CN101766626B - Blonanserin-contained oral preparation for treating schizophrenia - Google Patents
Blonanserin-contained oral preparation for treating schizophrenia Download PDFInfo
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Abstract
Disclosed is a Blonanserin-contained oral preparation for treating schizophrenia, using a 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine as ingredient, and one or more pharmaceutically acceptable excipients. The preparation method comprises the steps of mixing the 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine and the alternative thinner, adhesive, disintegrant, abhesive and lubricant with an appropriate amount of humectants to prepare soft wood, sieving to prepare wet granules, drying the wet granules, sieving and integrating the granules to prepare oral preparation, wherein, the Blonanserin is 0.1-30 per cent of the preparation by weight. The preparation is applicable to administrate 1-2 times per day in 1-2 preparation units each time, and used for controlling the concentration of the 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine in the plasma of human body, thus enabling the 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine to play a role in treatment.
Description
Technical field
The present invention relates to technical field of medicine, relate in particular to and contain 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9, oral formulations of 10-six hydrogen cycloocta-[b] pyridines and preparation method thereof.Take said preparation and make 2-(4-ethyl-1-the piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9 in the human plasma, 10-six hydrogen cycloocta-[b] pyridines maintain treatment level.
Background technology
Schizophrenia is a kind of disease that is split into characteristic with the cognitive power and the emotion degree of depth, shows as the most basic behavior of men and is affected, for example language, thought, consciousness and self-perception etc.The included scope of the symptom of this disease is wider, and modal is the obstacle of spiritual aspect, such as hallucinate, paranoea and illusion etc.
According to statistics, the prevalence rate of schizophrenia in the whole world is 0.5%～1.5%, and in the patient that all are received treatment, has only 5% finally can be able to return to one's perfect health.In addition; Because schizophrenia can cause complication usually; For example anxiety disorder, depression or mental drug abuse etc.; Show according to one of Datamonitor investigation, surpass the puzzlement that 1/3 (38%) schizophrenic will suffer at least one or diseases such as multinomial concurrent psychosis or cognitive disorder.Therefore; TB Ustun in 1999 in an investigation statistics that carries out to the global burden of mental disorder; Classify schizophrenia as global the third-largest disabling condition; Its rank forward even surpassed hemiplegia with blind, from then on, the too late disease that schizophrenia also becomes a complexion changed that makes us talking, keeps away.
The treatment schizophrenia drug is since early 1950s is found the antipsycholic action of chlorpromazine, and schizophrenia is main with Drug therapy always.Antipsychotic drug commonly used at present is divided into typical case and atypia two big classes by receptor blocking effect difference: typical psychosis is representative with chlorpromazine, haloperidol. the main mechanism of action is the blocking-up dopamine receptor; (hallucination, vain hope, excited restless, impulsive behavior etc.) have better curative effect to the schizoid positive symptom for they. and The extrapyramidal symptoms (EPS) is common simultaneously, and to negative symptoms (apathy, the poverty of thought, hypobulia etc.) weak curative effect; The anti-smart medicine that divides of atypia, the treatment spectrum is wider, and the negative symptoms effect obviously is superior to conventional medicament; Safe; Side effect is slighter, and taking dose is littler, a lot of more advanced dosage forms also occurred; Greatly improve patient's compliance, represented medicine that clozapine, risperidone, olanzapine, cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl etc. are arranged.
Blonanserin is 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7; 8; 9,10-six hydrogen cycloocta-[b] pyridines are atypia antischizophrinic things of new generation, are that European patent EP 0385237 is open the earliest; Explained its superior medical treatment public tender that, disclose it and be used to treat schizophrenia.The domestic no import of these article does not at present have the said preparation of production yet.The Spain and the U.S. are in the II clinical trial phase.2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9, the blonanserin general by name (Blonanserin) of 10-six hydrogen cycloocta-[b] pyridines, molecular formula: C
23H
30FN
3, molecular weight: 367.5, its structural formula is following:
It belongs to the medicine of the single-minded 5-HT2 of acting on receptor and D2 receptor, is the medicine that approaches selectively acting in the present atypical antipsychotic market most.Obviously improve schizoid positive shape (like hallucination, illusion etc.) and negative symptoms (as feel down in spirits, hypokinesia etc.); Reduce extrapyramidal system rate of side effects (parkinson's syndrome, acute dystonia, cathisophobia etc.) and other untoward reaction, the safety toleration obviously is superior to traditional antipsychotic drug.Appearance that we can say it is the much progress on the schizophrenia drug treatment history.As the schizoid line medication of treatment. will have broad application prospects in China.
Therefore be necessary to prepare a kind of being easy to carry, the oral formulations of taking convenience fills the domestic gaps.
Summary of the invention
The technical problem that the present invention will solve is to provide a kind of 2-of containing (4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9, oral formulations of 10-six hydrogen cycloocta-[b] pyridines and preparation method thereof.
The present invention provides the schizoid 2-of containing of a kind of treatment (4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9; The oral formulations of 10-six hydrogen cycloocta-[b] pyridines, said preparation contain 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7 of 0.1-30wt%; 8,9,10-six hydrogen cycloocta-[b] pyridines, said preparation has good moistening, disintegrating property; Can discharge medicine fast and fully, give full play to the therapeutical effect of active component, on the other hand, the present invention also provides 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5; 6,7,8,9; The method for preparing of the oral formulations of 10-six hydrogen cycloocta-[b] pyridines, said preparation is applicable to that the patient takes 1-2 time every day, each 1-2 preparation unit is with treatment schizophrenia.
" oral formulations " is meant disintegrate fully in gastrointestinal, and the preparation of release of active ingredients, said preparation are suitable for the patient to be taken 1-2 time easily every day, and each 1-2 preparation unit is with treatment schizophrenia.
Oral formulations of the present invention, it comprises 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6; 7; 8,9, the immixture of certain character that 10-six hydrogen cycloocta-[b] pyridines and suitable medicinal inert excipient are processed; Like compressed tablet or granule; Also can be in the outer gastric solubility coatings that covers of immixture with the outward appearance of improving preparation and stability etc., oral formulations of the present invention be meant active component in simulated gastric fluid in (common in vitro tests is the hydrochloric acid solution of preparation at 0.1mol/L) 30 minutes disintegrate discharge and be no less than 70%, promptly show discharge complete.Table 1 has been summarized the solubility property (with reference to Chinese Pharmacopoeia 2000 year version) of blonanserin under different pH value
Table 1 has been summarized the solubility property of blonanserin under different pH value
For active component disintegrate in human body is discharged fully, be necessary to select one or more inert excipients, this excipient can guarantee that the active component disintegrate discharges fully, and it is actual to meet China's industrialized great production again, and production technology is simple.If active agent preparation is stripping and being absorbed fully in human body, make that the activity component concentration in the individual blood plasma is widely different, be not easy to treatment, and unforeseeable untoward reaction might take place.
Therefore the schizoid oral formulations of treatment of the present invention comprises 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5 of 0.1-30wt%; 6; 7,8,9; 10-six hydrogen cycloocta-[b] pyridines and one or more pharmaceutically acceptable inert excipients, described oral formulations comprises tablet, capsule, granule; Described inert excipient comprises diluent, binding agent, disintegrating agent, antitack agent and lubricant; Described diluent be selected from lactose, microcrystalline Cellulose, pregelatinized Starch and starch, and composition thereof; Described binding agent be selected from sodium carboxymethyl cellulose, hyetellose, hyprolose, hydroxypropyl emthylcellulose, sodium alginate, methylcellulose, gelatin, polyvinylpyrrolidone, cellulose acetate, starch pregelatinized Starch, and composition thereof; Described disintegrating agent be selected from sodium carboxymethyl cellulose, microcrystalline Cellulose, cellulose powder, cross-linking sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, alginic acid, sodium alginate, pregelatinized Starch, starch, and composition thereof; Described antitack agent be selected from silicon dioxide, micropowder silica gel, magnesium trisilicate and Pulvis Talci, and composition thereof; Described lubricant be selected from magnesium stearate, Pulvis Talci, and composition thereof, described wetting agent is aqueous solution, ethanol water.
Contain in the oral formulations of the present invention: 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-six hydrogen cycloocta-[b] pyridine 0.1-30wt%, diluent 1-96wt%; Binding agent 2-20wt%; Disintegrating agent 0.5-15wt%; Antitack agent 0-5wt%; Lubricant 0.2-5wt%.
Oral formulations preferred ingredient of the present invention is formed: 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-six hydrogen cycloocta-[b] pyridine 0.2-25wt%, diluent 5-95wt%; Binding agent 4-18wt%; Disintegrating agent 2-8wt%; Antitack agent 0.3-4wt%; Lubricant 0.5-3wt%.
2-(4-ethyl-1-the piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9 that contains 2-16mg in the preparation of oral formulations of the present invention, 10-six hydrogen cycloocta-[b] pyridines are suitable for the patient and take 1-2 time every day, each 1-2 preparation unit.
Preferable absorbent is the mixture of pregelatinized Starch, lactose and microcrystalline Cellulose in the oral formulations of the present invention; Disintegrating agent is a cross-linking sodium carboxymethyl cellulose, and binding agent is a hydroxypropyl emthylcellulose, and antitack agent is micropowder silica gel, and lubricant is a magnesium stearate.
Also can be in the outer gastric solubility coatings that covers of preparation of the present invention to improve the outward appearance of preparation; The sense of taste and stability etc., the coating weightening finish is 0.1-20% with the weight ratio of compressed tablet, preferred 0.5-18%; The best is 1.0-15%, especially being made up of following component of preferred oral formulations of the present invention:
Wherein the concentration of alcohol in the ethanol water is 5-95wt%, preferred 20-75wt%.
The oral formulations of treatment schizophrenia of the present invention prepares as follows:
1) compressed tablet: active component and selectable diluent, binding agent and disintegrating agent are put in the mixer; Add an amount of wetting agent and process soft material; Soft material pressed suitable screen cloth to process granule, and it is dry immediately, and granulate sieves; With antitack agent and lubricant and the dried granule mix homogeneously of gained, tabletting promptly gets label.
Circular sheet character of the present invention, preferred method of granulating are to stir to granulate or the airpillow-dry granulation.
2) capsule: active component and selectable excipient are put in the mixer, added an amount of wetting agent and process soft material, soft material pressed suitable screen cloth to process granule; It is dry immediately; The granulate that sieves is with antitack agent and lubricant and the dried granule mix homogeneously of gained, in the snap fit capsule of packing into.
3) granule: active component and selectable excipient and correctives are put in the mixer, added an amount of wetting agent and process soft material, soft material pressed suitable screen cloth to process granule, and it is dry immediately, and the granulate that sieves is divided in the medicinal compound membrane bag.
The advantage of above-mentioned method for preparing is: the wetting agent of use is an ethanol water, and consumption is few, and preparation technology is simple, is suitable for domestic production technology and equipment condition.
The advantage of preparation of the present invention is:
Pharmaceutical preparation of the present invention is stable, and dissolubility is good in water, is convenient to preserve, transport, carry and clinical practice, and is clinical safe in utilization effective.
Preparation technology of the present invention is simple, is suitable for domestic production technology and equipment condition.
Therefore the present invention is favourable for enterprise and patient.
The specific embodiment
Below in conjunction with embodiment the present invention is done further explain, but should understand the non-scope that only limits to these embodiment of scope of the present invention.
Embodiment 1
Active component is the composition and the method for preparing of 2mg compressed tablet
With active component 2.0g, microcrystalline Cellulose 20.0g, pregelatinized Starch 15.0g, lactose 36.0g, cross-linking sodium carboxymethyl cellulose 6.0g, hydroxypropyl emthylcellulose 4.0g, mix homogeneously is a wetting agent system soft material with the 50wt% ethanol water; 30 eye mesh screens are granulated, 55 ℃ of aeration-dryings, granulate; Add micropowder silica gel 0.5g mixing; Press about 1000 round, every contains active component 2mg, promptly gets compressed tablet.
Embodiment 2
Active component is the composition and the method for preparing of 4mg compressed tablet
With active component 4.0g, microcrystalline Cellulose 40.0g, pregelatinized Starch 20.0g, lactose 66.0g, cross-linking sodium carboxymethyl cellulose 8.0g, hydroxypropyl emthylcellulose 8.0g, mix homogeneously is a wetting agent system soft material with the 50wt% ethanol water; 30 eye mesh screens are granulated, 55 ℃ of aeration-dryings, granulate; Add magnesium stearate 1g and micropowder silica gel 1g mixing; Press about 1000 round, every contains active component 4mg, promptly gets compressed tablet.
Embodiment 3
Active component is the composition and the method for preparing of 8mg compressed tablet
With active component 8.0g, microcrystalline Cellulose 60.0g, pregelatinized Starch 30.0g, lactose 100.0g, cross-linking sodium carboxymethyl cellulose 12.0g, mix homogeneously, be wetting agent system soft material with 3wt% hydroxypropyl emthylcellulose aqueous solution, 30 eye mesh screens are granulated; 55 ℃ of aeration-dryings; Granulate adds magnesium stearate 2g and micropowder silica gel 1g mixing, press about 1000 round; Every contains active component 8mg, promptly gets compressed tablet.
Embodiment 4
Active component is capsular composition of 4mg and method for preparing
With active component 4.0g, microcrystalline Cellulose 15.0g, pregelatinized Starch 15.0g, lactose 36.0g, cross-linking sodium carboxymethyl cellulose 4.0g, insert in the quick mixer granulator; Spraying the 40wt% ethanol water is wetting agent system soft material, and 40 eye mesh screens are granulated, 55 ℃ of aeration-dryings; Granulate; Add magnesium stearate 0.5g and micropowder silica gel 0.5g mixing, No. 4 bright hard capsules of fill make every capsules contain active component 4mg.
Embodiment 5
Active component is film-coated composition of 4mg and method for preparing
With active component 4.0g, microcrystalline Cellulose 40.0g, pregelatinized Starch 20.0g, lactose 66.0g, cross-linking sodium carboxymethyl cellulose 8.0g, hydroxypropyl emthylcellulose 8.0g, mix homogeneously is a wetting agent system soft material with the 50wt% ethanol water; 30 eye mesh screens are granulated, 55 ℃ of aeration-dryings, granulate; Add magnesium stearate 1g and micropowder silica gel 1g mixing tabletting; Compressed tablet bag OPADAY film, every contains active component 4mg, promptly gets Film coated tablets.
Embodiment 6
Active component is capsular composition of 16mg and method for preparing
With active component 16.0g, microcrystalline Cellulose 25.0g, pregelatinized Starch 25.0g, lactose 72.0g, cross-linking sodium carboxymethyl cellulose 10.0g, insert in the quick mixer granulator; Spraying the 30wt% ethanol water is wetting agent system soft material, and 40 eye mesh screens are granulated, 55 ℃ of aeration-dryings; Granulate; Add magnesium stearate 1g and micropowder silica gel 1g mixing, No. 2 bright hard capsules of fill make every capsules contain active component 16mg.
Embodiment 7
Active component is particulate composition of 8mg and method for preparing
With active component 8.0g, first class cellulose 50.0g, pregelatinized Starch 150.0g, lactose 150.0g, gelatin 10.0g, aspartame 0.05g, cross-linking sodium carboxymethyl cellulose 12.0g, mix homogeneously; With 3wt% hydroxypropyl emthylcellulose aqueous solution is wetting agent system soft material, and 18 eye mesh screens are granulated, 55 ℃ of aeration-dryings; Granulate; Be divided in the PVC clad aluminum foil bag, make every bag to contain active component 8mg, promptly get.
Embodiment 8
The preparation that external comparing embodiment 1-4 makes
Present embodiment is described not coated preparation that embodiment of the invention 1-4 the makes accordingly result according to relevant dissolution determination method test in two appendix of Chinese Pharmacopoeia version in 2005 in detail.
Dissolution: with 900ml, the 0.1mol/L hydrochloric acid solution is a dissolution medium according to dissolution method (two appendix X of Chinese Pharmacopoeia version in 2005 C, second method), and rotating speed is that per minute 50 changes; Operation in accordance with the law; In the time of 30 minutes, it is an amount of to get solution, filters; Subsequent filtrate 10ml measures, and table has been summed up the dissolution data of the prepared blonanserin preparation of embodiment of the invention 1-4.
The external stripping contrast of table embodiment 1-4
Last watch test data show that by embodiment 1-4 45 minutes basic releases fully in acid of technology implementation of the present invention, i.e. release is no less than 80%.
Claims (1)
1. the schizoid oral formulations that contains blonanserin of treatment is characterized in that, prepares 1000 its prescriptions and forms as follows:
Method for preparing comprises the steps:
1) with active component, microcrystalline Cellulose, pregelatinized Starch, lactose, cross-linking sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, mix homogeneously;
2) be wetting agent system soft material with the 50wt% ethanol water, 30 eye mesh screens are granulated;
3) 55 ℃ of aeration-dryings;
4) granulate adds magnesium stearate and micropowder silica gel mixing;
5) press 1000 round, every contains active component 4mg, promptly gets compressed tablet.
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102240270B (en) * | 2010-05-13 | 2013-01-02 | 丽珠医药集团股份有限公司 | Blonanserin tablet and preparation method thereof |
| JP5881700B2 (en) * | 2010-08-10 | 2016-03-09 | ルピン・リミテッド | Blonanserin oral release controlled pharmaceutical composition |
| CN102038685A (en) * | 2010-11-29 | 2011-05-04 | 天津市汉康医药生物技术有限公司 | Blonanserin medicine composition with capacity of improving oral absorbability |
| CN102078321A (en) * | 2010-12-31 | 2011-06-01 | 泰州万全医药科技有限公司 | Blonanserin-containing medicinal composition and preparation method thereof |
| CN102727453A (en) * | 2011-04-01 | 2012-10-17 | 北京德众万全医药科技有限公司 | Blonanserin dispersible tablet and its preparation method |
| CN102274162A (en) * | 2011-08-02 | 2011-12-14 | 无锡万全医药技术有限公司 | Solid composition comprising insoluble medicine and hydrophilic gel material and preparation method thereof |
| CN102949392A (en) * | 2012-11-27 | 2013-03-06 | 西安泰科迈医药科技有限公司 | Medicinal composition for treating schizophrenia and preparation method thereof |
| CN107080739A (en) * | 2017-04-17 | 2017-08-22 | 深圳市泛谷药业股份有限公司 | A kind of solid quick release blonanserin piece for being used to be administered orally and preparation method thereof |
| JP6946609B2 (en) * | 2017-06-08 | 2021-10-06 | 高田製薬株式会社 | Blonanserin-containing tablets |
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|---|---|---|---|---|
| EP0385237B1 (en) * | 1989-03-03 | 1994-06-29 | Dainippon Pharmaceutical Co., Ltd. | 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same |
| WO2007142295A1 (en) * | 2006-06-09 | 2007-12-13 | Dainippon Sumitomo Pharma Co., Ltd. | Novel tape preparation |
| CN101530412A (en) * | 2008-03-10 | 2009-09-16 | 北京德众万全医药科技有限公司 | Pharmaceutical composition of blonanserin and preparation method thereof |
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2008
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0385237B1 (en) * | 1989-03-03 | 1994-06-29 | Dainippon Pharmaceutical Co., Ltd. | 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same |
| WO2007142295A1 (en) * | 2006-06-09 | 2007-12-13 | Dainippon Sumitomo Pharma Co., Ltd. | Novel tape preparation |
| CN101530412A (en) * | 2008-03-10 | 2009-09-16 | 北京德众万全医药科技有限公司 | Pharmaceutical composition of blonanserin and preparation method thereof |
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| 王晓洁等.抗精神分裂症药布南色林的合成.《科教文汇(中旬刊)》.2007,(第12期),第219页. * |
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