CN101780161A - Capsule quality detection method - Google Patents
Capsule quality detection method Download PDFInfo
- Publication number
- CN101780161A CN101780161A CN200910306478A CN200910306478A CN101780161A CN 101780161 A CN101780161 A CN 101780161A CN 200910306478 A CN200910306478 A CN 200910306478A CN 200910306478 A CN200910306478 A CN 200910306478A CN 101780161 A CN101780161 A CN 101780161A
- Authority
- CN
- China
- Prior art keywords
- solution
- chromatograph
- methanol
- reference substance
- medicinal material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention discloses a Xietingfeng capsule quality detection method. On the basis of the original quality control, a TLC identification method of main ingredient radix tinosporae in the Xietingfeng capsule is added, and a preparation method for test object solution under a content determination item is revised; the content of benzene in developing solvent used in the identification method of the existing detection method is revised. The invention makes up for the shortage of the original detection method, improves the quality monitoring the level of the product, is favorable for monitoring products by management departments and ensures good health of inspection personal.
Description
Technical field
The invention belongs to the pharmaceutical technology field, relate to a kind of capsular quality determining method, the quality determining method of particularly a kind of anti-diarrheal capsule (the medicine name is rushed down and stopped the sealing capsule).
Background technology
Rush down and stop the sealing capsule and have heat-clearing and toxic substances removing, the function of dampness-eliminating and dysentery-stopping is used for diarrhoea, and dysentery is got ill from overeating and had loose bowels, epigastric pain, halitosis, belch, diseases such as acute chronic enteritis.Stop sealing in the capsular quality determining method existing rushing down, do not formulate the TLC discrimination method of characteristic index composition Radix Tinosporae, the content assaying method of Caulis Mahoniae is also perfect inadequately, and the control product quality is had certain influence; In the discrimination method of existing detection method, used developing solvent contains benzene, and easily the health to the testing staff damages.For further controlling the quality of this product, guarantee that the testing staff is healthy, should increase the TLC discrimination method of Radix Tinosporae, the preparation method of need testing solution under the revision assay item, the composition of " benzene " of used developing solvent in the discrimination method of the existing detection method of revision.
Summary of the invention
The objective of the invention is: provide a kind of rushing down to stop sealing capsular quality determining method.The present invention has increased on initial quality control basis rushes down the TLC discrimination method that stops main pharmaceutical compositions Radix Tinosporae in the sealing capsule, has revised the preparation method of need testing solution under the assay item; Revised the composition of " benzene " of used developing solvent in the discrimination method of existing detection method.The present invention has remedied the deficiency of former detection method, has improved the quality monitoring level of product, also helps administration section to product monitoring, has ensured that the testing staff's is healthy.
Purpose of the present invention can realize by following technical proposal: a kind of rushing down stops sealing capsular quality determining method, according to listed as parts by weight, rushes down that to stop the sealing capsule be to make 1000 capsules finished products with Radix Tinosporae 400g, Radix Sophorae Flavescentis 400g, Radix Sanguisorbae 250g, Caulis Mahoniae 250g; It is characterized in that this detection method may further comprise the steps:
Character: this product is a capsule, and content is that pale brown color is to tan granule and powder, feeble QI, bitter in the mouth;
Differentiate: (1) gets this product content 0.5g, adds methanol 10ml, and supersound process 15 minutes filters, and filtrate is as need testing solution.Other gets Caulis Mahoniae control medicinal material 0.1g, shines medical material solution in pairs with legal system, gets berberine hydrochloride, palmatine hydrochloride, Jatrorrhizine chloride reference substance again, adds methanol respectively and makes the solution that contains 0.5mg among every 1ml, in contrast product solution.Test according to thin layer chromatography, draw each 2 μ l of above-mentioned five kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with 6: 3: 1.5: toluene-ethyl acetate of 1.5: 0.5-methanol-isopropyl alcohol-strong ammonia solution was developing solvent, put in the pre-saturated expansion cylinder of ammonia steam, launch, take out, dry, put under the ultra-violet lamp of 365nm and inspect, in the test sample chromatograph, with control medicinal material chromatograph and the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color respectively;
(2) get this product content 2g, put in the apparatus,Soxhlet's, use ether extraction 2 hours, constantly replenish the ether amount.Extracting solution volatilizes, and residue adds methanol 1ml dissolving, as need testing solution.Other gets Radix Tinosporae control medicinal material 1g, shines medical material solution in pairs with legal system, according to the thin layer chromatography test, drawing each 3～5 μ l of above-mentioned two kinds of solution, put respectively in being on the silica gel g thin-layer plate of adhesive with a sodium carboxymethyl cellulose, is developing solvent with toluene-methanol of 9: 1, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, under 105 ℃ of temperature, it is clear to dry by the fire speckle colour developing, in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the aubergine speckle of same color;
(3) get this product content 2g, add chloroform 50ml, strong ammonia solution 0.6ml, placement is spent the night, and filters, and filtrate evaporate to dryness, residue add chloroform 0.5ml makes dissolving, as need testing solution.Other gets Radix Sophorae Flavescentis control medicinal material 0.5g, shines medical material solution in pairs with legal system, gets matrine, oxymatrine, sophoridine reference substance again and adds ethanol respectively and make the solution that every 1ml contains 0.2mg, in contrast product solution.Test according to thin layer chromatography, draw each 5 μ l of above-mentioned five kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with 6: 3: 1.5: toluene-ethyl acetate of 1.5: 0.5-methanol-isopropyl alcohol-strong ammonia solution was developing solvent, launch, take out, dry, spray is with rare bismuth potassium iodide test solution.In the test sample chromatograph, with control medicinal material chromatograph and the corresponding position of reference substance chromatograph on, show the speckle of same color respectively;
(4) get this product content 5g, add methanol 30ml, supersound process 1 hour, filter, filtrate evaporate to dryness, residue add water 30ml gradation dissolving, put in the separatory funnel, regulate pH value to 3～4 with hydrochloric acid, the jolting that adds diethyl ether is extracted twice, each 20ml merges ether solution, volatilizes, residue adds methanol 1ml makes dissolving, and as need testing solution, other gets Radix Sanguisorbae control medicinal material 2g, add water 50ml, reflux 30 minutes, put cold, centrifugal 10 minutes, get supernatant, extract 2 times with the ether jolting that hydrochloric acid is saturated, each 20ml merges ether solution, volatilize, residue adds methanol 1ml makes dissolving, and medical material solution is got the gallic acid reference substance more in contrast, add methanol and make the solution that every 1ml contains 0.5mg, in contrast product solution.Test according to thin layer chromatography, draw each 10 μ l of above-mentioned three kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, be developing solvent with the water saturated toluene-ethyl acetate of 6: 3: 1 usefulness-formic acid, launch, take out, dry, spray is with 1% ferric chloride alcoholic solution, in the test sample chromatograph, with control medicinal material chromatograph and the corresponding position of reference substance chromatograph on, show the speckle of same color.
Above-mentioned rushing down stops sealing in the capsular quality determining method, also comprises:
Check: should meet every regulation relevant under the capsule item:
Assay is according to high effective liquid chromatography for measuring;
Chromatographic condition and system suitability test: with octadecylsilane chemically bonded silica is filler; With 50: 25: 25 acetonitriles-0.025mol/L potassium dihydrogen phosphate-0.025mol/L sodium lauryl sulphate is mobile phase, and the detection wavelength is 345nm, 30 ℃ of column temperatures.Number of theoretical plate calculates by the berberine hydrochloride peak should be not less than 3000;
The preparation of reference substance solution: it is an amount of that precision takes by weighing the berberine hydrochloride reference substance, adds methanol and make the solution that every 1ml contains 0.04mg, promptly;
The preparation of need testing solution: get the content under this product content uniformity item, porphyrize is got 0.5g, the accurate title, decide, and puts in the 50ml measuring bottle, adds hydrochloric acid-methanol solution 30ml of 1: 100, use power 250W, the supersound process of frequency 50KHz 30 minutes is taken out, put cold, hydrochloric acid-the methanol solution that adds 1: 100 shakes up to scale, with the microporous filter membrane filtration of 0.45 μ m, get subsequent filtrate, promptly;
Algoscopy: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject chromatograph of liquid, measure, promptly;
Every of this capsule finished product contains Caulis Mahoniae with berberine hydrochloride (C
20H
17O
4HCl) meter must not be less than 1.4mg.
Aforementioned rushing down stops sealing in the capsular quality determining method, described rushing down stopped the sealing capsule and made according to following method: get above four flavors, Radix Tinosporae is ground into fine powder, sieve, the fine powder sterilization is standby, and three flavors such as coarse powder and all the other Radix Sophorae Flavescentiss decoct with water three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, and filtrate was left standstill 12 hours, get supernatant concentration to relative density and be 1.20～1.25 80 ℃ clear paste, add above-mentioned fine powder and appropriate amount of starch mixing, make granule, 80 ℃ of dryings, incapsulate, promptly.
Compared with prior art, the present invention controls to have increased on the basis in initial quality and rushes down TLC discrimination method that stops main pharmaceutical compositions Radix Tinosporae in the sealing capsule and the preparation method of having revised need testing solution; The composition " benzene " of existing discrimination method Central Plains developing solvent is replaced by safer " toluene ", has ensured that the testing staff's is healthy.The present invention has remedied the deficiency of proper mass control procedure, has improved the quality monitoring level of product, also helps administration section to product monitoring, has ensured that the testing staff's is healthy.
The specific embodiment
Embodiment: rush down and stop sealing capsular quality determining method,, rush down that to stop the sealing capsule be to make 1000 capsules finished products with Radix Tinosporae 400g, Radix Sophorae Flavescentis 400g, Radix Sanguisorbae 250g, Caulis Mahoniae 250g according to listed as parts by weight; It is characterized in that this detection method may further comprise the steps:
Character: this product is a capsule, and content is that pale brown color is to tan granule and powder, feeble QI, bitter in the mouth.
Differentiate: (1) gets this product content 0.5g, adds methanol 10ml, and supersound process 15 minutes filters, and filtrate is as need testing solution.Other gets Caulis Mahoniae control medicinal material 0.1g and (gets Caulis Mahoniae and each 0.1g of Radix Tinosporae control medicinal material in addition,), shine medical material solution in pairs with legal system, get berberine hydrochloride, palmatine hydrochloride, Jatrorrhizine chloride reference substance again, add methanol respectively and make the solution that contains 0.5mg among every 1ml, in contrast product solution.According to thin layer chromatography (" an appendix VI of Chinese pharmacopoeia version in 2005 B) test, draw each 2 μ l of above-mentioned five kinds of solution (drawing each 2 μ l of above-mentioned six kinds of solution), put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with toluene-ethyl acetate-methanol-isopropyl alcohol-strong ammonia solution (6: 3: 1.5: 1.5: 0.5) is developing solvent, put in the pre-saturated expansion cylinder of ammonia steam, launch, take out, dry, put under the ultra-violet lamp (365nm) and inspect, in the test sample chromatograph, with control medicinal material chromatograph and the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color respectively.
(2) get this product content 2g, put in the apparatus,Soxhlet's, use ether extraction 2 hours, constantly replenish the ether amount.Extracting solution volatilizes, and residue adds methanol 1ml dissolving, as need testing solution.Other gets Radix Tinosporae control medicinal material 1g, shine medical material solution in pairs with legal system, according to thin layer chromatography (" appendix IVB of Chinese pharmacopoeia version in 2005) test, draw each 3～5 μ l of above-mentioned two kinds of solution, put respectively in being on the silica gel g thin-layer plate of adhesive with a sodium carboxymethyl cellulose, with toluene-methanol (9: 1) is developing solvent, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, under 105 ℃ of temperature, it is clear to dry by the fire speckle colour developing, in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the aubergine speckle of same color.
(3) get this product content 2g, add chloroform 50ml, strong ammonia solution 0.6ml, placement is spent the night, and filters, and filtrate evaporate to dryness, residue add chloroform 0.5ml makes dissolving, as need testing solution.Other gets Radix Sophorae Flavescentis control medicinal material 0.5g, shines medical material solution in pairs with legal system, gets matrine, oxymatrine, sophoridine reference substance again and adds ethanol respectively and make the solution that every 1ml contains 0.2mg, in contrast product solution.According to thin layer chromatography (" an appendix VI of Chinese pharmacopoeia version in 2005 B) test, draw each 5 μ l of above-mentioned five kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with toluene-ethyl acetate-methanol-isopropyl alcohol-strong ammonia solution (6: 3: 1.5: 1.5: 0.5) is developing solvent, launch, take out, dry, spray is with rare bismuth potassium iodide test solution.In the test sample chromatograph, with control medicinal material chromatograph and the corresponding position of reference substance chromatograph on, show the speckle of same color respectively.
(4) get this product content 5g, add methanol 30ml, supersound process 1 hour, filter, filtrate evaporate to dryness, residue add water 30ml gradation dissolving, put in the separatory funnel, regulate pH value to 3～4 with hydrochloric acid, the jolting that adds diethyl ether is extracted twice, each 20ml merges ether solution, volatilizes, residue adds methanol 1ml makes dissolving, and as need testing solution, other gets Radix Sanguisorbae control medicinal material 2g, add water 50ml, reflux 30 minutes, put cold, centrifugal 10 minutes, get supernatant, extract 2 times with the ether jolting that hydrochloric acid is saturated, each 20ml merges ether solution, volatilize, residue adds methanol 1ml makes dissolving, and medical material solution is got the gallic acid reference substance more in contrast, add methanol and make the solution that every 1ml contains 0.5mg, in contrast product solution.According to thin layer chromatography (" an appendix VI of Chinese pharmacopoeia version in 2005 B) test, draw each 10 μ l of above-mentioned three kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, be developing solvent with toluene (using water saturation)-ethyl acetate-formic acid (6: 3: 1), launch, take out, dry, spray is with 1% ferric chloride alcoholic solution, in the test sample chromatograph, with control medicinal material chromatograph and the corresponding position of reference substance chromatograph on, show the speckle of same color.
Check: should meet every regulation relevant under the capsule item:
Assay: the photograph high performance liquid chromatography (" an appendix VI of Chinese pharmacopoeia version in 2005 D) measure.
Chromatographic condition and system suitability test: with octadecylsilane chemically bonded silica is filler; Acetonitrile-0.025mol/L potassium dihydrogen phosphate-0.025mol/L sodium lauryl sulphate (50: 25: 25) is a mobile phase, and the detection wavelength is 345nm, 30 ℃ of column temperatures.Number of theoretical plate calculates by the berberine hydrochloride peak should be not less than 3000.
The preparation of reference substance solution: it is an amount of that precision takes by weighing the berberine hydrochloride reference substance, adds methanol and make the solution that every 1ml contains 0.04mg, promptly.
The preparation of need testing solution: get the content under this product content uniformity item, porphyrize is got 0.5g, the accurate title, decide, and puts in the 50ml measuring bottle, adds hydrochloric acid-methanol solution (1: 100) 30ml, supersound process (power 250W, frequency 50KHz) 30 minutes is taken out, put cold, add hydrochloric acid-methanol solution (1: 100) to scale, shake up, filter with microporous filter membrane (0.45 μ m), get subsequent filtrate, promptly.
Algoscopy: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject chromatograph of liquid, measure, promptly.
Every of this capsule finished product contains Caulis Mahoniae with berberine hydrochloride (C
20H
17O
4HCl) meter must not be less than 1.4mg.
Rush down and stop the sealing capsule and make according to following method: get above four flavors, Radix Tinosporae is ground into fine powder, sieves, the fine powder sterilization is standby, and three flavors such as coarse powder and all the other Radix Sophorae Flavescentiss decoct with water three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, filtrate was left standstill 12 hours, got the clear paste that supernatant concentration to relative density is 1.20～1.25 (80 ℃), added above-mentioned fine powder and appropriate amount of starch mixing, make granule, 80 ℃ of dryings incapsulate, promptly.
Claims (3)
1. one kind rushes down and stops sealing capsular quality determining method, according to listed as parts by weight, rushes down that to stop the sealing capsule be to make 1000 capsules finished products with Radix Tinosporae 400g, Radix Sophorae Flavescentis 400g, Radix Sanguisorbae 250g, Caulis Mahoniae 250g; It is characterized in that this detection method may further comprise the steps:
Character: this product is a capsule, and content is that pale brown color is to tan granule and powder, feeble QI, bitter in the mouth;
Differentiate: (1) gets this product content 0.5g, adds methanol 10ml, and supersound process 15 minutes filters, and filtrate is as need testing solution.Other gets Caulis Mahoniae control medicinal material 0.1g, shines medical material solution in pairs with legal system, gets berberine hydrochloride, palmatine hydrochloride, Jatrorrhizine chloride reference substance again, adds methanol respectively and makes the solution that contains 0.5mg among every 1ml, in contrast product solution.Test according to thin layer chromatography, draw each 2 μ l of above-mentioned five kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with 6: 3: 1.5: toluene-ethyl acetate of 1.5: 0.5-methanol-isopropyl alcohol-strong ammonia solution was developing solvent, put in the pre-saturated expansion cylinder of ammonia steam, launch, take out, dry, put under the ultra-violet lamp of 365nm and inspect, in the test sample chromatograph, with control medicinal material chromatograph and the corresponding position of reference substance chromatograph on, show the fluorescence speckle of same color respectively;
(2) get this product content 2g, put in the apparatus,Soxhlet's, use ether extraction 2 hours, constantly replenish the ether amount.Extracting solution volatilizes, and residue adds methanol 1ml dissolving, as need testing solution.Other gets Radix Tinosporae control medicinal material 1g, shines medical material solution in pairs with legal system, according to the thin layer chromatography test, drawing each 3～5 μ l of above-mentioned two kinds of solution, put respectively in being on the silica gel g thin-layer plate of adhesive with a sodium carboxymethyl cellulose, is developing solvent with 9: 1 methylbenzene methanols, launch, take out, dry, spray is with 10% ethanol solution of sulfuric acid, under 105 ℃ of temperature, it is clear to dry by the fire speckle colour developing, in the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the aubergine speckle of same color;
(3) get this product content 2g, add chloroform 50ml, strong ammonia solution 0.6ml, placement is spent the night, and filters, and filtrate evaporate to dryness, residue add chloroform 0.5ml makes dissolving, as need testing solution.Other gets Radix Sophorae Flavescentis control medicinal material 0.5g, shines medical material solution in pairs with legal system, gets matrine, oxymatrine, sophoridine reference substance again and adds ethanol respectively and make the solution that every 1ml contains 0.2mg, in contrast product solution.Test according to thin layer chromatography, draw each 5 μ l of above-mentioned five kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with 6: 3: 1.5: toluene-ethyl acetate of 1.5: 0.5-methanol-isopropyl alcohol-strong ammonia solution was developing solvent, launch, take out, dry, spray is with rare bismuth potassium iodide test solution.In the test sample chromatograph, with control medicinal material chromatograph and the corresponding position of reference substance chromatograph on, show the speckle of same color respectively;
(4) get this product content 5g, add methanol 30ml, supersound process 1 hour, filter, filtrate evaporate to dryness, residue add water 30ml gradation dissolving, put in the separatory funnel, regulate pH value to 3～4 with hydrochloric acid, the jolting that adds diethyl ether is extracted twice, each 20ml merges ether solution, volatilizes, residue adds methanol 1ml makes dissolving, and as need testing solution, other gets Radix Sanguisorbae control medicinal material 2g, add water 50ml, reflux 30 minutes, put cold, centrifugal 10 minutes, get supernatant, extract 2 times with the ether jolting that hydrochloric acid is saturated, each 20ml merges ether solution, volatilize, residue adds methanol 1ml makes dissolving, and medical material solution is got the gallic acid reference substance more in contrast, add methanol and make the solution that every 1ml contains 0.5mg, in contrast product solution.Test according to thin layer chromatography, draw each 10 μ l of above-mentioned three kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, be developing solvent with the water saturated toluene-ethyl acetate of 6: 3: 1 usefulness-formic acid, launch, take out, dry, spray is with 1% ferric chloride alcoholic solution, in the test sample chromatograph, with control medicinal material chromatograph and the corresponding position of reference substance chromatograph on, show the speckle of same color.
2. according to claim 1 rushing down stops sealing capsular quality determining method, it is characterized in that, this detection method also comprises:
Check, should meet every regulation relevant under the capsule item;
Assay is according to high effective liquid chromatography for measuring;
Chromatographic condition and system suitability test: with octadecylsilane chemically bonded silica is filler; With 50: 25: 25 acetonitriles-0.025mol/L potassium dihydrogen phosphate-0.025mol/L sodium lauryl sulphate is mobile phase, and the detection wavelength is 345nm, 30 ℃ of column temperatures.Number of theoretical plate calculates by the berberine hydrochloride peak should be not less than 3000;
The preparation of reference substance solution: it is an amount of that precision takes by weighing the berberine hydrochloride reference substance, adds methanol and make the solution that every 1ml contains 0.04mg, promptly;
The preparation of need testing solution: get the content under this product content uniformity item, porphyrize is got 0.5g, the accurate title, decide, and puts in the 50ml measuring bottle, adds hydrochloric acid-methanol solution 30ml of 1: 100, use power 250W, the supersound process of frequency 50KHz 30 minutes is taken out, put cold, hydrochloric acid-the methanol solution that adds 1: 100 shakes up to scale, with the microporous filter membrane filtration of 0.45 μ m, get subsequent filtrate, promptly;
Algoscopy: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject chromatograph of liquid, measure, promptly;
Every of this capsule finished product contains Caulis Mahoniae in berberine hydrochloride (C20H17O4HCl), must not be less than 1.4mg.
3. quality determining method according to claim 1 and 2 is characterized in that, described rushing down stopped the sealing capsule and made according to following method:
Get above four flavors, Radix Tinosporae is ground into fine powder, sieves, the fine powder sterilization is standby, and three flavors such as coarse powder and all the other Radix Sophorae Flavescentiss decoct with water three times, 2 hours for the first time, second and third time each 1 hour, collecting decoction filters, filtrate was left standstill 12 hours, and getting supernatant concentration to 80 ℃ relative density is 1.20～1.25 clear paste, added above-mentioned fine powder and appropriate amount of starch mixing, make granule, 80 ℃ of dryings incapsulate, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009103064786A CN101780161B (en) | 2009-09-02 | 2009-09-02 | Capsule quality detection method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009103064786A CN101780161B (en) | 2009-09-02 | 2009-09-02 | Capsule quality detection method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101780161A true CN101780161A (en) | 2010-07-21 |
| CN101780161B CN101780161B (en) | 2011-09-21 |
Family
ID=42520385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009103064786A Active CN101780161B (en) | 2009-09-02 | 2009-09-02 | Capsule quality detection method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101780161B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552478A (en) * | 2010-12-16 | 2012-07-11 | 贵州万胜药业有限责任公司 | Quality detection method of Nine Ingredient Hemorrhoid Capsules |
| CN102961563A (en) * | 2012-12-11 | 2013-03-13 | 青岛农业大学 | Pharmaceutical composition for treating livestock and poultry dysentery and preparation method thereof |
| CN103245754A (en) * | 2013-05-15 | 2013-08-14 | 西南大学 | Improved radix sophorae flavescentis thin-layer chromatography identification method |
| CN103424501A (en) * | 2013-08-20 | 2013-12-04 | 广西迪泰制药有限公司 | Quality control method for TCM superfine preparation for hemorrhoids |
| CN104645151A (en) * | 2015-03-05 | 2015-05-27 | 于巧媛 | Traditional Chinese medicine for treating diarrhea due to improper diet |
| CN105287732A (en) * | 2015-11-25 | 2016-02-03 | 四川农业大学 | Pharmaceutical formulation for treating gastric ulcer and preparation method of pharmaceutical formulation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100548330C (en) * | 2005-08-08 | 2009-10-14 | 贵州百灵企业集团制药股份有限公司 | A kind of preparation method for the treatment of the pharmaceutical preparation of intestinal tract disease |
-
2009
- 2009-09-02 CN CN2009103064786A patent/CN101780161B/en active Active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552478A (en) * | 2010-12-16 | 2012-07-11 | 贵州万胜药业有限责任公司 | Quality detection method of Nine Ingredient Hemorrhoid Capsules |
| CN102961563A (en) * | 2012-12-11 | 2013-03-13 | 青岛农业大学 | Pharmaceutical composition for treating livestock and poultry dysentery and preparation method thereof |
| CN102961563B (en) * | 2012-12-11 | 2015-02-18 | 青岛农业大学 | Pharmaceutical composition for treating livestock and poultry dysentery and preparation method thereof |
| CN103245754A (en) * | 2013-05-15 | 2013-08-14 | 西南大学 | Improved radix sophorae flavescentis thin-layer chromatography identification method |
| CN103245754B (en) * | 2013-05-15 | 2014-11-12 | 西南大学 | Improved radix sophorae flavescentis thin-layer chromatography identification method |
| CN103424501A (en) * | 2013-08-20 | 2013-12-04 | 广西迪泰制药有限公司 | Quality control method for TCM superfine preparation for hemorrhoids |
| CN104645151A (en) * | 2015-03-05 | 2015-05-27 | 于巧媛 | Traditional Chinese medicine for treating diarrhea due to improper diet |
| CN105287732A (en) * | 2015-11-25 | 2016-02-03 | 四川农业大学 | Pharmaceutical formulation for treating gastric ulcer and preparation method of pharmaceutical formulation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101780161B (en) | 2011-09-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101780161B (en) | Capsule quality detection method | |
| CN102854281B (en) | Detection method of sugar-free strong loquat syrup | |
| CN102100818B (en) | Quality control method for lophanthus antifebrile tablets | |
| CN102139039B (en) | Quality control method of coptis tablet for clearing away stomach heat | |
| CN102038908B (en) | Detection method of tambac depression-alleviating pill as traditional Chinese medical preparation | |
| CN101204434A (en) | Quality standard for thrombus dispelling pill and test method thereof | |
| CN102038795B (en) | Detection method of five-nut demulcent pill as traditional Chinese medical preparation | |
| CN101229323B (en) | Lily oral liquid and quality standard and test method of pharmaceutical preparation thereof | |
| CN102379927B (en) | Preparation methods of poppy shell extract and cough tablet | |
| CN101623469B (en) | Detection method of Guwei collaterals-activating tincture | |
| CN101385808B (en) | Detection method of Zhubai tranquilizing pill | |
| CN1692930A (en) | Method for preparing tablet for treating rheumatism and bone-ache, and tech. for controlling its quality | |
| CN101607037B (en) | Detecting method of lanzhi brain-tranquilizing capsule | |
| CN101690756B (en) | Method for detecting cholecytitis rehabilitation capsules | |
| CN101711834A (en) | Method for preparing medicine composition preparation of refined tuber fleeceflower preparation | |
| CN101181562B (en) | Detection method of fructus momordicae compound preparations | |
| CN102166264A (en) | Shenshitong quality control method | |
| CN101366856B (en) | Quality control method for Chinese medicinal composition for treating ichthyosis | |
| CN101632804B (en) | Quality control method for wind-dispelling heat-dissipating capsules | |
| CN100522198C (en) | Prostatitis-treating capsule and its preparing method and quality control method | |
| CN102139048B (en) | Quality control method of tablet capable of improving eyesight and clearing heat | |
| CN101518619B (en) | Compound brain activation and comfort capsule and quality control method thereof | |
| CN102038807A (en) | Quality control method of traditional Chinese medicine preparation anti-rheumatoid arthritis pill | |
| CN100495023C (en) | Kidney-yang invigorating capsule with male larva, its preparation method and quality control method | |
| CN102048954A (en) | Quality control method for traditional Chinese medicine preparation of haworthia cooperi lung-protecting pill |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |