CN101757957A - Variable channel miniature blood separator - Google Patents
Variable channel miniature blood separator Download PDFInfo
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- CN101757957A CN101757957A CN201010300876A CN201010300876A CN101757957A CN 101757957 A CN101757957 A CN 101757957A CN 201010300876 A CN201010300876 A CN 201010300876A CN 201010300876 A CN201010300876 A CN 201010300876A CN 101757957 A CN101757957 A CN 101757957A
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- raceway groove
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Abstract
The invention relates to a variable channel miniature blood separator in the technical field of medical apparatuses. The blood separator comprises a storage cavity, a plurality of channels, a collecting cavity, a substrate and a glass cover, wherein the storage cavity is arranged at one ends of the channels, and the collecting cavity is arranged at the other ends of the channels; the storage cavity, the channels and the collecting cavity are arranged on the substrate; the glass cover is connected with the substrate; and the glass cover is positioned above the storage cavity, the channels and the collecting cavity. The blood separator utilizes capillary action, and can be used in various environments without additionally supplied power. An ordinary blood separation technology at least needs that the magnitude order of collected blood is a milliliter order, while the blood separator adopts a micro processing technology, and the sizes of devices are small; and blood separation can be realized only by collecting blood of a nanoliter order, and obtained blood plasma is enough to be used for blood detection.
Description
Technical field
What the present invention relates to is a kind of device of technical field of medical instruments, in particular a kind of variable channel miniature blood separator.
Background technology
In recent years, along with the change of environment and eating habit, various lifestyle diseases and metabolic syndrome are perplexing many patients, as diabetes etc.And these diseases can be checked by blood testing.By detection to blood plasma in the blood, can draw the content of blood sugar, triglycerides, HDL-C etc., just can infer that with this health has or not this type of disease.Therefore, from blood, isolate blood plasma and become the important step that modern medicine detects.
Find through literature search prior art, China's document: modern mechanical, 2008 the 6th phases, people such as Xia Weidong disclose a kind of application study of new type auto blood separation system, this technology discloses two kinds of blood separators: a kind of is the automatic method blood separator that adopts automatic control chip, another kind is the separator that adopts artificial process, and both is essential identical, is based on all that the different densities characteristic that heterogeneity had of blood separates.The artificial process separator relies on more manpower, and the method separator is by carrying out blood the high speed rotation automatically, because action of centrifugal force, the cell that density is bigger will come with the less plasma separation of density.The equipment volume that this separator relied on is bigger, also need the power support, limited its environment for use, the disclosed automatic blood separator of this technology need add automatic chip control, further improved the cost of equipment, this separator only is fit to the separation of a large amount of blood, and the detection of disease only needs few blood to get final product sometimes, adopts this separator will cause unnecessary loss.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, a kind of variable channel miniature blood separator is provided, as power source, successively stop haemocyte, finally realize separating of blood plasma and haemocyte by becoming raceway groove with capillarity.The mechanism of this separator is simple, and separating rate is fast, and it is few to consume blood, need not the power support, can adopt micromachined to produce in batches, and is with low cost.
The present invention is achieved by the following technical solutions: the present invention includes: storage chamber, some raceway grooves, collecting chamber, substrate and glass covers, wherein: storage chamber is arranged at an end of raceway groove, collecting chamber is arranged at the other end of raceway groove, storage chamber, raceway groove and collecting chamber are arranged on the substrate, glass cover links to each other with substrate, and glass cover is positioned on storage chamber, raceway groove and the collecting chamber.
The length of described raceway groove is 700 ~ 7000 microns, and the diameter of raceway groove one end is 20 microns, and the diameter of the other end is that 2 microns described diameters are per 100 ~ 1000 microns and successively decrease 2 ~ 10 microns.
Described raceway groove is arranged in parallel, and the spacing of two raceway grooves is 20 microns.
The length of described storage chamber and collecting chamber and width are 800 ~ 1000 microns, and the degree of depth is 20 microns.
The length of described glass cover is 2500 ~ 10000 microns, and width is 1000 ~ 1200 microns, highly is 10 microns.
Described glass cover is provided with input hole and delivery outlet, and input hole links to each other with storage chamber, and delivery outlet links to each other with collecting chamber.
The present invention has the following advantages compared to existing technology: the present invention utilizes capillarity, do not need additionally to provide power, can in various environment, use, the blood magnitude that common blood isolation technics needs to gather at least is the milliliter level, and the present invention adopts Micrometer-Nanometer Processing Technology, and device size is little, only need to gather and receive the blood of upgrading and just can realize the blood separation, gained blood plasma is enough to be used in blood testing, can adopt micromachined to produce in batches, and is with low cost.
Description of drawings
Fig. 1 is a structural representation of the present invention;
Fig. 2 is the profile of single raceway groove.
The specific embodiment
Below in conjunction with accompanying drawing embodiments of the invention are elaborated: present embodiment is being to implement under the prerequisite with the technical solution of the present invention, provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
As shown in Figure 1, present embodiment comprises: storage chamber 1, raceway groove 2, collecting chamber 3, glass cover 4 and substrate 5, wherein: storage chamber 1 is arranged at an end of the maximum open of raceway groove 2, collecting chamber 3 is arranged at an end of the minimal openings of raceway groove 2, storage chamber 1, raceway groove 2 and collecting chamber 3 are made by Micrometer-Nanometer Processing Technology and are arranged on the substrate 5, glass cover 4 links to each other with substrate 5, glass cover 4 is positioned at storage chamber 1, on raceway groove 2 and the collecting chamber 3, glass cover 4 is provided with input hole 6 and delivery outlet 7, input hole 6 links to each other with storage chamber 1, delivery outlet 7 links to each other with collecting chamber 3, as the input of blood and the output of blood plasma.
The length of storage chamber 1 and collecting chamber 3 and width are 800 microns, and the degree of depth is 20 microns.
The length of glass cover 4 is 2500 microns, and width is 1000 microns, and thickness is 10 microns.
As shown in Figure 2, the length of raceway groove 2 is 700 microns, and maximum open place diameter is 20 microns, reduces to 15 microns, 10 microns, 8 microns, 6 microns, 4 microns and 2 microns every 100 micron diameters, and minimal openings place diameter is 2 microns.
Present embodiment is made mask plate earlier, makes the planar graph of raceway groove 2 figures and storage chamber 1 and collecting chamber 3 on mask plate; Spin coating photoresist on substrate 5 utilizes mask plate that substrate 5 is exposed then; Substrate 5 after further will exposing develops and etching, forms storage chamber 1, collecting chamber 3 and raceway groove 2; The glass cover 4 that will be provided with input hole 6 and delivery outlet 7 at last and substrate 5 be bonding mutually.
During present embodiment work, by the input hole on the glass cover 46 blood is splashed into storage chamber 1, according to capillarity, blood can flow to collecting chamber 3 along raceway groove 2, because the diameter of raceway groove 2 is along with the direction of advance of blood is constantly dwindled, so the cell in the blood just is blocked in the raceway groove 2.Cell dia in the blood is greatly between 20 to 3 microns, most of cell can be stopped that all blood plasma just comes with cell separation like this by raceway groove 2, and final blood plasma all flows into collecting chamber 3, by the delivery outlet on the glass cover 47 plasma flow is gone out at last, test.
Claims (6)
1. variable channel miniature blood separator, it is characterized in that, comprise: storage chamber, some raceway grooves, collecting chamber, substrate and glass covers, wherein: storage chamber is arranged at an end of raceway groove, collecting chamber is arranged at the other end of raceway groove, storage chamber, raceway groove and collecting chamber are arranged on the substrate, and glass cover links to each other with substrate, and glass cover is positioned on storage chamber, raceway groove and the collecting chamber.
2. variable channel miniature blood separator according to claim 1, it is characterized in that, the length of described raceway groove is 700 ~ 7000 microns, and the diameter of raceway groove one end is 20 microns, and the diameter of the other end is that 2 microns described diameters are per 100 ~ 1000 microns and successively decrease 2 ~ 10 microns.
3. according to claim 1 or 2 described variable channel miniature blood separators, it is characterized in that described raceway groove is arranged in parallel, the spacing of two raceway grooves is 20 microns.
4. variable channel miniature blood separator according to claim 1 is characterized in that, the length of described storage chamber and collecting chamber and width are 800 ~ 1000 microns, and the degree of depth is 20 microns.
5. variable channel miniature blood separator according to claim 1 is characterized in that, the length of described glass cover is 2500 ~ 10000 microns, and width is 1000 ~ 1200 microns, highly is 10 microns.
6. according to claim 1 or 5 described variable channel miniature blood separators, it is characterized in that described glass cover is provided with input hole and delivery outlet, input hole links to each other with storage chamber, and delivery outlet links to each other with collecting chamber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010300876A CN101757957A (en) | 2010-01-28 | 2010-01-28 | Variable channel miniature blood separator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010300876A CN101757957A (en) | 2010-01-28 | 2010-01-28 | Variable channel miniature blood separator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101757957A true CN101757957A (en) | 2010-06-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010300876A Pending CN101757957A (en) | 2010-01-28 | 2010-01-28 | Variable channel miniature blood separator |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103706413A (en) * | 2013-12-18 | 2014-04-09 | 上海交通大学 | Microfluidic phase change type bubble micro-pump valve and method thereof |
-
2010
- 2010-01-28 CN CN201010300876A patent/CN101757957A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103706413A (en) * | 2013-12-18 | 2014-04-09 | 上海交通大学 | Microfluidic phase change type bubble micro-pump valve and method thereof |
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Open date: 20100630 |