.

Acute toxicity testing data of the present invention:

Finish by Changchun University of Traditional Chinese Medicine new drug center (or claiming State Administration of Traditional Chinese Medicine's Chinese medicine management three grades of laboratorys).

Purpose: observe the maximum dosage-feeding of heavy dose of administration of the present invention to gastric infusion in acute toxic reaction that animal produced and the 24h.

Experiment material:

Experimental animal: Kunming mouse, body weight 20～22g, male and female half and half are purchased the high-new medical animal experiment center in Changchun, the quality certification number: (Ji) SCXK2003-2004.

Be subjected to the reagent thing: medicine 100ml/ bag of the present invention, contain crude drug amount 1.15g/ml, provide by Pharmacy department of No.1 Hospital of Jilin Univ..With 8 times (800%), 4 times (400%) of medicine simmer down to stock solution of the present invention, 2 times (200%), concentrating the back Cmax is that stock solution 800% contains crude drug amount 9.2g.ml during experiment.

Experimental technique:

LD50 measures: press the relevant requirements of provisions for new drugs approval, the LD50 that medicine of the present invention has been carried out gastric infusion measures.

Trial test: get 12 of mices, be divided into 3 groups at random, behind every group of 4 fasting 16h, irritate the medicinal liquid concentrated solution 400ml/kg body weight that stomach is given medicinal liquid 800%, 400% of the present invention and 200% respectively, animals administer is after observed continuously 7 days, and animal subject there is no overt toxicity reaction and dead as a result.

Experimental result:

Observation shows that animals administer rear section moving animals obviously reduces, and active state recovers normal behind the 24h, and body weight is observed and shown that the weight of animals is not subjected to obviously to influence, and breathing, diet, drinking-water etc. are normal, mouth, eye, the no abnormal secretions of nose.Observation period does not have animal dead.Can prove that thus toxicity of the present invention is lower, oral safer.

Clinical data:

1, case is selected: infantile acute bronchitis, bronchitis, panting property arm inflammation, bronchopneumonia diagnostic criteria are with reference to " the pediatrics of being compiled by Xue Xin owner.

2, ordinary circumstance: outpatient service reaches and accepts 62 routine infants in hospital for medical treatment, is divided into two groups at random, treatment group (of the present invention group) 32 examples, male 17 examples, woman's 15 examples, 4.5～8 years old 8 age example, 9～14 years old 24 example, diagnosing acute bronchitis 12 examples, bronchitis 6 examples, asthmatic bronchitis 5 examples, bronchopneumonia 9 examples.Matched group (infantile lung heat cough with asthma oral liquid), 4～7.5 years old 7 example, 8～14 years old 23 example is diagnosed as acute bronchitis 14 examples, bronchitis 7 examples, asthmatic bronchitis 4 examples, bronchopneumonia 5 examples.Two groups of clinical bronchitis 4 examples of infant, bronchopneumonia 5 examples.Two groups of infant clinical data there was no significant differences (P＞0.05) have comparability.

3, Therapeutic Method: the treatment group is at first made water decoction with the present invention, the 50ml/ bag/time, 2 times on the 1st, serve on 7 days.The oral infantile lung heat cough with asthma of matched group oral liquid (producing) by Heilungkiang sunflower pharmaceutcal corporation, Ltd.Authentication code: the accurate word z1095080 of traditional Chinese medicines, 10ml/1 props up, and 2 times on the 1st, two groups was a course of treatment with 7 days all.

4, observation index: after the treatment in 7 days of two groups of cases, observe its clinical cardinal symptom and sign, and sign extinction time and the comparison of disease cure rate aspect, treatment group as a result obviously is better than matched group.See table 1, table 2 for details.

Table 1 liang group symptom and sign again often between relatively

With matched group more 1. P＜0.05,2. P＜0.01.

Table 2 liang group curative effect of disease relatively

With matched group more 1. P＜0.05,2. P＜0.01.

Claims

1. Chinese medicine for the treatment of infantile chronic cough and asthma is characterized in that: make the raw materials of effective components weight portion and consist of:

Tangerine 3～15 Radix Peucedanis, 5～15 Semen Ginkgoes, 3～15 Pumexs 5～15

Poria 5～15.

2. Chinese medicine for the treatment of infantile chronic cough and asthma is characterized in that: make raw materials of effective components optimum weight part and consist of:

Tangerine 10 Radix Peucedanis, 5 Semen Ginkgoes, 5 Pumexs 10

Poria 10.