CN101766723B - Chinese medicine preparation for treating traumatic injury and rheumatic pain and preparation method thereof - Google Patents
Chinese medicine preparation for treating traumatic injury and rheumatic pain and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicine preparation for treating traumatic injury and rheumatic pain and a preparation method thereof. The Chinese medicine preparation comprises ardisia crenata, spotted ardisia, radix zanthoxyli, ichnocarpus oliganthous, ramulus cinnamomi, rhizome of Sichuan lovage, common fibraurea stem and camphor. The preparation method thereof comprises: performing percolation and other treatments, and finally obtaining the Chinese medicine preparation that can effectively treat wind-cold dampness arthralgia, scapulohumeral periarthritis, acute anklebone wrench and contuse and other diseases, and has good social and economic effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and method for making thereof for the treatment of traumatic injury, rheumatic ostalgia.
Background technology
According to " China's rheumatic four diseases epidemiology sampling survey ", rheumatism is 14% at natural person group's sickness rate of China, and special trade (weaving, steel machinery, chemical industry, mine oil, harbour, army) is up to 23.1%.Rheumatism comprises rheumatic fever, rheumatoid arthritis etc., and main ill crowd was at 40～60 years old; Present China estimates at 1.82 hundred million people and suffers from rheumatism.And rheumatic arthritis is one of main performance of rheumatic fever, show as migratory polyarthritis clinically, the joint of getting involved mostly is big joint such as knee joint, ankle, shoulder, elbow, wrist, commonly be transferred to another joint by a joint; the pathological changes part presents red, swollen, scorching hot, severe pain, the Chang Fanfu outbreak has had a strong impact on causing in daily life and work of patient; physiology, psychology to the patient cause very big influence, forms burden greatly for society.Though the Chinese medicine preparation of many treatment traumatic injury, rheumatic ostalgia is arranged at present clinically, and clinical effectiveness is all not satisfactory, and certain sense of discomfort and side effect are arranged.
Therefore, provide a kind of evident in efficacy, effect rapidly, the little treatment traumatic injury of side effect, the Chinese medicine preparation of rheumatic ostalgia have positive effect.
Summary of the invention
The present invention relates to a kind of Chinese medicine preparation for the treatment of traumatic injury, rheumatic ostalgia and preparation method thereof, that Chinese medicine preparation provided by the invention has is evident in efficacy, effect rapidly, the little characteristics of side effect.
A kind of Chinese medicine preparation for the treatment of traumatic injury, rheumatic ostalgia of the present invention is that the feedstock production by following weight parts forms:
DALUOSAN 90-120 Radix Ardisiae punctatae 60-80 Radix Zanthoxyli 90-120
Cortex Acanthopancis 60-80 Herba Asari 30-60 Rhizoma Chuanxiong 30-60
A kind of Chinese medicine preparation for the treatment of traumatic injury, rheumatic ostalgia of the present invention can also add the Fructus Gardeniae of 80～100 weight portions and the Camphora of 40～70 weight portions makes as assistant, promotes therapeutic effect.
A kind of preferred raw material of Chinese medicine preparation for the treatment of traumatic injury, rheumatic ostalgia of the present invention forms and the raw material weight proportioning is:
DALUOSAN 100 Radix Ardisiae punctatae 70 Radix Zanthoxylis 100 Cortex Acanthopanciss 70
Herba Asari 47 Rhizoma Chuanxiongs 47 Fructus Gardeniae 95 Camphoras 55
A kind of Chinese medicine preparation for the treatment of traumatic injury, rheumatic ostalgia of the present invention is formed by following prepared:
Above medicinal materials in part by weight, except Camphora, all the other are ground into coarse powder, according to the percolation under Chinese Pharmacopoeia appendix fluid extract and the extractum item, make solvent with 40～60% ethanol, with the speed of the about 2～6ml of per minute percolation slowly, collect the liquid of filtering of 4000～6000 weight portions, device is preserved in addition; After getting ethanol that Camphora adds 500～900 weight portions and making dissolving, with the above-mentioned liquid mixing of filtering, filter, namely.
A kind of preferred for preparation technology for the treatment of the Chinese medicine preparation of traumatic injury, rheumatic ostalgia of the present invention is:
Above medicinal materials in part by weight, except Camphora, all the other are ground into coarse powder, according to the percolation under Chinese Pharmacopoeia appendix fluid extract and the extractum item, make solvent with 53% ethanol, with the speed of the about 3ml of per minute percolation slowly, collect the liquid of filtering of 5300 weight portions, device is preserved in addition; After getting ethanol that Camphora adds 700 weight portions and making dissolving, with the above-mentioned liquid mixing of filtering, filter, namely.
The traditional Chinese medical science thinks, rheumatism belongs to the sick category of numbness, is that You Yifeng, cold, wet three heresies are main because wind, cold, wet, pathogenic heat gas cut are gone into human body and caused morbidity.The migratory BI-syndrome caused mainly by pathogenic wind; The cold survivor is arthralgia aggravated by cold; The dampness victor is damp arthralgia.Wind-cold damp pathogen impatency meridians and joint, stagnation of QI and blood may bring about pain is so cause joint swelling and pain.
The present invention is with DALUOSAN detumescence, pain relieving, blood stasis dispelling, and Radix Ardisiae punctatae is invigorated blood circulation, wind-damp dispelling is principal agent altogether.Be equipped with drug for invigorating blood circulation and eliminating stasis such as Radix Zanthoxyli, Rhizoma Chuanxiong, to strengthen principal agent reducing swelling and alleviating pain effect, be equipped with Herba Asari, Cortex Acanthopancis dispelling wind cold relieving again, the meridian dredging, bone and muscle strengthening is ministerial drug altogether.In above one warm drugs, the Fructus Gardeniae heat-clearing and toxic substances removing that is equipped with cold and cool product is adjuvant drug.Multiply each other on the contrary.Joining Camphora again with reducing swelling and alleviating pain and coordinating the actions of various ingredients in a prescription, serves as that assistant makes to be used for the refrigerant sense of skin or mucosa generation.All medicines share, and reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, wind dispelling collateral dredging, cold relieving removing dampness effect are arranged, and are used for anemofrigid-damp arthralgia, scapulohumeral periarthritis, acute jerk contused wound etc.
The specific embodiment
Embodiment 1
DALUOSAN 100g Radix Ardisiae punctatae 70g Radix Zanthoxyli 100g Cortex Acanthopancis 70g
Herba Asari 47g Rhizoma Chuanxiong 47g Fructus Gardeniae 95g Camphora 55g
The medical material of above recipe quantity, except Camphora, all the other are ground into coarse powder, according to the percolation under Chinese Pharmacopoeia appendix fluid extract and the extractum item, make solvent with 53% ethanol, with the speed of the about 3ml of per minute percolation slowly, the liquid of filtering of collection 5300g, other device preservation; After getting ethanol that Camphora adds 700g and making dissolving, with the above-mentioned liquid mixing of filtering, filter, namely.
Embodiment 2
DALUOSAN 90g Radix Ardisiae punctatae 60g Radix Zanthoxyli 90g Cortex Acanthopancis 60g
Herba Asari 30g Rhizoma Chuanxiong 30g Fructus Gardeniae 80g Camphora 40g
The medical material of above recipe quantity, except Camphora, all the other are ground into coarse powder, according to the percolation under Chinese Pharmacopoeia appendix fluid extract and the extractum item, make solvent with 40% ethanol, with the speed of the about 2ml of per minute percolation slowly, the liquid of filtering of collection 4000g, other device preservation; After getting ethanol that Camphora adds 500g and making dissolving, with the above-mentioned liquid mixing of filtering, filter, namely.
Embodiment 3
DALUOSAN 120g Radix Ardisiae punctatae 80g Radix Zanthoxyli 120g Cortex Acanthopancis 80g
Herba Asari 60g Rhizoma Chuanxiong 60g Fructus Gardeniae 100g Camphora 70g
The medical material of above recipe quantity, except Camphora, all the other are ground into coarse powder, according to the percolation under Chinese Pharmacopoeia appendix fluid extract and the extractum item, make solvent with 60% ethanol, with the speed of the about 6ml of per minute percolation slowly, the liquid of filtering of collection 6000g, other device preservation; After getting ethanol that Camphora adds 900g and making dissolving, with the above-mentioned liquid mixing of filtering, filter, namely.
Embodiment 4
DALUOSAN 100g Radix Ardisiae punctatae 70g Radix Zanthoxyli 100g
Cortex Acanthopancis 70g Herba Asari 47g Rhizoma Chuanxiong 47g
The medical material of above recipe quantity, except Camphora, all the other are ground into coarse powder, according to the percolation under Chinese Pharmacopoeia appendix fluid extract and the extractum item, make solvent with 50% ethanol, with the speed of the about 46ml of per minute percolation slowly, the liquid of filtering of collection 5000g, other device preservation; After getting ethanol that Camphora adds 600g and making dissolving, with the above-mentioned liquid mixing of filtering, filter, namely.
Embodiment 5
Medicinal liquid of the present invention is to exempting from the effect of ear perfusion flow
Get 20 rabbits, be divided into 4 groups at random, every group of 5 rabbits.Medicinal liquid low dose group of the present invention (abbreviation low dose group): once smear 0.3ml; Dosage group in the medicinal liquid of the present invention (dosage group in the abbreviation): once smear 0.6ml; Medicinal liquid high dose group of the present invention (abbreviation high dose group): once smear 1ml; Contrast medicine group: repercussive and analgesic tincture, once smear 0.5g.With rabbit pentobarbital sodium intraperitoneal injection of anesthesia, face upward the position and be fixed in the rabbit platform, cut off basal part of the ear portion hair, separate ear center tremulous pulse, and under it, wear the two wires, the proximal part ligation, heart side far away is done a kerf at the ligation position, inserts intubate, and the full rabbit ear is cut with pleasing to the ear of shears in the fixing back of ligation, pour into krebs solution through intubate immediately, blood in the flushing blood vessel, colourless until drip, at the glass plate that is 45 ° the rabbit ear is fixed, perfusate is dripped along the plate angle, adjust and drip 30 droplets/minute of speed, 37 ℃ of constant temperature of perfusate.Continuous record 5min drips number, averages as contrasting before the administration.After the administration, every the 10min record once, recorded 1 minute at every turn, measure the mean droplet number, calculate the per minute perfusion and drip several means standard deviation, take statistics to learn with the t check and handle.Result of the test sees Table 1.
Table 1: medicinal liquid of the present invention is to the influence of the rabbit ear perfusion flow that exsomatizes
*: with compare before the administration, P＜0.05 has significant difference.
As shown in Table 1, the trend (P＜0.05) of the perfusion flow that increases the rabbit ear that exsomatizes was arranged in 10 minutes behind high, the middle dosage medicinal liquid medicine of the present invention, the high dose group effect is more obvious; The effect of repercussive and analgesic tincture group is similar to medicinal liquid high dose group of the present invention.High dose in the medicinal liquid of the present invention (0.6ml/ only, 1ml/ only) has the trend that increases the rabbit ear perfusion flow that exsomatizes, this prompting, and medicinal liquid of the present invention has blood vessel dilating, blood circulation promoting effect.Medicinal liquid antiinflammatory action research of the present invention (to the influence of rat agar granulation)
Get female rats, be divided into 5 groups at random, be followed successively by blank group (distilled water), repercussive and analgesic tincture group (2.3ml/kg), dosage group (2.3ml/kg), medicinal liquid low dose group (1.15ml/kg of the present invention in medicinal liquid high dose group of the present invention (4.6ml/kg), the medicinal liquid of the present invention,), under the ether light anaesthesia, the sterile working, at rat back center line subcutaneous injection 2% agar solution 2ml, injection namely began administration the same day.Each group is evenly smeared corresponding test liquid every day 1 time respectively at back unhairing district, successive administration 14 days, and 24h takes off neck and puts to death rat after the last administration, and it is heavy to peel off the granuloma agar block, carries out the t check, and each group and blank group comparing difference significance the results are shown in Table 2.
Table 2 medicinal liquid of the present invention is to the granulomatous influence of rat (χ ± SD)
| Group | Number of animals | Dosage (ml/kg) | Granuloma weight (g/100g body weight) |
| The blank group | 10 | 2.3 | 0.648±0.231 |
| Low dose group | 10 | 1.15 | 0.639±0.271 |
| Middle dosage group | 10 | 2.3 | 0.431±0.147* |
| High dose group | 10 | 4.6 | 0.319±0.15** |
| The repercussive and analgesic tincture group | 10 | 2.3 | 0.367±0.123** |
Compare * P＜0.05, * *＜0.01 with the blank group
Result of the test shows, compares with the blank group, and positive control drug reducing swelling and alleviating pain group and medicinal liquid high dose group of the present invention can obviously suppress rat agar granuloma hypertrophy, have highly significant meaning (P＜0.01); Dosage group and matched group relatively through the t check, have statistical significance (P＜0.05) in the medicinal liquid of the present invention.The middle and high dosage of medicinal liquid of the present invention can obviously suppress the granuloma hypertrophy.
Medicinal liquid analgesic activity research of the present invention
Mice being put into the super thermostatic bath of heating, and keep on the metallic plate of 55 ℃ of temperature, serves as the pain indicator reaction to lick metapedes.From mice drop into hot plate to the time of licking metapedes as the pain threshold of reaction, the mice of selecting for use pain threshold to be no more than for 30 seconds, surpassing that the person rejects need not.
50 of the responsive mices of choosing are divided into 5 groups at random, are respectively the basic, normal, high dosage group of medicinal liquid of the present invention, repercussive and analgesic tincture group, blank group (distilled water).Each group of medicinal liquid of the present invention gives medicinal liquid 1.67 of the present invention, 3.33,6.67ml/kg respectively; The repercussive and analgesic tincture group gives repercussive and analgesic tincture 6.67ml/kg, and the blank group gives distilled water 6.67ml/kg.Every kind of medicine evenly is coated on respectively organizes the mice extremity.Be coated with continuous 7 days every day 2 times.The pain threshold of 30,60,120 minutes each mices of sequentially determining after the administration in the 7th day, and by different time measure respectively organize the medication of Mus pain threshold mean value calculation after pain threshold improve percentage rate, pain threshold surpassed 60 seconds persons in 60 seconds.Carry out the t check before respectively organizing pain threshold and administration after the administration, administration group pain threshold time expand and negative group are carried out the t check, the results are shown in Table 3.
Table 3 medicinal liquid of the present invention is to the influence of mice hot plate method pain threshold
Each organize after the pain threshold administration with administration before * P＜0.05 * * P＜0.01 of comparing
Mice external medicinal liquid of the present invention is used in conjunction 7 days, and 30,60 and 120 minutes pain thresholds, pain threshold each dosage group of time expand all have raising in various degree, and are dose dependent after the last administration.Onset in 30 minutes was kept about 2 hours after the analgesic effect administration.Behind (1.67,3.33 and 6.67ml/kg) medicinal liquid of the present invention of 3 kinds of dosage of mice external, pain threshold and threshold of pain time expand, all be dose dependent and improve.
Claims (1)
1. Chinese medicine preparation for the treatment of traumatic injury, rheumatic ostalgia is characterized in that it is that feedstock production by following weight portion forms:
DALUOSAN 90-120 Radix Ardisiae punctatae 60-80 Radix Zanthoxyli 90-120
Cortex Acanthopancis 60-80 Herba Asari 30-60 Rhizoma Chuanxiong 30-60.
2, the Chinese medicine preparation for the treatment of traumatic injury as claimed in claim 1, rheumatic ostalgia is characterized in that it is that feedstock production by following weight portion forms:
DALUOSAN 100 Radix Ardisiae punctatae 70 Radix Zanthoxylis 100
Cortex Acanthopancis 70 Herba Asaris 47 Rhizoma Chuanxiongs 47.
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| CN104940623B (en) * | 2015-06-05 | 2018-12-07 | 方惠章 | The preparation method of the traditional Chinese medicinal ointment of cure scapulohumeral periarthritis and cervical spondylosis |
| CN105168273A (en) * | 2015-10-15 | 2015-12-23 | 王仕珍 | Phododendron championae wine and preparation method thereof |
| CN105233077A (en) * | 2015-11-24 | 2016-01-13 | 黎世建 | External injury and rheumatism medicinal liquor and preparation method thereof |
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Address after: 545007 the Guangxi Zhuang Autonomous Region the Liujiang River County Liu Bao Liuzhou City Road No. 529 Patentee after: Huahong Pharmaceutical Group Co.,Ltd. of Guangxi Zhuang Autonomous Region Address before: 545007 the Guangxi Zhuang Autonomous Region the Liujiang River County Liu Bao Liuzhou City Road No. 529 Patentee before: HUAHONG PHARMACEUTICAL Co.,Ltd. GUANGXI ZHUANG AUTONOMOUS REGION |