CN101703554A - Preparation and use of semen cuscutae flavonoids - Google Patents
Preparation and use of semen cuscutae flavonoids Download PDFInfo
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- CN101703554A CN101703554A CN200910230096A CN200910230096A CN101703554A CN 101703554 A CN101703554 A CN 101703554A CN 200910230096 A CN200910230096 A CN 200910230096A CN 200910230096 A CN200910230096 A CN 200910230096A CN 101703554 A CN101703554 A CN 101703554A
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- ethanol
- semen cuscutae
- total flavones
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- extract
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- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 210000000582 semen Anatomy 0.000 title claims description 40
- 229930003935 flavonoid Natural products 0.000 title abstract description 4
- 150000002215 flavonoids Chemical class 0.000 title abstract description 4
- 235000017173 flavonoids Nutrition 0.000 title abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 90
- 239000003814 drug Substances 0.000 claims abstract description 16
- 238000010992 reflux Methods 0.000 claims abstract description 7
- 229930003944 flavone Natural products 0.000 claims description 28
- 235000011949 flavones Nutrition 0.000 claims description 28
- 150000002213 flavones Chemical class 0.000 claims description 26
- 238000010828 elution Methods 0.000 claims description 19
- 238000000746 purification Methods 0.000 claims description 14
- 238000005406 washing Methods 0.000 claims description 10
- 239000011347 resin Substances 0.000 claims description 8
- 229920005989 resin Polymers 0.000 claims description 8
- -1 reflux Substances 0.000 claims description 7
- 238000001179 sorption measurement Methods 0.000 claims description 7
- 239000000047 product Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 230000006837 decompression Effects 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 5
- 235000019634 flavors Nutrition 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000012567 medical material Substances 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 abstract description 9
- 210000004185 liver Anatomy 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 238000000605 extraction Methods 0.000 abstract description 5
- 230000004438 eyesight Effects 0.000 abstract description 4
- 240000007371 Cuscuta campestris Species 0.000 abstract 1
- 206010000210 abortion Diseases 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 239000008187 granular material Substances 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 241001609679 Cuscuta japonica Species 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000007779 soft material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 2
- 241000207782 Convolvulaceae Species 0.000 description 1
- 241000207892 Convolvulus Species 0.000 description 1
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 description 1
- OVSQVDMCBVZWGM-SJWGPRHPSA-N Hyperin Natural products O[C@H]1[C@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-SJWGPRHPSA-N 0.000 description 1
- FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 235000008777 kaempferol Nutrition 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- OVSQVDMCBVZWGM-DTGCRPNFSA-N quercetin 3-O-beta-D-galactopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-DTGCRPNFSA-N 0.000 description 1
- BBFYUPYFXSSMNV-UHFFFAOYSA-N quercetin-7-o-galactoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 BBFYUPYFXSSMNV-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明属于医药技术领域，涉及一种菟丝子总黄酮的制备及应用，即采用乙醇回流提取法。其具有补肝肾、益精明目、安胎等功效，是中医补肾、壮阳、圊精之要药，具有良好的发展前景。The invention belongs to the technical field of medicine, and relates to the preparation and application of total flavonoids of dodder seeds, which adopts an ethanol reflux extraction method. It has the effects of invigorating the liver and kidney, improving eyesight, and anti-abortion. It is an important medicine for invigorating the kidney, strengthening yang, and eliminating essence in traditional Chinese medicine, and has a good development prospect.
Description
Technical field:
The present invention relates to Uigurs medicine composition purification process, relate in particular to its preparation of Semen Cuscutae total flavones extract and application, belong to medical technical field.
Background technology:
Semen Cuscutae is the mature seed of Convolvulaceae annual parasitics MANCAO Semen Cuscutae or cuscuta japonica Choisy.Have invigorating the liver and kidney, replenishing vital essence to improve eyesight, controlling nocturnal emission with astringent drugs reducing urination, the antiabortive effect of antidiarrheal.2000 editions the Pharmacopoeia of the People's Republic of China records it and is the dry mature seed of convolvulus cuscuta plant.Semen Cuscutae is recorded in Shennong's Herbal the earliest as a kind of YANG invigorating medicine commonly used, and is widely distributed in China place of production, main product Shandong, Hebei, Shanxi, Shaanxi, Jiangsu, Heilungkiang, Jilin, Xinjiang etc.What 29 provinces in the whole nation formed commodity is mainly derived from 4: Semen Cuscutae, southern Semen Cuscutae, European Semen Cuscutae, cuscuta japonica Choisy.
The chemical constituent of Semen Cuscutae mainly comprises chemical compounds such as flavonoid, polysaccharide, alkaloids, terpenoid, steroidal class, volatile oil and lignin.Wherein, content of total flavone is about 3.0%.Flavonoid is the main effective ingredient of Semen Cuscutae.Main flavone compound has kaempferol, Quercetin, hyperin, Herba Astragali Melilotoidis (Herba Astragali Sinici) glycosides etc.
The Semen Cuscutae place of production distributes wide, and output is big, is a kind of conventional Chinese medicine, property of medicine neutralization, and sweet hot tepor is gone into the Liver and kidney warp.Nourishing YIN Yiyang, Wen Erxiao is dry, benefit and little stagnate.Be the good medicine of flat invigorating the liver and kidney simply.Because the remarkable effect of Semen Cuscutae aspect kidney invigorating and YANG supporting, immunity, cardiovascular, find that in addition it is also having certain effect aspect antioxidation, the defying age, therefore become focus for the research of Semen Cuscutae in recent years, and to the research of Semen Cuscutae also mainly at aspects such as its process of preparing Chinese medicine, chemical constituent, pharmacology.Separation and purification for the Semen Cuscutae effective ingredient then awaits further research, to disclose its mechanism of action, is the clinical practice developing wide prospect of Semen Cuscutae.
Summary of the invention:
The weak point that exists on the extraction and purification method at total flavones in the existing Semen Cuscutae, the invention provides a kind of extraction and purification method and application thereof of Semen Cuscutae total flavones, the main ethanol reflux extraction that adopts, adopt this method, reduced the application of organic solvent in whole purification process, prevented the influence of organic solvent to end product, the prepared Semen Cuscutae total flavones extract of the inventive method has invigorating the liver and kidney, replenishing vital essence to improve eyesight, effect such as antiabortive, be the key medicine of traditional Chinese medical science the kidney invigorating, tonifying YANG, defecation essence, have bright development prospect.
Semen Cuscutae total flavones preparation method of extract of the present invention, its extraction purification step is:
1) gets dry Semen Cuscutae medical material, grind into powder; With ethanol is solvent, soaked 12 hours, be extractant with 95% ethanol of 6～8 times of amounts of quality of medicinal material, reflux, extract, 2～3 hours is collected extracting solution, decompression recycling ethanol is not to there being the alcohol flavor, concentrated solution;
2) extracting solution that step 1) is obtained is concentrated to every milliliter and contains total flavones 0.3g, filter, filtrate is carried out purification with HPD-100 or HPD-400 or AB-8 or D101 macroporous resin, last sample adsorption time is 0.1～2.5h, and the washing volume is 1BV～3BV, and the washing flow velocity is 1BV/h～5BV/h, eluant is an ethanol, the eluting concentration of alcohol is 30%～60%, and the ethanol elution amount is 2.5BV～4BV, and ethanol elution speed is 1BV/h～3BV/h.
3) ethanol elution collection step 2), vacuum drying must extract product.
Wherein preferred processing condition is in the step (2): HPD-400 or D101 macroporous resin carry out purification, and adsorption time is 0.5～1.0h, and volume fraction 40%～50% ethanol is eluant, and elution amount is 3BV, and elution speed is 2BV/h;
Use the Chinese medicine preparation of this Semen Cuscutae total flavones, it is characterized in that with described Semen Cuscutae total flavones be the medicine active ingredient, add tablet, the capsule made behind the pharmaceutic adjuvant.
Can be used for developing preparation invigorating the liver and kidney, replenishing vital essence to improve eyesight, antiabortive medicine.
The present invention has the following advantages:
1. Semen Cuscutae total flavones preparation method of extract provided by the invention is simple to operate, quick;
2. selected macroporous resin has the function that adsorbance is big, desorption efficiency is big;
3. with ethanol be solvent and eluant, inexpensive, nontoxic.
The specific embodiment:
Understand technical scheme of the present invention for better, below describe in further detail by specific embodiment.
Embodiment 1:
Get dry Semen Cuscutae medical material 100g, grind into powder; With ethanol is solvent, soaked 12 hours, be extractant with 95% ethanol of 6 times of amounts of quality of medicinal material, reflux, extract, 2 hours is collected extracting solution, decompression recycling ethanol is not to there being the alcohol flavor, concentrated solution; The extracting solution that step is obtained is concentrated to every milliliter and contains total flavones 0.3g, filter, filtrate is carried out purification with the HPD-100 macroporous resin, last sample adsorption time is 1.0h, and the washing volume is 3BV, and the washing flow velocity is 3BV/h, eluant is an ethanol, the eluting concentration of alcohol is 60%, and the ethanol elution amount is 4BV, and ethanol elution speed is 3BV/h.The ethanol elution of collecting, 50 ℃ of vacuum dryings get product.Yield is 2.91%.
Embodiment 2:
Get dry Semen Cuscutae medical material 100g, grind into powder; With ethanol is solvent, soaked 12 hours, be extractant with 95% ethanol of 8 times of amounts of quality of medicinal material, reflux, extract, 2 hours is collected extracting solution, decompression recycling ethanol is not to there being the alcohol flavor, concentrated solution; The extracting solution that step is obtained is concentrated to every milliliter and contains total flavones 0.3g, filter, filtrate is carried out purification with the HPD-400 macroporous resin, last sample adsorption time is 2.5h, and the washing volume is 3BV, and the washing flow velocity is 2BV/h, eluant is an ethanol, the eluting concentration of alcohol is 60%, and the ethanol elution amount is 3BV, and ethanol elution speed is 2BV/h.The ethanol elution of collecting, 50 ℃ of vacuum dryings get product.Yield is 3.12%.
Embodiment 3:
Get dry Semen Cuscutae medical material 100g, grind into powder; With ethanol is solvent, soaked 12 hours, be extractant with 95% ethanol of 8 times of amounts of quality of medicinal material, reflux, extract, 2 hours is collected extracting solution, decompression recycling ethanol is not to there being the alcohol flavor, concentrated solution; The extracting solution that step is obtained is concentrated to every milliliter and contains total flavones 0.3g, filter, filtrate is carried out purification with the D101 macroporous resin, last sample adsorption time is 2.5h, and the washing volume is 3BV, and the washing flow velocity is 3BV/h, eluant is an ethanol, the eluting concentration of alcohol is 40%, and the ethanol elution amount is 3BV, and ethanol elution speed is 3BV/h.The ethanol elution of collecting, 50 ℃ of vacuum dryings get product.Yield is 3.18%.
Embodiment 4 Semen Cuscutae total flavones sheets
Group component
Total flavones 1-100g
Sodium Hydroxymethyl Stalcs 25g
6% starch slurry 20ml
Magnesium stearate 3g
Preparation process: Semen Cuscutae total flavones, Sodium Hydroxymethyl Stalcs, magnesium stearate pulverize separately are crossed 80 mesh sieves; Semen Cuscutae total flavones, Sodium Hydroxymethyl Stalcs, 6% starch slurry are mixed, grind evenly, the system soft material; After 20 mesh sieve system granules, drying adds the magnesium stearate mixing again, presses 1000; Pack after the assay was approved.
Embodiment 5 Semen Cuscutae total flavones capsules
Group component
Semen Cuscutae total flavones 10-100g
Starch 50g
70% alcoholic solution 15ml
Preparation process: with starch and Semen Cuscutae total flavones mixing, cross 80 mesh sieves, add 70% alcoholic solution of 15ml, the system soft material, after 20 mesh sieve system granules, drying, granulate, encapsulated, make 1000 altogether, every contains Semen Cuscutae total flavones extract 10-100mg.
Claims (3)
1. Semen Cuscutae total flavones preparation method of extract is characterized in that: extracting purification step is:
1) gets dry Semen Cuscutae medical material, grind into powder; With ethanol is solvent, soaked 12 hours, be extractant with 95% ethanol of 6～8 times of amounts of quality of medicinal material, reflux, extract, 2～3 hours is collected extracting solution, decompression recycling ethanol is not to there being the alcohol flavor, concentrated solution;
2) extracting solution that step 1) is obtained is concentrated to every milliliter and contains total flavones 0.3g, filter, filtrate is carried out purification with HPD-100 or HPD-400 or AB-8 or D101 macroporous resin, last sample adsorption time is 0.1～2.5h, and the washing volume is 1BV～3BV, and the washing flow velocity is 1BV/h～5BV/h, eluant is an ethanol, the eluting concentration of alcohol is 30%～60%, and the ethanol elution amount is 2.5BV～4BV, and ethanol elution speed is 1BV/h～3BV/h.
3) ethanol elution collection step 2), vacuum drying must extract product.
2. Semen Cuscutae total flavones preparation method of extract according to claim 1, it is characterized in that: preferred processing condition is in the described step (2): HPD-400 or D101 macroporous resin carry out purification, adsorption time is 0.5～1.0h, volume fraction 40%～50% ethanol is eluant, elution amount is 3BV, and elution speed is 2BV/h
3. use the Chinese medicine preparation of Semen Cuscutae total flavones as claimed in claim 1, it is characterized in that with described Semen Cuscutae total flavones be the medicine active ingredient, add tablet, the capsule made behind the pharmaceutic adjuvant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910230096XA CN101703554B (en) | 2009-11-13 | 2009-11-13 | Preparation and application of a kind of dodder total flavonoids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910230096XA CN101703554B (en) | 2009-11-13 | 2009-11-13 | Preparation and application of a kind of dodder total flavonoids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101703554A true CN101703554A (en) | 2010-05-12 |
| CN101703554B CN101703554B (en) | 2011-10-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910230096XA Expired - Fee Related CN101703554B (en) | 2009-11-13 | 2009-11-13 | Preparation and application of a kind of dodder total flavonoids |
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| Country | Link |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846696A (en) * | 2012-10-15 | 2013-01-02 | 江苏省中国科学院植物研究所 | Traditional Chinese flavones extract for resisting ovarian function decline as well as preparation method and application thereof |
| CN103816204A (en) * | 2013-11-19 | 2014-05-28 | 新乡医学院 | Preparation method and clinical application of chemical modification of Chinese medicine semen cuscutae extract |
| CN108029727A (en) * | 2018-01-15 | 2018-05-15 | 广州聚澜健康产业研究院有限公司 | One kind smears tea multi-layer steamed bread and preparation method thereof |
| CN111358826A (en) * | 2020-04-13 | 2020-07-03 | 宁夏医科大学 | Total flavone extract with antidepressant effect, and preparation method and application thereof |
-
2009
- 2009-11-13 CN CN200910230096XA patent/CN101703554B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846696A (en) * | 2012-10-15 | 2013-01-02 | 江苏省中国科学院植物研究所 | Traditional Chinese flavones extract for resisting ovarian function decline as well as preparation method and application thereof |
| CN102846696B (en) * | 2012-10-15 | 2013-09-11 | 江苏省中国科学院植物研究所 | Traditional Chinese flavones extract for resisting ovarian function decline as well as preparation method and application thereof |
| CN103816204A (en) * | 2013-11-19 | 2014-05-28 | 新乡医学院 | Preparation method and clinical application of chemical modification of Chinese medicine semen cuscutae extract |
| CN108029727A (en) * | 2018-01-15 | 2018-05-15 | 广州聚澜健康产业研究院有限公司 | One kind smears tea multi-layer steamed bread and preparation method thereof |
| CN111358826A (en) * | 2020-04-13 | 2020-07-03 | 宁夏医科大学 | Total flavone extract with antidepressant effect, and preparation method and application thereof |
| CN111358826B (en) * | 2020-04-13 | 2022-03-15 | 宁夏医科大学 | Total flavone extract with antidepressant effect, and preparation method and application thereof |
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| Publication number | Publication date |
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| CN101703554B (en) | 2011-10-05 |
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