CN101661109A - Novel signal-ion micro-beam detector based on plastic scintillating fiber - Google Patents
Novel signal-ion micro-beam detector based on plastic scintillating fiber Download PDFInfo
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- CN101661109A CN101661109A CN200910145007A CN200910145007A CN101661109A CN 101661109 A CN101661109 A CN 101661109A CN 200910145007 A CN200910145007 A CN 200910145007A CN 200910145007 A CN200910145007 A CN 200910145007A CN 101661109 A CN101661109 A CN 101661109A
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Abstract
The invention relates to a novel single-ion microbeam detector based on a plastic scintillating fiber, comprising a microscope, wherein a single-ion microbeam is arranged below the objective lens of the microscope; an exit port of the single-ion microbeam rightly faces the objective lens of the microscope; and a sample to be measured is arranged between the objective lens of the microscope and theexit port of the single-ion microbeam. The novel single-ion microbeam detector based on the plastic scintillating fiber also comprises a plastic scintillating fiber which is squashed and a photomultiplier, wherein the squashed part of the plastic scintillating fiber is located between the exit port of the single-ion microbeam and the sample to be measured; two ends of the plastic scintillating fiber are respectively coupled with the photomultiplier; the single-ion microbeam sends out an ion to the sample to be measured when the ion passes through the plastic scintillating fiber, the plastic scintillating fiber generates a photon and transmits the photon to the photomultiplier which converts an optical signal into an electrical signal, and then the ion passes through the plastic scintillating fiber and bombards the sample.
Description
Technical field
The present invention relates to ion detection and optical field, especially a kind of novel single ion microbeam detector based on plastic scintillating fiber.
Background technology
Along with the continuous accumulation of human knowledge level, the ability of the knowledge of natural environment further improves, and people more and more pay close attention to the living environment of self, and especially ionising radiation is to health affected.The researcher is in order to seek biosome damage, the especially inherent mechanism of low dose irradiation and active somatic cell or tissue interaction that causes owing to ionising radiation, a kind of device that can accurately locate the quantitative particle of projection of exigence, promptly single ion microbeam.
Single ion microbeam is a kind ofly can accurately produce the irradiation technique platform that single ion, bearing accuracy reach micro-meter scale, can exactly the ion that ascertains the number be projected the specific site of target sample cell, bearing accuracy at micron to sub-micrometer scale.Up to now, in numerous in the world microbeam apparatus, just single-particle microbeam is used as a kind of accurate irradiation bomb, developing direction be ion how to beat more accurately, faster, and the target of studying remains the biology terminal effect.If the ion detection system to existing single ion microbeam platform improves, structure is based on the online detection and the analysis platform of single ion beam apparatus, survey physiological parameter variation in the cell under single ion beam irradiation environment by online harmless quantitative, as free calcium ion concentration, endochylema pH value, cell membrane potential, mitochondrial membrane potential, cell membrane phospholipid and acceptor flowability, the intracellular protein change procedure waits low energy ion and the interactional process originally of active somatic cell of determining quantity, then can not only be to understanding under the effect of the external disturbance factor, the physics that on cell and even molecular level, is taken place, the chemistry and biology effect has crucial meaning, and will be to ion beam biology, radiologic medicine, Developmental Biology, researchs such as space life science and material radiation damage microscopic mechanism have great impetus (Kadhim et al.Transmission of Chromosomal Instability after Plutonium Alpha-Particle Irradiation.Nature (1992)).
Current on the microbeam platform of countries in the world employed ion detection system can be divided into two kinds basically, a kind of is the preposition detection system of part, the breadboard GCI microbeam of CRC Gray that Britain is famous and the CAS-LIBB microbeam of Hefei Inst. of Plasma Physics, Chinese Academy of Sciences have all adopted this pattern, and accompanying drawing 1 (a) has provided its synoptic diagram (Hu ZW et al.High-localized cell irradiation at the CAS-LIBBsingle-particle microbeam.Nuclear Instruments ﹠amp; Methods m Physics ResearchSection B-Beam Interactions with Materials and Atoms 2006; 244 (2): 462-466.Folkard et al.The use of radiation microbeams to investigate the bystander effect incells and tissues.Nuclear Instruments ﹠amp; Methods in Physics Research Sectiona-Accelerators Spectrometers Detectors and Associated Equipment2007; 580 (1): 446-450.), another kind is rearmounted detection system, the famous RARAFmicrobeam of Columbia Univ USA has just adopted this kind pattern, and accompanying drawing 1 (b) has provided synoptic diagram (the Bigelow etal.Single-particle/single-cell ion microbeams as probes of biological mechanisms.Ieee Transactions on Plasma Science 2008 of this kind detection mode; 36 (4): 1424-1431).The principle of work of these two kinds of detection modes is as follows:
(1) the preposition detection mode of part.Adopt film scintillator loose coupling photomultiplier (PMT) combined detection list ion signal.Line emits from collimating apparatus, pass the multi-layer film structure that comprises plastic scintillant after, the irradiation cell sample.Ion passes scintillator and produces photon, and photon sees through to be collected by PMT behind the sample and be converted into electric signal, is converted into corresponding particle number after treatment, and when the particle number for the treatment of irradiation sample reached preset value, detection system will be sent instruction and close line.But in this structure, ion needs behind multilayer film just can irradiation sample, so the unipotency of ion and beam diameter all be affected, and has influenced bearing accuracy to a certain extent; Owing to adopting the scintillator detector counting, the light signal that single ion produces is very weak again, so detecting chamber needs strictness to block ambient light to reduce interference.Because the photon that scintillator produces need pass sample, could be collected by photomultiplier and be converted into electric signal, therefore can not be used for the experiment of the opaque or thicker sample of irradiation.
(2) rearmounted detection mode.This mode generally adopts the gas ionization chamber detector, ionization chamber places the micro objective mouth, because detector window is transparent, and the gas of the inside also is colourless, the real-time change information of sample in the irradiation process can not stop that the light that sends from sample enters object lens, so be observed or be write down to this kind detection mode can with microscope in irradiation sample.Line passes from alignment clamp outlet, pass thin vacuum seal film after, directly irradiation is on sample, ion enters gas ionization chamber after passing sample again, the signal of gas ionization chamber metering-in control system control after treatment electronic switch comes the break-make line.Be positioned at the back of sample but the shortcoming of this kind detection mode is a detector, sample can not be blocked up, arrives gas ionization chamber otherwise ion can't pass sample.In practical operation, cannot be with nutrient solution by the irradiation cell, can only utilize moistening air to be sprayed onto on the cell sample, in case the cell sample dehydration by ad hoc passage.
More than two kinds of methods, though all can realize single ion micro irradiation sample experiment is realized counting, but all exist certain shortcoming,, can not in irradiation sample, carry out the seizure and the ion detection of fluorescence information as can not thick sample of irradiation or opaque sample.
Summary of the invention
The invention provides a kind of novel single ion microbeam detector based on plastic scintillating fiber, to solve the problem of the real-time change that current microbeam can't the test sample fluorescence signal in irradiation sample, but also can carry out irradiation to opaque thick sample, enlarge the range of application of microbeam, improved conventional efficient.
In order to achieve the above object, the technical solution adopted in the present invention is:
A kind of novel single ion microbeam detector based on plastic scintillating fiber, include microscope, described microscopical object lens below is provided with single ion microbeam, the exit portal of described single ion microbeam is over against described microscopical object lens, testing sample is positioned between the exit portal of described microscopical object lens and single ion microbeam, it is characterized in that: the plastic scintillating fiber that also includes flattening, photomultiplier, the part that described plastic scintillating fiber flattens is between the exit portal and testing sample of described single ion microbeam, and described plastic scintillating fiber two ends are coupled with photomultiplier respectively; Single ion microbeam sends ion to testing sample, and when ion passed plastic scintillating fiber, plastic scintillating fiber produced photon, and with photon transmission to photomultiplier, by photomultiplier light signal is converted into electric signal, after ion passes plastic scintillant, the bombardment sample.
Described a kind of novel single ion microbeam detector based on plastic scintillating fiber is characterized in that: described plastic scintillating fiber adopts hot extrusion briquetting technique to flatten, and its thickness that flattens part is less than 50 microns.
Described a kind of novel single ion microbeam detector based on plastic scintillating fiber is characterized in that: the space between the part that described plastic scintillating fiber flattens and the exit portal of described single ion microbeam is the smaller the better.
Described a kind of novel single ion microbeam detector based on plastic scintillating fiber, it is characterized in that: described photomultiplier is installed in the seal box, be injected with the optocoupler mixture in the seal box, have aperture on the seal box, the two ends of described plastic scintillating fiber are stretched in the seal box by aperture, join with the receiver window of photomultiplier.
Among the present invention, earlier plastic scintillating fiber is suppressed, is made its thickness below 50 microns, the press portion of optical fiber be fixed on the line outlet directly over, and reduce the air air gap as much as possible.The two ends of optical fiber are coupled with the photomultiplier that is fixed in line outlet both sides respectively, the photon that flash fiber produces ion bombardment fibre core reaches photomultiplier and is converted into electric signal, signal amplifies and shaping through the rear end electronics circuit, thereby realizes the detection and the counting of ion.
The present invention has solved current single ion microbeam detection system effectively can't work in the problem that real-time online is surveyed, and sample that can be bigger to opaque thickness (as metal material, semiconductor material etc.) carries out the irradiation counting, has enlarged the range of application of microbeam.In addition because optical fiber itself promptly is the generation device of photon is again the transmission medium of photon, so the transfer efficiency height is simple in structure.
The present invention is applied to realize the online measuring ability of microbeam platform in single ion microbeam apparatus, and can carry out the irradiation counting to the bigger sample of opaque thickness, widened the microbeam range of application.The present invention has utilized the characteristics of the transmission apparatus of signal generation device of flash fiber and signal, reduced the loss that optical signals causes in coupling, strengthen the collection efficiency of light signal, improved signal to noise ratio (S/N ratio), effectively solved the problem that light signal is submerged in background signal.The present invention is simple in structure, and is easy to assembly, and it is reliable to be easy to maintenance and working stability.
Description of drawings
Fig. 1 is common employed two kinds of ion detection patterns on the current microbeam platform, and wherein: (a) being the preposition detection mode of part, (b) is rearmounted detection mode.
Fig. 2 is a system schematic of the present invention.
Embodiment
As shown in Figure 1.A kind of novel single ion microbeam detector based on plastic scintillating fiber, include microscope, described microscopical object lens below is provided with single ion microbeam, the exit portal of single ion microbeam is over against microscopical object lens, testing sample is positioned between the exit portal of microscopical object lens and single ion microbeam, also include the plastic scintillating fiber of flattening, photomultiplier, the part that plastic scintillating fiber flattens is between the exit portal and testing sample of single ion microbeam, plastic scintillating fiber adopts hot extrusion briquetting technique to flatten, its thickness that flattens part is less than 50 microns, and the space between the part that plastic scintillating fiber flattens and the exit portal of single ion microbeam is the smaller the better.The plastic scintillating fiber two ends are coupled with photomultiplier respectively; Single ion microbeam sends ion to testing sample, and when ion passed plastic scintillating fiber, plastic scintillating fiber produced photon, and with photon transmission to photomultiplier, by photomultiplier light signal is converted into electric signal, after ion passes plastic scintillant, the bombardment sample.Photomultiplier is installed in the seal box, is injected with the optocoupler mixture in the seal box, has aperture on the seal box, and the two ends of described plastic scintillating fiber are stretched in the seal box by aperture, joins with the receiver window of photomultiplier.
Among the present invention, the compacting of optical fiber is as follows:
Because the softening temperature of plastic scintillating fiber is 70 ℃, so adopt hot-forming scheme that optical fiber is processed.Job operation is: 1) fiber cut is become needed length; 2) optical fiber is put into the groove of self-control optical fiber suppressor base, turn suppressor knob makes hammer optical fiber is choked gently; 3) whole optical fiber suppressor is put into water-bath; 4) the bath switch of fetching boiling water, temperature adjustment be to the temperature of wanting, treat that temperature rises to preset temperature after, according to Preset Time turn suppressor knob, hammer is pressed to preseting length, repeat until being depressed into needed thickness; 5) from water-bath, take out the optical fiber suppressor, take off optical fiber after treating to cool off fully.
The coupling of optical fiber and photomultiplier is as follows among the present invention:
The assembling of optical fiber and photomultiplier: at first the optical fiber multiplier tube is put into metallic envelope, fill with the optical coupled agent in big envelope, open an aperture on the lid of metallic envelope, bore dia is suitable with the cross section of optic fibre diameter.Then according to accompanying drawing 2 the flash fibers that process be fixed in the line outlet directly over, make the press portion line that is attached to tightly of optical fiber export the top, reduce the air gap between line outlet and the optical fiber as far as possible, guarantee to beat on sample after ion beam passes optical fiber.After fixing plastic optical fiber, the two ends of optical fiber are inserted in the aperture of metallic envelope lid, guarantee that the two ends of optical fiber closely contact with the receiver window of photomultiplier, improve coupling efficiency as far as possible.
Claims (4)
1, a kind of novel single ion microbeam detector based on plastic scintillating fiber, include microscope, described microscopical object lens below is provided with single ion microbeam, the exit portal of described single ion microbeam is over against described microscopical object lens, testing sample is positioned between the exit portal of described microscopical object lens and single ion microbeam, it is characterized in that: the plastic scintillating fiber that also includes flattening, photomultiplier, the part that described plastic scintillating fiber flattens is between the exit portal and testing sample of described single ion microbeam, and described plastic scintillating fiber two ends are coupled with photomultiplier respectively; Single ion microbeam sends ion to testing sample, and when ion passed plastic scintillating fiber, plastic scintillating fiber produced photon, and with photon transmission to photomultiplier, by photomultiplier light signal is converted into electric signal, after ion passes plastic scintillant, the bombardment sample.
2, a kind of novel single ion microbeam detector based on plastic scintillating fiber according to claim 1 is characterized in that: described plastic scintillating fiber adopts hot extrusion briquetting technique to flatten, and its thickness that flattens part is less than 50 microns.
3, a kind of novel single ion microbeam detector based on plastic scintillating fiber according to claim 1 is characterized in that: the space between the part that described plastic scintillating fiber flattens and the exit portal of described single ion microbeam is the smaller the better.
4, a kind of novel single ion microbeam detector according to claim 1 based on plastic scintillating fiber, it is characterized in that: described photomultiplier is installed in the seal box, be injected with the optocoupler mixture in the seal box, have aperture on the seal box, the two ends of described plastic scintillating fiber are stretched in the seal box by aperture, join with the receiver window of photomultiplier.
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Cited By (6)
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| CN102455431A (en) * | 2010-11-25 | 2012-05-16 | 上海新漫传感技术研究发展有限公司 | Channel type radioactive detector with low detection limit |
| CN103901462A (en) * | 2014-03-21 | 2014-07-02 | 上海大学 | Totally-closed optical fiber radiation detection sensor |
| CN104035123A (en) * | 2014-06-27 | 2014-09-10 | 中国电子科技集团公司第八研究所 | Beta surface contamination detection device and method based on scintillant and optical fiber coupling |
| CN106324656A (en) * | 2015-06-30 | 2017-01-11 | 中国辐射防护研究院 | Neutron-sensitive substance plutonium-doped plastic scintillator and thermal neutron measurement method thereof |
| CN106324658A (en) * | 2015-06-30 | 2017-01-11 | 中国辐射防护研究院 | Neutron-sensitive substance cadmium-doped plastic scintillator and thermal neutron measurement method thereof |
| CN112099072A (en) * | 2020-08-19 | 2020-12-18 | 复旦大学 | High-flux anti-electromagnetic interference proton energy spectrum and intensity detector |
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| US5308986A (en) * | 1992-12-17 | 1994-05-03 | Nanoptics Incorporated | High efficiency, high resolution, real-time radiographic imaging system |
| CN1218193C (en) * | 2002-07-26 | 2005-09-07 | 中国科学院等离子体物理研究所 | Predetection method for single particle radiation device |
| US7460240B2 (en) * | 2005-10-17 | 2008-12-02 | Arryx, Inc. | Apparatus and method for detecting deformability of cells using spatially modulated optical force microscopy |
| CN201021941Y (en) * | 2007-04-02 | 2008-02-13 | 中国科学院等离子体物理研究所 | Single ion bundle remote counting detector |
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| CN102455431A (en) * | 2010-11-25 | 2012-05-16 | 上海新漫传感技术研究发展有限公司 | Channel type radioactive detector with low detection limit |
| CN102455431B (en) * | 2010-11-25 | 2013-08-28 | 上海新漫传感技术研究发展有限公司 | Channel type radioactive detector with low detection limit |
| CN103901462A (en) * | 2014-03-21 | 2014-07-02 | 上海大学 | Totally-closed optical fiber radiation detection sensor |
| CN103901462B (en) * | 2014-03-21 | 2016-06-29 | 上海大学 | A kind of totally-enclosed optical fiber radiation detection sensor |
| CN104035123A (en) * | 2014-06-27 | 2014-09-10 | 中国电子科技集团公司第八研究所 | Beta surface contamination detection device and method based on scintillant and optical fiber coupling |
| CN106324656A (en) * | 2015-06-30 | 2017-01-11 | 中国辐射防护研究院 | Neutron-sensitive substance plutonium-doped plastic scintillator and thermal neutron measurement method thereof |
| CN106324658A (en) * | 2015-06-30 | 2017-01-11 | 中国辐射防护研究院 | Neutron-sensitive substance cadmium-doped plastic scintillator and thermal neutron measurement method thereof |
| CN106324658B (en) * | 2015-06-30 | 2019-04-23 | 中国辐射防护研究院 | The method adulterated the plastic scintillant of neutron-sensitive substance cadmium and its measure thermal neutron |
| CN112099072A (en) * | 2020-08-19 | 2020-12-18 | 复旦大学 | High-flux anti-electromagnetic interference proton energy spectrum and intensity detector |
| CN112099072B (en) * | 2020-08-19 | 2024-03-08 | 复旦大学 | High flux anti-electromagnetic interference proton energy spectrum and intensity detector |
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