CN101747328A - Synthesis method of single-ring imipenem p-nitro benzyl ester - Google Patents
Synthesis method of single-ring imipenem p-nitro benzyl ester Download PDFInfo
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- CN101747328A CN101747328A CN200910231289A CN200910231289A CN101747328A CN 101747328 A CN101747328 A CN 101747328A CN 200910231289 A CN200910231289 A CN 200910231289A CN 200910231289 A CN200910231289 A CN 200910231289A CN 101747328 A CN101747328 A CN 101747328A
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- monocycle
- nitrobenzyl ester
- south
- synthetic method
- bromine
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Batch | Temperature of reaction/℃ | Brominated reagent | Yield |
??1 | ??0~-5 | Bromine | ??81.0% |
Batch | Temperature of reaction/℃ | Brominated reagent | Yield |
??2 | ??0~-5 | Potassium Bromide | ??82.5% |
??3 | ??-10~-15 | The N-bromo-succinimide | ??84.2% |
??4 | ??-10~-15 | Potassium Bromide | ??88.2% |
??5 | ??-20~-25 | Bromine | ??83.2% |
??6 | ??-20~-25 | Potassium Bromide | ??84.8% |
Batch | Temperature of reaction/℃ | Reaction times/h | Yield |
??1 | ??-5~-10 | ??4.5 | ??86.4% |
??2 | ??0~-5 | ??3 | ??85.8% |
??3 | ??0~5 | ??2.5 | ??90.0% |
??4 | ??5~10 | ??2 | ??86.2% |
??5 | ??10~15 | ??1 | ??85.2% |
??6 | ??15~20 | ??0.5 | ??83.2% |
Batch | Oxygenant | Catalyzer | Yield |
??1 | Hydrogen peroxide | The molybdenum ammonium vanadate | ??98.9% |
??2 | Peracetic Acid | ??--- | ??94.2% |
??3 | Potassium bichromate | Tetramethyl Ethylene Diamine | ??94.6% |
Batch | Oxygenant | Catalyzer | Yield |
??4 | Potassium Persulphate | N, the N-dimethyl benzylamine | ??94.3% |
??5 | Potassium permanganate | Sulfuric acid | ??93.7% |
??6 | Manganse Dioxide | Ammonium meta-vanadate | ??93.2% |
Batch | Temperature of reaction ℃ | Reaction times h | Product purity | Product yield |
??1 | ??70~75 | ??8 | ??95.5% | ??82.9% |
??2 | ??75~80 | ??6 | ??96.3% | ??83.0% |
??3 | ??80~90 | ??5 | ??98.5% | ??83.1% |
??4 | ??90~100 | ??4 | ??98.8% | ??83.2% |
??5 | ??100~105 | ??4 | ??99.7% | ??90.2% |
??6 | ??120~130 | ??3 | ??95.3% | ??83.1% |
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN200910231289A CN101747328A (en) | 2009-12-22 | 2009-12-22 | Synthesis method of single-ring imipenem p-nitro benzyl ester |
Applications Claiming Priority (1)
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CN200910231289A CN101747328A (en) | 2009-12-22 | 2009-12-22 | Synthesis method of single-ring imipenem p-nitro benzyl ester |
Publications (1)
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CN101747328A true CN101747328A (en) | 2010-06-23 |
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CN200910231289A Pending CN101747328A (en) | 2009-12-22 | 2009-12-22 | Synthesis method of single-ring imipenem p-nitro benzyl ester |
Country Status (1)
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CN (1) | CN101747328A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111004231A (en) * | 2019-12-18 | 2020-04-14 | 凯莱英医药集团(天津)股份有限公司 | Continuous synthesis method of tazobactam intermediate |
-
2009
- 2009-12-22 CN CN200910231289A patent/CN101747328A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111004231A (en) * | 2019-12-18 | 2020-04-14 | 凯莱英医药集团(天津)股份有限公司 | Continuous synthesis method of tazobactam intermediate |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: SHANDONG RUNZE PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: HEZE RUICHANG CHEMICAL CO., LTD. Effective date: 20110111 |
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C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Wang Hui Inventor after: Sun Peng Inventor after: Sun Jiancai Inventor after: Sun Fusuo Inventor after: Han Zhenyu Inventor after: Guo Heguang Inventor before: Sun Peng Inventor before: Han Zhenyu Inventor before: Guo Heguang Inventor before: Wang Mingqing |
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COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: SUN PENG HAN ZHENYU GUO HEGUANG WANG MINGQING TO: WANG HUI SUN PENG SUN JIANCAI SUN FUSUO HAN ZHENYU GUO HEGUANG Free format text: CORRECT: ADDRESS; FROM: 274000 HEZE RUICHANG CHEMICAL CO., LTD., HELOU OFFICE, MUDAN DISTRICT, HEZECITY, SHANDONG PROVINCE TO: 274000 NORTH SECTION OF KUNMING ROAD, MUDAN INDUSTRIAL PARK, HEZE CITY, SHANDONG PROVINCE |
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TA01 | Transfer of patent application right |
Effective date of registration: 20110111 Address after: 274000 north section of Kunming Road, peony Industrial Park, Shandong, Heze Applicant after: Shandong Runze Pharmaceutical Co., Ltd. Address before: 274000, Shandong, Heze Province Peony District office building Heze Rui Chang Chemical Co., Ltd. Applicant before: Heze Ruichang Chemical Co., Ltd. |
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C12 | Rejection of a patent application after its publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20100623 |