CN101732623A - Medicament for treating acute gouty arthritis and preparation method thereof - Google Patents
Medicament for treating acute gouty arthritis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medicament for treating acute gouty arthritis and a preparation method thereof. The medicament is characterized in that: the medicament comprises the following Chinese medicinal components in part by weight: 4 to 7 parts of swordlike atractylodes rhizome, 6 to 9 parts of Mongolian dandelion herb, 5 to 8 parts of honeysuckle flower, 6 to 9 parts of gypsum, 4 to 7 parts of ginseng, 5 to 8 parts of Chinese flowering quince, 4 to 7 parts of cinnamomvine, 6 to 9 parts of coix seed, 6 to 9 parts of talc, 3 to 6 parts of common lophatherum herb, 3 to 6 parts of anemarrhena, 2 to 4 parts of agaric, 6 to 9 parts of glabrous greenbrier rhizome, 5 to 8 parts of hiraute shiny bugleweed herb, 0.3 to 0.6 part of mix-fried nux vomica and 6 to 9 parts of dahurian patrinia herb. The Chinese medicinal components are used together and have the collaborative and complementary effects of excreting dampness and expelling turbidity, clearing heat and detoxicating, dissolving stasis and relieving pain, stopping mutual metaplasia of damp-heat noxious blood stasis, and ending pathological links. The medicament has a total effective rate of 93 percent.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of acute gouty arthritis and preparation method thereof.Particularly relate to the Chinese medicine preparation of taking in a kind of.
Background technology
Acute gouty arthritis is one of common rheumatism, and primary disease often is acute attack, and the course of disease is long, and easily outbreak repeatedly.The medicine of treatment commonly used is allopurinol, colchicine, indometacin, probenecid etc. at present, though evident in efficacy, its side effect often makes many patients be difficult to tolerance.A kind of safe and effective in order to seek, the Chinese medicine preparation of few side effects, medicine of the treatment acute gouty arthritis of describing among Chinese patent 200510053918.3,200510023218.X, 200610037498.4, the 200710303697.X etc. and preparation method thereof has certain effect to relief of symptoms or control recurrence.However, the curative effect of these medicines still can not be satisfactory.So still there is demand in the medicine that people better treat acute gouty arthritis to curative effect.Up to now, the report that does not also have the medicine of the relevant treatment acute gouty arthritis of the present invention of discovery.The inventor is through research repeatedly for many years, and the checking repeatedly by clinical trial, has found the medicine that the treatment of better curative effect acute gouty arthritis is arranged finally, thereby has finished the present invention.
Summary of the invention
Purpose of the present invention just provides a kind of medicine for the treatment of acute gouty arthritis.
Another object of the present invention has provided the preparation method of the medicine of this treatment treatment acute gouty arthritis.
Acute gouty arthritis belongs to the Chinese medicine arthromyodynia, and categories such as gout, severe and migratory arthralgia, primary disease due to illness machine mostly are the damp and hot heresy of diseases caused by exogenous pathogenic factor, the retardance meridians, and the QI and blood that stagnates causes the redness and swelling of joints burning pain, muscle numbness, joint stuffiness.How insufficiency of the spleen primary disease is.With advancing age, sickness rate is gradually high, and patient's body mostly is the overweight people.This is that plain body is insufficiency of the spleen, the fortuneization functional disorder, the anti-turbid damp of making is annotated the skin and flesh joint outward, in stay internal organs, so the morbidity.The many turbid damp of primary disease, damp pathogen being heavy and turbid in nature viscous, the internal organs of being detained, blockage of meridian is not smooth.Damp is detained, and influences taste again.The primary disease pilosity is born in lower limb clinically, and just disease very can be not bitterly.So gradually day of year is of a specified duration, more stagnates more, forms hyperuricemia, hyperlipemia, and the osteoarthrosis that must happen suddenly eventually swells and ache, and accumulates in the turbid damp, and tongue sees turbid greasy, rolling pulse.The choice of drug Rhizoma Atractylodis of treatment acute gouty arthritis of the present invention, Herba Taraxaci, Flos Lonicerae, Gypsum Fibrosum: the spleen invigorating eliminating dampness by diuresis, heat-clearing and toxic substances removing is as monarch drug; Selected Radix Ginseng, Fructus Chaenomelis, Rhizoma Dioscoreae, Semen Coicis again for use: spleen invigorating and body surface resistance strengthening, promoting the circulation of QI to relieve pain, promoting the production of body fluid to quench thirst is as ministerial drug; Also selected Talcum, Herba Lophatheri, the Rhizoma Anemarrhenae, Polyporus, Rhizoma Smilacis Glabrae for use: the diuresis eliminating dampness by diuresis, heat-clearing and toxic substances removing is as adjuvant drug; At last, selected Herba Lycopi, Semen Strychni (processed), Herba Patriniae for use: blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain is as messenger drug.All medicines share the effect cooperative compensating, play the effect that turbid, heat-clearing and toxic substances removing, blood-activating analgetic are let out in eliminating dampness by diuresis altogether, stop hot and humid ecchymosis to change life mutually, and the pathology link is stopped.
The consumption of the drug component of treatment acute gouty arthritis of the present invention also is to grope to sum up each compositional range that draws in a large number through the inventor to have better curative effect.
According to a kind of medicine for the treatment of acute gouty arthritis of the present invention, it is characterized in that Chinese medicinal components presses row weight portion proportioning and form: Rhizoma Atractylodis 4～7, Herba Taraxaci 6～9, Flos Lonicerae 5～8, Gypsum Fibrosum 6～9, Radix Ginseng 4～7, Fructus Chaenomelis 5～8, Rhizoma Dioscoreae 4～7, Semen Coicis 6～9, Talcum 6～9, Herba Lophatheri 3～6, the Rhizoma Anemarrhenae 3～6, Polyporus 2～4, Rhizoma Smilacis Glabrae 6～9, Herba Lycopi 5～8, Semen Strychni (processed) 0.3～0.6, Herba Patriniae 6～9.
Preparation method according to the medicine of treatment acute gouty arthritis of the present invention, it is characterized in that taking by weighing the Chinese medicinal components of pressing row weight portion proportioning composition: Rhizoma Atractylodis 4～7, Herba Taraxaci 6～9, Flos Lonicerae 5～8, Gypsum Fibrosum 6～9, Radix Ginseng 4～7, Fructus Chaenomelis 5～8, Rhizoma Dioscoreae 4～7, Semen Coicis 6～9, Talcum 6～9, Herba Lophatheri 3～6, the Rhizoma Anemarrhenae 3～6, Polyporus 2～4, Rhizoma Smilacis Glabrae 6～9, the Herba Lycopi 5～8, Semen Strychni (processed) 0.3～0.6, Herba Patriniae 6～9, with described Chinese medicinal components water extraction 2-3 time extraordinarily by weight, for the first time adding water 1.5-3 doubly measures, soak after 2 hours and extracted 1.5 hours, for the second time and add water 1-1.5 for the third time and doubly measure, extracted 1 hour, merge twice or three extracting solution, filter to get filtrate, again filtrate is condensed into 0.5-1.5 and doubly measures.
Chinese medicinal components according to the amount of drug scope proportioning of treatment acute gouty arthritis of the present invention can also be according to the method for Chinese medicinal of routine, or add required various conventional adjuvant, be prepared into any peroral dosage form commonly used, as pill, tablet, powder, capsule, slow-releasing microcapsule agent etc.
The specific embodiment
The following examples and clinical trial can illustrate in greater detail the present invention, but do not limit the present invention in any form.
Embodiment 1:
Chinese medicinal components and consumption: 5 kilograms of Rhizoma Atractylodis, 8 kilograms of Herba Taraxacis, 6 kilograms of Flos Loniceraes, 8 kilograms in Gypsum Fibrosum, 5 kilograms of Radix Ginsengs, 6 kilograms of Fructus Chaenomeliss, 5 kilograms of Rhizoma Dioscoreaes, 7 kilograms of Semen Coiciss, 7 kilograms in Talcum, 4 kilograms of Herba Lophatheris, 4 kilograms of the Rhizoma Anemarrhenaes, 3 kilograms of Polyporus, 7 kilograms of Rhizoma Smilacis Glabraes, 6 kilograms of Herba Lycopi, 0.5 kilogram of Semen Strychni (processed), 7 kilograms of Herba Patriniae;
Preparation method: above-mentioned Chinese medicinal components is put into extraction pot, extracting in water 3 times, for the first time add 200 kilograms in water, soak after 2 hours, extracted 1.5 hours, collect extracting solution, respectively add 100 kilograms in water for the second time, for the third time, extracted respectively 1 hour, collect extracting solution, the extracting solution concentrating under reduced pressure that merges three times becomes 100 kilograms, is distributed into every bag 100 gram.
Embodiment 2:
Chinese medicinal components and consumption: 6 kilograms of Rhizoma Atractylodis, 7 kilograms of Herba Taraxacis, 7 kilograms of Flos Loniceraes, 8 kilograms in Gypsum Fibrosum, 7 kilograms of Radix Ginsengs, 6 kilograms of Fructus Chaenomeliss, 6 kilograms of Rhizoma Dioscoreaes, 8 kilograms of Semen Coiciss, 6 kilograms in Talcum, 4 kilograms of Herba Lophatheris, 4 kilograms of the Rhizoma Anemarrhenaes, 2 kilograms of Polyporus, 6 kilograms of Rhizoma Smilacis Glabraes, 5 kilograms of Herba Lycopi, 0.5 kilogram of Semen Strychni (processed), 7 kilograms of Herba Patriniae;
Preparation method: above-mentioned Chinese medicinal components is put into extraction pot, extracting in water 2 times, for the first time add 200 kilograms in water, soak after 2 hours, extracted 1.5 hours, collect extracting solution, for the second time add 100 kilograms in water, extracted 1 hour, collect extracting solution, the extracting solution concentrating under reduced pressure that merges twice becomes 100 kilograms, is distributed into every bag 100 gram.
Embodiment 3:
Chinese medicinal components and consumption: 7 kilograms of Rhizoma Atractylodis, 7 kilograms of Herba Taraxacis, 7 kilograms of Flos Loniceraes, 8 kilograms in Gypsum Fibrosum, 5 kilograms of Radix Ginsengs, 5 kilograms of Fructus Chaenomeliss, 5 kilograms of Rhizoma Dioscoreaes, 7 kilograms of Semen Coiciss, 6 kilograms in Talcum, 3 kilograms of Herba Lophatheris, 6 kilograms of the Rhizoma Anemarrhenaes, 2 kilograms of Polyporus, 9 kilograms of Rhizoma Smilacis Glabraes, 7 kilograms of Herba Lycopi, 0.3 kilogram of Semen Strychni (processed), 9 kilograms of Herba Patriniae;
Preparation method: with embodiment 1.
Embodiment 4:
Chinese medicinal components and consumption: 7 kilograms of Rhizoma Atractylodis, 6 kilograms of Herba Taraxacis, 5 kilograms of Flos Loniceraes, 8 kilograms in Gypsum Fibrosum, 6 kilograms of Radix Ginsengs, 8 kilograms of Fructus Chaenomeliss, 7 kilograms of Rhizoma Dioscoreaes, 6 kilograms of Semen Coiciss, 6 kilograms in Talcum, 6 kilograms of Herba Lophatheris, 5 kilograms of the Rhizoma Anemarrhenaes, 4 kilograms of Polyporus, 6 kilograms of Rhizoma Smilacis Glabraes, 5 kilograms of Herba Lycopi, 0.6 kilogram of Semen Strychni (processed), 8 kilograms of Herba Patriniae;
Preparation method: with embodiment 2.
Clinical trial
1, clinical data
Physical data and diagnostic criteria: selected case meet all that American Rheumatism Association in 1977 formulates about the acute gouty arthritis diagnostic criteria.Differential diagnosis in tcm is with reference to the standard of gout syndrome of accumulated dampness-heat among the 001.1-001.9-94 " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " [S], observe case totally 118 people, man's 101 examples wherein, girl's 17 examples, in age 26-70 year, the course of disease 1 year is with interior 37 examples, 1-3 person's 65 examples, 3-5 person's 11 examples, 5 examples more than 5 years.32 examples of falling ill first, repeated multiple times is sent out patient's 86 examples.Merge disease hypertension 17 examples, hyperlipidemia 9 examples, coronary heart disease 8 examples.Damp-heat accumulation type 106 examples in 118 examples, hot accumulation type 10 examples of expectorant, the turbid retardance of expectorant, each 1 example of liver-kidney yin deficiency.
Write down the arthralgia situation every day, observed the situation of change of patient's blood uric acid, erythrocyte sedimentation rate, c reactive protein, blood fat and other routine examination, and observed the untoward reaction that occurs during the medication in every 3-5 days.
2, Therapeutic Method and usage and dosage
Primary Care: the trouble limb is lain up, raised in (1), avoids overworked, nervous, catches a cold, is subjected to risk factors such as wet and joint injury; (2) low purine diet, forbid drinking; (3) polydipsia water, increase urine amount; (4) alkalized urine, each 1.0 grams of oral soda sheet, every day 3 times.
Drug therapy: all cases all adopt the pharmaceutical preparation of embodiment of the invention 1-4 method preparation, and are oral, and 2 times on the 1st, each 100 grams.7 days was 1 course of treatment, observed 2 courses of treatment.
3, criterion of therapeutical effect
With reference to the curative effect judging standard among the 001.1-001.9-94 " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " [S].Recovery from illness: arthralgia, tenderness and swelling Signs disappear, and it is normal that blood uric acid recovers; Take a turn for the better: arthralgia, tenderness and swelling Signs disappear substantially, and blood uric acid obviously descends near normal value; Invalid: no significant change before and after the medication.
4, therapeutic outcome
Treatment time is the longest 14 days, and is the shortest 4 days, and average 7 days, 86 examples of fully recovering, 24 examples that take a turn for the better, invalid 8 examples, total effective rate 93%.
Blood uric acid, erythrocyte sedimentation rate, c reactive protein, cholesterol, cholesterol are learned by statistics and are handled the t check relatively before and after the patient, and former three difference has highly significant meaning (P＜0.01), and both differences of back have significance meaning (P＜0.05).
The side effect aspect: have 9 examples and gastrointestinal reaction occurs, wherein 6 examples occur that mild nausea appears in laxativeness, 2 examples, 1 routine stomach slightly expands, and patient all can stand, and does not meet quick reaction and takes place.
Blood uric acid, erythrocyte sedimentation rate, c reactive protein, cholesterol, cholesterol change relatively before and after the treatment
| Project | Before the treatment | After the treatment | Difference before and after the treatment |
| Blood uric acid μ mol/L | ??650.60±99.93 | ??464.78±93.05 | ??(P＜0.01) |
| Erythrocyte sedimentation rate mm/1h | ??31.65±9.34 | ??21.83±18.15 | ??(P＜0.01) |
| C reactive protein mg/L | ??23.68±16.33 | ??9.28±11.63 | ??(P＜0.01) |
| Cholesterol mmol/L | ??6.31±0.05 | ??5.02±0.06 | ??(P＜0.05) |
| Cholesterol mmol/L | ??2.46±0.07 | ??1.43±0.07 | ??(P＜0.05) |
Claims (7)
1. medicine for the treatment of acute gouty arthritis is characterized in that Chinese medicinal components presses row weight portion proportioning and form: Rhizoma Atractylodis 4～7, Herba Taraxaci 6～9, Flos Lonicerae 5～8, Gypsum Fibrosum 6～9, Radix Ginseng 4～7, Fructus Chaenomelis 5～8, Rhizoma Dioscoreae 4～7, Semen Coicis 6～9, Talcum 6～9, Herba Lophatheri 3～6, the Rhizoma Anemarrhenae 3～6, Polyporus 2～4, Rhizoma Smilacis Glabrae 6～9, Herba Lycopi 5～8, Semen Strychni (processed) 0.3～0.6, Herba Patriniae 6～9.
2. the medicine of treatment acute gouty arthritis according to claim 1 is characterized in that Chinese medicinal components presses row weight portion proportioning and form: 5 kilograms of Rhizoma Atractylodis, 8 kilograms of Herba Taraxacis, 6 kilograms of Flos Loniceraes, 8 kilograms in Gypsum Fibrosum, 5 kilograms of Radix Ginsengs, 6 kilograms of Fructus Chaenomeliss, 5 kilograms of Rhizoma Dioscoreaes, 7 kilograms of Semen Coiciss, 7 kilograms in Talcum, 4 kilograms of Herba Lophatheris, 4 kilograms of the Rhizoma Anemarrhenaes, 3 kilograms of Polyporus, 7 kilograms of Rhizoma Smilacis Glabraes, 6 kilograms of Herba Lycopi, 0.5 kilogram of Semen Strychni (processed), 7 kilograms of Herba Patriniae.
3. the medicine of treatment acute gouty arthritis according to claim 1 is characterized in that Chinese medicinal components presses row weight portion proportioning and form: 6 kilograms of Rhizoma Atractylodis, 7 kilograms of Herba Taraxacis, 7 kilograms of Flos Loniceraes, 8 kilograms in Gypsum Fibrosum, 7 kilograms of Radix Ginsengs, 6 kilograms of Fructus Chaenomeliss, 6 kilograms of Rhizoma Dioscoreaes, 8 kilograms of Semen Coiciss, 6 kilograms in Talcum, 4 kilograms of Herba Lophatheris, 4 kilograms of the Rhizoma Anemarrhenaes, 2 kilograms of Polyporus, 6 kilograms of 6 kilograms of Herba Lycopi of Rhizoma Smilacis Glabrae, 0.5 kilogram of Semen Strychni (processed), 7 kilograms of Herba Patriniae.
4. the medicine of treatment acute gouty arthritis according to claim 1 is characterized in that Chinese medicinal components presses row weight portion proportioning and form: 7 kilograms of Rhizoma Atractylodis, 7 kilograms of Herba Taraxacis, 7 kilograms of Flos Loniceraes, 8 kilograms in Gypsum Fibrosum, 5 kilograms of Radix Ginsengs, 5 kilograms of Fructus Chaenomeliss, 5 kilograms of Rhizoma Dioscoreaes, 7 kilograms of Semen Coiciss, 6 kilograms in Talcum, 3 kilograms of Herba Lophatheris, 6 kilograms of the Rhizoma Anemarrhenaes, 2 kilograms of Polyporus, 9 kilograms of Rhizoma Smilacis Glabraes, 7 kilograms of Herba Lycopi, 0.3 kilogram of Semen Strychni (processed), 9 kilograms of Herba Patriniae.
5. the medicine of treatment acute gouty arthritis according to claim 1 is characterized in that Chinese medicinal components presses row weight portion proportioning and form: 7 kilograms of Rhizoma Atractylodis, 6 kilograms of Herba Taraxacis, 5 kilograms of Flos Loniceraes, 8 kilograms in Gypsum Fibrosum, 6 kilograms of Radix Ginsengs, 8 kilograms of Fructus Chaenomeliss, 7 kilograms of Rhizoma Dioscoreaes, 6 kilograms of Semen Coiciss, 6 kilograms in Talcum, 6 kilograms of Herba Lophatheris, 5 kilograms of the Rhizoma Anemarrhenaes, 4 kilograms of Polyporus, 6 kilograms of Rhizoma Smilacis Glabraes, 5 kilograms of Herba Lycopi, 0.6 kilogram of Semen Strychni (processed), 8 kilograms of Herba Patriniae.
6. the preparation method of the medicine of the described treatment acute gouty arthritis of claim 1, it is characterized in that taking by weighing the Chinese medicinal components of pressing row weight portion proportioning composition: Rhizoma Atractylodis 4～7, Herba Taraxaci 6～9, Flos Lonicerae 5～8, Gypsum Fibrosum 6～9, Radix Ginseng 4～7, Fructus Chaenomelis 5～8, Rhizoma Dioscoreae 4～7, Semen Coicis 6～9, Talcum 6～9, Herba Lophatheri 3～6, the Rhizoma Anemarrhenae 3～6, Polyporus 2～4, Rhizoma Smilacis Glabrae 6～9, the Herba Lycopi 5～8, Semen Strychni (processed) 0.3～0.6, Herba Patriniae 6～9, with described Chinese medicinal components water extraction 2-3 time extraordinarily by weight, for the first time adding water 1.5-3 doubly measures, soak after 2 hours and extracted 1.5 hours, for the second time and add water 1-1.5 for the third time and doubly measure, extracted 1 hour, merge twice or three extracting solution, filter to get filtrate, again filtrate is condensed into 0.5-1.5 and doubly measures.
7. the preparation method of the medicine of treatment acute gouty arthritis according to claim 6, it is characterized in that taking by weighing the Chinese medicinal components of pressing row weight portion proportioning composition: 5 kilograms of Rhizoma Atractylodis, 8 kilograms of Herba Taraxacis, 6 kilograms of Flos Loniceraes, 8 kilograms in Gypsum Fibrosum, 5 kilograms of Radix Ginsengs, 6 kilograms of Fructus Chaenomeliss, 5 kilograms of Rhizoma Dioscoreaes, 7 kilograms of Semen Coiciss, 7 kilograms in Talcum, 4 kilograms of Herba Lophatheris, 4 kilograms of the Rhizoma Anemarrhenaes, 3 kilograms of Polyporus, 7 kilograms of Rhizoma Smilacis Glabraes, 6 kilograms of Herba Lycopi, 0.5 kilogram of Semen Strychni (processed), 7 kilograms of Herba Patriniae, described Chinese medicinal components is put into extraction pot, extracting in water 3 times, add for the first time 200 kilograms in water, soak after 2 hours, extracted 1.5 hours, collect extracting solution, for the second time, respectively add 100 kilograms in water for the third time, extracted respectively 1 hour, collect extracting solution, the extracting solution concentrating under reduced pressure that merges three times becomes 100 kilograms, is distributed into every bag 100 gram.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367770A (en) * | 2014-09-29 | 2015-02-25 | 洛阳御平国生物科技有限公司 | Formula of traditional Chinese medicine for treating gouty arthritis |
| CN104758920A (en) * | 2015-04-29 | 2015-07-08 | 唐凯 | Gout health care product based on homology of medicine and food |
| CN105943958A (en) * | 2016-06-03 | 2016-09-21 | 黑龙江省玄鸟生物科技股份有限公司 | Inonotus obliquus composite solid particles for treating gout and preparing method thereof |
| CN106421555A (en) * | 2016-09-27 | 2017-02-22 | 余泽恒 | Chinese herbal medicinal liquor and preparation method thereof |
-
2009
- 2009-12-08 CN CN2009102205255A patent/CN101732623B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367770A (en) * | 2014-09-29 | 2015-02-25 | 洛阳御平国生物科技有限公司 | Formula of traditional Chinese medicine for treating gouty arthritis |
| CN104758920A (en) * | 2015-04-29 | 2015-07-08 | 唐凯 | Gout health care product based on homology of medicine and food |
| CN105943958A (en) * | 2016-06-03 | 2016-09-21 | 黑龙江省玄鸟生物科技股份有限公司 | Inonotus obliquus composite solid particles for treating gout and preparing method thereof |
| CN106421555A (en) * | 2016-09-27 | 2017-02-22 | 余泽恒 | Chinese herbal medicinal liquor and preparation method thereof |
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| CN101732623B (en) | 2011-05-04 |
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