CN101708220B - Method for preparing Chinese medicinal stomach medicament preparation and quality test method thereof - Google Patents
Method for preparing Chinese medicinal stomach medicament preparation and quality test method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of Chinese medicaments, in particular relates to a method for preparing a Chinese medicinal stomach medicament preparation and a quality test method thereof. The conventional preparation method is fussy, needs to prepare particles in four different colours, and has complicated granulation process and inconvenient operation; and the conventional test method does not have very high accuracy and reliability, and cannot determine the source of contained tetrahydropalmatine. The method for preparing the Chinese medicinal stomach medicament and the quality test method thereof, the Chinese medicinal stomach medicament consists of rhizoma corydalis (vinegar processed), drift cuttlebone, elecampane, calcined alum, fried chicken eggshell and calcined nacre. The Chinese medicament treats ache, stops pain, and is used for treating gastric cavity ache, acid stomach, and noisy acid regurgitation caused by liver-stomach disharmony. The method for preparing the Chinese medicinal stomach medicament preparation of the invention is simple and easy to operate, simplifies preparation processes, and ensures the uniformity of a product better; and the quality test method has simple operation, and accurate and reliable testing result.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, be specifically related to a kind of preparation method and quality determining method thereof of Chinese medicine stomach medicament preparation.
Background technology
Record at present in the stomach Drug Capsule of " Drug Standard of Ministry of Public Health of the Peoples Republic of China Chinese traditional patent formulation preparation " the 6th, its preparation method is loaded down with trivial details, need be prepared into the particle of four kinds of different colours, the pelletization complexity, inconvenient operation, and the discriminating item of the stomach Drug Capsule detection method that ministerial standard is contained has 5 contents wherein to have three to be to adopt chemical method to differentiate, other two is that microscopical identification and thin-layer chromatography are differentiated, thin-layer chromatography is differentiated mainly and is determined by make contrast of tetrahydropalmatine whether the stomach Drug Capsule contains corydalis tuber, but this detection method accuracy, reliability is not very high, can't determine the source of contained tetrahydropalmatine.
Summary of the invention
The invention provides a kind of preparation method and quality determining method thereof of Chinese medicine stomach medicament preparation, easy, the easy operating of this preparation method has been simplified preparation process and has better been guaranteed the homogeneity of product; This quality determining method is simple to operate, testing result accurately and reliably.
Technical scheme of the present invention is: a kind of preparation method of Chinese medicine stomach medicament preparation, form by following Chinese medicine raw materials by weight proportion, 120 parts of Rhizoma Corydalis (processed with vinegar), 60 parts of the egg capsule of a mantis of going overseas, 60 parts of elecampanes, forge 90 parts of alums, 120 parts on scrambled eggs shell, forge 120 parts of mother-of-pearls, it is characterized in that: the preparation method of described Chinese medicine stomach medicament preparation is: corydalis tuber adds 1% glacial acetic acid solution, decocts collecting decoction 3 times, filter, leave standstill, get supernatant, be condensed into thick paste; Go overseas the egg capsule of a mantis, elecampane, forge alum, scrambled eggs shell and forge the mother-of-pearl ground spice and be broken into fine powder, mixing is mixed thoroughly with above-mentioned thick paste, makes pill or adds auxiliary material, makes capsule, granule or tablet.
A kind of Chinese medicine stomach medicament preparation, by 120 parts of Rhizoma Corydalis (processed with vinegar), 60 parts of the egg capsule of a mantis of going overseas, 60 parts of elecampanes, forge 90 parts of alums, 120 parts on scrambled eggs shell, forge 120 parts of Six-element medicines of mother-of-pearl and form, its quality determining method is as follows:
Differentiate:
(1) get the stomach medicament preparation powder, put microscopically and observe: the complete person's minority of reticulate vessel, fragment is as seen, and is not of uniform size, xylogen spindle shape or fragment into strip, the tool oblique pit;
(2) get stomach medicament preparation 4g, porphyrize adds 30 ℃～60 ℃ sherwood oil 30ml, cold soaking spends the night, and filters, and filtrate volatilizes, residue adds methyl alcohol 1ml makes dissolving, as need testing solution, other banksia rose control medicinal material 0.5g that fetches earth shines medicinal material solution in pairs with legal system, test according to thin-layered chromatography, drawing each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, is developping agent with 4: 160 ℃～90 ℃ petroleum ether-ethyl acetates, launch, take out, dry, spray is with 5% anisaldehyde sulfuric acid solution, 105 ℃ to be heated to spot colour developing clear, in the test sample chromatogram, with the corresponding position of control medicinal material chromatogram on, show the spot of same color;
Assay: according to high effective liquid chromatography for measuring
Chromatographic condition and system suitability test: with the octadecylsilane chemically bonded silica is filling agent; With 55: 45 methyl alcohol-with 0.1% phosphoric acid solution of triethylamine adjust pH to 6.0 is moving phase; The detection wavelength is 280nm, and number of theoretical plate calculates by the tetrahydropalmatine peak should be not less than 2000;
The preparation of reference substance solution: it is an amount of to get the tetrahydropalmatine reference substance, and accurate the title decides, and adds methyl alcohol and makes the solution that every 1ml contains 20 μ g, promptly;
The preparation of need testing solution: get stomach medicament preparation, porphyrize is got about 2.5g, the accurate title, decide, and adding 2ml strong ammonia solution makes moistening, adds 3: 1 methenyl choloride-methyl alcohol mixed solution 50ml again, sonicated 30 minutes, power are 250W, and frequency is 40kHz, put coldly, filter, it is on the neutral alumina post of 1.5cm that filtrate adds diameter, the aluminium oxide fineness is 100～200 orders, weight is 15g, collect eluent, use methenyl choloride 20ml wash-out again, merge eluent, put evaporate to dryness in 70 ℃ of water-baths, residue adds methyl alcohol makes dissolving, and changes molten to the 5ml measuring bottle, adds methyl alcohol and is diluted to scale, shake up, filter, get subsequent filtrate, promptly;
Accurate respectively reference substance solution and each the 10 μ l of need testing solution of drawing of determination method inject liquid chromatograph, measure, promptly.
The every 1g of described a kind of Chinese medicine stomach medicament preparation contains corydalis tuber in tetrahydropalmatine, is no less than 32 μ g.
The described used auxiliary material of capsule of making is in starch, dextrin, Icing Sugar, lactose, sodium carboxymethyl cellulose, superfine silica gel powder, pregelatinized starch and the dolomol one or more; Make the used auxiliary material of granule and be in dextrin, Icing Sugar and the lactose one or more; Making the used auxiliary material of tablet and be starch, dextrin, Icing Sugar, lactose, carboxylic adds basic Starch Sodium, pregelatinized starch, super carboxylic and adds in basic Starch Sodium, sodium carboxymethyl cellulose, calcium carboxymethylcellulose, L-HPC, polyvidone, Ac-Di-Sol, dolomol, talcum powder and the superfine silica gel powder one or more.
The preparation method of a kind of Chinese medicine stomach medicament preparation provided by the present invention is simple, is convenient to production operation, has shortened the production cycle, has improved efficiency, and it is better that corydalis tuber medicinal extract and mixed powder are mixed prepared preparation homogeneity thoroughly simultaneously; The present invention provides a kind of quality determining method of Chinese medicine stomach medicament preparation in addition, and this quality determining method is easy and simple to handle, selects for use the elecampane control medicinal material to carry out thin-layer chromatography and differentiates, selects for use tetrahydropalmatine to carry out assay, makes accuracy, reliability higher.
Embodiment
Specify the present invention below with reference to embodiment.Embodiments of the invention only are used to technical scheme of the present invention is described, and non-limiting essence of the present invention.
Embodiment 1
Corydalis tuber (vinegar system) 120g, cuttlebone (floating) 60g, elecampane 60g, alum (forging) 90g, egg shell (stir-fry) 120g, forge mother-of-pearl 120g, corydalis tuber adds 1% glacial acetic acid solution, decocts 3 times, collecting decoction filters, and leaves standstill, get supernatant, be condensed into thick paste; Ground spices such as all the other elecampanes are broken into fine powder, and mixing is mixed thoroughly with above-mentioned thick paste, close to stick together the system concentrated pill.
Stomach pill quality determining method is as follows:
Differentiate:
(1) get this product, pulverize, the powder of getting it filled is put microscopically and observed: the complete person's minority of reticulate vessel, fragment as seen, and is not of uniform size.Xylogen spindle shape or fragment into strip, the tool oblique pit.
(2) get this product 4g, porphyrize adds sherwood oil (30 ℃～60 ℃) 30ml, and cold soaking spends the night, and filters, and filtrate volatilizes, and residue adds methyl alcohol 1ml makes dissolving, as need testing solution.Other banksia rose control medicinal material 0.5g that fetches earth shines medicinal material solution in pairs with legal system.According to the thin-layered chromatography test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, so that sherwood oil (60 ℃～90 ℃)-ethyl acetate (4: 1) is developping agent, launch, take out, dry, spray is with 5% anisaldehyde sulfuric acid solution, and 105 ℃ to be heated to spot colour developing clear.In the test sample chromatogram, with the corresponding position of control medicinal material chromatogram on, show the spot of same color.
Assay: according to high effective liquid chromatography for measuring
Chromatographic condition and system suitability test: with the octadecylsilane chemically bonded silica is filling agent; With methyl alcohol-0.1% phosphoric acid solution (with triethylamine adjust pH to 6.0) (55: 45) is moving phase; The detection wavelength is 280nm.Number of theoretical plate calculates by the tetrahydropalmatine peak should be not less than 2000.
The preparation of reference substance solution: it is an amount of to get the tetrahydropalmatine reference substance, and accurate the title decides, and adds methyl alcohol and makes the solution that every 1ml contains 20 μ g, promptly.
The preparation of need testing solution: get this product, porphyrize is got about 2.5g, the accurate title, decide, and adding 2ml strong ammonia solution makes moistening, adds methenyl choloride-methyl alcohol (3: 1) mixed solution 50ml again, sonicated (power 250W, frequency 40kHz) 30 minutes is put cold, filter, filtrate adds neutral alumina post (100～200 orders, 15g, diameter 1.5cm) on, collect eluent, use methenyl choloride 20ml wash-out again, merge eluent, put evaporate to dryness in 70 ℃ of water-baths, residue adds an amount of methyl alcohol makes dissolving, and changes molten to the 5ml measuring bottle, adds methyl alcohol and is diluted to scale, shake up, filter, get subsequent filtrate, promptly.
Determination method: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject liquid chromatograph, measure, that is: the every 1g of stomach pill contains corydalis tuber with tetrahydropalmatine (C
21H
25NO
4) meter, must not be less than 32 μ g.
Embodiment 2
Corydalis tuber (vinegar system) 120g, cuttlebone (floating) 60g, elecampane 60g, alum (forging) 90g, egg shell (stir-fry) 120g, forge mother-of-pearl 120g, corydalis tuber adds 1% glacial acetic acid solution, decocts 3 times, collecting decoction filters, and leaves standstill, get supernatant, be condensed into thick paste; Ground spices such as all the other elecampanes are broken into fine powder, and mixing is mixed thoroughly with above-mentioned thick paste, add appropriate amount of starch and granulate, and mixing is made capsule.
Stomach Drug Capsule quality determining method is as follows:
Differentiate:
(1) get this product, put microscopically and observe: the complete person's minority of reticulate vessel, fragment as seen, and is not of uniform size.Xylogen spindle shape or fragment into strip, the tool oblique pit.
(2) get this product 4g, porphyrize adds sherwood oil (30 ℃～60 ℃) 30ml, and cold soaking spends the night, and filters, and filtrate volatilizes, and residue adds methyl alcohol 1ml makes dissolving, as need testing solution.Other banksia rose control medicinal material 0.5g that fetches earth shines medicinal material solution in pairs with legal system.According to the thin-layered chromatography test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, so that sherwood oil (60 ℃～90 ℃)-ethyl acetate (4: 1) is developping agent, launch, take out, dry, spray is with 5% anisaldehyde sulfuric acid solution, and 105 ℃ to be heated to spot colour developing clear.In the test sample chromatogram, with the corresponding position of control medicinal material chromatogram on, show the spot of same color.
Assay: according to high effective liquid chromatography for measuring
Chromatographic condition and system suitability test: with the octadecylsilane chemically bonded silica is filling agent; With methyl alcohol-0.1% phosphoric acid solution (with triethylamine adjust pH to 6.0) (55: 45) is moving phase; The detection wavelength is 280nm.Number of theoretical plate calculates by the tetrahydropalmatine peak should be not less than 2000.
The preparation of reference substance solution: it is an amount of to get the tetrahydropalmatine reference substance, and accurate the title decides, and adds methyl alcohol and makes the solution that every 1ml contains 20 μ g, promptly.
The preparation of need testing solution: get this product, porphyrize is got about 2.5g, the accurate title, decide, and adding 2ml strong ammonia solution makes moistening, adds methenyl choloride-methyl alcohol (3: 1) mixed solution 50ml again, sonicated (power 250W, frequency 40kHz) 30 minutes is put cold, filter, filtrate adds neutral alumina post (100～200 orders, 15g, diameter 1.5cm) on, collect eluent, use methenyl choloride 20ml wash-out again, merge eluent, put evaporate to dryness in 70 ℃ of water-baths, residue adds an amount of methyl alcohol makes dissolving, and changes molten to the 5ml measuring bottle, adds methyl alcohol and is diluted to scale, shake up, filter, get subsequent filtrate, promptly.
Determination method: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject liquid chromatograph, measure, that is: the every 1g of stomach Drug Capsule contains corydalis tuber with tetrahydropalmatine (C
21H
25NO
4) meter, must not be less than 32 μ g.
Embodiment 3
Corydalis tuber (vinegar system) 120g, cuttlebone (floating) 60g, elecampane 60g, alum (forging) 90g, egg shell (stir-fry) 120g, forge mother-of-pearl 120g, corydalis tuber adds 1% glacial acetic acid solution, decocts 3 times, collecting decoction filters, and leaves standstill, get supernatant, be condensed into thick paste; Ground spices such as all the other elecampanes are broken into fine powder, and mixing is mixed thoroughly with above-mentioned thick paste, adds an amount of Icing Sugar and dextrin, granulate, and mixing is made granule.
Stomach medicine granular mass detection method is as follows:
Differentiate:
(1) get this product, put microscopically and observe: the complete person's minority of reticulate vessel, fragment as seen, and is not of uniform size.Xylogen spindle shape or fragment into strip, the tool oblique pit.
(2) get this product 4g, porphyrize adds sherwood oil (30 ℃～60 ℃) 30ml, and cold soaking spends the night, and filters, and filtrate volatilizes, and residue adds methyl alcohol 1ml makes dissolving, as need testing solution.Other banksia rose control medicinal material 0.5g that fetches earth shines medicinal material solution in pairs with legal system.According to the thin-layered chromatography test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, so that sherwood oil (60 ℃～90 ℃)-ethyl acetate (4: 1) is developping agent, launch, take out, dry, spray is with 5% anisaldehyde sulfuric acid solution, and 105 ℃ to be heated to spot colour developing clear.In the test sample chromatogram, with the corresponding position of control medicinal material chromatogram on, show the spot of same color.
Assay: according to high effective liquid chromatography for measuring
Chromatographic condition and system suitability test: with the octadecylsilane chemically bonded silica is filling agent; With methyl alcohol-0.1% phosphoric acid solution (with triethylamine adjust pH to 6.0) (55: 45) is moving phase; The detection wavelength is 280nm.Number of theoretical plate calculates by the tetrahydropalmatine peak should be not less than 2000.
The preparation of reference substance solution: it is an amount of to get the tetrahydropalmatine reference substance, and accurate the title decides, and adds methyl alcohol and makes the solution that every 1ml contains 20 μ g, promptly.
The preparation of need testing solution: get this product, porphyrize is got about 2.5g, the accurate title, decide, and adding 2ml strong ammonia solution makes moistening, adds methenyl choloride-methyl alcohol (3: 1) mixed solution 50ml again, sonicated (power 250W, frequency 40kHz) 30 minutes is put cold, filter, filtrate adds neutral alumina post (100～200 orders, 15g, diameter 1.5cm) on, collect eluent, use methenyl choloride 20ml wash-out again, merge eluent, put evaporate to dryness in 70 ℃ of water-baths, residue adds an amount of methyl alcohol makes dissolving, and changes molten to the 5ml measuring bottle, adds methyl alcohol and is diluted to scale, shake up, filter, get subsequent filtrate, promptly.
Determination method: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject liquid chromatograph, measure, that is: the every 1g of stomach medicine particle contains corydalis tuber with tetrahydropalmatine (C
21H
25NO
4) meter, must not be less than 32 μ g.
Embodiment 4
Corydalis tuber (vinegar system) 120g, cuttlebone (floating) 60g, elecampane 60g, alum (forging) 90g, egg shell (stir-fry) 120g, forge mother-of-pearl 120g, corydalis tuber adds 1% glacial acetic acid solution, decocts 3 times, collecting decoction filters, and leaves standstill, get supernatant, be condensed into thick paste; Ground spices such as all the other elecampanes are broken into fine powder, and mixing is mixed thoroughly with above-mentioned thick paste, adds an amount of pregelatinized starch, granulate, and add an amount of talcum powder, and mixing is made tablet.
The tablet for gastrosis quality determining method is as follows:
Differentiate:
(1) get this product, put microscopically and observe: the complete person's minority of reticulate vessel, fragment as seen, and is not of uniform size.Xylogen spindle shape or fragment into strip, the tool oblique pit.
(2) get this product 4g, porphyrize adds sherwood oil (30 ℃～60 ℃) 30ml, and cold soaking spends the night, and filters, and filtrate volatilizes, and residue adds methyl alcohol 1ml makes dissolving, as need testing solution.Other banksia rose control medicinal material 0.5g that fetches earth shines medicinal material solution in pairs with legal system.According to the thin-layered chromatography test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, so that sherwood oil (60 ℃～90 ℃)-ethyl acetate (4: 1) is developping agent, launch, take out, dry, spray is with 5% anisaldehyde sulfuric acid solution, and 105 ℃ to be heated to spot colour developing clear.In the test sample chromatogram, with the corresponding position of control medicinal material chromatogram on, show the spot of same color.
Assay: according to high effective liquid chromatography for measuring
Chromatographic condition and system suitability test: with the octadecylsilane chemically bonded silica is filling agent; With methyl alcohol-0.1% phosphoric acid solution (with triethylamine adjust pH to 6.0) (55: 45) is moving phase; The detection wavelength is 280nm.Number of theoretical plate calculates by the tetrahydropalmatine peak should be not less than 2000.
The preparation of reference substance solution: it is an amount of to get the tetrahydropalmatine reference substance, and accurate the title decides, and adds methyl alcohol and makes the solution that every 1ml contains 20 μ g, promptly.
The preparation of need testing solution: get this product, porphyrize is got about 2.5g, the accurate title, decide, and adding 2ml strong ammonia solution makes moistening, adds methenyl choloride-methyl alcohol (3: 1) mixed solution 50ml again, sonicated (power 250W, frequency 40kHz) 30 minutes is put cold, filter, filtrate adds neutral alumina post (100～200 orders, 15g, diameter 1.5cm) on, collect eluent, use methenyl choloride 20ml wash-out again, merge eluent, put evaporate to dryness in 70 ℃ of water-baths, residue adds an amount of methyl alcohol makes dissolving, and changes molten to the 5ml measuring bottle, adds methyl alcohol and is diluted to scale, shake up, filter, get subsequent filtrate, promptly.
Determination method: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject liquid chromatograph, measure, that is: the every 1g of tablet for gastrosis contains corydalis tuber with tetrahydropalmatine (C
21H
25NO
4) meter, must not be less than 32 μ g.
Claims (1)
1. the quality determining method of a Chinese medicine stomach medicament preparation is characterized in that:
(1) get the stomach medicament preparation powder, put microscopically and observe: the complete person's minority of reticulate vessel, fragment is as seen, and is not of uniform size, xylogen spindle shape or fragment into strip, the tool oblique pit;
(2) get stomach medicament preparation 4g, porphyrize adds 30 ℃～60 ℃ sherwood oil 30ml, and cold soaking spends the night, and filters, and filtrate volatilizes, and residue adds methyl alcohol 1ml makes dissolving, as need testing solution; Other banksia rose control medicinal material 0.5g that fetches earth shines medicinal material solution with legal system, in pairs according to the thin-layered chromatography test, drawing each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, is developping agent with 60 ℃～90 ℃ petroleum ether-ethyl acetates of 4:1, launch, take out, dry, spray is with 5% anisaldehyde sulfuric acid solution, 105 ℃ to be heated to spot colour developing clear, in the test sample chromatogram, with the corresponding position of control medicinal material chromatogram on, show the spot of same color;
(3) assay: according to high effective liquid chromatography for measuring
Chromatographic condition and system suitability test
:With the octadecylsilane chemically bonded silica is filling agent; With 55:45 methyl alcohol-with 0.1% phosphoric acid solution of triethylamine adjust pH to 6.0 is moving phase; The detection wavelength is 280nm;
Number of theoretical plate calculates by the tetrahydropalmatine peak should be not less than 2000;
The preparation of reference substance solution
:It is an amount of to get the tetrahydropalmatine reference substance, and accurate the title decides, and adds methyl alcohol and makes the solution that every 1ml contains 20 μ g, promptly;
The preparation of need testing solution: get stomach medicament preparation, porphyrize is got 2.5g, the accurate title, decide, and adding 2ml strong ammonia solution makes moistening, adds 3: 1 methenyl choloride-methyl alcohol mixed solution 50ml again, sonicated 30 minutes, power are 250W, and frequency is 40kHz, put coldly, filter, it is on the neutral alumina post of 1.5cm that filtrate adds diameter, the aluminium oxide fineness is 100～200 orders, weight is 15g, collect eluent, use methenyl choloride 20ml wash-out again, merge eluent, put evaporate to dryness in 70 ℃ of water-baths, residue adds methyl alcohol makes dissolving, and changes molten to the 5ml measuring bottle, adds methyl alcohol and is diluted to scale, shake up, filter, get subsequent filtrate, promptly;
Accurate respectively reference substance solution and each the 10 μ l of need testing solution of drawing of determination method inject liquid chromatograph, measure, promptly;
Described stomach medicament preparation is made by following Chinese medicine raw materials by weight proportion, 120 parts of Rhizoma Corydalis (processed with vinegar), 60 parts of the egg capsule of a mantis of going overseas, 60 parts of elecampanes, forge 90 parts of alums, 120 parts on scrambled eggs shell, forge 120 parts of mother-of-pearls, its preparation method is that corydalis tuber adds 1% glacial acetic acid solution, decoct 3 times, collecting decoction filters, and leaves standstill, get supernatant, be condensed into thick paste; Go overseas the egg capsule of a mantis, elecampane, forge alum, scrambled eggs shell and forge the mother-of-pearl ground spice and be broken into fine powder, mixing is mixed thoroughly with above-mentioned thick paste, makes pill or adds auxiliary material, makes capsule, granule or tablet.
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| CN104407092A (en) * | 2014-08-29 | 2015-03-11 | 湖南九典制药有限公司 | Quality detection method of traditional Chinese medicinal composition with efficacy of appetizing and invigorating spleen |
| CN106176981A (en) * | 2016-08-26 | 2016-12-07 | 江苏七O七天然制药有限公司 | A kind of extracting method of vinegar Rhizoma Corydalis |
| CN109045116A (en) * | 2018-09-11 | 2018-12-21 | 江苏七0七天然制药有限公司 | A kind of Weiyang-an capsule and preparation method thereof |
| CN109316543A (en) * | 2018-10-22 | 2019-02-12 | 江苏七0七天然制药有限公司 | A kind of compound analgesic capsule of corydalis tuber and preparation method thereof |
| CN113433244A (en) * | 2021-07-08 | 2021-09-24 | 辽宁华润本溪三药有限公司 | Method for determining tetrahydropalmatine content in qi stagnation stomachache granules and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249192A (en) * | 2008-03-31 | 2008-08-27 | 王水 | Stomach healing capsules for curing gastropathy |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249192A (en) * | 2008-03-31 | 2008-08-27 | 王水 | Stomach healing capsules for curing gastropathy |
Non-Patent Citations (2)
| Title |
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| 中华人民共和国卫生部药典委员会.胃药胶囊.《中华人民共和国卫生部药品标准中药成方制剂（第六册）》.1992,110. * |
| 李贻奎等.中药不良反应对策探讨.《中国新药杂志》.2008,第17卷(第4期),265-267. * |
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