CN101703580A - Externally used medicinal preparation for detumescence and analgesia and preparation method thereof - Google Patents
Externally used medicinal preparation for detumescence and analgesia and preparation method thereof Download PDFInfo
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- CN101703580A CN101703580A CN200910309994A CN200910309994A CN101703580A CN 101703580 A CN101703580 A CN 101703580A CN 200910309994 A CN200910309994 A CN 200910309994A CN 200910309994 A CN200910309994 A CN 200910309994A CN 101703580 A CN101703580 A CN 101703580A
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Abstract
The invention discloses an externally used medicinal preparation for detumescence and analgesia and a preparation method thereof. The externally used medicinal preparation is prepared from giant knotweed rhizome, gypsum ustum, borneol, ground sesameseed oil and hard paraffin. Compared with the prior art, the medicinal preparation is safe and effective and has stable properties, a simple preparation process and low-price and readily-available basic remedy raw materials. Years of clinical verification show that the medicinal preparation does not have adverse reaction and toxic and side effects, and when the medicinal preparation is used for treating parotitis through external application, the total clinical effective rate for treating the parotitis reaches 89.6 percent.
Description
Technical field
The present invention relates to external medicine preparation of a kind of heat-clearing and toxic substances removing, Repercusion analgesia and preparation method thereof.
Background technology
Swollen, pain is the general symptom of inflammation, and inflammation is exactly people's said " inflammation " at ordinary times, be body for a kind of defense reaction that stimulates, show as red, swollen, hot, bitterly.Inflammation can be to infect the infective inflammation that causes, also can be non-infective inflammation.Generally, inflammation is useful, is the automatic defense reaction of human body, but sometimes, and inflammation also is deleterious, for example to the attack of human body self tissue, occur in inflammation of hyaline tissue or the like.For example parotitis, pancreatitis etc. are all with edema pain phenomenon.
Parotitis is to invade the acute respiration infectious disease that the parotid gland causes by mumps virus, mainly show as enlargement under the ear-lobe of one or both sides, the parotid gland of enlargement often is hemispherical, with the ear-lobe is that center edge is unclear, and surface heat has angle pain, dehisce or when chewing the part feel pain, at the initial stage of a disease, heating, weak, General Symptoms such as be reluctant to eat can be arranged, and mainly are antiviral therapy and symptomatic treatment, and such poisonous side effect of medicine is bigger.Pancreatitis be pancreas because of the inflammation that tryptic autodigestion effect causes, be one group of disease that pancreatic tissue is impaired, pancreatic function is subjected to influence in various degree that different reasons cause.At present, pancreatitic treatment is not still had effect method, mainly take expectant treatment, for example No Food or Drink, and the medicine of inhibition pancreatic secretion etc. is used in gastrointestinal decompression.To the treatment of the above inflammation that swells and ache, adopt the therapy of heat-clearing and toxic substances removing, Repercusion analgesia more, it is effective medicine that Polygoni Cuspidati Composite is stuck with paste the external application affected part.
Summary of the invention
Technical problem to be solved by this invention provide a kind of have no side effect and treat effective percentage higher external medicine preparation and preparation method thereof of Repercusion analgesia, thereby overcome the deficiencies in the prior art.
In order to solve the problems of the technologies described above, the present invention adopts following technical scheme:
According to listed as parts by weight, the external medicine preparation of Repercusion analgesia of the present invention is to be prepared from for 35～50 parts by 200～256 parts of Rhizoma Polygoni Cuspidati, 150～400 parts of Gypsum Fibrosum Preparatum, 25～45 parts of Borneolum Syntheticums, 650～750 parts of ground sesameseed oils and hard paraffin.
Further, the external medicine preparation of above-mentioned Repercusion analgesia is to be prepared from for 40～45 parts by 200～256 parts of Rhizoma Polygoni Cuspidati, 200～300 parts of Gypsum Fibrosum Preparatum, 30～40 parts of Borneolum Syntheticums, 680～720 parts of ground sesameseed oils and hard paraffin.
The preparation method of the external medicine preparation of aforementioned Repercusion analgesia: get Rhizoma Polygoni Cuspidati, Gypsum Fibrosum Preparatum and Borneolum Syntheticum respectively, it is standby to be ground into fine powder, gets ground sesameseed oil and hard paraffin, heats 170～200 ℃, stop heating, be cooled to 75～85 ℃, add Borneolum Syntheticum fine powder and Gypsum Fibrosum Preparatum fine powder, stir, treat to add the Rhizoma Polygoni Cuspidati fine powder again after its temperature drops to 50～60 ℃, stir, be cooled to 45～50 ℃, make external medicine preparation according to a conventional method.
Rhizoma Polygoni Cuspidati is dry rhizome and the root of Polygonaceae (Polygonaceae) plant polygonum cuspidatum (Polygonum cuspidatum Sieb.et Zucc.), mildly bitter flavor, cold nature is returned liver, gallbladder, lung meridian has expelling wind and removing dampness, the dissipating blood stasis analgesic therapy, the effect of relieving cough and resolving phlegm, be used for arthralgia, jaundice due to damp-heat, amenorrhea WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus. Gypsum Fibrosum Preparatum is the processed product of Gypsum Fibrosum, sweet in the mouth, hot, puckery, cold in nature, return lung, the stomach warp has removing dampness, granulation promoting, hold back skin ulcer, the effect of hemostasis is used for the external treatment ulcer being unable to heal, the eczema pruritus, burn due to hot liquid or fire, traumatic hemorrhage. Borneolum Syntheticum claims Borneolum Syntheticum or 2 baras camphors again, the translucent hexagon crystal of white, acrid in the mouth, hardship, cold nature, GUIXIN, spleen, the lung hydrocarbon, has the refreshment of having one's ideas straightened out, the effect of clearing away heat to alleviate pain. ground sesameseed oil is an adjuvant, extracts, dissolve, dispersion medicine. hard paraffin has the effect of curing molding.
The function of pharmaceutical preparation of the present invention cures mainly: heat-clearing and toxic substances removing, Repercusion analgesia, external application for curing parotitis, pancreatitis etc.
Clinical observation: pharmaceutical preparation of the present invention (Polygoni Cuspidati Composite paste), according to the agents area size, the Polygoni Cuspidati Composite paste is tiled in being lined with on the gauze or other clothes of one deck plastic foil (preventing that medicinal liquid from exosmosing), thickness is 0.3～0.6cm.Through the clinical practice in surplus 20 years, had 300 in every month surplus example time patient, amount to 7.2 ten thousand surplus example time patient, external application for curing parotitis, its total effective rate of pancreatitis reaches 89.6%, model case is as follows:
One, treatment parotitis
Case 1: patient Wang, the woman, 10 years old, heating, headache, muscular soreness, cheek overflows and swelled and ache 2 days under the ear, heating, fear of cold, headache, pharyngalgia is off one's feed, and feels sick, vomits, and pain increased the weight of when laboratory rodent chow was particularly eaten acidic food.38.9 ℃ of body temperature are the center redness with the ear-lobe, and blur margin is touched a tender spot, and surface skin is not red, and burn feeling, limitation of mouth opening are arranged, swallow red, parotid gland mouth hyperemia, do not have flow dense.
Treatment:
Polygoni Cuspidati Composite is stuck with paste the external application affected part, changes every day and applies 1 time, continuous 5 days; Also can obey Radix Isatidis granules simultaneously, get final product rehabilitation.
Case 2: patient Liu, the man, 8 years old, heating, fear of cold, headache, pharyngalgia were off one's feed, feel sick, are vomitted, whole body pain 3 days.39.3 ℃ of body temperature, refreshing clear, calentura is held, neck is soft, cardiopulmonary (-), ears hang down for center redness, tenderness, and burn feeling is arranged, and dehisce, pain increases the weight of when chewing, and swallows red, pharyngeal and soft palate can have swelling, tonsil is shifted to the midline, orifice of parotid duct hyperemia, do not have flow dense.
Treatment:
Polygoni Cuspidati Composite is stuck with paste the external application affected part, changes every day and applies 1 time, continuous 7 days; Also can obey antivirus oral liquid simultaneously and get final product rehabilitation.
Case 3: patient Lee, the man, 11 years old, heating, headache, muscular soreness, cheek overflows swollen pain 2 days under the ear, is off one's feed, feels sick, vomits, and dehisces, chews that pain increases the weight of when particularly eating acidic food.39.1 ℃ of body temperature, refreshing clear, be center swelling with the right side ear-lobe, tenderness is obvious, swallow red, tonsil I
0Enlargement, parotid gland mouth is not red, and soft, the two lung of neck is thick, and abdomen is flat soft.
Treatment:
Polygoni Cuspidati Composite is stuck with paste the external application affected part, changes every day and applies 1 time, 4 days; Also Radix Isatidis granules can be obeyed simultaneously or antivirus oral liquid gets final product rehabilitation.
Two, treatment pancreatitis
Case 1: patient Zhang, the woman, 46 years old, upper left abdomen lasting pain was felt sick, vomits, was generated heat 1 day, is admitted to hospital.
Body is looked into: upper left abdominal pressure pain, rebound tenderness, 38.0 ℃ of body temperature.
CT: the pancreas volume increases, and oozes out on every side.
Clinical diagnosis: acute edematous pancreatitis.
Treatment: Polygoni Cuspidati Composite is stuck with paste 1 week of external application, and clinical symptoms disappears substantially, and CT check pancreas pancreas peripheral edema oozes out and is clearly better.
Case 2: patient Lee, the man, 56 years old, stomachache, abdominal distention 12 days is admitted to hospital.
Body is looked into: abdominal distention is obvious, full abdominal pressure pain, rebound tenderness, muscle tonus.At the tenderness enclosed mass that upper abdomen can be laid one's hand on and boundary is unclear.
B ultrasonic: seroperitoneum.
CT: pancreas is fuzzy, and low-density shadow is oozed out on every side.
Clinical diagnosis: acute critical pancreatitis.
Treatment: after Polygoni Cuspidati Composite is stuck with paste 2 weeks of external application, the CT check, ascites disappears, and the pancreas peripheral edema oozes out obviously and alleviates.
Case 3: patient week certain, the man, 39 years old, stomachache, abdominal distention is felt sick, vomiting 2 days, is admitted to hospital.
Body is looked into: abdominal distention is obvious, abdominal tenderness, rebound tenderness, tension of abdominal muscle.
B ultrasonic: seroperitoneum.
CT: pancreas is fuzzy, and low-density shadow is oozed out on every side.
Clinical diagnosis: acute critical pancreatitis.
Treatment: Polygoni Cuspidati Composite is stuck with paste external application 10 days, and the state of an illness is alleviated, and through the CT check, ascites disappears, and the pancreas peripheral edema oozes out and is clearly better.
Compared with prior art, pharmaceutical preparation of the present invention is safe and effective, stable in properties, and preparation technology is simple, and the principal agent raw material is cheap and easy to get, does not find untoward reaction and toxic and side effects through clinical verification for many years, and clinical total effective rate reaches 89.6%.
The specific embodiment
Embodiment 1: get Rhizoma Polygoni Cuspidati 240g, Gypsum Fibrosum Preparatum 180g and Borneolum Syntheticum 35g respectively, it is standby to be ground into fine powder.Other gets ground sesameseed oil 700g and hard paraffin 45g, is heated to 180 ℃ of temperature, stops heating, be cooled to 80 ℃, slowly add Borneolum Syntheticum fine powder and Gypsum Fibrosum Preparatum fine powder, stir, treat to add the Rhizoma Polygoni Cuspidati fine powder again after its temperature drops to 55 ℃, stir, continue to be cooled to 50 ℃, according to the agents area size, the Polygoni Cuspidati Composite paste is tiled in being lined with on the gauze or other clothes of one deck plastic foil (preventing that medicinal liquid from exosmosing), thickness is 0.4cm, spreads on the affected part outward, and fixing.
Embodiment 2: get Rhizoma Polygoni Cuspidati 180g, Gypsum Fibrosum Preparatum 350g and Borneolum Syntheticum 25g respectively, it is standby to be ground into fine powder.Other gets ground sesameseed oil 660g and hard paraffin 38g, stops heating when being heated to 185 ℃ of temperature, is cooled to 75 ℃, slowly add Borneolum Syntheticum fine powder and Gypsum Fibrosum Preparatum fine powder, stir, treat to add the Rhizoma Polygoni Cuspidati fine powder again after its temperature drops to 57 ℃, stir, continue to be cooled to 45 ℃, according to the agents area size, the Polygoni Cuspidati Composite paste is tiled in being lined with on the gauze or other clothes of one deck plastic foil (preventing that medicinal liquid from exosmosing), thickness is 0.6cm, spread on the affected part outward, and fixing.
Embodiment 3: get Rhizoma Polygoni Cuspidati 300g, Gypsum Fibrosum Preparatum 250g and Borneolum Syntheticum 28g respectively, it is standby to be ground into fine powder.Other gets ground sesameseed oil 650g and hard paraffin 50g, stops heating when being heated to 190 ℃, is cooled to 85 ℃, slowly add Borneolum Syntheticum fine powder and Gypsum Fibrosum Preparatum fine powder, stir, treat to add the Rhizoma Polygoni Cuspidati fine powder again after its temperature drops to 58 ℃, stir, continue to be cooled to 50 ℃, according to the agents area size, the Polygoni Cuspidati Composite paste is tiled in being lined with on the gauze or other clothes of one deck plastic foil (preventing that medicinal liquid from exosmosing), thickness is 0.5cm, spread on the affected part outward, and fixing.
Embodiment 4: get raw material Rhizoma Polygoni Cuspidati 220g, Gypsum Fibrosum Preparatum 150g, Borneolum Syntheticum 45g, ground sesameseed oil 750g and hard paraffin 35g, according to the method preparation of embodiment 1.
Embodiment 5: get raw material Rhizoma Polygoni Cuspidati 280g, Gypsum Fibrosum Preparatum 400g, Borneolum Syntheticum 40g, ground sesameseed oil 720g and hard paraffin 48g, according to the method preparation of embodiment 2.
Claims (3)
1. the external medicine preparation of a Repercusion analgesia, it is characterized in that: according to listed as parts by weight, it is to be prepared from for 35～50 parts by 200～256 parts of Rhizoma Polygoni Cuspidati, 150～400 parts of Gypsum Fibrosum Preparatum, 25～45 parts of Borneolum Syntheticums, 650～750 parts of ground sesameseed oils and hard paraffin.
2. according to the external medicine preparation of the described Repercusion analgesia of claim 1, it is characterized in that: it is to be prepared from for 40～45 parts by 200～256 parts of Rhizoma Polygoni Cuspidati, 200～300 parts of Gypsum Fibrosum Preparatum, 30～40 parts of Borneolum Syntheticums, 680～720 parts of ground sesameseed oils and hard paraffin.
3. the preparation method of the external medicine preparation of claim 1 or 2 described Repercusion analgesias, it is characterized in that: get Rhizoma Polygoni Cuspidati, Gypsum Fibrosum Preparatum and Borneolum Syntheticum respectively, it is standby to be ground into fine powder, get ground sesameseed oil and hard paraffin, heat 170～200 ℃, stop heating, be cooled to 75～85 ℃, add Borneolum Syntheticum fine powder and Gypsum Fibrosum Preparatum fine powder, stir, treat to add the Rhizoma Polygoni Cuspidati fine powder again after its temperature drops to 50～60 ℃, stir, be cooled to 45～50 ℃, make external medicine preparation according to a conventional method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910309994A CN101703580A (en) | 2009-11-19 | 2009-11-19 | Externally used medicinal preparation for detumescence and analgesia and preparation method thereof |
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| CN200910309994A CN101703580A (en) | 2009-11-19 | 2009-11-19 | Externally used medicinal preparation for detumescence and analgesia and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511714A (en) * | 2016-10-30 | 2017-03-22 | 贵州黄平靓鸥桑综合开发有限公司 | Medicine for relieving swelling and alleviating pain through external application |
| CN107095912A (en) * | 2017-06-20 | 2017-08-29 | 遵义医学院 | A kind of Ultramicro-powder ointment of Repercusion analgesia and preparation method thereof |
| CN108524611A (en) * | 2018-07-03 | 2018-09-14 | 遵义医学院附属医院 | A kind of giant knotweed cream and preparation method thereof |
-
2009
- 2009-11-19 CN CN200910309994A patent/CN101703580A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511714A (en) * | 2016-10-30 | 2017-03-22 | 贵州黄平靓鸥桑综合开发有限公司 | Medicine for relieving swelling and alleviating pain through external application |
| CN107095912A (en) * | 2017-06-20 | 2017-08-29 | 遵义医学院 | A kind of Ultramicro-powder ointment of Repercusion analgesia and preparation method thereof |
| CN108524611A (en) * | 2018-07-03 | 2018-09-14 | 遵义医学院附属医院 | A kind of giant knotweed cream and preparation method thereof |
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Application publication date: 20100512 |