CN101780161B - Capsule quality detection method - Google Patents
Capsule quality detection method Download PDFInfo
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- CN101780161B CN101780161B CN2009103064786A CN200910306478A CN101780161B CN 101780161 B CN101780161 B CN 101780161B CN 2009103064786 A CN2009103064786 A CN 2009103064786A CN 200910306478 A CN200910306478 A CN 200910306478A CN 101780161 B CN101780161 B CN 101780161B
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Abstract
The invention discloses a Xietingfeng capsule quality detection method. On the basis of the original quality control, a TLC identification method of main ingredient radix tinosporae in the Xietingfeng capsule is added, and a preparation method for test object solution under a content determination item is revised; the content of benzene in developing solvent used in the identification method of the existing detection method is revised. The invention makes up for the shortage of the original detection method, improves the quality monitoring the level of the product, is favorable for monitoring products by management departments and ensures good health of inspection personal.
Description
Technical field
The invention belongs to the pharmaceutical technology field, relate to a kind of quality determining method of capsule, the quality determining method of particularly a kind of anti-diarrheal capsule (the medicine name is rushed down and stopped the sealing capsule).
Background technology
Rush down stop the sealing capsule have clearing heat and detoxicating, the function of dampness-eliminating and dysentery-stopping, be used for diarrhoea, dysentery is got ill from overeating and is had loose bowels, epigastric pain, halitosis, belch, diseases such as acute chronic enteritis.Rush down in the quality determining method that stops the sealing capsule existing, do not formulate the TLC discrimination method of characteristic index composition tinosporae, the content assaying method of leatherleaf mahonia is also perfect inadequately, and the control product quality is had certain influence; In the discrimination method of existing detection method, used developping agent contains benzene, and easily the health to the testing staff damages.For further controlling the quality of this product, guarantee that the testing staff is healthy, should increase the TLC discrimination method of tinosporae, the preparation method of need testing solution under the revision assay item, the composition of " benzene " of used developping agent in the discrimination method of the existing detection method of revision.
Summary of the invention
The objective of the invention is: a kind of quality determining method that stops the sealing capsule that rushes down is provided.The present invention has increased on initial quality control basis rushes down the TLC discrimination method that stops main pharmaceutical compositions tinosporae in the sealing capsule, has revised the preparation method of need testing solution under the assay item; Revised the composition of " benzene " of used developping agent in the discrimination method of existing detection method.The present invention has remedied the deficiency of former detection method, has improved the quality monitoring level of product, also helps administrative authority to product monitoring, has ensured that the testing staff's is healthy.
Purpose of the present invention can realize by following technical proposal: a kind of quality determining method that stops the sealing capsule that rushes down, according to listed as parts by weight, rush down that to stop the sealing capsule be to make 1000 capsules finished products with tinosporae 400g, kuh-seng 400g, garden burnet 250g, leatherleaf mahonia 250g; It is characterized in that this detection method may further comprise the steps:
Proterties: this product is a capsule, and content is extremely tan particle and a powder of pale brown look, and gas is little, bitter;
Differentiate: (1) gets this product content 0.5g, adds methyl alcohol 10ml, and sonicated 15 minutes filters, and filtrate is as need testing solution.Other gets leatherleaf mahonia control medicinal material 0.1g, shines medicinal material solution in pairs with legal system, gets Berberine hydrochloride, palmatin hydrochloride, Jatrorrhizine chloride reference substance again, adds methyl alcohol respectively and makes the solution that contains 0.5mg among every 1ml, in contrast product solution.Test according to thin-layered chromatography, draw each 2 μ l of above-mentioned five kinds of solution, put respectively in same be on the silica gel g thin-layer plate of binder with the sodium carboxymethyl cellulose, with 6: 3: 1.5: toluene-ethyl acetate of 1.5: 0.5-methyl alcohol-isopropyl alcohol-strong ammonia solution was a developping agent, put in the pre-saturated expansion cylinder of ammonia steam, launch, take out, dry, put under the ultraviolet lamp of 365nm and inspect, in the test sample chromatogram, with control medicinal material chromatogram and the corresponding position of reference substance chromatogram on, show the fluorescence spot of same color respectively;
(2) get this product content 2g, put in the apparatus,Soxhlet's, use extracted by ether 2 hours, constantly replenish the ether amount.Extract volatilizes, and residue adds methyl alcohol 1ml dissolving, as need testing solution.Other gets tinosporae control medicinal material 1g, shines medicinal material solution in pairs with legal system, according to the thin-layered chromatography test, drawing each 3～5 μ l of above-mentioned two kinds of solution, put respectively in being on the silica gel g thin-layer plate of binder with a sodium carboxymethyl cellulose, is developping agent with toluene-methyl alcohol of 9: 1, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, under 105 ℃ of temperature, it is clear to dry by the fire spot colour developing, in the test sample chromatogram, with the corresponding position of control medicinal material chromatogram on, show the aubergine spot of same color;
(3) get this product content 2g, add chloroform 50ml, strong ammonia solution 0.6ml, placement is spent the night, and filters, and filtrate evaporate to dryness, residue add chloroform 0.5ml makes dissolving, as need testing solution.Other gets kuh-seng control medicinal material 0.5g, shines medicinal material solution in pairs with legal system, gets matrine, oxymatrine, Sophoridine reference substance again and adds ethanol respectively and make the solution that every 1ml contains 0.2mg, in contrast product solution.Test according to thin-layered chromatography, draw each 5 μ l of above-mentioned five kinds of solution, put respectively in same be on the silica gel g thin-layer plate of binder with the sodium carboxymethyl cellulose, with 6: 3: 1.5: toluene-ethyl acetate of 1.5: 0.5-methyl alcohol-isopropyl alcohol-strong ammonia solution was a developping agent, launch, take out, dry, spray is with rare bismuth potassium iodide test solution.In the test sample chromatogram, with control medicinal material chromatogram and the corresponding position of reference substance chromatogram on, show the spot of same color respectively;
(4) get this product content 5g, add methyl alcohol 30ml, sonicated 1 hour, filter, filtrate evaporate to dryness, residue add water 30ml gradation dissolving, put in the separating funnel, regulate pH value to 3～4 with hydrochloric acid, the jolting that adds diethyl ether is extracted twice, each 20ml merges ether solution, volatilizes, residue adds methyl alcohol 1ml makes dissolving, and as need testing solution, other gets garden burnet control medicinal material 2g, add water 50ml, reflux 30 minutes, put cold, centrifugal 10 minutes, get supernatant, extract 2 times with the ether jolting that hydrochloric acid is saturated, each 20ml merges ether solution, volatilize, residue adds methyl alcohol 1ml makes dissolving, and medicinal material solution is got the gallic acid reference substance more in contrast, add methyl alcohol and make the solution that every 1ml contains 0.5mg, in contrast product solution.Test according to thin-layered chromatography, draw each 10 μ l of above-mentioned three kinds of solution, put respectively in same be on the silica gel g thin-layer plate of binder with the sodium carboxymethyl cellulose, be developping agent with the water saturated toluene ethyl acetate formic acid of 6: 3: 1 usefulness, launch, take out, dry, spray is with 1% ferric trichloride ethanolic solution, in the test sample chromatogram, with control medicinal material chromatogram and the corresponding position of reference substance chromatogram on, show the spot of same color.
Above-mentioned rushing down in the quality determining method that stops the sealing capsule also comprises:
Check: should meet every regulation relevant under the capsule item:
Assay is according to high effective liquid chromatography for measuring;
Chromatographic condition and system suitability test: with octadecylsilane chemically bonded silica is filling agent; With 50: 25: 25 acetonitriles-0.025mol/L potassium dihydrogen phosphate 0.025mol/L lauryl sodium sulfate is moving phase, and the detection wavelength is 345nm, 30 ℃ of column temperatures.Number of theoretical plate calculates by the Berberine hydrochloride peak should be not less than 3000;
The preparation of reference substance solution: it is an amount of that precision takes by weighing the Berberine hydrochloride reference substance, adds methyl alcohol and make the solution that every 1ml contains 0.04mg, promptly;
The preparation of need testing solution: get the content under this product content uniformity item, porphyrize is got 0.5g, the accurate title, decide, and puts in the 50ml measuring bottle, adds 1: 100 methanol hydrochloride solution 30ml, use power 250W, the sonicated of frequency 50KHz 30 minutes is taken out, put cold, the methanol hydrochloride solution that adds 1: 100 shakes up to scale, with the miillpore filter filtration of 0.45 μ m, get subsequent filtrate, promptly;
Determination method: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject liquid chromatograph, measure, promptly;
Every of this capsule finished product contains leatherleaf mahonia with Berberine hydrochloride (C
20H
17O
4HCl) meter must not be less than 1.4mg.
Aforementioned rushing down in the quality determining method that stops the sealing capsule, described rushing down stopped the sealing capsule and made according to following method: get above four flavors, tinosporae is ground into fine powder, sieve, the fine powder sterilization is standby, three flavor boilings such as meal and all the other kuh-sengs three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, and filtrate was left standstill 12 hours, get supernatant concentration to relative density and be 1.20～1.25 80 ℃ clear cream, add above-mentioned fine powder and appropriate amount of starch mixing, make particle, 80 ℃ of dryings, incapsulate, promptly.
Compared with prior art, the present invention controls to have increased on the basis in initial quality and rushes down TLC discrimination method that stops main pharmaceutical compositions tinosporae in the sealing capsule and the preparation method who has revised need testing solution; The composition " benzene " of existing discrimination method Central Plains developping agent is replaced by safer " toluene ", has ensured that the testing staff's is healthy.The present invention has remedied the deficiency of proper mass control procedure, has improved the quality monitoring level of product, also helps administrative authority to product monitoring, has ensured that the testing staff's is healthy.
Embodiment
Embodiment: rush down the quality determining method that stops the sealing capsule,, rush down that to stop the sealing capsule be to make 1000 capsules finished products with tinosporae 400g, kuh-seng 400g, garden burnet 250g, leatherleaf mahonia 250g according to listed as parts by weight; It is characterized in that this detection method may further comprise the steps:
Proterties: this product is a capsule, and content is extremely tan particle and a powder of pale brown look, and gas is little, bitter.
Differentiate: (1) gets this product content 0.5g, adds methyl alcohol 10ml, and sonicated 15 minutes filters, and filtrate is as need testing solution.Other gets leatherleaf mahonia control medicinal material 0.1g and (gets leatherleaf mahonia and each 0.1g of tinosporae control medicinal material in addition,), shine medicinal material solution in pairs with legal system, get Berberine hydrochloride, palmatin hydrochloride, Jatrorrhizine chloride reference substance again, add methyl alcohol respectively and make the solution that contains 0.5mg among every 1ml, in contrast product solution.According to thin-layered chromatography (" an appendix VI of Chinese pharmacopoeia version in 2005 B) test, draw each 2 μ l of above-mentioned five kinds of solution (drawing each 2 μ l of above-mentioned six kinds of solution), put respectively in same be on the silica gel g thin-layer plate of binder with the sodium carboxymethyl cellulose, with toluene-ethyl acetate-methyl alcohol-isopropyl alcohol-strong ammonia solution (6: 3: 1.5: 1.5: 0.5) is developping agent, put in the pre-saturated expansion cylinder of ammonia steam, launch, take out, dry, put under the ultraviolet lamp (365nm) and inspect, in the test sample chromatogram, with control medicinal material chromatogram and the corresponding position of reference substance chromatogram on, show the fluorescence spot of same color respectively.
(2) get this product content 2g, put in the apparatus,Soxhlet's, use extracted by ether 2 hours, constantly replenish the ether amount.Extract volatilizes, and residue adds methyl alcohol 1ml dissolving, as need testing solution.Other gets tinosporae control medicinal material 1g, shine medicinal material solution in pairs with legal system, according to thin-layered chromatography (" appendix IVB of Chinese pharmacopoeia version in 2005) test, draw each 3～5 μ l of above-mentioned two kinds of solution, put respectively in being on the silica gel g thin-layer plate of binder with a sodium carboxymethyl cellulose, with methylbenzene methanol (9: 1) is developping agent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, under 105 ℃ of temperature, it is clear to dry by the fire spot colour developing, in the test sample chromatogram, with the corresponding position of control medicinal material chromatogram on, show the aubergine spot of same color.
(3) get this product content 2g, add chloroform 50ml, strong ammonia solution 0.6ml, placement is spent the night, and filters, and filtrate evaporate to dryness, residue add chloroform 0.5ml makes dissolving, as need testing solution.Other gets kuh-seng control medicinal material 0.5g, shines medicinal material solution in pairs with legal system, gets matrine, oxymatrine, Sophoridine reference substance again and adds ethanol respectively and make the solution that every 1ml contains 0.2mg, in contrast product solution.According to thin-layered chromatography (" an appendix VI of Chinese pharmacopoeia version in 2005 B) test, draw each 5 μ l of above-mentioned five kinds of solution, put respectively in same be on the silica gel g thin-layer plate of binder with the sodium carboxymethyl cellulose, with toluene ethyl acetate methyl alcohol isopropyl alcohol strong ammonia solution (6: 3: 1.5: 1.5: 0.5) is developping agent, launch, take out, dry, spray is with rare bismuth potassium iodide test solution.In the test sample chromatogram, with control medicinal material chromatogram and the corresponding position of reference substance chromatogram on, show the spot of same color respectively.
(4) get this product content 5g, add methyl alcohol 30ml, sonicated 1 hour, filter, filtrate evaporate to dryness, residue add water 30ml gradation dissolving, put in the separating funnel, regulate pH value to 3～4 with hydrochloric acid, the jolting that adds diethyl ether is extracted twice, each 20ml merges ether solution, volatilizes, residue adds methyl alcohol 1ml makes dissolving, and as need testing solution, other gets garden burnet control medicinal material 2g, add water 50ml, reflux 30 minutes, put cold, centrifugal 10 minutes, get supernatant, extract 2 times with the ether jolting that hydrochloric acid is saturated, each 20ml merges ether solution, volatilize, residue adds methyl alcohol 1ml makes dissolving, and medicinal material solution is got the gallic acid reference substance more in contrast, add methyl alcohol and make the solution that every 1ml contains 0.5mg, in contrast product solution.According to thin-layered chromatography (" an appendix VI of Chinese pharmacopoeia version in 2005 B) test, draw each 10 μ l of above-mentioned three kinds of solution, put respectively in same be on the silica gel g thin-layer plate of binder with the sodium carboxymethyl cellulose, be developping agent with toluene (using water saturation)-ethyl acetate formic acid (6: 3: 1), launch, take out, dry, spray is with 1% ferric trichloride ethanolic solution, in the test sample chromatogram, with control medicinal material chromatogram and the corresponding position of reference substance chromatogram on, show the spot of same color.
Check: should meet every regulation relevant under the capsule item:
Assay: the photograph high performance liquid chromatography (" an appendix VI of Chinese pharmacopoeia version in 2005 D) measure.
Chromatographic condition and system suitability test: with octadecylsilane chemically bonded silica is filling agent; Acetonitrile-0.025mol/L potassium dihydrogen phosphate-0.025mol/L lauryl sodium sulfate (50: 25: 25) is a moving phase, and the detection wavelength is 345nm, 30 ℃ of column temperatures.Number of theoretical plate calculates by the Berberine hydrochloride peak should be not less than 3000.
The preparation of reference substance solution: it is an amount of that precision takes by weighing the Berberine hydrochloride reference substance, adds methyl alcohol and make the solution that every 1ml contains 0.04mg, promptly.
The preparation of need testing solution: get the content under this product content uniformity item, porphyrize is got 0.5g, the accurate title, decide, and puts in the 50ml measuring bottle, adds methanol hydrochloride solution (1: 100) 30ml, sonicated (power 250W, frequency 50KHz) 30 minutes is taken out, put cold, add methanol hydrochloride solution (1: 100) to scale, shake up, filter with miillpore filter (0.45 μ m), get subsequent filtrate, promptly.
Determination method: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject liquid chromatograph, measure, promptly.
Every of this capsule finished product contains leatherleaf mahonia with Berberine hydrochloride (C
20H
17O
4HCl) meter must not be less than 1.4mg.
Rush down and stop the sealing capsule and make according to following method: get above four flavors, tinosporae is ground into fine powder, sieves, the fine powder sterilization is standby, three flavor boilings such as meal and all the other kuh-sengs three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, filtrate was left standstill 12 hours, got the clear cream that supernatant concentration to relative density is 1.20～1.25 (80 ℃), added above-mentioned fine powder and appropriate amount of starch mixing, make particle, 80 ℃ of dryings incapsulate, promptly.
Claims (3)
1. the quality determining method of a capsule according to listed as parts by weight, rushes down that to stop the sealing capsule be to make 1000 capsules finished products with tinosporae 400g, kuh-seng 400g, garden burnet 250g, leatherleaf mahonia 250g; It is characterized in that this detection method may further comprise the steps:
Proterties: this product is a capsule, and content is extremely tan particle and a powder of pale brown look, and gas is little, bitter;
Differentiate: (1) gets this product content 0.5g, adds methyl alcohol 10ml, and sonicated 15 minutes filters, and filtrate is as need testing solution; Other gets leatherleaf mahonia control medicinal material 0.1g, shines medicinal material solution in pairs with legal system, gets Berberine hydrochloride, palmatin hydrochloride, Jatrorrhizine chloride reference substance again, adds methyl alcohol respectively and makes the solution that contains 0.5mg among every 1ml, in contrast product solution; Test according to thin-layered chromatography, draw each 2 μ l of above-mentioned five kinds of solution, put respectively in same be on the silica gel g thin-layer plate of binder with the sodium carboxymethyl cellulose, with 6: 3: 1.5: toluene-ethyl acetate of 1.5: 0.5-methyl alcohol-isopropyl alcohol-strong ammonia solution was a developping agent, put in the pre-saturated expansion cylinder of ammonia steam, launch, take out, dry, put under the ultraviolet lamp of 365nm and inspect, in the test sample chromatogram, with control medicinal material chromatogram and the corresponding position of reference substance chromatogram on, show the fluorescence spot of same color respectively;
(2) get this product content 2g, put in the apparatus,Soxhlet's, use extracted by ether 2 hours, constantly replenish the ether amount; Extract volatilizes, and residue adds methyl alcohol 1ml dissolving, as need testing solution; Other gets tinosporae control medicinal material 1g, shines medicinal material solution in pairs with legal system, according to the thin-layered chromatography test, drawing each 3～5 μ l of above-mentioned two kinds of solution, put respectively in being on the silica gel g thin-layer plate of binder with a sodium carboxymethyl cellulose, is developping agent with toluene-methyl alcohol of 9: 1, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, under 105 ℃ of temperature, it is clear to dry by the fire spot colour developing, in the test sample chromatogram, with the corresponding position of control medicinal material chromatogram on, show the aubergine spot of same color;
(3) get this product content 2g, add chloroform 50ml, strong ammonia solution 0.6ml, placement is spent the night, and filters, and filtrate evaporate to dryness, residue add chloroform 0.5ml makes dissolving, as need testing solution; Other gets kuh-seng control medicinal material 0.5g, shines medicinal material solution in pairs with legal system, gets matrine, oxymatrine, Sophoridine reference substance again and adds ethanol respectively and make the solution that every 1ml contains 0.2mg, in contrast product solution; Test according to thin-layered chromatography, draw each 5 μ l of above-mentioned five kinds of solution, put respectively in same be on the silica gel g thin-layer plate of binder with the sodium carboxymethyl cellulose, with 6: 3: 1.5: toluene-ethyl acetate of 1.5: 0.5-methyl alcohol-isopropyl alcohol-strong ammonia solution was a developping agent, launch, take out, dry, spray is with rare bismuth potassium iodide test solution; In the test sample chromatogram, with control medicinal material chromatogram and the corresponding position of reference substance chromatogram on, show the spot of same color respectively;
(4) get this product content 5g, add methyl alcohol 30ml, sonicated 1 hour, filter, filtrate evaporate to dryness, residue add water 30ml gradation dissolving, put in the separating funnel, regulate pH value to 3～4 with hydrochloric acid, the jolting that adds diethyl ether is extracted twice, each 20ml merges ether solution, volatilizes, residue adds methyl alcohol 1ml makes dissolving, and as need testing solution, other gets garden burnet control medicinal material 2g, add water 50ml, reflux 30 minutes, put cold, centrifugal 10 minutes, get supernatant, extract 2 times with the ether jolting that hydrochloric acid is saturated, each 20ml merges ether solution, volatilize, residue adds methyl alcohol 1ml makes dissolving, and medicinal material solution is got the gallic acid reference substance more in contrast, add methyl alcohol and make the solution that every 1ml contains 0.5mg, in contrast product solution; Test according to thin-layered chromatography, draw each 10 μ l of above-mentioned three kinds of solution, put respectively in same be on the silica gel g thin-layer plate of binder with the sodium carboxymethyl cellulose, be developping agent with the water saturated toluene-ethyl acetate of 6: 3: 1 usefulness-formic acid, launch, take out, dry, spray is with 1% ferric trichloride ethanolic solution, in the test sample chromatogram, with control medicinal material chromatogram and the corresponding position of reference substance chromatogram on, show the spot of same color.
2. the quality determining method of capsule according to claim 1 is characterized in that, this detection method also comprises:
Check, should meet every regulation relevant under the capsule item;
Assay is according to high effective liquid chromatography for measuring;
Chromatographic condition and system suitability test: with octadecylsilane chemically bonded silica is filling agent; With 50: 25: 25 acetonitriles-0.025mol/L potassium dihydrogen phosphate-0.025mol/L lauryl sodium sulfate is moving phase, and the detection wavelength is 345nm, 30 ℃ of column temperatures; Number of theoretical plate calculates by the Berberine hydrochloride peak should be not less than 3000;
The preparation of reference substance solution: it is an amount of that precision takes by weighing the Berberine hydrochloride reference substance, adds methyl alcohol and make the solution that every 1ml contains 0.04mg, promptly;
The preparation of need testing solution: get the content under this product content uniformity item, porphyrize is got 0.5g, the accurate title, decide, and puts in the 50ml measuring bottle, adds hydrochloric acid-methanol solution 30ml of 1: 100, use power 250W, the sonicated of frequency 50KHz 30 minutes is taken out, put cold, hydrochloric acid-the methanol solution that adds 1: 100 shakes up to scale, with the miillpore filter filtration of 0.45 μ m, get subsequent filtrate, promptly;
Determination method: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject liquid chromatograph, measure, promptly;
Every of this capsule finished product contains leatherleaf mahonia with Berberine hydrochloride (C
20H
17O
4HCl) meter must not be less than 1.4mg.
3. quality determining method according to claim 1 and 2 is characterized in that, described rushing down stopped the sealing capsule and made according to following method:
Get above four flavors, tinosporae is ground into fine powder, sieves, the fine powder sterilization is standby, three flavor boilings such as meal and all the other kuh-sengs three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, filtrate was left standstill 12 hours, and getting supernatant concentration to 80 ℃ relative density is 1.20～1.25 clear cream, adds above-mentioned fine powder and appropriate amount of starch mixing, make particle, 80 ℃ of dryings incapsulate, promptly.
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| CN102552478A (en) * | 2010-12-16 | 2012-07-11 | 贵州万胜药业有限责任公司 | Quality detection method of Nine Ingredient Hemorrhoid Capsules |
| CN102961563B (en) * | 2012-12-11 | 2015-02-18 | 青岛农业大学 | Pharmaceutical composition for treating livestock and poultry dysentery and preparation method thereof |
| CN103245754B (en) * | 2013-05-15 | 2014-11-12 | 西南大学 | Improved radix sophorae flavescentis thin-layer chromatography identification method |
| CN103424501A (en) * | 2013-08-20 | 2013-12-04 | 广西迪泰制药有限公司 | Quality control method for TCM superfine preparation for hemorrhoids |
| CN104645151A (en) * | 2015-03-05 | 2015-05-27 | 于巧媛 | Traditional Chinese medicine for treating diarrhea due to improper diet |
| CN105287732A (en) * | 2015-11-25 | 2016-02-03 | 四川农业大学 | Pharmaceutical formulation for treating gastric ulcer and preparation method of pharmaceutical formulation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857478A (en) * | 2005-08-08 | 2006-11-08 | 贵州百灵企业集团制药有限公司 | Xietingfeng medicine preparation and its preparing process |
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| CN1857478A (en) * | 2005-08-08 | 2006-11-08 | 贵州百灵企业集团制药有限公司 | Xietingfeng medicine preparation and its preparing process |
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| 国家药品监督管理局编.泻停封胶囊.《国家药品中药标准》.2002,680. * |
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