Circadian rhythm disorder therapeutic instrument and preparation method thereof
Technical field
The present invention relates to circadian rhythm disorder therapeutic instrument, particularly a kind of manufacture method of utilizing therapeutic instrument He this instrument of monochromatic light therapy circadian rhythm disorder.
Background technology
Recently a great discovery is arranged in field of biology, exactly in retina except rod cell that everybody was familiar with experience the cone cell of red, green, blue, also have a kind of photoreceptor cell to come judgement time, can adjust people's circadian rhythm (circadian rhythm) by their response by light.The main sensitive wave length of these found new photoreceptor cells is between 420-500nm, and this wave band that is to say that in the aeruginous spectral region these cells are very responsive to high colour temperature.At noon the time-division, the colour temperature of natural light will reach 6000-20000K, and time-division between the lights, colour temperature is reduced to about 2000K.The cyclically-varying of natural light colour temperature and people's circadian rhythm are synchronous.The evolution in millions of years of human process has formed circadian system, and it is coordinating the running of health each several part, makes it neat as one, with the biochemical function operation in an orderly manner on time of guaranteeing health.
But the circadian rhythm system that this natural light forms in human body in the industrial society of today, is changed regularly, and the mankind have been formed many adverse influences.In nowadays nearly all industry, round-the-clock running has become standard, people more are the irradiation that receives dull artificial light source daytimes, add the break tour at night and stride time zone flight travelling, these all affect the normal operation of the rhythm and pace of moving things system of human body, make it phase shift, even various biorhythies get muddled in the body.Regular circadian rhythm variation has brought huge physical and psychological pressure, is having a strong impact on people's health, activity in production, jeopardizes people's life sometimes or causes great accident.Therefore develop that a kind of effectively to regulate the circadian brand-new lighting source of human body very necessary, the circadian position phase that it can change the people both economical, easily reduces the resistance of position phase shift, works at night and strides time zone flight travelling thereby adapt to rapidly; Simultaneously, the best performance time that it can also adjustment movement person's competitiveness, adapt to the needs of match; Regulate patient's biorhythm, adapt to needs of medical treatment or the like.
Visible light therapy is meant the method for using the luminous ray treatment disease that can cause the retina light sensation with suitable intensity and time, and it can influence the time and the length of sleep, improves the emotion and the physiological situation of depressive illness.Up to the present, the used instrument of treatment has developed the three generations.The light source of first generation instrument is full gloss spectrum or the fluorescent lamp that produces cold white light, and about 2500lx illumination is provided; Second generation instrument is through improving, and has advantages such as miniaturization, portable, aesthetic in appearance, easy operating, and it has filtered out ultraviolet and blue light fully, and about 10000lx illumination can be provided.About 1 foot away from eyes of patient be of the fluorescent screen of this light source reaches work surface from top to bottom, and the light of a not too dazzling undertint is provided, and generally can both tolerate; The instrument of the third generation and dazzling rayed relatively, with outdoor morning of computer simulation spring and summer and dusk progressive dim light, the situation in the time can sleeping according to the patient after the dark adaptation provides the rayed of dim relatively dynamic change.Use strong illumination, energy antidepressant, correction is drowsiness, change is slept cycle and pattern.
During treatment, be divided into daystart, noon, treatment at night by the time for the treatment of.The time that daystart generally begins serial therapy can be arranged in clear-headedly carries out after 10 minutes morning, all should be in the Most patients treatment early than the recovery time on basis, the benefit of daystart treatment is to make the 24 hours period rhythm and pace of moving things in advance, and the change of this available mensuration melatonin at night secretion time confirms; The situation that the quality of antidepressant effect can shift to an earlier date according to the cycle and deciding, after waking up, custom carries out 10000lx, 30 minutes treatment, antidepressant effect and melatonin secretion and treatment time are remarkable negative correlation, in order to improve therapeutic effect as far as possible, the clinicist can measure the melatonin in patient's saliva or measure the method for hypothermia period and infer the excretory time of its melatonin.Noon treatment, effect be not as good as daystart and night, but can be used for the adjustment of the 24 hours period rhythm and pace of moving things.Night, treatment generally was arranged in 9:00~10:00 in evening, the precontract of promptly sleeping 2 hours.Treat used light source and be divided into high light, weak (secretly) light according to the size of illuminance.The high light treatment refers to illuminance 〉=2500lx; Weak (secretly) light treatment refers to illuminance≤500lx.In addition, the length according to treatment time is divided into long time and treatment in short-term.Long time refers to treatment time 〉=2 hour; Refer to treatment time≤1 hour in short-term, in general illuminance is big more, and used light application time is short more, and vice versa.
Long-time high-intensity white light will be brought nearly 42 kinds side effect, the most important thing is, nearest theoretical research shows, in traditional white light phototherapy, the existence of spectrum opposition effect (spectral opponency) make white light to circadian draw far below monochromatic light, and the circadian rhythm draw with blue light (420-500nm) is the strongest in the monochromatic light.It is calculated that, under the equal-wattage, the 2-5 that the draw of blue light is about reddish yellow light doubly, 185 times of white light.On the other hand, when 100 times of the light intensity decreasings of blue light, its traction effect to the rhythm and pace of moving things just reduces half, thus use at present monochromatic light particularly blue light to change the research of biorhythm a lot.
Usually adopt LED as blue light source.LED is that semiconductor electronic, hole-recombination are luminous, realizes that than being easier to monochromatic light light source, traditional light source obtain the monochromatic light light source and then must can cause higher optical energy loss but use electric filament lamp to add optical filter by professional equipments such as monochromators.Along with the development of GaN sill and device technology, the monochromatic light LED of the long-life blue light-green glow of high efficiency is very easy to obtain.
The someone has applied for the patent that some utilize led light source change human body circadian rhythm (or biological clock) at present.As the United States Patent (USP) (US 6350275) in June, 1998, its used light source is the blue green light LED of 420-575nm, and paster (SMD) LED is installed on the interior embodiment as it of spectacle frame.This patent has also been used the application-specific IC system that transfers bundle, regulates wavelength and regulate brightness, and LED drives by rechargeable battery.The difficult point of this patent is the design of integrated circuit, and weak point is, the one, because the luminescent spectrum width of LED is in 20nm in the market, if wavelength-tunable, then the number of devices of SMD LED will be very many, be unfavorable for the installation in mirror holder, and the 2nd, angular adjustment is in fact also quite difficult, need be installed in the LED of diverse location, different encapsulation angles in a large number, this will increase cost in light source and mirror holder design.Crucial a bit is, the method that this patent provides can't weaken the axial light intensity of led light source, and this may cause local damage to retina, causes very big risk thereby it is promoted the use of.
Summary of the invention
The objective of the invention is to overcome the defective of above-mentioned prior art, the instrument of a kind of LED of utilization institute bill coloured light treatment circadian rhythm disorder is provided, utilize liquid crystal backlight (backlight) principle of LED, led light source is evenly scattered in exiting surface, make the lens of similar liquid crystal backlight, to guarantee amphiblestroid safety in the irradiation treatment.The present invention also provides a kind of manufacture method of circadian rhythm disorder therapeutic instrument.
For achieving the above object, technical scheme of the present invention provides a kind of circadian rhythm disorder therapeutic instrument, comprise that spectacle is framed, patch light-emitting diode module and power supply, also comprise and be assemblied in the LGP of described spectacle in framed, described LGP is positioned at the exiting surface below of described patch light-emitting diode module, evenly scatter with output light described patch light-emitting diode module, weaken axial light intensity, wherein, described LGP utilizes the liquid crystal backlight principle of LED, and led light source is evenly scattered in exiting surface.
Wherein, two exiting surfaces of described LGP post diffusion barrier, prismatic lens, protecting film respectively symmetrically, and luminous energy is penetrated from the LGP surface equably.
Wherein, described patch light-emitting diode module comprises:
Patch light-emitting diode is used to obtain monochromatic light;
Reflecting mirror is used to reflect light and veiling glare dorsad;
Drive circuit is used to drive patch light-emitting diode work;
Fin, the heat that produces when being used to discharge drive circuit works.
Wherein, described power supply comprises rechargeable battery, booster circuit and variable constant current drive circuit, is installed in the power pack, and power pack is connected by lead with described patch light-emitting diode.
Wherein, be carved with reflective groove, metallic channel, leaded light board slot in described spectacle is framed, reflective rooved face all posts reflective membrane, has guaranteed the maximization to optical energy utilization efficiency; Metallic channel is used for lead-in conductor; The leaded light board slot is used to the LGP of packing into.
The present invention also provides a kind of manufacture method of circadian rhythm disorder therapeutic instrument, at first makes the framed structure of spectacle, and making step afterwards comprises:
S1. LGP is installed on described spectacle framed in;
S2. the patch light-emitting diode module that is welded with patch light-emitting diode, band reflecting mirror is fixed on the edge of described LGP, described LGP is positioned at the exiting surface below of described patch light-emitting diode module;
S3. stick diffusion barrier, prismatic lens, protecting film respectively symmetrically at described LGP two exiting surfaces;
S4. rechargeable battery, booster circuit and variable constant current drive circuit are put into power pack and be connected access switch and regulating current device in described circuit connects successively;
S5. described power pack is connected by lead with described patch light-emitting diode;
Wherein, described LGP utilizes the liquid crystal backlight principle of LED, led light source
In exiting surface, evenly scatter.
Compared with prior art, technical scheme of the present invention has following advantage:
The invention has the advantages that, weaken, to guarantee the safety of human eye retina in the irradiation treatment by the axial light intensity of LGP technology to led light source.Simultaneously, the present invention also have portable, succinct, merrily and lightheartedly, do not disturb lot of advantages such as normal activity, energy-conservation, not heat production, no harmful radiation.
Description of drawings
Fig. 1 is the overall structure sketch map of the circadian rhythm disorder therapeutic instrument of the embodiment of the invention;
Fig. 2-1,2-2 are the framed internal structure sketch map of spectacle in the circadian rhythm disorder therapeutic instrument of the embodiment of the invention;
Fig. 3 is a patch light-emitting diode modular structure sketch map in the circadian rhythm disorder therapeutic instrument of the embodiment of the invention;
Fig. 4 is a guiding device structural representation in the circadian rhythm disorder therapeutic instrument of the embodiment of the invention;
Fig. 5 is a patch light-emitting diode module drive power supply sketch map in the circadian rhythm disorder therapeutic instrument of the embodiment of the invention;
Wherein, the 1-spectacle is framed; The 2-LED light source; The 3-guiding device; The 4-power supply; The 5-flexible circuit conductor; The reflective groove of 11-; 12-mirror lower limb; The 13-metallic channel; 14-leaded light board slot; The 15-reflective membrane; 21-SMD LED; The 22-reflecting mirror; The 23-fin; The 24-circuit; The 31-LGP; The 32-diffusion barrier; The 33-prismatic lens; The 34-protecting film; The 41-rechargeable battery; The 42-booster circuit; The 43-constant-current circuit.
The specific embodiment
Below in conjunction with drawings and Examples, the specific embodiment of the present invention is described in further detail.Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
As shown in Figure 1, one of most preferred embodiment of the present invention has been made a kind of spectacle LED LGP therapeutic instrument, and critical piece comprises that the 1-spectacle is framed; The 2-LED light source; The 3-guiding device; The 4-power supply; The 5-flexible circuit conductor.At first make the framed structure of spectacle, making step afterwards comprises:
S1. LGP is installed on described spectacle framed in;
S2. the patch light-emitting diode module that is welded with patch light-emitting diode, band reflecting mirror is fixed on the edge of described LGP;
S3. stick diffusion barrier, prismatic lens, protecting film respectively symmetrically at described LGP two exiting surfaces;
S4. rechargeable battery, booster circuit and variable constant current drive circuit are put into power pack and be connected access switch and regulating current device in described circuit connects successively;
S5. described power pack is connected by lead with described patch light-emitting diode.
Below in conjunction with accompanying drawing above steps is described in more detail:
Fig. 2-1,2-2 are the framed internal structure sketch map of spectacle in the circadian rhythm disorder therapeutic instrument of the embodiment of the invention; The reflective groove of 11-wherein; 12-mirror lower limb; The 13-metallic channel; 14-leaded light board slot; The 15-reflective membrane.
Shown in Fig. 2-1, metallic channel is positioned at mirror lower limb and framework junction, is used for lead-in conductor; Reflective groove and leaded light board slot are in same position, all are positioned among the framework lower frame.Can find out the particular location relation of reflective groove and leaded light board slot among Fig. 2-2, the leaded light board slot is positioned at reflective groove central authorities, is used to the LGP of packing into; Reflective rooved face all posts reflective membrane, has guaranteed the maximization to optical energy utilization efficiency.
Fig. 3 is a patch light-emitting diode modular structure sketch map in the circadian rhythm disorder therapeutic instrument of the embodiment of the invention; 21-SMD LED wherein; The 22-reflecting mirror; The 23-fin; The 24-circuit.SMD LED is linked together (on each LGP 4, totally 8) by circuit, add reflecting mirror and fin, form the patch light-emitting diode module, wherein illuminator is positioned at LED eyeglass top, has guaranteed the optical energy utilization efficiency maximization; Circuit bar the top is equipped with fin, the heat that produces when being used to discharge drive circuit works.
It is single wavelength SMD LED that the present invention adopts light source, this has just been avoided the infringement to human eye of subband spectrum that the whole chromatogram light source sends, present embodiment is equipped with the SMD LED (comprising white light) of multi-wavelength's model, can replace the SMD LED in the above-mentioned instrument with the SMDLED of other wave-length coverages or the SMD LED of other wave-length coverages added in the above-mentioned instrument so that instrument sends the light of needs according to the needs of treatment.Use the therapeutic effect that can reach best according to the selection of treatment needs like this, also can adapt to the hobby of different crowd simultaneously.
Fig. 4 is a guiding device structural representation in the circadian rhythm disorder therapeutic instrument of the embodiment of the invention; 31-LGP wherein; The 32-diffusion barrier; The 33-prismatic lens; The 34-protecting film.The concrete installation steps of guiding device are:
(1) utilize the leaded light board slot with LGP be installed on framed among;
(2) the patch light-emitting diode module is fixed on the top edge of LGP;
(3) stick diffusion barrier, prismatic lens, protecting film respectively symmetrically at LGP two exiting surfaces;
The LGP technology is to utilize the liquid crystal backlight of LED (backlight) principle, point source that led light source is sent out is evenly scattered in the LGP exiting surface, thereby the light source axle to LED weakens to light intensity, and to guarantee amphiblestroid safety in the irradiation treatment, this is a key of the present invention.LGP in the embodiment of the invention is non-printed form LGP, and two exiting surfaces of LGP post diffusion barrier, prismatic lens, protecting film respectively symmetrically, and luminous energy is penetrated from the LGP surface equably.
Fig. 5 is a supply unit sketch map in the above-mentioned most preferred embodiment, 41-rechargeable battery wherein, 3000mAh; The 42-booster circuit, 1.2V-5V, 2000mA; The 43-constant-current circuit, 0-200mA is adjustable.The characteristics of this supply unit have been to adopt booster circuit to solve the circuit common problem that voltage is decayed gradually along with the increase of service time, guaranteed the stability of supply voltage in the use, also reached service efficiency maximization simultaneously the power supply electric energy; Another characteristics of this power supply are to have adopted the adjustable constant-flow circuit to control size of current, and then change intensity of illumination, so just can adopt different exposure rates to carry out irradiation treatment according to the concrete condition of sufferer.
Application prospect
Because it has lot of advantages, this invention is great prospect in syndrome, aircraft jet lag, seasonal emotion disorders diseases such as (SAD) are for example had a sleepless night, worked at night to the treatment circadian rhythm disorder.
Cure for insomnia: the insomniac uses the irradiation of this instrument to make retina accept illumination in advance in several hours before the sunrise in the morning, simultaneously also increase retina and accept light application time, such irradiation will make patient's melatonin secretion curve phase place shift to an earlier date, thereby reaches the effect of Cure for insomnia.
Treatment aircraft jet lag: can be chosen in morning eastwards or westwards according to heading in advance in the time of by air or accept the irradiation of instrument at dusk, also can journey any time use or arrival destination after make and be used for further alleviating jet lag.In general shine several hrs and just can reach promising result, but need sometimes suitably to increase or reduce irradiation time according to characteristic symptom.
The person does not for a long time work at night: in night shift, before the night shift or after the night shift, the staff can use this instrument to improve to work at night efficient or the treatment syndrome of working at night as required.
Treatment SAD: early morning or dusk are used this quasi-instrument irradiation minimizing with compensation nature light application time in several hours in the winter time, reach therapeutic purposes.
The above only is a preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.