CN101732278A - Coating technology of chlorophyll copper sodium tablet film - Google Patents
Coating technology of chlorophyll copper sodium tablet film Download PDFInfo
- Publication number
- CN101732278A CN101732278A CN200910156612A CN200910156612A CN101732278A CN 101732278 A CN101732278 A CN 101732278A CN 200910156612 A CN200910156612 A CN 200910156612A CN 200910156612 A CN200910156612 A CN 200910156612A CN 101732278 A CN101732278 A CN 101732278A
- Authority
- CN
- China
- Prior art keywords
- coating
- film
- tablet
- copper sodium
- chlorophyll copper
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to the coating technology of a chlorophyll copper sodium tablet film, which is characterized in that the coating technique process of a film coat comprises the following steps of: properly and completely dissolving medicinal film coating powder to prepare 15 percent coating mixed suspension liquid to keep the temperature and store; placing a white tablet into a film coating pot at 40-50 DEG C; operating according to an operation program and setting a rotation speed to be 8-10rpm; starting a peristaltic pump when the white tablet is slightly heated; and adjusting the position of an adjusting spraying gun with a spraying speed of 5-8ml/min. The drying is carried out layer by layer, the surface color of the tablet is uniform and the tablet is discharged after blowing the cold air for 15-20 minutes. The tablet appearance quality, the weight difference, the disintegration time limitation and the like accord with quality standard requirement, thereby the coating time and the coating materials are saved.
Description
Technical field:
This technology is used for the coating process of chlorophyll copper sodium tablet, with secluding air, and lucifuge, protection against the tide increases stability of drug.
Background technology
The oral formulations that chlorophyll copper sodium tablet system is processed from strand by the derivant of chlorophyll (extracting from silkworm excrement), be used for the treatment of the leukopenia that a variety of causes causes clinically, also can be used for the treatment of hepatomegaly that acute, chronic hepatitis, chronic persistent hepatitis and hepatitis causes, liver cirrhosis etc.The present domestic four tame pharmaceutical producing enterprise productions that have of this product, its coating is coated tablet.
The shortcoming of coated tablet:
1, syrup coat technology is the adjuvant that the multiple and Drug therapy based on sucrose, Pulvis Talci, gelatin has no to concern, is attached to the top layer of medicine label, therefore, takes for a long time and is not suitable for diabetics.
2, occur easily sliver, piebald, mildew, disintegrate is overtime, content descends, hygroscopicity is strong, be difficult for preserving.
3, rely on the operator by rule of thumb mostly in the operating process, with feel control coating quality, the uncontrollable factor in the syrup coat process is more.
4, the extra weightening finish of coated tablet adjuvant reaches 50-100%.
5, the coated tablet coating time longer, need 8-10h.
Summary of the invention
In order to overcome above-mentioned defective, 1, the thin film dress material is to be made of macromolecular compound, nonpoisonous and tasteless, the patient takes non-evident effect for a long time.
2, be difficult for to produce sliver, piebald, mildew, be easy to disintegrate, improved the effect duration that dissolution, bioavailability, the medicine of medicine are preserved greatly.
3, save material, can save adjuvant with the coated tablet comparison is 90% of substrate.The weightening finish of Film coated tablets adjuvant only is the 2-4% of label.
4, the film-coat coating time shorter, only need 2-3h.
To achieve these goals, the present invention adopts following technical scheme:
Coating technology of chlorophyll copper sodium tablet film is characterized in that:
1, chlorophyll copper sodium flake products prescription
1.1 plain tablet recipe (1000)
Chlorophyll copper sodium 15-25g
Starch 80-85g
Dextrin 35-45g
Cane sugar powder 40-50g
Magnesium stearate 0.6-2g
1.2 bag film-coat coating prescription (1000 of plain sheets)
The weight 4-8% of the plain sheet of stomach dissolution type film coating powder
Purified water is an amount of
2, chlorophyll copper sodium piece preparation method
Get chlorophyll copper sodium, starch, Icing Sugar, dextrin, mixing, the starch slurry (binding agent) of adding 8%, continue to stir, cross 14 mesh sieves and make granule, 70 ℃ of oven dry, moisture Control is in 6.5%%, 14 mesh sieve granulate add magnesium stearate, total mixing, the bag film-coat, the plastic-aluminum bubble-cap, packing, promptly.
3, film-coat art for coating flow process
Medicinal film coating powder is made 15% coating suspension with purified water dissolving fully in right amount, and insulation is deposited.Plain sheet put in 40 ℃-50 ℃ the film coating pot, operation is in operation sequence set rotating speed 8-10rpm and is changeed, and opens peristaltic pump when treating plain sheet slight fever, regulates the spray gun position, and hydrojet speed is 5-8ml/min.Dry layer by layer, treat the discharging in 15-20 minute of blowing a cold wind over after unilateral color and luster is evenly.
Experiment control by plain sheet hardness, hydrojet speed, coating pan rotating speed, sheet bed tempertaure, hydrojet pressure and other parameters, the tablet behind the coating increases weight approximately 4% as a result, all meets tablet presentation quality, weight differential, disintegration etc. the quality standard requirement.Save coating time, coating material simultaneously.
The specific embodiment
Below in conjunction with further specifying by embodiment:
Embodiment 1, chlorophyll copper sodium flake products prescription:
Chlorophyll copper sodium 20g
Starch 85g
Dextrin 40g
Cane sugar powder 45g
Magnesium stearate 0.6g
Bag film-coat coating prescription (1000 of plain sheets):
4.0% of the plain sheet weight of stomach dissolution type film coating powder;
Medicinal film coating powder with purified water dissolving fully in right amount, is made 15% coating suspension, and insulation is deposited.Plain sheet put in 40 ℃-50 ℃ the film coating pot, operation is in operation sequence set rotating speed 8-10rpm and is changeed, and opens peristaltic pump when treating plain sheet slight fever, regulates the spray gun position, and hydrojet speed is 5-8ml/min.Dry layer by layer, treat the discharging in 15-20 minute of blowing a cold wind over after unilateral color and luster is evenly.
At last, should be pointed out that above embodiment only is the more representational example of the present invention.Obviously, technical scheme of the present invention is not limited to the foregoing description, and many distortion can also be arranged.All distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention all should be thought protection scope of the present invention.
Claims (2)
1. coating technology of chlorophyll copper sodium tablet film is characterized in that:
1), chlorophyll copper sodium flake products prescription
1.1 plain tablet recipe (1000) weight
Chlorophyll copper sodium 15-25g
Starch 80-85g
Dextrin 35-45g
Cane sugar powder 40-50g
Magnesium stearate 0.6-2g;
1.2 bag film-coat coating prescription (1000 of plain sheets)
The 4.0-8% of the plain sheet weight of stomach dissolution type film coating powder
Purified water is an amount of;
2), chlorophyll copper sodium piece preparation method
Get chlorophyll copper sodium, starch, Icing Sugar, dextrin, mixing, the starch slurry (binding agent) of adding 8%, continue to stir, cross 14 mesh sieves and make granule, 70 ℃ of oven dry, moisture Control is in 6.5%%, 14 mesh sieve granulate add magnesium stearate, total mixing, the bag film-coat, the plastic-aluminum bubble-cap, packing, promptly;
3), film-coat art for coating flow process
Medicinal film coating powder is made 15% coating suspension with purified water dissolving fully in right amount, and insulation is deposited; Plain sheet put in 40 ℃-50 ℃ the film coating pot, operation is in operation sequence set rotating speed 8-10rpm and is changeed, and opens peristaltic pump when treating plain sheet slight fever, regulates the spray gun position, and hydrojet speed is 5-8ml/min.Dry layer by layer, treat the discharging in 15-20 minute of blowing a cold wind over after unilateral color and luster is evenly.
2. according to the described coating technology of chlorophyll copper sodium tablet film of claim, it is characterized in that:
Chlorophyll copper sodium flake products prescription:
Chlorophyll copper sodium 20g
Starch 85g
Dextrin 40g
Cane sugar powder 45g
Magnesium stearate 0.6g
Bag film-coat coating prescription (1000 of plain sheets):
4.0% of the plain sheet weight of stomach dissolution type film coating powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910156612A CN101732278A (en) | 2009-12-29 | 2009-12-29 | Coating technology of chlorophyll copper sodium tablet film |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910156612A CN101732278A (en) | 2009-12-29 | 2009-12-29 | Coating technology of chlorophyll copper sodium tablet film |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101732278A true CN101732278A (en) | 2010-06-16 |
Family
ID=42456652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910156612A Pending CN101732278A (en) | 2009-12-29 | 2009-12-29 | Coating technology of chlorophyll copper sodium tablet film |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101732278A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102440978A (en) * | 2011-11-22 | 2012-05-09 | 浙江万马药业有限公司 | Copper sodium chlorophyllate tablets and preparation method thereof |
| CN104606477A (en) * | 2015-01-28 | 2015-05-13 | 广西日田药业集团有限责任公司 | Fire-clearing jasmine and radix ophiopogonis film-coated tablets and preparation method thereof |
| CN105250267A (en) * | 2015-10-12 | 2016-01-20 | 成都通德药业有限公司 | New application of sodium copper chlorophyllin |
| CN105796553A (en) * | 2016-03-25 | 2016-07-27 | 浙江前进药业有限公司 | Sodium copper chlorophyll tablets and preparing technology thereof |
| CN106727359A (en) * | 2017-02-08 | 2017-05-31 | 成都通德药业有限公司 | A kind of preparation method for improving chlorophyll copper sodium stability |
| CN110090212A (en) * | 2018-01-29 | 2019-08-06 | 武汉联合药业有限责任公司 | The phyllins of transition metal chelate improve the purposes of Mesentery microcirculation obstacle |
-
2009
- 2009-12-29 CN CN200910156612A patent/CN101732278A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102440978A (en) * | 2011-11-22 | 2012-05-09 | 浙江万马药业有限公司 | Copper sodium chlorophyllate tablets and preparation method thereof |
| CN102440978B (en) * | 2011-11-22 | 2013-09-18 | 浙江万马药业有限公司 | Copper sodium chlorophyllate tablets and preparation method thereof |
| CN104606477A (en) * | 2015-01-28 | 2015-05-13 | 广西日田药业集团有限责任公司 | Fire-clearing jasmine and radix ophiopogonis film-coated tablets and preparation method thereof |
| CN105250267A (en) * | 2015-10-12 | 2016-01-20 | 成都通德药业有限公司 | New application of sodium copper chlorophyllin |
| CN105250267B (en) * | 2015-10-12 | 2017-11-07 | 成都通德药业有限公司 | The purposes of chlorophyll copper sodium |
| CN105796553A (en) * | 2016-03-25 | 2016-07-27 | 浙江前进药业有限公司 | Sodium copper chlorophyll tablets and preparing technology thereof |
| CN106727359A (en) * | 2017-02-08 | 2017-05-31 | 成都通德药业有限公司 | A kind of preparation method for improving chlorophyll copper sodium stability |
| CN110090212A (en) * | 2018-01-29 | 2019-08-06 | 武汉联合药业有限责任公司 | The phyllins of transition metal chelate improve the purposes of Mesentery microcirculation obstacle |
| CN110090212B (en) * | 2018-01-29 | 2021-12-31 | 武汉联合药业有限责任公司 | Use of transition metal chelated chlorophyll derivatives to improve mesenteric microcirculation disorders |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101732278A (en) | Coating technology of chlorophyll copper sodium tablet film | |
| KR20060132586A (en) | Film-forming starchy composition | |
| CN106903814A (en) | A kind of method for melt processing for preparing thermoplastic shell glycan | |
| CN100475215C (en) | Cefuroxime axetil taste masking pellet and method of preparing the same | |
| CN106666026B (en) | Plum slice fruitcake and preparation method thereof | |
| CN115212180A (en) | Compound preparation of aspirin and clopidogrel hydrogen sulfate and preparation method thereof | |
| CN111955749A (en) | Composition of dietary fiber particles and preparation process thereof | |
| CN101791296A (en) | Orlistat tablets and preparation method thereof | |
| CN110818751A (en) | Preparation method of glucosamine sulfate sodium chloride double salt | |
| CN109414438A (en) | Composition and method for treating cancer | |
| CN107375393B (en) | Honeysuckle organic acid component pellet coating granule and preparation method thereof | |
| Lee et al. | Decrease in the particle size of paclitaxel by increased surface area fractional precipitation | |
| CN106822027A (en) | A kind of Alpha-Linolenic Acid acid and its derivative enteric soft capsules and preparation method thereof | |
| CN108244155B (en) | Antimicrobial agent prepared based on microbiological method and antimicrobial packaging material | |
| CN1280257C (en) | Coated lycine or its salt, and coating technique | |
| CN105168168A (en) | Preparation method for pancreatic kininogenase enteric-coated tablets | |
| CN107099567A (en) | A kind of enzyme of general glycoside 95% modifies the production method of stevioside | |
| CN109588618B (en) | Method for producing BCAA granules by fluidized bed drying technology | |
| JPH0970285A (en) | Coating method and coating material obtained thereby | |
| CN1857256A (en) | Coated norcantharidin tablet and its preparing method | |
| CN107056961A (en) | Pulullan polysaccharide purifying technique | |
| CN104606477A (en) | Fire-clearing jasmine and radix ophiopogonis film-coated tablets and preparation method thereof | |
| CN2894699Y (en) | Film-coated tablet of norcantharidin | |
| RU2337143C1 (en) | Method of manufacturing granular sugar-containing product | |
| CN100522200C (en) | Pills for preventing osteoproliferation and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20100616 |