CN101766561B - Antibacterial gel and preparation method thereof - Google Patents
Antibacterial gel and preparation method thereof Download PDFInfo
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- CN101766561B CN101766561B CN 200810107445 CN200810107445A CN101766561B CN 101766561 B CN101766561 B CN 101766561B CN 200810107445 CN200810107445 CN 200810107445 CN 200810107445 A CN200810107445 A CN 200810107445A CN 101766561 B CN101766561 B CN 101766561B
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Abstract
The invention discloses an antibacterial gel with good sterilizing and itch relieving efficacies and a preparation process thereof. The antibacterial gel comprises polyhexamthylene guanidine hydrochloride and borneol. The preparation method comprises the processes of preparing a substrate, proportioning and the like, and finally the antibacterial gel with exact curative effects and low toxic side effect is obtained. The antibacterial gel is mainly used for killing pathogens of staphyiococcus aureus, candida albicans, colibacillus and the like which result in gynecological inflammation, and has good social benefit and economic benefit.
Description
Technical field
The present invention relates to a kind of antibacterial gel and preparation technology thereof.
Background technology
Gynaecopathia threatens China's female body healthy, is rejuvenation trend; Women of child-bearing age's gynaecopathia sickness rate is more than 70%; The women is 100% vaginitis of suffering from various degree almost in life, and wherein having more than 5% due to illness, feelings have had a strong impact on normal operation and life; China has 400,000,000 women of surpassing will relate to Amino-Cerv.Gynecological inflammation mainly is divided into vaginitis, cervicitis and pelvic inflammatory disease, China married woman's gynaecopathia prevalence is 46.10%, rural women's prevalence 48.85%, city 41.26%, prevalence is high, the relapse rate height is the main feature of gynaecological inflammation disease, and this field medicine market demand is huge.
At present, antibiotic various in style on the market mostly is anti-bacterial lotion, exists administration time short, and drug effect waits not enough not lastingly.And water-soluable gel can fully contact the affected part, and effect is remarkable, lasting medicine, and the present invention aims to provide a kind of determined curative effect, the antibacterial gel that toxic and side effects is low.Mainly kill the pathogen such as the staphylococcus aureus that causes gynecological inflammation, Candida albicans, escherichia coli.
Summary of the invention
The invention provides a kind of antibacterial gel and preparation technology thereof, this antibacterial gel has good sterilization, antipruritic effect.
Antibacterial gel of the present invention is that the raw material by following weight portion is prepared from:
Polyhexamethylene biguanidine hydrochloride 3～7 Borneolum Syntheticums 0.5～1.5 propylene glycol 80～120
Hydroxyethyl-cellulose 20～30 purified water 800～1000
The preferred raw material weight proportioning of anti-bacterial lotion of the present invention is:
Polyhexamethylene biguanidine hydrochloride 5 Borneolum Syntheticums 1 propylene glycol 100
Hydroxyethyl-cellulose 25 purified water 900
Antibacterial gel of the present invention is prepared from by following technique:
The polyhexamethylene biguanidine hydrochloride of getting weight portion joins in the purified water of 600～900 weight portions and dissolves, and then adds hydroxyethyl-cellulose and stirs 20～60 minutes, places and makes abundant swelling in 3～6 hours, gets gel-type vehicle;
The Borneolum Syntheticum of getting weight portion adds in the propylene glycol of weight portion, stirs and makes it dissolving, gets mixed liquor;
Then mixed liquor is added and enter into gel-type vehicle, add again the purified water of 100～200 weight portions, stir, namely obtain antibacterial gel of the present invention.
The preferred preparation technology of anti-bacterial lotion of the present invention is:
The polyhexamethylene biguanidine hydrochloride of getting weight portion joins in the purified water of 800 weight portions and dissolves, and then adds hydroxyethyl-cellulose and stirs 30 minutes, places and makes abundant swelling in 4 hours, gets gel-type vehicle;
The Borneolum Syntheticum of getting weight portion adds in the propylene glycol of weight portion, stirs and makes it dissolving, gets mixed liquor;
Mixed liquor is added in the gel-type vehicle, add again the purified water of 100 weight portions, stir, namely obtain antibacterial gel of the present invention.
Water-soluable gel of the present invention can fully contact the affected part, and effect is remarkable, lasting medicine, and toxic and side effects is hanged down glue.Mainly kill the pathogen such as the staphylococcus aureus that causes gynecological inflammation, Candida albicans, escherichia coli, solved the defective of prior art.
The specific embodiment
Embodiment 1
Polyhexamethylene biguanidine hydrochloride 50g Borneolum Syntheticum 10g propylene glycol 1000g
Hydroxyethyl-cellulose 250g purified water 9000g
Method for making:
The polyhexamethylene biguanidine hydrochloride of getting recipe quantity joins in the purified water of 8000g and dissolves, and then adds hydroxyethyl-cellulose and stirs 30 minutes, places and makes abundant swelling in 4 hours, gets gel-type vehicle;
Get recipe quantity Borneolum Syntheticum add in the propylene glycol of recipe quantity, stir and make it dissolving, get mixed liquor;
Mixed liquor is added in the gel-type vehicle, add again the purified water of 1000g, stir, namely obtain antibacterial gel of the present invention.
Embodiment 2
Polyhexamethylene biguanidine hydrochloride 3g Borneolum Syntheticum 0.5g propylene glycol 80g
Hydroxyethyl-cellulose 20g purified water 800g
Method for making:
The polyhexamethylene biguanidine hydrochloride of getting recipe quantity joins in the purified water of 600g and dissolves, and then adds hydroxyethyl-cellulose and stirs 20 minutes, places and makes abundant swelling in 3 hours, gets gel-type vehicle;
Get recipe quantity Borneolum Syntheticum add in the propylene glycol of recipe quantity, stir and make it dissolving, get mixed liquor;
Mixed liquor is added in the gel-type vehicle, add again the purified water of 200g, stir, namely obtain antibacterial gel of the present invention.
Embodiment 3
Polyhexamethylene biguanidine hydrochloride 7g Borneolum Syntheticum 1.5g propylene glycol 120g
Hydroxyethyl-cellulose 30g purified water 1000g
Method for making:
The polyhexamethylene biguanidine hydrochloride of getting recipe quantity joins in the purified water of 900g and dissolves, and then adds hydroxyethyl-cellulose and stirs 60 minutes, places and makes abundant swelling in 6 hours, gets gel-type vehicle;
Get recipe quantity Borneolum Syntheticum add in the propylene glycol of recipe quantity, stir and make it dissolving, get mixed liquor;
Mixed liquor is added in the gel-type vehicle, add again the purified water of 100g, stir, namely obtain antibacterial gel of the present invention.
Embodiment 4
Get the antibacterial gel of the embodiment of the invention 1, effect 2min, 5min, 10min, 20min the results are shown in following table:
| Project | Experimental result |
| The test of Rabbits with Acute skin irritation | Nonirritant |
| The test of rabbit vagina mucosa irritation | Nonirritant |
| The abnormal reflection of guinea pig skin | Have no skin allergic reaction |
Embodiment 4
Get the anti-bacterial lotion of the embodiment of the invention 1, effect 2min, 5min, 10min, 20min the results are shown in following table:
Embodiment 5
The toxicological test situation:
| Project | Experimental result |
| The test of Rabbits with Acute skin irritation | Nonirritant |
| The test of rabbit vagina mucosa irritation | Nonirritant |
| The abnormal reflection of guinea pig skin | Have no skin allergic reaction |
Claims (4)
1. antibacterial gel it is characterized in that raw material by following weight portion is prepared from:
Polyhexamethylene biguanidine hydrochloride 0.6～1.4 Borneolum Syntheticum 0.5～1.5 propylene glycol 80～120
Hydroxyethyl-cellulose 20～30 purified water 800～1000.
2. antibacterial gel as claimed in claim 1 is characterized in that preferred raw material weight proportioning is:
Polyhexamethylene biguanidine hydrochloride 1 Borneolum Syntheticum 1 propylene glycol 100
Hydroxyethyl-cellulose 25 purified water 900.
3. antibacterial gel as claimed in claim 1 it is characterized in that being prepared from by following technique:
The polyhexamethylene biguanidine hydrochloride of getting weight portion joins in the purified water of 600～900 weight portions and dissolves, and then adds hydroxyethyl-cellulose and stirs 20～60 minutes, places and makes abundant swelling in 3～6 hours, gets gel-type vehicle;
The Borneolum Syntheticum of getting weight portion adds in the propylene glycol of weight portion, stirs and makes it dissolving, gets mixed liquor;
Then mixed liquor is added and enter into gel-type vehicle, add again the purified water of 100～200 weight portions, make the gross weight of final purified water be divided into 800～1000, stir, namely obtain antibacterial gel of the present invention.
4. antibacterial gel as claimed in claim 3 is characterized in that its preparation technology is:
The polyhexamethylene biguanidine hydrochloride of getting weight portion joins in the purified water of 800 weight portions and dissolves, and then adds hydroxyethyl-cellulose and stirs 30 minutes, places and makes abundant swelling in 4 hours, gets gel-type vehicle;
The Borneolum Syntheticum of getting weight portion adds in the propylene glycol of weight portion, stirs and makes it dissolving, gets mixed liquor;
Mixed liquor is added in the gel-type vehicle, add again the purified water of 100 weight portions, stir, namely obtain antibacterial gel of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200810107445 CN101766561B (en) | 2008-12-31 | 2008-12-31 | Antibacterial gel and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 200810107445 CN101766561B (en) | 2008-12-31 | 2008-12-31 | Antibacterial gel and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101766561A CN101766561A (en) | 2010-07-07 |
| CN101766561B true CN101766561B (en) | 2013-01-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200810107445 Active CN101766561B (en) | 2008-12-31 | 2008-12-31 | Antibacterial gel and preparation method thereof |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102204880A (en) * | 2011-01-31 | 2011-10-05 | 普正药业股份有限公司 | Disinfectant gellant for gynaecological external use and its preparation method |
| CN103741448B (en) * | 2013-12-17 | 2015-11-18 | 江苏金太阳纺织科技有限公司 | Cotton clothes treatment fluid that a kind of resisted shrinkage is fungi-proofing and preparation method thereof |
| CN109528631A (en) * | 2018-12-29 | 2019-03-29 | 南京神奇科技开发有限公司 | A kind of gynecological antibacterial hydrogel and preparation method thereof |
| CN110404009A (en) * | 2019-08-09 | 2019-11-05 | 吉安市御美丽健康产业股份有限公司 | A kind of antibacterial gel preparation and its preparation method and application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101124001A (en) * | 2004-12-21 | 2008-02-13 | 拜尔创新有限责任公司 | Infection-resistant polyurethane foams, method for producing the same and use thereof in antiseptic wound dressings |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101124001A (en) * | 2004-12-21 | 2008-02-13 | 拜尔创新有限责任公司 | Infection-resistant polyurethane foams, method for producing the same and use thereof in antiseptic wound dressings |
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| CN101766561A (en) | 2010-07-07 |
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Address after: 545100 no.529 Liubao Road, Liujiang District, Liuzhou City, Guangxi Zhuang Autonomous Region Patentee after: Huahong Pharmaceutical Group Co.,Ltd. of Guangxi Zhuang Autonomous Region Address before: 545007 the Guangxi Zhuang Autonomous Region the Liujiang River County Liu Bao Liuzhou City Road No. 529 Patentee before: HUAHONG PHARMACEUTICAL Co.,Ltd. GUANGXI ZHUANG AUTONOMOUS REGION |
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