CN101745138A - Dressing preparation method of antibacterial amorphous hydrogel based on biological properties - Google Patents
Dressing preparation method of antibacterial amorphous hydrogel based on biological properties Download PDFInfo
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- CN101745138A CN101745138A CN201010017661A CN201010017661A CN101745138A CN 101745138 A CN101745138 A CN 101745138A CN 201010017661 A CN201010017661 A CN 201010017661A CN 201010017661 A CN201010017661 A CN 201010017661A CN 101745138 A CN101745138 A CN 101745138A
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Abstract
The invention discloses a dressing preparation method of an antibacterial amorphous hydrogel based on biological properties, which comprises the following steps: step 1, weighing water, adding sodium carboxymethyl cellulose to the water slowly at normal temperature, stirring, completely dissolving the sodium carboxymethyl cellulose, and putting aside to prepare a component A; step 2, weighing water, adding sodium alginate to the water at normal temperature, quickly stirring, completely dissolving the sodium alginate, and putting aside for future use to prepare a component B, step 3, weighing water, adding Saxifraga dshagalensis rubber to the water at normal temperature, stirring at a high shearing speed, completely dissolving the Saxifraga dshagalensis rubber, and putting aside for future use to prepare a component C; step 4, weighing water, adding epsilon-polylysine to the water, slowly stirring, and putting aside for future use to prepare a component D; and step 5, mixing the component A, the component B and the component C together, stirring at the high shearing speed, slowly stirring so that the components A, B and C are dissolved mutually, and slowly adding the component D, adequately dissolving the component D to form a gel, sterilizing and packaging in a bottle for use.
Description
Technical field
The present invention relates to a kind of based on biological nature can antibacterial amorphous hydrogel dressing preparation method.
Background technology
At present clinically at wound care, all be to adopt common absorbent carbasus, microporous membrane to wait nuring wound, this method makes wound be in a kind of dried state easily, has influenced the progress of wound healing greatly, and may produce a large amount of cicatrixs.
Summary of the invention
The invention provides a kind of based on biological nature can antibacterial amorphous hydrogel dressing preparation method, the dressing that it makes can stop blooding, sterilize, promote wound healing, and can reduce cicatrix.
The present invention has adopted following technical scheme: a kind of based on biological nature can antibacterial amorphous hydrogel dressing preparation method, it may further comprise the steps: step 1, take by weighing water, slowly in water, add sodium carboxymethyl cellulose and stirring at room temperature, make it dissolve the back placement fully and leave standstill on one side, make the A component; Step 2 takes by weighing water, adds sodium alginate under the room temperature and stir fast in water, makes it dissolve the back fully and places stand-byly on one side, makes the B component; Step 3 takes by weighing water, adds the high shear of pawl ear glue under the room temperature and stir in water, makes it dissolve the back fully and places stand-byly on one side, makes the component into C.Step 4 takes by weighing water, adds epsilon-polylysine and stir at a slow speed in water, and placement is stand-by on one side, makes the D component.Step 5 is mixed A component, B component, C component being clipped in one, stirs under the speed of high shear, stirs at a slow speed again, slowly adds the D component again after it is dissolved each other, and it is fully dissolved form gelinite sterilization back bottling and use.
Water in the described step 1 is 1000 grams, and sodium carboxymethyl cellulose is 5 grams-30 grams, and sodium carboxymethyl cellulose is the sodium carboxymethyl cellulose of medical grade, and the particle diameter of sodium carboxymethyl cellulose is the 500-1000 order, and the time of leaving standstill is 2 hours.Water in the described step 2 is 1000 grams, and sodium alginate is 10 grams-20 grams, and sodium alginate is the sodium alginate of medical grade, and the content of glucuronic acid is more than 20% in sodium alginate, and the time of stirring is 15-20 minute fast.Water in the described step 3 is 1000 grams, and pawl ear glue is 5 grams-10 grams, and pawl ear glue is the pawl ear glue of medical grade.Water in the step 4 is the 300-500 milliliter, and epsilon-polylysine is the 2-5 gram, and epsilon-polylysine is the epsilon-polylysine of medical grade, and the purity of epsilon-polylysine is more than 99%, and the time of Jiao Baning is 10 minutes at a slow speed.The time of stirring under the speed of high shear in the step 5 is 10 minutes, and the time of Jiao Baning is 20 minutes, sterilizes and adopt cobalt 60 to sterilize at a slow speed.The viscosity of the gelinite that makes in the step 5 is 1000-5000 li primary.
The present invention has following beneficial effect: the present invention adopts sodium alginate, sodium carboxymethyl cellulose and pawl ear glue are carrier, add the antibacterial epsilon-polylysine and be the indefinite form hydrogel that the aerogel dressing of main body forms through the sterilization of cobalt 60 irradiation-induced degradations, sodium carboxymethyl cellulose plays and has played debridement when absorbing transudate again, sodium alginate, sodium carboxymethyl cellulose and pawl ear glue are with after wound contacts, its active function can be through biodegradation, be dissolved in the sepage, make wound keep moistening, dressing and wound also keep peeling off fully state, and prevent teleneuron death, can be used for postoperative nursing, short, hemostasis, debridement, antimicrobial effect, and can make wound keep wet microenvironment and promote wound healing, the hypertrophy that suppresses cicatrix simultaneously, play the effect that reduces cicatrix, and because its flexibility, compliance and do not damage wound surface.
The specific embodiment
The present invention be a kind of based on biological nature can antibacterial amorphous hydrogel dressing preparation method, it may further comprise the steps: step 1, take by weighing water 1000 grams, slowly in water, add-30 gram medical grade sodium carboxymethyl cellulose and the stirrings of 5 grams at room temperature, making it dissolve the back placement fully left standstill 2 hours on one side, make the A component, the particle diameter of sodium carboxymethyl cellulose is the 500-1000 order; Step 2 takes by weighing water 1000 gram, adds 10 grams-20 gram medical grade sodium alginates under the room temperature and stirred fast 15-20 minute in water, makes it dissolve the back fully and places stand-byly on one side, makes the B component, and the content of glucuronic acid is more than 20% in sodium alginate; Step 3 takes by weighing water 1000 gram, adds-10 gram medical grade pawl ear glue high shears of 5 grams under the room temperature and stir in water, makes it dissolve the back fully and places stand-byly on one side, makes the component into C; Step 4 is measured 500 milliliters in water, adds 2-5 gram medical grade epsilon-polylysine and stirred at a slow speed 10 minutes in water, and the purity of epsilon-polylysine is more than 99%, and placement is stand-by on one side, makes the D component; Step 5, A component, B component, the mixing of C component are clipped in one, under the speed of high shear, stirred 10 minutes, stirred at a slow speed again 20 minutes, after being dissolved each other, it slowly adds the D component again, it is fully dissolved adopt cobalt 60 sterilization back bottlings to use after the back forms gelinite, the viscosity of the gelinite that makes is 1000-5000 li primary.
Claims (7)
- One kind based on biological nature can antibacterial amorphous hydrogel dressing preparation method, it may further comprise the steps:Step 1 takes by weighing water, slowly adds sodium carboxymethyl cellulose and stirring at room temperature in water, makes it dissolve the back placement fully and leaves standstill on one side, makes the A component;Step 2 takes by weighing water, adds sodium alginate under the room temperature and stir fast in water, makes it dissolve the back fully and places stand-byly on one side, makes the B component;Step 3 takes by weighing water, adds the high shear of pawl ear glue under the room temperature and stir in water, makes it dissolve the back fully and places stand-byly on one side, makes the component into C;Step 4 takes by weighing water, adds epsilon-polylysine and stir at a slow speed in water, and placement is stand-by on one side, makes the D component;Step 5 is mixed A component, B component, C component being clipped in one, stirs under the speed of high shear, stirs at a slow speed again, slowly adds the D component again after it is dissolved each other, make its fully dissolve the back form gelinite after the sterilization bottling use.
- 2. according to claim 1 based on biological nature can antibacterial amorphous hydrogel dressing preparation method, it is characterized in that the water in the described step 1 is 1000 grams, sodium carboxymethyl cellulose is 5 grams-30 grams, sodium carboxymethyl cellulose is the sodium carboxymethyl cellulose of medical grade, the particle diameter of sodium carboxymethyl cellulose is the 500-1000 order, and the time of leaving standstill is 2 hours.
- 3. according to claim 1 based on biological nature can antibacterial amorphous hydrogel dressing preparation method, it is characterized in that the water in the described step 2 is 1000 grams, sodium alginate is 10 grams-20 grams, sodium alginate is the sodium alginate of medical grade, the content of glucuronic acid is more than 20% in the sodium alginate, and the time of stirring is 15-20 minute fast.
- 4. according to claim 1 based on biological nature can antibacterial amorphous hydrogel dressing preparation method, it is characterized in that the water in the described step 3 is 1000 grams, pawl ear glue is 5 grams-10 grams, pawl ear glue is the pawl ear glue of medical grade.
- 5. according to claim 1 based on biological nature can antibacterial amorphous hydrogel dressing preparation method, it is characterized in that the water in the step 4 is the 300-500 milliliter, epsilon-polylysine is the 2-5 gram, epsilon-polylysine is the epsilon-polylysine of medical grade, the purity of epsilon-polylysine is more than 99%, and the time of Jiao Baning is 10 minutes at a slow speed.
- 6. according to claim 1 based on biological nature can antibacterial amorphous hydrogel dressing preparation method, it is characterized in that the time of stirring in the step 5 is 10 minutes under the speed of high shear, the time of Jiao Baning is 20 minutes at a slow speed, and sterilization adopts cobalt 60 to sterilize.
- 7. according to claim 1 based on biological nature can antibacterial amorphous hydrogel dressing preparation method, the viscosity that it is characterized in that the gelinite that makes in the step 5 is 1000-5000 li primary.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101954114A (en) * | 2010-08-13 | 2011-01-26 | 北京赛奇科科技有限公司 | Gel coating accessory capable of preventing brain surgery cerebrospinal fluid leakage |
| CN101954113A (en) * | 2010-08-13 | 2011-01-26 | 北京赛奇科科技有限公司 | Gel coating suite capable of preventing infection and leakage after eye surgery |
| CN101961504A (en) * | 2010-08-13 | 2011-02-02 | 北京赛奇科科技有限公司 | Gel coating accessory capable of preventing spinal surgery cerebrospinal fluid leakage |
| CN103705966A (en) * | 2013-12-18 | 2014-04-09 | 褚加冕 | Preparation method of biological water flow gelatin dressings |
| CN104857556A (en) * | 2015-05-15 | 2015-08-26 | 东华大学 | Chemical grafted type long-acting sustained-release silk suture with antibacterial function and preparation method of silk suture |
| CN104871037A (en) * | 2012-12-21 | 2015-08-26 | 库柏维景国际控股公司 | Antimicrobial ophthalmic contact lenses |
| CN104857550A (en) * | 2015-05-29 | 2015-08-26 | 南京工业大学 | Epsilon-polylysine-p-hydroxybenzene propanoic acid antibiotic hydrogel dressing and preparation method thereof |
| CN105052928A (en) * | 2015-08-25 | 2015-11-18 | 钱夕华 | Preparing method for high-concentration NAA gel |
| CN107519541A (en) * | 2017-08-21 | 2017-12-29 | 上海鹏冠生物医药科技有限公司 | A kind of hydrogel for preventing Postoperative Adhesion of Abdominal Cavity Surgery and its preparation method and application |
| CN107746433A (en) * | 2017-09-14 | 2018-03-02 | 天津科技大学 | A kind of preparation method of cellulose base antibacterial material dialdehyde cellulose lysine |
Citations (2)
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| CN1919350A (en) * | 2006-09-18 | 2007-02-28 | 俞锋 | New pattern compress for treating skin mucosa injury and its preparation method |
| CN1944495A (en) * | 2006-09-29 | 2007-04-11 | 北京大学 | Water gel containing natural high molecule and its radiation preparing method |
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2010
- 2010-01-09 CN CN201010017661A patent/CN101745138A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1919350A (en) * | 2006-09-18 | 2007-02-28 | 俞锋 | New pattern compress for treating skin mucosa injury and its preparation method |
| CN1944495A (en) * | 2006-09-29 | 2007-04-11 | 北京大学 | Water gel containing natural high molecule and its radiation preparing method |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101954113A (en) * | 2010-08-13 | 2011-01-26 | 北京赛奇科科技有限公司 | Gel coating suite capable of preventing infection and leakage after eye surgery |
| CN101961504A (en) * | 2010-08-13 | 2011-02-02 | 北京赛奇科科技有限公司 | Gel coating accessory capable of preventing spinal surgery cerebrospinal fluid leakage |
| CN101961504B (en) * | 2010-08-13 | 2014-03-19 | 北京赛奇科科技有限公司 | Gel coating accessory capable of preventing spinal surgery cerebrospinal fluid leakage |
| CN101954114B (en) * | 2010-08-13 | 2014-03-19 | 北京赛奇科科技有限公司 | Gel coating accessory capable of preventing brain surgery cerebrospinal fluid leakage |
| CN101954113B (en) * | 2010-08-13 | 2014-03-19 | 北京赛奇科科技有限公司 | Gel coating suite capable of preventing infection and leakage after eye surgery |
| CN101954114A (en) * | 2010-08-13 | 2011-01-26 | 北京赛奇科科技有限公司 | Gel coating accessory capable of preventing brain surgery cerebrospinal fluid leakage |
| CN104871037A (en) * | 2012-12-21 | 2015-08-26 | 库柏维景国际控股公司 | Antimicrobial ophthalmic contact lenses |
| CN103705966A (en) * | 2013-12-18 | 2014-04-09 | 褚加冕 | Preparation method of biological water flow gelatin dressings |
| CN104857556A (en) * | 2015-05-15 | 2015-08-26 | 东华大学 | Chemical grafted type long-acting sustained-release silk suture with antibacterial function and preparation method of silk suture |
| CN104857550A (en) * | 2015-05-29 | 2015-08-26 | 南京工业大学 | Epsilon-polylysine-p-hydroxybenzene propanoic acid antibiotic hydrogel dressing and preparation method thereof |
| CN105052928A (en) * | 2015-08-25 | 2015-11-18 | 钱夕华 | Preparing method for high-concentration NAA gel |
| CN107519541A (en) * | 2017-08-21 | 2017-12-29 | 上海鹏冠生物医药科技有限公司 | A kind of hydrogel for preventing Postoperative Adhesion of Abdominal Cavity Surgery and its preparation method and application |
| CN107746433A (en) * | 2017-09-14 | 2018-03-02 | 天津科技大学 | A kind of preparation method of cellulose base antibacterial material dialdehyde cellulose lysine |
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Application publication date: 20100623 |