CN101732689A - 一种含有米诺地尔的药物 - Google Patents
一种含有米诺地尔的药物 Download PDFInfo
- Publication number
- CN101732689A CN101732689A CN200910244418A CN200910244418A CN101732689A CN 101732689 A CN101732689 A CN 101732689A CN 200910244418 A CN200910244418 A CN 200910244418A CN 200910244418 A CN200910244418 A CN 200910244418A CN 101732689 A CN101732689 A CN 101732689A
- Authority
- CN
- China
- Prior art keywords
- minoxidil
- compositions
- chinese medicine
- ethanol
- hypertensive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 25
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 title claims abstract description 13
- 229960003632 minoxidil Drugs 0.000 title claims abstract description 10
- 206010020772 Hypertension Diseases 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 14
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 10
- 230000001631 hypertensive effect Effects 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 2
- 238000012869 ethanol precipitation Methods 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 230000037396 body weight Effects 0.000 description 4
- 206010008190 Cerebrovascular accident Diseases 0.000 description 3
- 239000003390 Chinese drug Substances 0.000 description 3
- 208000006011 Stroke Diseases 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 208000026106 cerebrovascular disease Diseases 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 230000001077 hypotensive effect Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 208000019468 Iatrogenic Disease Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 230000002079 cooperative effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009102444186A CN101732689B (zh) | 2009-12-30 | 2009-12-30 | 一种含有米诺地尔的药物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009102444186A CN101732689B (zh) | 2009-12-30 | 2009-12-30 | 一种含有米诺地尔的药物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101732689A true CN101732689A (zh) | 2010-06-16 |
CN101732689B CN101732689B (zh) | 2011-09-14 |
Family
ID=42457057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009102444186A Expired - Fee Related CN101732689B (zh) | 2009-12-30 | 2009-12-30 | 一种含有米诺地尔的药物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101732689B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105943539A (zh) * | 2016-05-24 | 2016-09-21 | 成都市斯贝佳科技有限公司 | 一种有效安全降低血压的药物复方制剂 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1150930C (zh) * | 2001-10-26 | 2004-05-26 | 中国中医研究院中药研究所 | 用于防治高血压症的桂枝汤提取物 |
-
2009
- 2009-12-30 CN CN2009102444186A patent/CN101732689B/zh not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105943539A (zh) * | 2016-05-24 | 2016-09-21 | 成都市斯贝佳科技有限公司 | 一种有效安全降低血压的药物复方制剂 |
Also Published As
Publication number | Publication date |
---|---|
CN101732689B (zh) | 2011-09-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: NINGBO YINZHOU AOSHENG BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: ZHANG XIXIN Effective date: 20110721 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Xiao Yu Inventor after: Zhang Xixin Inventor before: Zhang Xixin |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHANG XIXIN TO: XIAO YU ZHANG XIXIN Free format text: CORRECT: ADDRESS; FROM: 100020 B320, BUILDING 3, DACHENG INTERNATIONAL, NO. 80, EAST 4TH RING ROAD MIDDLE, CHAOYANG DISTRICT, BEIJING TO: 315194 ROOM 1308, TOWER A, NO. 1, HUAMAO XUEFU, SHOUNAN SUBDISTRICT, YINZHOU DISTRICT, NINGBO CITY, ZHEJIANG PROVINCE |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20110721 Address after: 315194 Zhejiang city of Ningbo province Yinzhou District South Street Huamao a number of institutions A building room 1308 Applicant after: Ningbo Yinzhou Aosheng Biological Technology Co., Ltd. Address before: 100020, B320, building 3, Dacheng International, No. 80 East Fourth Ring Road, Beijing, Chaoyang District Applicant before: Zhang Xixin |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110914 Termination date: 20111230 |