CN101702920B - 癌细胞的检测方法及其在诊断和监测疾病治疗中的应用 - Google Patents

癌细胞的检测方法及其在诊断和监测疾病治疗中的应用 Download PDF

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CN101702920B
CN101702920B CN2008800182996A CN200880018299A CN101702920B CN 101702920 B CN101702920 B CN 101702920B CN 2008800182996 A CN2008800182996 A CN 2008800182996A CN 200880018299 A CN200880018299 A CN 200880018299A CN 101702920 B CN101702920 B CN 101702920B
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cells
cell
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cancer
electrical signal
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CN101702920A (zh
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J·里什庞
R·波波夫特泽
Y·沙钱-戴曼德
T·纽费尔德
S·弗尼克
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Ramot at Tel Aviv University Ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Chemical Kinetics & Catalysis (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Electrochemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2008800182996A 2007-04-02 2008-04-02 癌细胞的检测方法及其在诊断和监测疾病治疗中的应用 Expired - Fee Related CN101702920B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90744107P 2007-04-02 2007-04-02
US60/907,441 2007-04-02
PCT/IL2008/000457 WO2008120216A1 (en) 2007-04-02 2008-04-02 Methods of detecting cancer cells and use of same for diagnosing and monitoring treatment of the disease

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CN101702920A CN101702920A (zh) 2010-05-05
CN101702920B true CN101702920B (zh) 2013-03-13

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US (2) US8268577B2 (https=)
EP (1) EP2142661B1 (https=)
JP (1) JP2010523104A (https=)
KR (1) KR20100015774A (https=)
CN (1) CN101702920B (https=)
WO (1) WO2008120216A1 (https=)

Families Citing this family (13)

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JP2010523104A (ja) 2007-04-02 2010-07-15 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド ガン細胞検出方法ならびにガン疾患の診断およびガン疾患の処置のモニタリングのためのその使用
US9707403B2 (en) 2007-12-12 2017-07-18 Neuro Code Tech Holdings, Llc Rapid destruction of malignant tumors by excitotoxicity and osmotic-shock medical tactics
US8656930B2 (en) 2008-01-10 2014-02-25 Neuro-Code Tech Holdings, LLC Method and system for processing cancer cell electrical signals for medical therapy
KR20110009162A (ko) 2008-04-17 2011-01-27 더 뉴로-시그널링 파운데이션 의약적 치료를 위해 악성 종양 세포에서 세포자멸사를 유도해내는 시스템 및 방법
WO2013011513A1 (en) * 2011-07-21 2013-01-24 Ramot at Tel- Aviv University Ltd. Methods of determinig enzyme activity in preserved cell samples
RU2489710C1 (ru) * 2012-02-20 2013-08-10 Владимир Вадимович Мошкин Способ коммутационной хроноамперометрии
EP2855697A1 (en) * 2012-05-31 2015-04-08 Ramot at Tel-Aviv University Ltd. Methods and system for detecting melanoma
KR20150074487A (ko) 2013-12-24 2015-07-02 삼성전자주식회사 식각 부산물 검출 방법 및 이를 이용한 자기 저항 메모리 장치의 제조 방법
JP2015144904A (ja) * 2015-04-20 2015-08-13 佐藤　洋 位置制御システム
US11154238B2 (en) 2015-08-07 2021-10-26 Electroceuticals, Llc Systems, methods and apparatuses for providing bioelectronic neurocode-based therapies to mammals
US12472480B2 (en) * 2018-09-12 2025-11-18 Ohio State Innovation Foundation Chemical actuators
CN113720893B (zh) * 2021-09-01 2024-08-16 致慧医疗科技(上海)有限公司 一种基于癌细胞表面电荷强度的评估肿瘤恶性程度的方法
CN115224272A (zh) * 2022-06-09 2022-10-21 广东马车动力科技有限公司 一种正极浆料、正极极片及锂离子电池

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015595A1 (en) * 1990-04-03 1991-10-17 Oncotherapeutics An electronic technique of identifying an effective drug for treating a cancer patient
CN1588078A (zh) * 2004-09-24 2005-03-02 南京大学 肿瘤细胞表面抗原的原位电化学免疫测定方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US6682648B1 (en) * 1997-08-12 2004-01-27 University Of Southern California Electrochemical reporter system for detecting analytical immunoassay and molecular biology procedures
US20060205090A1 (en) * 2005-03-14 2006-09-14 Newton Michael W Water-soluble conjugates for electrochemical detection
JP2010523104A (ja) 2007-04-02 2010-07-15 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド ガン細胞検出方法ならびにガン疾患の診断およびガン疾患の処置のモニタリングのためのその使用
KR101281761B1 (ko) * 2009-03-27 2013-07-26 서강대학교산학협력단 전기검출기반 줄기세포 분화 측정용 센서

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991015595A1 (en) * 1990-04-03 1991-10-17 Oncotherapeutics An electronic technique of identifying an effective drug for treating a cancer patient
CN1588078A (zh) * 2004-09-24 2005-03-02 南京大学 肿瘤细胞表面抗原的原位电化学免疫测定方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
陈尔真,曹伟新等.丁酸对人结肠癌细胞株SW1116增殖及分化状态的影响.《外科理论与实践》.2003,第8卷(第3期),摘要，200页右栏. *

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Publication number Publication date
EP2142661A1 (en) 2010-01-13
JP2010523104A (ja) 2010-07-15
KR20100015774A (ko) 2010-02-12
US8530179B2 (en) 2013-09-10
CN101702920A (zh) 2010-05-05
US8268577B2 (en) 2012-09-18
EP2142661B1 (en) 2012-08-29
WO2008120216A1 (en) 2008-10-09
US20090232740A1 (en) 2009-09-17
US20120288877A1 (en) 2012-11-15

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