CN101690476A - Aqueous emulsion formulated by abamectin and indoxacarb and preparation method thereof - Google Patents
Aqueous emulsion formulated by abamectin and indoxacarb and preparation method thereof Download PDFInfo
- Publication number
- CN101690476A CN101690476A CN200910040983A CN200910040983A CN101690476A CN 101690476 A CN101690476 A CN 101690476A CN 200910040983 A CN200910040983 A CN 200910040983A CN 200910040983 A CN200910040983 A CN 200910040983A CN 101690476 A CN101690476 A CN 101690476A
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- China
- Prior art keywords
- aqueous emulsion
- avermectin
- worm prestige
- indenes worm
- solvent
- Prior art date
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Links
- 239000000839 emulsion Substances 0.000 title claims abstract description 62
- 239000005660 Abamectin Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 title abstract description 5
- 239000005907 Indoxacarb Substances 0.000 title abstract description 5
- 229950008167 abamectin Drugs 0.000 title abstract description 5
- VBCVPMMZEGZULK-NRFANRHFSA-N indoxacarb Chemical compound C([C@@]1(OC2)C(=O)OC)C3=CC(Cl)=CC=C3C1=NN2C(=O)N(C(=O)OC)C1=CC=C(OC(F)(F)F)C=C1 VBCVPMMZEGZULK-NRFANRHFSA-N 0.000 title abstract description 5
- 239000002904 solvent Substances 0.000 claims abstract description 28
- 239000004094 surface-active agent Substances 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- -1 alkyl phthalate class Chemical class 0.000 claims description 41
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims description 40
- 125000003454 indenyl group Chemical class C1(C=CC2=CC=CC=C12)* 0.000 claims description 39
- 239000002131 composite material Substances 0.000 claims description 21
- 239000003814 drug Substances 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 11
- 239000013530 defoamer Substances 0.000 claims description 10
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 10
- 239000004359 castor oil Substances 0.000 claims description 8
- 235000019438 castor oil Nutrition 0.000 claims description 8
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 8
- 239000002562 thickening agent Substances 0.000 claims description 8
- 229920005682 EO-PO block copolymer Polymers 0.000 claims description 7
- 239000003112 inhibitor Substances 0.000 claims description 7
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 5
- 239000002608 ionic liquid Chemical class 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 4
- 150000002170 ethers Chemical class 0.000 claims description 4
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 4
- NJPQAIBZIHNJDO-UHFFFAOYSA-N 1-dodecylpyrrolidin-2-one Chemical class CCCCCCCCCCCCN1CCCC1=O NJPQAIBZIHNJDO-UHFFFAOYSA-N 0.000 claims description 3
- RNMDNPCBIKJCQP-UHFFFAOYSA-N 5-nonyl-7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-ol Chemical class C(CCCCCCCC)C1=C2C(=C(C=C1)O)O2 RNMDNPCBIKJCQP-UHFFFAOYSA-N 0.000 claims description 3
- OWYSSKOUATWAAO-UHFFFAOYSA-N C1(=CC=CC=C1)C=1C(=C(C(=C(C1)O)C=C)C1=CC=CC=C1)C1=CC=CC=C1 Chemical compound C1(=CC=CC=C1)C=1C(=C(C(=C(C1)O)C=C)C1=CC=CC=C1)C1=CC=CC=C1 OWYSSKOUATWAAO-UHFFFAOYSA-N 0.000 claims description 3
- WPPOGHDFAVQKLN-UHFFFAOYSA-N N-Octyl-2-pyrrolidone Chemical class CCCCCCCCN1CCCC1=O WPPOGHDFAVQKLN-UHFFFAOYSA-N 0.000 claims description 3
- 239000003799 water insoluble solvent Substances 0.000 claims description 3
- ZZXUZKXVROWEIF-UHFFFAOYSA-N 1,2-butylene carbonate Chemical compound CCC1COC(=O)O1 ZZXUZKXVROWEIF-UHFFFAOYSA-N 0.000 claims description 2
- 229910016467 AlCl 4 Inorganic materials 0.000 claims description 2
- 125000005210 alkyl ammonium group Chemical group 0.000 claims description 2
- 125000000129 anionic group Chemical group 0.000 claims description 2
- 230000002528 anti-freeze Effects 0.000 claims description 2
- 150000001768 cations Chemical class 0.000 claims description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims description 2
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims description 2
- FFZANLXOAFSSGC-UHFFFAOYSA-N phosphide(1-) Chemical compound [P-] FFZANLXOAFSSGC-UHFFFAOYSA-N 0.000 claims 1
- 150000003014 phosphoric acid esters Chemical group 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 239000012752 auxiliary agent Substances 0.000 abstract description 4
- 230000002411 adverse Effects 0.000 abstract description 3
- 230000036541 health Effects 0.000 abstract description 3
- 230000000361 pesticidal effect Effects 0.000 abstract description 2
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 239000012071 phase Substances 0.000 description 65
- 239000003921 oil Substances 0.000 description 26
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 22
- 239000002245 particle Substances 0.000 description 20
- 238000012360 testing method Methods 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- 229920001296 polysiloxane Polymers 0.000 description 10
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 9
- 230000006641 stabilisation Effects 0.000 description 9
- 238000011105 stabilization Methods 0.000 description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- 230000008859 change Effects 0.000 description 8
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 7
- 241000238631 Hexapoda Species 0.000 description 7
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical group COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 7
- 239000012046 mixed solvent Substances 0.000 description 7
- 229910019142 PO4 Inorganic materials 0.000 description 5
- 239000002518 antifoaming agent Substances 0.000 description 5
- 235000021317 phosphate Nutrition 0.000 description 5
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical group [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 5
- 239000004299 sodium benzoate Substances 0.000 description 5
- 235000010234 sodium benzoate Nutrition 0.000 description 5
- 229920001285 xanthan gum Polymers 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical class OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- 150000002191 fatty alcohols Chemical class 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 description 4
- 230000003449 preventive effect Effects 0.000 description 4
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- 241000500437 Plutella xylostella Species 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 241000607479 Yersinia pestis Species 0.000 description 3
- 239000003945 anionic surfactant Substances 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical group C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 231100001261 hazardous Toxicity 0.000 description 3
- 239000002917 insecticide Substances 0.000 description 3
- ZIYVHBGGAOATLY-UHFFFAOYSA-N methylmalonic acid Chemical compound OC(=O)C(C)C(O)=O ZIYVHBGGAOATLY-UHFFFAOYSA-N 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 239000004334 sorbic acid Chemical group 0.000 description 3
- 235000010199 sorbic acid Nutrition 0.000 description 3
- 229940075582 sorbic acid Drugs 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- BOLQUPOXTWHXIX-UHFFFAOYSA-N OC1=CC=CC=C1.C=1C=CC=CC=1C=C(C=1C=CC=CC=1)C1=CC=CC=C1 Chemical compound OC1=CC=CC=C1.C=1C=CC=CC=1C=C(C=1C=CC=CC=1)C1=CC=CC=C1 BOLQUPOXTWHXIX-UHFFFAOYSA-N 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000004495 emulsifiable concentrate Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- IXQGCWUGDFDQMF-UHFFFAOYSA-N o-Hydroxyethylbenzene Natural products CCC1=CC=CC=C1O IXQGCWUGDFDQMF-UHFFFAOYSA-N 0.000 description 2
- 150000007524 organic acids Chemical group 0.000 description 2
- 239000000575 pesticide Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 230000000452 restraining effect Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
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- 238000001238 wet grinding Methods 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- 229940114072 12-hydroxystearic acid Drugs 0.000 description 1
- 241000219193 Brassicaceae Species 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
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- 229920000742 Cotton Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
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- 241001465754 Metazoa Species 0.000 description 1
- 241000209094 Oryza Species 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241000255969 Pieris brassicae Species 0.000 description 1
- ULQISTXYYBZJSJ-UHFFFAOYSA-N R-12-HOA Natural products CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 1
- 108010052164 Sodium Channels Proteins 0.000 description 1
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- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
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- 210000003169 central nervous system Anatomy 0.000 description 1
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- 150000001875 compounds Chemical class 0.000 description 1
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- 235000013305 food Nutrition 0.000 description 1
- 238000010413 gardening Methods 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000002161 motor neuron Anatomy 0.000 description 1
- 230000036403 neuro physiology Effects 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides an aqueous emulsion formulated by abamectin and indoxacarb, comprising the following components by mass percent: 0.1-20% of abamectin, 0.3-15% of indoxacarb, 5-50% of solvent which is insoluble in water, 0.1-20% of surface active agent and a proper amount of water. Compared with the prior art, the aqueous emulsion formulated by abamectin and indoxacarb of the invention uses relatively green and environment protective solvent, and reaches a certain stability under the coordination of corresponding surface active agent and other auxiliary agent; the pesticide effect thereof is similar with the traditional missible oil when the aqueous emulsion is used in the same dilution factor; and meanwhile a large amount of harmful solvent used in aqueous emulsion is avoided, thus avoiding the adverse effects of the harmful solvent on the environment and the health of users. The invention also relates to a preparation method of the aqueous emulsion.
Description
Technical field
The present invention relates to a kind of pesticidal preparations and preparation method thereof, especially a kind of composite aqueous emulsion and preparation method thereof.
Background technology
Aqueous emulsion is domestic and international a kind of environmental protection type agricultural chemical formulation of development in recent years and since in the preparation solvent for use than traditional missible oil much less, little to environmental hazard, to user's safety, therefore be to replace a kind of in the Water-borne modification formulation of missible oil.
Indenes worm prestige (Indoxacarb) is E.I.Du Pont Company's a kind of oxadiazines insecticides newly developed, have and tag and stomach poison function, all effective to each instar larvae, and there is not cross resistance with other insecticides such as organic phosphates, chrysanthemum ester classes, its mechanism of action is to make the nerve cell loss of function by the sodium-ion channel in the blocking-up insect nerve cell.Indenes worm prestige is lower to mammal, domestic animal toxicity, as safe as a house to the useful insects such as non-target biology in the environment simultaneously, be mainly used in the gardening pest insect on the crops such as control vegetables, fruit tree, grain, cotton, especially comparatively ideal control efficiency arranged for lepidoptera pest.Avermectin (Abamectin) is a kind of wide spectrum, efficient, safe macrolide antibiotic compounds, has strong desinsection, kills mite, eelworm-killing activity.Avermectin has stomach toxicity and action of contace poison, no systemic action, can not kill ovum, its mechanism of action is for passing through to disturb the activity of insect neurophysiology, stimulate and discharge γ-An Jidingsuan, make insect central nervous system signal be that constantly motor neuron accepts, thus in several hours paralysis, food refusal, slow-action or motionlessly cause death rapidly, be widely used in insects such as crop diamond-back moth, cabbage caterpillar such as control vegetables, fruit tree.But the long-term use of single medicament often causes the raising of pest resistance to insecticide, increases the difficulty of control, influences the output of crop.Therefore, increase drug effect, reduce cost, enlarge insecticidal spectrum, increase economic efficiency, become most of countries and regions agriculturist's selection by using Recompounded pesticide.Avermectin and indenes worm prestige complex preparation have synergistic effect, are mainly used in control paddy rice rice leaf roll snout moth's larva, insects such as Cruciferae diamond-back moth.
A kind of pesticide original medicine is made aqueous emulsion, but its particle diameter can be littler than the particle diameter of traditional wet-milling (WP), suspending agent (SC), and drug effect is better, but and compare with wet-milling, aqueous emulsion does not have dust in making, using, endanger little to producer, user.But the aqueous emulsion solvent for use must be water insoluble, and Avermectin and indenes worm prestige are difficult to be dissolved in the general organic solvent, therefore, make aqueous emulsion and have certain difficulty.
Do not occur relevant for the more stable aqueous emulsion of Avermectin and indenes worm prestige as yet at present, in view of this, we provide composite aqueous emulsion of a kind of Avermectin and indenes worm prestige and preparation method thereof at this.
Summary of the invention
The objective of the invention is to: composite aqueous emulsion of a kind of high stability Avermectin and indenes worm prestige and preparation method thereof is provided.
Research and development Avermectin and the composite water emulsion formula of indenes worm prestige, its key problem is the selection of solvent and surfactant, the inventor through big quantity research and experiment sieving, determines that the prescription of aqueous emulsion is as follows: Avermectin 0.1%-20% on the basis of in the past researching and developing experience; Indenes worm prestige 0.3%-15%; Solvent 5%-50%; Surfactant 0.1%-20%; UV-protectant 0.2%-2%; Antifreezing agent 4%-12%; Thickener 0.01%-3%; Mould inhibitor 0.01%-3%; Defoamer 0.2%-0.5%; PH regulator agent 0%-2%; Water: surplus; The percentage of above-mentioned substance is mass percent.
As a kind of improvement of the composite aqueous emulsion of Avermectin of the present invention and indenes worm prestige, described Avermectin and indenes worm prestige composite than with 0.5%-15%: 0.5%-10% for good, 1.5%-3%: 1%-2% is best.
Described solvent all is a water-immiscible solvent, as being wherein a kind of or its combination in alkyl phthalate class, alkylene carbonate class, ionic liquid class, N-alkyl pyrrolidine ketone, the high boiling point aromatic hydrocarbons.
Described surfactant can be for anionic phosphoric acid ester, alkylated aromatic sulfonic acid salt and nonionic surface active agent such as EO/PO block copolymer, triphenyl vinyl phenol polyoxyethylene groups ethers, castor oil polyoxyethylene ether class, the polyoxyethylene nonylphenol ether class is wherein a kind of or its combination.
Described UV-protectant is a butylhydroxy anisole (BHA), 2,6-Butylated Hydroxytoluene (BHT).
Described antifreezing agent is one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol, ethylene glycol monoalkyl ether (as butyl), the urea.
Described thickener is one or more in xanthans, gelatin, starch, methylol (ethyl, propyl group) cellulose, polyvinylpyrrolidone, the polyvinyl alcohol.
Described mould inhibitor is Sodium Benzoate, formaldehyde, benzisothiazole ketone, sorbic acid, 2-bromo-2-nitro-propyl group-1, one or more in the 3-glycol.
Described defoamer is silicone based.
Described pH regulator agent is organic and inorganic acid alkali.
For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of Avermectin and the composite aqueous emulsion of indenes worm prestige, it is characterized in that may further comprise the steps: 1) Avermectin and the former medicine of indenes worm prestige are dissolved in water-insoluble solvent in, and the surfactant that adds UV-protectant and/or low HLB (5-7) obtains disperse phase; 2) surfactant, antifreeze, defoamer, thickener, the mould inhibitor of high HLB (＞10) mixed with water obtain continuous phase; 3) under high shear, disperse phase joined in the continuous phase or with continuous phase join in the disperse phase, make the aqueous emulsion of high stability; Wherein, the 1st) step and the 2nd) order in step can be adjusted.
Compared with prior art, Avermectin of the present invention and the composite aqueous emulsion of indenes worm prestige are selected the solvent of relative environmental protection for use, and under the cooperation of corresponding surfactant and other auxiliary agent, have reached certain stability.When using under identical extension rate, its drug effect and traditional missible oil are similar, have avoided a large amount of hazardous solvents of using in the missible oil simultaneously, have avoided the adverse effect of hazardous solvent to environment and user's health.
Embodiment
Aqueous emulsion is oil phase and the aqueous mixture that utilizes in the machine power shearing system, makes oil phase be dispersed in aqueous phase with minimum drop, and surfactant in the liquid phase and various auxiliary agent make emulsion keep stable.During the preparation aqueous emulsion, after including continuous phase (water) homogeneous phase of surfactant and various auxiliary agents, under high speed shear (4000-10000 rev/min), join in the disperse phase (oil phase), can make the product of particle diameter at the 0.3-10 micron, perhaps disperse phase is added in the continuous phase under the condition of high shear (5000-10000 rev/min), also can makes the product of same quality.
Because Avermectin and the former medicine of indenes worm prestige are difficult to be dissolved in the general organic solvent, therefore at first need to select appropriate organic solvent that it is prepared into oil phase.Trials and screening through a large amount of tests find, the mixture of alkyl phthalate class, alkylene carbonate class, ionic liquid class, N-alkyl pyrrolidine ketone and they and high boiling point aromatic hydrocarbons etc. are applicable.
The concrete preparation method of aqueous emulsion of the present invention mainly comprised for three steps: at first, with Avermectin and the former medicine of indenes worm prestige be dissolved in water-insoluble above-mentioned solvent in, and the surfactant that adds UV-protectant and/or low HLB (HLB is 5-7) obtains even disperse phase; Then, the surfactant of high HLB (HLB＞10), antifreezing agent, defoamer, thickener, mould inhibitor etc. are mixed with water obtain even continuous phase; At last, under high shear, disperse phase slowly joined in the continuous phase or with continuous phase join in the disperse phase, can make the stabilize water emulsion of particle diameter at the 0.2-10 micron.
Above-mentioned phthalate solvent can be repefral, diethylester, dibutyl ester, butyl benzyl ester etc.; The alkylene carbonate kind solvent can be propylene carbonate base, butylene carbonate base etc.; Cation commonly used in the ionic liquid kind solvent has glyoxaline cation, pyridylium, alkyl ammonium cation, alkyl phosphorus cation etc., and anion commonly used has Cl
-, Br
-, AlCl
4 -, [BF
4]
-, [PF
6]
-, [CF
3SO
3]
-, [(CF
3SO
3)
2N]
-Deng; N-alkyl pyrrolidine ketones solvent can be N-n-octyl pyrrolidones, N-dodecyl pyrrolidones etc.; High boiling point aromatic hydrocarbon solvent such as Solvesso 100,150,200 etc.The content of solvent in aqueous emulsion is the 5%-50% mass ratio, is preferably 20%-50% mass ratio (look the solvability of former medicine and different).
Described surfactant can be anionic, nonionic, or its mixture.The anion surfactant that is suitable for has the triphenyl vinyl phenol polyoxyethylene ether phosphate, the phosphate of EO/PO block copolymer etc., the non-ionic surface active agent that is suitable for has fatty alcohol EO/PO block copolymer (HLB 7-16), oleyl alcohol and (or) hexadecanol APEO (5-5.5EO), the sorbitol anhydride monolaurate, monopalmitate, single stearyl ester, monoleate etc., polyoxyethylene nonylphenol ether (EO 4-20), castor oil polyoxyethylene ether (EO 12-40), poly-(the hard ester acid of 12-hydroxyl) polyoxyethylene ether block copolymers (ABA type), poly-isosuccinic acid acid anhydride-ethylene glycol copolymer etc.Mixing use or the moon/nonionic use separately between anion and nonionic mixing or the moon/nonionic, and usage amount is the 0.1%-20% mass ratio, is preferably the 0.5%-15% mass ratio, is preferably the 2%-8% mass ratio.
Because Avermectin is responsive to light, also need add the UV-protectant in the preparation, being suitable for has antioxidant butylhydroxy anisole (BHA), 2,6-Butylated Hydroxytoluene (BHT) etc.The content of UV-protectant in aqueous emulsion is the 0.2%-2% mass ratio.
The antifreezing agent that is applicable to low-temperature stabilization has ethylene glycol, propane diols, glycerine, polyethylene glycol, ethylene glycol monoalkyl ether (as butyl), and urea also is suitable for, and the usage amount of antifreezing agent is between the 4%-12% mass ratio.
Thickener can be selected xanthans, gelatin, starch, methylol (ethyl, propyl group) cellulose, polyvinylpyrrolidone, polyvinyl alcohol etc. for use, and viscosity is preferably between 100-2000cP, makes that material can free-flow.The consumption of thickener is the 0.01%-3% mass ratio.
Mould inhibitor can be selected Sodium Benzoate, formaldehyde, benzisothiazole ketone, sorbic acid, 2-bromo-2-nitro-propyl group-1 for use, 3-glycol etc., and consumption is the 0.01%-3% mass ratio.
Defoamer is silicone based, and as poly-alkyl silicon oxirane, usage amount is between 0.2%-0.5%.
Described pH regulator agent is organic and inorganic acid alkali.
In order to make purpose of the present invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to these examples absolutely not.The following stated only is the present invention embodiment preferably, only is used to explain the present invention, can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that all any modifications of being made within the spirit and principles in the present invention, be equal to replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with appended claims.
Embodiment 1:
Avermectin 0.5 gram with 92%, 95% indenes worm prestige 15 grams are dissolved in the 22 gram mixed solvents that contain N-octylpyrrolidone and Solvesso 150, after treating that solution is transparent, add 1 gram BHT, the diffusing phase of poly-(12-hydroxy stearic acid) the polyoxyethylene ether block copolymers emulsified component of 2 grams, under high shear (5000-10000rpm), slowly join and contain 3 gram triphen ethyl phenol APEOs (agricultural newborn 600#), 0.3 restrain silicone based defoamer, 4 gram ethylene glycol, 0.1 gram Sodium Benzoate, 0.25 in the continuous phase (water) of gram xanthans and 51.85 water, add the back and continue to shear a few minutes.Gained aqueous emulsion viscosity is 200cP (No. 2 rotor speeds 60 of ROOKFIELD DV-+Proviscometer record, and following examples together), and particle diameter is 0.3-5 micron (Ma Erwen laser particle size distribution instrument records, and following examples together).
Change feed way, 59.5 above-mentioned gram continuous phases (water) under high shear (5000-10000rpm), are added in the 40.5 gram disperse phase, make the aqueous emulsion of equal in quality.
Two groups of samples were deposited 7 days at 0 degree centigrade, deposited laggard line stabilization test in 14 days for 54 degrees centigrade, and phenomenons such as no layering, bleed, oil slick occur.
Embodiment 2:
With 92% Avermectin, 2.0 grams, 95% indenes worm prestige, 13 grams are dissolved in the 25 gram mixed solvents that contain diethyl phthalate and Solvsso 200, treat former medicine be dissolved into fully transparent after, add 1 gram BHA therein, 1.5 the poly-isosuccinic acid acid anhydride-ethylene glycol copolymer of gram non-ionic surface active agent is emulsified into and disperses phase (oil phase), under high shear (5000-10000rpm), be added to and contain 4 gram Nonyl pheno base ether (OP-20, HLB=16), 0.3 restrain silicone based defoamer, 4 gram propane diols, 0.1 gram formaldehyde, 0.25 in the continuous phase that gram gelatin and 48.85 gram water are formed, oil phase adds the back to be continued to shear a few minutes, make aqueous emulsion, its viscosity is 185cP, and particle diameter is the 0.25-4 micron.
Change feed way, 57.5 above-mentioned gram continuous phases under high shear (5000-10000rpm), are added in the 42.5 gram disperse phase, shear a few minutes after adding again to make aqueous emulsion, its viscosity is 190cP, and particle diameter is the 0.28-4.2 micron.
Two groups of samples were deposited 7 days at 0 degree centigrade, deposited laggard line stabilization test in 14 days for 54 degrees centigrade, and phenomenons such as no layering, bleed, oil slick occur.
Embodiment 3:
92% Avermectin, 5.0 grams, 95% indenes worm prestige, 11 grams are dissolved in and contain JEFFSOL AG 1723 (alkylene carbonate class, produce by Huntsman company) and 25.5 the restraining in the mixed solvents of Solvesso200, heat at＜60 degree celsius temperature ends, after making former medicine be dissolved into transparence fully, add 1 gram BHT therein, 2.5 gram non-ionic surface active agent castor oil polyoxyethylene ethers (By-125) are emulsified into and disperse phase (oil phase).Under high shear (5000-10000rpm), disperse phase is added to contains 3.5 gram anion surfactant triphenylethylene phenol polyethenoxy ether phosphates and (neutralize with triethanolamine, Soprophor FL is produced by Rhdia company), in the continuous phase (water) formed of the silicone based defoamer of 0.3 gram, 4 gram polyethylene glycol, 0.1 gram sorbic acid, 0.25 gram polyvinyl alcohol, 1 gram phosphoric acid and 45.85 gram water, oil phase adds the back and continues high shear a few minutes, and making viscosity is that 175cP, particle diameter are the aqueous emulsion of 0.3-4.6 micron.
Change feed way, 55 above-mentioned gram waters under high shear (5000-10000rpm), are added in the 45 gram disperse phase, add the back and continue to shear a few minutes again, make aqueous emulsion, its viscosity is 183cP, and particle diameter is the 0.32-5.4 micron.
Two groups of samples were deposited 7 days at 0 degree centigrade, deposited laggard line stabilization test in 14 days for 54 degrees centigrade, and phenomenons such as no layering, bleed, oil slick occur.
Embodiment 4:
92% Avermectin, 8.0 grams, 95% indenes worm prestige, 10 grams are dissolved in the 26.5 gram mixed solvents that contain dodecyl pyrrolidones and Solvesso150, after the heating of＜60 degree celsius temperature ends makes former medicine be dissolved into transparence fully, add 1 gram BHT therein, make it be dissolved into the dispersion phase fully.Under high shear (5000-10000rpm), disperse phase is added to non-ionic surface active agent, 0.2 gram silicone defoaming agent, 4 gram glycerine, the 0.1 gram 2-bromo-2-nitro-propyl group-1 that contains 2.5 gram fatty alcohol EO/PO block copolymers and mix with 1.5 gram castor oil polyoxyethylene ethers (By-130), in the continuous phase that 3-glycol, 0.25 gram polyvinylpyrrolidone, 1.5 gram phosphoric acid and 44.45 gram water are formed, add the back and continue to shear a few minutes, make aqueous emulsion.Sample viscosity is 192cP after tested, and particle diameter is at the 0.25-3.7 micron.
Change feed way, 54.5 above-mentioned gram continuous phases are added under high shear (5000-10000rpm) in the 45.5 gram disperse phase, continue to shear a few minutes after adding again to make aqueous emulsion, sample viscosity after testing is 190cP, and particle diameter is the 0.3-3.9 micron.
Two groups of samples were deposited 7 days at 0 degree centigrade, deposited laggard line stabilization test in 14 days for 54 degrees centigrade, and phenomenons such as no layering, bleed, oil slick occur.
Embodiment 5:
92% Avermectin, 10 grams, 95% indenes worm prestige, 9 grams are dissolved in 25 gram [C
4Mim] [PF
6] in (methyl butyl imidazoles hexafluorophosphate), after the heating of＜60 degree celsius temperature ends makes former medicine be dissolved into transparence fully, add 1 gram BHA therein, make it be dissolved into the dispersion phase fully.Under high shear (5000-10000rpm), disperse phase is added to the mixture, the 0.3 gram silicone defoaming agent, 4 that contain 2 gram fatty alcohol EO/PO block copolymers and 1.5 gram castor oil polyoxyethylene ethers to be restrained in the continuous phase of ethylene glycol, 0.1 gram Sodium Benzoate, 0.25 gram xanthans, 1 gram glacial acetic acid and 45.85 gram water compositions, add the back and continue to shear a few minutes, make aqueous emulsion.Sample viscosity is 196cP after tested, and particle diameter is at the 0.22-3.5 micron.
Change feed way, 55 above-mentioned gram continuous phases are added under high shear (5000-10000rpm) in the 45 gram disperse phase, continue to shear a few minutes after adding again to make corresponding aqueous emulsion, its sample viscosity after testing is 182cP, and particle diameter is the 0.25-3.3 micron.
Two groups of samples were deposited 7 days at 0 degree centigrade, deposited laggard line stabilization test in 14 days for 54 degrees centigrade, and phenomenons such as no layering, bleed, oil slick occur.
Embodiment 6:
92% Avermectin, 12 grams, 95% indenes worm prestige, 7.0 grams are dissolved in the 25.4 gram mixed solvents that contain diethyl phthalate and Solvsso 200, treat former medicine be dissolved into fully transparent after, add 1 gram BHT therein, the poly-isosuccinic acid acid anhydride-ethylene glycol copolymer of 1.5 gram non-ionic surface active agents is emulsified into and disperses phase (oil phase).Under high shear (5000-10000rpm), disperse phase is added to contains in the continuous phase that 3 gram dodecanol APEOs, 0.3 gram silicone defoaming agent, 4 gram ethylene glycol, 0.2 gram benzisothiazole ketone, 0.25 gram starch, 1 gram phosphoric acid and 44.35 gram water form, oil phase adds the back to be continued to shear a few minutes, make aqueous emulsion, its viscosity is 190cP, and particle diameter is the 0.20-4.5 micron.
Change feed way, 53.1 above-mentioned gram continuous phases are added under high shear (5000-10000rpm) in the 46.9 gram disperse phase, shear a few minutes after adding again to make aqueous emulsion, its viscosity is 210cP, and particle diameter is the 0.24-5.0 micron.
Two groups of samples were deposited 7 days at 0 degree centigrade, deposited laggard line stabilization test in 14 days for 54 degrees centigrade, and phenomenons such as no layering, bleed, oil slick occur.
Embodiment 7:
92% Avermectin, 15 grams, 95% indenes worm prestige, 3.0 grams are dissolved in and contain JEFFSOLAG 1723 (alkylene carbonate class, produce by Huntsman company) and 24.5 the restraining in the mixed solvents of Solvesso200, temperature end heating at＜60 degrees centigrade, after making former medicine be dissolved into transparence fully, add 1 gram BHA therein, 2.5 gram non-ionic surface active agent castor oil polyoxyethylene ethers are emulsified into and disperse phase (oil phase).Under high shear (5000-10000rpm), disperse phase is added to contains 3.5 gram anion surfactant triphenylethylene phenol polyethenoxy ether phosphates and (neutralize with triethanolamine, Soprophor FL is produced by Rhdia company), in the continuous phase (water) formed of 0.3 gram silicone defoaming agent, 4 gram propane diols, 0.1 gram formaldehyde, 0.25 gram xanthans, 1.4 gram phosphoric acid and 44.45 gram water, oil phase adds the back and continues high shear a few minutes, make aqueous emulsion, its viscosity is 185cP, and particle diameter is the 0.37-4.8 micron.
Change feed way, 54 above-mentioned gram waters are added under high shear (5000-10000rpm) in the 46 gram disperse phase, add the back and continue to shear a few minutes again, make aqueous emulsion, its sample viscosity is 203cP, and particle diameter is the 0.35-5.5 micron.
Two groups of samples were deposited 7 days at 0 degree centigrade, deposited laggard line stabilization test in 14 days for 54 degrees centigrade, and phenomenons such as no layering, bleed, oil slick occur.
Embodiment 8:
92% Avermectin, 20 grams, 95% indenes worm prestige, 0.5 gram are dissolved in 25 gram [C
4Mim] [(CF
3SO
3)
2N] in the mixed solvent of (methyl butyl imidazoles trifluoromethane sulfonic acid amine salt) and Solvesso150, in the heating of＜60 degree celsius temperature ends, make former medicine be dissolved into transparence fully after, add 1 gram BHT therein, make it be dissolved into the dispersion phase fully.Under high shear (5000-10000rpm), disperse phase is added in the continuous phase of 3 gram fatty alcohol EO/PO block copolymers and 2 gram castor oil polyoxyethylene ether mixtures, 0.3 gram silicone defoaming agent, 4 gram glycerine, 0.1 gram Sodium Benzoate, 0.25 gram polyvinyl alcohol, 1 gram glacial acetic acid and 42.85 gram water compositions, adding the back continues to shear a few minutes, make aqueous emulsion, its viscosity is 206cP, and particle diameter is at the 0.21-4.5 micron.
Change feed way, 53.5 above-mentioned gram continuous phases are added under high shear (5000-10000rpm) in the 46.5 gram disperse phase, continue after adding to shear a few minutes again, make aqueous emulsion, its sample viscosity after testing is 192cP, and particle diameter is the 0.20-3.8 micron.
Two groups of samples were deposited 7 days at 0 degree centigrade, deposited laggard line stabilization test in 14 days for 54 degrees centigrade, and phenomenons such as no layering, bleed, oil slick occur.
Prevent and treat diamond-back moth with the aqueous emulsion that embodiment 2 makes by active ingredient 2.5g/ mu, 3 days preventive effect is 93.2% behind the medicine, and the preventive effect of the emulsifiable concentrate formulation of same amount under the same medicine amount is 89.4%, and both differences are not remarkable.
Prevent and treat rice leaf roller with the aqueous emulsion that embodiment 6 makes by active ingredient 2g/ mu, 3 days preventive effect is 95.8% behind the medicine, and the preventive effect of the emulsifiable concentrate formulation of same amount under the same medicine amount is 96.1%, is more or less the same between the two.
By above embodiment as can be known, Avermectin that makes according to the present invention and the composite aqueous emulsion of indenes worm prestige, product cut size are substantially in the 0.2-10 micron, and good stability.When aqueous emulsion of the present invention used under identical extension rate, drug effect and traditional missible oil were similar, but need not to use a large amount of hazardous solvents in the missible oil, thereby have avoided the adverse effect to environment and user's health.
Claims (10)
1. Avermectin and the composite aqueous emulsion of indenes worm prestige, it is characterized in that: comprise in the described aqueous emulsion Avermectin 0.1%-20%, indenes worm prestige 0.3%-15%, with water-insoluble solvent 5%-50%, surfactant 0.1%-20% and suitable quantity of water, more than be mass percent.
2. Avermectin according to claim 1 and the composite aqueous emulsion of indenes worm prestige is characterized in that: the better composite ratio of described Avermectin and indenes worm prestige is 0.5%-15%: the 0.5%-10% mass ratio is preferably 1.5%-3%: the 1%-2% mass ratio.
3. Avermectin according to claim 1 and the composite aqueous emulsion of indenes worm prestige is characterized in that: the mass ratio of described solvent is 20%-50%.
4. Avermectin according to claim 1 and the composite aqueous emulsion of indenes worm prestige is characterized in that: the better mass ratio of described surfactant is 0.5%-15%, is preferably 2%-8%.
5. Avermectin according to claim 1 and the composite aqueous emulsion of indenes worm prestige; it is characterized in that: described aqueous emulsion also comprises UV-protectant 0.2%-2%, antifreezing agent 4%-12%, thickener 0.01%-3%, mould inhibitor 0.01%-3%, defoamer 0.2%-0.5% and pH regulator agent 0%-2%, more than is mass percent.
6. according to each described Avermectin in the claim 1 to 5 and the composite aqueous emulsion of indenes worm prestige, it is characterized in that: described solvent is wherein a kind of or its combination in alkyl phthalate class, alkylene carbonate class, ionic liquid class, N-alkyl pyrrolidine ketone, the high boiling point aromatic hydrocarbons.
7. Avermectin according to claim 6 and the composite aqueous emulsion of indenes worm prestige is characterized in that: described phthalate solvent is one or more in repefral, diethylester, dibutyl ester, the butyl benzyl ester; Described alkylene carbonate kind solvent is one or more of propylene carbonate base, butylene carbonate base; Cation in the described ionic liquid kind solvent is one or more in glyoxaline cation, pyridylium, alkyl ammonium cation, the alkyl phosphorus cation, and anion is Cl
-, Br
-, AlCl
4 -, [BF
4]
-, [PF
6]
-, [CF
3SO
3]
-, [(CF
3SO
3)
2N]
-In one or more; Described N-alkyl pyrrolidine ketones solvent is one or more of N-n-octyl pyrrolidones, N-dodecyl pyrrolidones; Described high boiling point aromatic hydrocarbon solvent is one or more among the Solvesso 100,150,200.
8. according to each described Avermectin in the claim 1 to 5 and the composite aqueous emulsion of indenes worm prestige, it is characterized in that: described surfactant is phosphoric acid ester, alkylated aromatic sulfonic acid salt surfactant or nonionic surface active agent or its mixture of anionic.
9. Avermectin according to claim 8 and the composite aqueous emulsion of indenes worm prestige is characterized in that: described nonionic surface active agent is EO/PO block copolymer, triphenyl vinyl phenol polyoxyethylene groups ethers, castor oil polyoxyethylene ether class, the polyoxyethylene nonylphenol ether class is wherein a kind of or its combination.
10. the preparation method of Avermectin and the composite aqueous emulsion of indenes worm prestige, it is characterized in that may further comprise the steps: 1) Avermectin and the former medicine of indenes worm prestige are dissolved in water-insoluble solvent in, and the surfactant that adds UV-protectant and/or low HLB (5-7) obtains disperse phase; 2) surfactant, antifreeze, defoamer, thickener, the mould inhibitor of high HLB (＞10) mixed with water obtain continuous phase; 3) under high shear, disperse phase joined in the continuous phase or with continuous phase join in the disperse phase, make the aqueous emulsion of high stability; Wherein, the 1st) step and the 2nd) order in step in no particular order.
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| CN103598176B (en) * | 2013-05-13 | 2015-03-11 | 北京农学院 | 1,2-dihydroxyl- hexacosanyl-4-one emulsion in water and preparation method thereof |
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Address after: 518102 No. 113 Reservoir Road, Baoan District, Guangdong, Shenzhen, Xixiang Patentee after: Shenzhen Novozon Crop Science Co.,Ltd. Country or region after: China Address before: 518102 No. 113 Reservoir Road, Baoan District, Guangdong, Shenzhen, Xixiang Patentee before: SHENZHEN NOPOSION AGROCHEMICALS Co.,Ltd. Country or region before: China |