CN101657102B - Pesticidal mixtures comprising cyanosulfoximine compounds - Google Patents

Pesticidal mixtures comprising cyanosulfoximine compounds Download PDF

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CN101657102B
CN101657102B CN200880011720.0A CN200880011720A CN101657102B CN 101657102 B CN101657102 B CN 101657102B CN 200880011720 A CN200880011720 A CN 200880011720A CN 101657102 B CN101657102 B CN 101657102B
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compound
mixture
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seed
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CN101657102A (en
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D·布罗伊宁格
H·M·M·巴斯蒂安斯
W·冯戴恩
J·兰杰瓦德
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BASF SE
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A01N43/38—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/88—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with three ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to pesticidal mixtures comprising as active compounds 1) at least one cyanosulfoximine compound I of the formula (I) wherein R<1>, R<2> and G are defined in the description; and 2) at least one active compound II selected from a group A comprising acteylcholine esterase inhibitors, GABA-gated chloride channel antagonists, sodium channel modulators, nicotinic acetylcholine receptor agonists/antagonists, chloride channel activators, juvenile hormone mimics, compounds affecting the oxidative phosphorylation, inhibitors of the chitin biosynthesis, moulting disruptors, inhibitors of the MET, voltage-dependent sodium channel blockers, inhibitors of the lipid synthesis and other compounds as defined in the description, in synergistically effective amounts. The invention relates further to methods and use of these mixtures for combating insects, arachnids or nematodes in and on plants, and for protecting such plants being infested with pests and also for protecting seeds.

Description

The pesticide combination that comprises cyanosulfoximine compounds
The present invention relates to the novel pesticide mixture that comprises cyano group sulfenimide (cyanosulfoximine) compound and other agricultural chemicals active compound.The invention further relates to insect, spider or nematode in these mixtures antagonism plants and on plant, and protect this Plants in case insect is infected and protects method and the purposes of seed.
The typical problem occurring in field of pest control is that the dose rate that need to reduce active component, to reduce or to avoid undesired environment or toxicology effect, still allows effective control of insect simultaneously.
Another problem meeting with relates to the available pest control agent need to effective antagonism wide region insect.
Also exist and need to knock down (knock-down) activity and long-term control combination, there is the pest control agent of the snap action of dauer effect.
Another difficulty relevant to using agricultural chemicals is that repetition and the single administration of single agricultural chemical compound causes the fast selective of insect in many cases, and insect has had drug resistance natural or that adapt to described active component.Therefore, need to contribute to prevent and treat or overcome the pest control agent of drug resistance.
Therefore, the object of this invention is to provide the problem described at least one of solving as depressant dose rate, enhanced activity spectrum or knock down active and long-term control in conjunction with or the pesticide combination administered of drug resistance.
We have found that the combination of the reactive compound that this object partially or completely defines by beginning realizes.In addition, we have found with compared with the possible control rate of each compound, meanwhile, i.e. and associating or separate administration reactive compound I and one or more Compound I I or use successively reactive compound I and control of insect that one or more Compound I I is enhanced.
Therefore, the present invention relates to comprise the pesticide combination of following component as reactive compound using cooperative effective quantity:
1) the active cyano group sulfenimide Compound I of at least one formula I or its enantiomer or diastereomer, it is pure or as the mixture of these enantiomers and/or diastereomer:
Wherein:
G is selected from:
The wherein tie point in # expression I;
R 1for Cl or CF 3
And
R 2be selected from hydrogen, chlorine, CH 3or C 2h 5; With
2) at least one is selected from the reactive compound II of group A:
A.1 acetylcholinesteraseinhibitors inhibitors: be selected from triazemate or carbamates: Aldicarb (aldicarb), alanycarb (alanycarb), Benfuracard micro (benfuracarb), carbaryl (carbaryl), furadan (carbofuran), carbosulfan (carbosulfan), mercaptodimethur (methiocarb), methomyl (methomyl), methomyl (oxamyl), Aphox (pirimicarb), unden (propoxur) and thiodicarb (thiodicarb), or organophosphorus compounds: orthen (acephate), triazotion (azinphos-ethyl), gusathion m (azinphos-methyl), chlorfenviphos (chlorfenvinphos), chlopyrifos (chlorpyrifos), chlorpyrifos-methyl (chlorpyrifos-methyl), the thiol formula isomer (demeton-S-methyl) of methyl one O five or nine, basudin (diazinon), dichlorvos (dichlorvos)/DDVP, Carbicron (dicrotophos), Rogor (dimethoate), disulfoton (disulfoton), ethion (ethion), Folithion (fenitrothion), fenthion (fenthion), karphos (isoxathion), malathion (malathion), acephatemet (methamidophos), methidathion (methidathion), Menite (mevinphos), nuvacron (monocrotophos), omethoate (oxymethoate), metilomerkaptofosoksid (oxydemeton-methyl), one six zero five (parathion), parathion-methyl (parathion-methyl), phenthoate dimephenthoate cidial (phenthoate), thimet (phorate), zolone (phosalone), phosmet (phosmet), phosphamidon (phosphamidon), Actellic (pirimiphos-methyl), , quinalphos (quinalphos), Terbufos (terbufos), Ravap (tetrachlorvinphos), Hostathion (triazophos) and chlorophos (trichlorfon),
A.2GABA door chloride channel antagonist: be selected from cyclic diolefine, organochlorine, 5a,6,9,9a-hexahydro-6,9-methano-2,4 (endosulfan), N-ethyl-2, 2-dimethyl propylene acid amides-2-(2, the chloro-α of 6-bis-, α, the fluoro-p-methylphenyl of α-tri-) hydrazone, N-ethyl-2, the chloro-1-methyl cyclopropane-carboxylic acid amides-2-(2 of 2-bis-, the chloro-α of 6-bis-, α, the fluoro-p-methylphenyl of α-tri-) hydrazone, or phenyl pyrazoles: acetoprole, ethiprole (ethiprole), Frontline (fipronil), pyrafluprole, pyriprole, fluorine pyrazoles worm (vaniliprole) and phenyl pyrazole compounds II.A 2.1:
A.3 sodium channel modulators: be selected from pyrethroids: allethrin (allethrin), bifenthrin (bifenthrin), cyfloxylate (cyfluthrin), cyhalothrin (lambda-cyhalothrin), cypermethrin (cypermethrin), nail body cypermethrin (alpha-cypermethrin), Cypermethrin (beta-cypermethrin), own body cypermethrin (zeta-cypermethrin), decis (deltamethrin), esfenvalerate (esfenvalerate), ether chrysanthemum ester (etofenprox), fenpropathrin (fenpropathrin), kill chrysanthemum ester (fenvalerate), flucythrinate (flucythrinate), taufluvalinate (tau-fluvalinate), permethrin (permethrin), deinsectization silicon ether (silafluofen) and tralomethrin (tralomethrin),
A.4 nAChR agonist/antagonist: be selected from nicotine, Padan (cartaphydrochloride), thiocyclarn (thiocyclam), or anabasine: pyrrole worm clear (acetamiprid), chlothianidin, MTI-446 (dinotefuran), Imidacloprid (imidacloprid), nitenpyram (nitenpyram), thiacloprid (thiacloprid), Diacloden (thiamethoxam) and AKD-1022; Or allosteric nAChR activator: spinosad (spinosad);
A.5 chloride channel activator: be selected from Olivomitecidin (abamectin), emamectin-benzoate (emamectin benzoate), lepimectin or milbemycin (milbemectin);
A.6 juvenoid: be selected from Entocon ZR 512 (hydroprene), cover 7 (kinoprene), ABG-6215 (fenoxycarb) or pyriproxyfen (pyriproxyfen);
A.7 affect the compound of oxidative phosphorylation: be selected from and kill mite sulphur grand (diafenthiuron), fenbutatin oxide (fenbutatin oxide), propargite (propargite) or fluorine azoles worm clear (chlorfenapyr);
A.8 benzoylurea derivertives: be selected from Buprofezin (buprofezin) or benzyl ureas: bistrifluron (bistrifluron), TH-6040 (diflubenzuron), flufenoxuron (flufenoxuron), HEXAFLUMURON (hexaflumuron), fluorine the third oxygen urea (lufenuron), Rimon (novaluron) and Teflubenzuron (teflubenzuron);
A.9 the disrupting agent of casting off a skin: be selected from cyromazine (cyromazine) or moulting hormone antagonist: Runner (methoxyfenozide), RH-5992 (tebufenozide) and Ai Zhading (azadirachtin);
A.10 mitochondria electronics transfer inhibitor: be selected from pyridaben (pyridaben), Tolfenpyrad (tolfenpyrad) or the worm amine (flufenerim) of crowing;
A.11 the relevant sodium channel blockers: Xuan Zi oxadiazole worm (indoxacarb) of voltage or metaflumizone (metaflumizone);
A.12 lipoid synthetic inhibitor: be selected from spiral shell mite ester (spirodiclofen), Spiromesifen (spiromesifen) or spiral shell worm ethyl ester (spirotetramat);
A.13 various compounds: sulfanilamide (SN) dragonfly ester (amidoflumet), amitraz (amitraz), Bifenazate (bifenazate), clofentezine (clofentezine), cyenopyrafen, cyflumetofen (cyflumetofen), Te Ben oxazole (Etoxazole), flonicamid (flonicamid), flubendiamine, flupyrazophos, Hexythiazox (hexythiazox), Butacide (piperonylbutoxide), pymetrozine (pymetrozine), pyridalyl (pyridalyl), pyrifluquinazon, chlorantraniliprole (Chlorantraniliprole), anthranilamide (anthranilamide) Compound I I.A 13.1:
With the fluoro-3-methoxyl group-benzsulfamide of phenyl-sulfamide compound 2-cyano group-N-ethyl-4-, 2-cyano group-N-ethyl-3-methoxyl group-benzsulfamide, the fluoro-benzsulfamide of 2-cyano group-3-difluoro-methoxy-N-ethyl-4-, 2-cyano group-3-difluoro-methoxy-N-ethyl-benzsulfamide, the fluoro-3-methoxyl group-N of 2-cyano group-6-, N-dimethyl-benzsulfamide, 2-cyano group-3-methoxyl group-N, N-dimethyl-benzsulfamide, the fluoro-3-methoxyl group-N-methyl-benzsulfamide of 2-cyano group-N-ethyl-6-and 2-cyano group-3-difluoro-methoxy-N, N-dimethyl-benzsulfamide.
The present invention also provides the method for control insect, mite or nematode, and it comprises makes insect, mite or nematode or their food source, habitat, breeding spot or their place contact with the mixture of at least one reactive compound II with the reactive compound I of insecticidal effective dose.
In addition, the invention still further relates to a kind of protective plant with protection against insect, mite or nematosis or the method that infects, it comprises makes the soil of plant or plant growth or water contact with the mixture of at least one reactive compound II with the reactive compound I of insecticidal effective dose.
The present invention also provide a kind of protect seed in case soil insect and protection seedling root and branch in case the method for soil and blade face insect, it was included in before sowing and/or vernalization makes seed contact with the mixture of at least one reactive compound II with the reactive compound I of insecticidal effective dose later.
The invention still further relates to the mixture of reactive compound I and at least one reactive compound II in the purposes of resisting in insect, spider or nematode.
The invention still further relates to a kind of watching for animals in case the method for parasite infestation or invasion and attack, it comprises the mixture of the reactive compound I of antiparasitic effective dose and at least one reactive compound II is delivered medicine to the animal that needs it.
The invention still further relates to a kind of method that treatment is subject to the animal of parasite infestation or invasion and attack, it comprises the mixture of the reactive compound I of antiparasitic effective dose and at least one reactive compound II is delivered medicine to animal.
Compound I
The Compound I of formula I, their preparation method and they have been described in WO 2006/060029 effect of insect and mite insect.The preparation method of the reactive compound I of formula I can find therein.
The unexposed concrete pesticide combination that shows the selectivity cyano group sulfenimide compound of unexpected and synergy with other insecticidal active compound combination that comprises of prior art.
The Compound I of formula I provides in following table C.I:
Table C.I:
Compound I numbering G R 1 R 2
C.I.1 G 1 Cl H
C.I.2 G 1 Cl CH 3
C.I.3 G 1 Cl CH 2-CH 3
C.I.4 G 1 Cl Cl
C.I.5 G 2 Cl H
C.I.6 G 2 Cl CH 3
C.I.7 G 2 Cl CH 2-CH 3
C.I.8 G 2 Cl Cl
C.I.9 G 1 CF 3 H
C.I.10 G 1 CF 3 CH 3
C.I.11 G 1 CF 3 CH 2-CH 3
C.I.12 G 1 CF 3 Cl
C.I.13 G 2 CF 3 H
C.I.14 G 2 CF 3 CH 3
C.I.15 G 2 CF 3 CH 2-CH 3
C.I.16 G 2 CF 3 Cl
Formula I compound comprises racemic mixture, each pure enantiomer and diastereomer and optional active mixture.
Compound I I
The Compound I I of commercially available group A can be at The Pesticide Manual, the 13rd edition, in BritishCrop Protection Council (2003) and other publication, finds.
Formula II.A 2.1thiamides derivative and their preparation method have been described in WO 98/28279.Lepimectin is by Agro Project, and PJB Publications Ltd is known in 2004 11 months.Benclothiaz and preparation method thereof has been described in EP-A1 454621.Methidathion (Methidathion) and paraoxon (Paraoxon) and their preparation method have been described in FarmChemicals Handbook, the 88th volume, and Meister Publishing Company, in 2001.Acetoprole and its preparation method have been described in WO 98/28277.Metaflumizone (Metaflumizone) and its preparation method have been described in EP-A1462456.Pyrrole fluorine sulphur phosphorus (flupyrazofos) has been described in Pesticide Science 54,1988, in 237-243 page and US4822779.Pyrafluprole and its preparation method have been described in JP-A 2002-193709 and WO 01/00614.Pyriprole and its preparation method have been described in WO 98/45274 and US6335357.Sulfanilamide (SN) dragonfly ester (amidoflumet) and its preparation method have been described in US 6221890 and JP-A 21010907.Worm amine (flufenerim) and its preparation method of crowing has been described in WO03/007717 and WO 03/007718.Cyflumetofen (cyflumetofen) and its preparation method have been described in WO 04/080180.The preparation method who is similar to the anabasine of AKD-1022 has been described in Zhang, A. etc., and J.Neurochemistry, in 75 (3), 2000, AKD 1022 and its preparation method have been described in US 6300348.Chloranthraniliprole has been described in WO01/70671, WO 03/015519 and WO 05/118552.Formula II.A 13.1anthranilamide (anthranilamide) derivative have been described in WO 01/70671; WO 02/48137; WO03/24222, WO 03/15518, WO 04/67528; In WO 04/33468 and WO 05/118552.The fluoro-3-methoxyl group-benzsulfamide of phenyl-sulfamide compound 2-cyano group-N-ethyl-4-, 2-cyano group-N-ethyl-3-methoxyl group-benzsulfamide, the fluoro-benzsulfamide of 2-cyano group-3-difluoro-methoxy-N-ethyl-4-, 2-cyano group-3-difluoro-methoxy-N-ethyl-benzsulfamide, the fluoro-3-methoxyl group-N of 2-cyano group-6-, N-dimethyl-benzsulfamide, 2-cyano group-3-methoxyl group-N, N-dimethyl-benzsulfamide, the fluoro-3-methoxyl group-N-methyl-benzsulfamide of 2-cyano group-N-ethyl-6-and 2-cyano group-3-difluoro-methoxy-N, N-dimethyl-benzsulfamide has been described in WO2005/035486, in WO2006/056433 and inedited USSN 60/843606.
Preferably
Preferred formula I Compound I
Purposes about them in pesticide combination of the present invention, preferably R wherein 1for CF 3formula I Compound I, or its enantiomer or diastereomer, pure or as these enantiomers and/mixture of diastereomer.
Purposes about them in pesticide combination of the present invention, preferably R wherein 1for the formula I Compound I of Cl, or its enantiomer or diastereomer, pure or as these enantiomers and/mixture of diastereomer.
Purposes about them in pesticide combination of the present invention, preferably wherein G is G 1and R is CH 3formula I Compound I, or its enantiomer or diastereomer, pure or as these enantiomers and/mixture of diastereomer.
Purposes about them in pesticide combination of the present invention, also preferably wherein G is G 2and the formula I Compound I that R is hydrogen, or its enantiomer or diastereomer, pure or as these enantiomers and/mixture of diastereomer.
Purposes about them in pesticide combination of the present invention, preferably wherein G is G 1and R is hydrogen, chlorine or C 2h 5formula I Compound I, or its enantiomer or diastereomer, pure or as these enantiomers and/mixture of diastereomer.
Be selected from the preferred reactive compound II of group A
Purposes about them in pesticide combination of the present invention, particularly preferably listed Compound C .II in following paragraph.
About the purposes in pesticide combination of the present invention, be selected from the as above preferred triazemate of definitions section Compound I I A.1 or Aphox (primicarb).
About the purposes in pesticide combination of the present invention, be selected from the as above preferred 5a,6,9,9a-hexahydro-6,9-methano-2,4 of definitions section Compound I I A.2 (endosulfan), N-ethyl-2, 2-dimethyl propylene acid amides-2-(2, the chloro-α of 6-bis-, α, the fluoro-p-methylphenyl of α-tri-) hydrazone, N-ethyl-2, the chloro-1-methyl cyclopropane-carboxylic acid amides-2-(2 of 2-bis-, the chloro-α of 6-bis-, α, the fluoro-p-methylphenyl of α-tri-) hydrazone, acetoprole, ethiprole (ethiprole), Frontline (fipronil), pyrafluprole, pyriprole or fluorine pyrazoles worm (vaniliprole) or phenyl pyrazole compounds II.A 2.1.
More preferably Compound I I is N-ethyl-2,2-dimethyl propylene acid amides-2-(2, the chloro-α of 6-bis-, α, the fluoro-p-methylphenyl of α-tri-) hydrazone, N-ethyl-2, the chloro-1-methyl cyclopropane-carboxylic acid amides-2-of 2-bis-(the chloro-α of 2,6-bis-, α, the fluoro-p-methylphenyl of α-tri-) hydrazone, acetoprole or Frontline (fipronil).
About the purposes in pesticide combination of the present invention, be selected from the as above preferred allethrin of definitions section Compound I I A.3 (allethrin), bifenthrin (bifenthrin), cyfloxylate (cyfluthrin), cyhalothrin (lambda-cyhalothrin), cypermethrin (cypermethrin), nail body cypermethrin (alpha-cypermethrin), Cypermethrin (beta-cypermethrin), own body cypermethrin (zeta-cypermethrin), decis (deltamethrin), ether chrysanthemum ester (etofenprox), fenpropathrin (fenpropathrin), kill chrysanthemum ester (fenvalerate), flucythrinate (flucythrinate), taufluvalinate (tau-fluvalinate), deinsectization silicon ether (silafluofen) or tralomethrin (tralomethrin).
More preferably Compound I I is nail body cypermethrin (alpha-cypermethrin) or decis (deltamethrin).
About the purposes in pesticide combination of the present invention, be selected from the as above preferred thiocyclarn of definitions section Compound I I A.4 (thiocyclam), or anabasine: pyrrole worm clear (acetamiprid), chlothianidin, MTI-446 (dinotefuran), Imidacloprid (imidacloprid), nitenpyram (nitenpyram), thiacloprid (thiacloprid), Diacloden (thiamethoxam) and AKD-1022; Or allosteric nAChR activator: spinosad (spinosad).
More preferably Compound I I is clothianidin (clothianidine), Imidacloprid (imidacloprid) or Diacloden (thiamethoxam).
About the purposes in pesticide combination of the present invention, be selected from the as above preferred Olivomitecidin of definitions section Compound I I A.5 (abamectin), emamectin-benzoate (emamectinbenzoate), lepimectin or milbemycin (milbemectin).
More preferably Compound I I is Olivomitecidin (abamectin).
About the purposes in pesticide combination of the present invention, be selected from as above definitions section Compound I I A.7 and preferably kill mite sulphur grand (diafenthiuron).
About the purposes in pesticide combination of the present invention, be selected from the as above preferred Buprofezin of definitions section Compound I I A.8 (buprofezin).
About the purposes in pesticide combination of the present invention, be selected from the as above preferred pyridaben of definitions section Compound I I A.10 (pyridaben) or the worm amine (flufenerim) of crowing.
About the purposes in pesticide combination of the present invention, be selected from as above definitions section Compound I I You Xuan oxadiazole worm (indoxacarb) or metaflumizone (metaflumizone) A.11.
More preferably Compound I I is metaflumizone (metaflumizone).
About the purposes in pesticide combination of the present invention, be selected from the as above preferred spiral shell mite of definitions section Compound I I A.12 ester (spirodiclofen), Spiromesifen (spiromesifen) or spiral shell worm ethyl ester (spirotetramat).
More preferably Compound I I is Spiromesifen (spiromesifen) or spiral shell worm ethyl ester (spirotetramat).
About the purposes in pesticide combination of the present invention, be selected from the as above preferred amitraz of definitions section Compound I I A.13 (amitraz), flonicamid (flonicamid), flubendiamine, pymetrozine (pymetrozine), pyridalyl (pyridalyl), pyrifluquinazon, chlorantraniliprole (Chlorantraniliprole), anthranilamide (anthranilamide) Compound I I.A 13.1, the fluoro-3-methoxyl group-benzsulfamide of 2-cyano group-N-ethyl-4-, 2-cyano group-N-ethyl-3-methoxyl group-benzsulfamide, the fluoro-benzsulfamide of 2-cyano group-3-difluoro-methoxy-N-ethyl-4-, 2-cyano group-3-difluoro-methoxy-N-ethyl-benzsulfamide, the fluoro-3-methoxyl group-N of 2-cyano group-6-, N-dimethyl-benzsulfamide, 2-cyano group-3-methoxyl group-N, N-dimethyl-benzsulfamide, the fluoro-3-methoxyl group-N-methyl-benzsulfamide of 2-cyano group-N-ethyl-6-or 2-cyano group-3-difluoro-methoxy-N, N-dimethyl-benzsulfamide.
More preferably Compound I I is flonicamid (flonicamid), pymetrozine (pymetrozine), pyrifluquinazon, chlorantraniliprole (Chlorantraniliprole), anthranilamide (anthranilamide) Compound I I.A 13.1, the fluoro-3-methoxyl group-benzsulfamide of 2-cyano group-N-ethyl-4-, 2-cyano group-N-ethyl-3-methoxyl group-benzsulfamide, the fluoro-benzsulfamide of 2-cyano group-3-difluoro-methoxy-N-ethyl-4-, 2-cyano group-3-difluoro-methoxy-N-ethyl-benzsulfamide, the fluoro-3-methoxyl group-N of 2-cyano group-6-, N-dimethyl-benzsulfamide, 2-cyano group-3-methoxyl group-N, N-dimethyl-benzsulfamide, the fluoro-3-methoxyl group-N-methyl-benzsulfamide of 2-cyano group-N-ethyl-6-or 2-cyano group-3-difluoro-methoxy-N, N-dimethyl-benzsulfamide.
Especially preferably, containing N-ethyl-2,2-dimethyl propylene acid amides-2-(the chloro-α of 2,6-bis-, α, the fluoro-p-methylphenyl of α-tri-) hydrazone is as the pesticide combination of Compound I I.
Especially preferably, containing N-ethyl-2, the chloro-1-methyl cyclopropane-carboxylic acid amides-2-of 2-bis-(the chloro-α of 2,6-bis-, α, the fluoro-p-methylphenyl of α-tri-) hydrazone is as the pesticide combination of Compound I I.
Especially the preferably pesticide combination as Compound I I containing acetoprole.
Especially the preferably pesticide combination as Compound I I containing Frontline (fipronil).
Especially the preferably pesticide combination as Compound I I containing nail body cypermethrin (alpha-cypermethrin).
Especially preferably clothianidin-containing (clothianidine) is as the pesticide combination of Compound I I.
Especially the preferably pesticide combination as Compound I I containing Imidacloprid (imidacloprid).
Especially the preferably pesticide combination as Compound I I containing Diacloden (thiamethoxam).
Especially the preferably pesticide combination as Compound I I containing pymetrozine (pymetrozine).
Especially the preferably pesticide combination as Compound I I containing flonicamid (flonicamid).
Especially the preferably pesticide combination as Compound I I containing Spiromesifen (spiromesifen).
Especially the preferably pesticide combination as Compound I I containing spiral shell worm ethyl ester (spirotetramat).
Especially the preferably pesticide combination as Compound I I containing pyrifluquinazon.
Especially the preferably pesticide combination as Compound I I containing chlorantraniliprole (Chlorantraniliprole).
Especially preferably containing anthranilamide (anthranilamide) Compound I I.A 13.1pesticide combination as Compound I I:
Especially preferably contain the pesticide combination of the fluoro-3-methoxyl group-benzsulfamide of phenyl-sulfamide compound 2-cyano group-N-ethyl-4-:
Especially preferably contain the pesticide combination of phenyl-sulfamide compound 2-cyano group-N-ethyl-3-methoxyl group-benzsulfamide.
Especially preferably contain the pesticide combination of the fluoro-benzsulfamide of phenyl-sulfamide compound 2-cyano group-3-difluoro-methoxy-N-ethyl-4-.
Especially preferably contain the pesticide combination of phenyl-sulfamide compound 2-cyano group-3-difluoro-methoxy-N-ethyl-benzsulfamide.
Especially preferably contain the fluoro-3-methoxyl group-N of phenyl-sulfamide compound 2-cyano group-6-, the pesticide combination of N-dimethyl-benzsulfamide.
Especially preferably contain phenyl-sulfamide compound 2-cyano group-3-methoxyl group-N, the pesticide combination of N-dimethyl-benzsulfamide.
Especially preferably contain the pesticide combination of the fluoro-3-methoxyl group-N-of phenyl-sulfamide compound 2-cyano group-N-ethyl-6-methyl-benzsulfamide.
Especially preferably contain phenyl-sulfamide compound 2-cyano group-3-difluoro-methoxy-N, the pesticide combination of N-dimethyl-benzsulfamide.
Preferred mixture of the present invention
Following table M represents the formula I reactive compound I defining in C as shown in mixture of the present invention and the preferred compositions of organizing the reactive compound II of A:
Table M:
Mixture Compound I Compound I I Mixture Compound I Compound I I
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.1 C.I.1 acetoprole M.113 C.I.1 Kill mite sulphur grand (diafenthiuron)
M.2 C.I.2 acetoprole M.114 C.I.2 Kill mite sulphur grand (diafenthiuron)
M.3 C.I.3 acetoprole M.115 C.I.3 Kill mite sulphur grand (diafenthiuron)
M.4 C.I.4 acetoprole M.116 C.I.4 Kill mite sulphur grand (diafenthiuron)
M.5 C.I.5 acetoprole M.117 C.I.5 Kill mite sulphur grand (diafenthiuron)
M.6 C.I.6 acetoprole M.118 C.I.6 Kill mite sulphur grand (diafenthiuron)
M.7 C.I.7 acetoprole M.119 C.I.7 Kill mite sulphur grand (diafenthiuron)
M.8 C.I.8 acetoprole M.120 C.I.8 Kill mite sulphur grand (diafenthiuron)
M.9 C.I.9 acetoprole M.121 C.I.9 Kill mite sulphur grand (diafenthiuron)
M.10 C.I.10 acetoprole M.122 C.I.10 Kill mite sulphur grand (diafenthiuron)
M.11 C.I.11 acetoprole M.123 C.I.11 Kill mite sulphur grand (diafenthiuron)
M.12 C.I.12 acetoprole M.124 C.I.12 Kill mite sulphur grand (diafenthiuron)
M.13 C.I.13 acetoprole M.125 C.I.13 Kill mite sulphur grand (diafenthiuron)
M.14 C.I.14 acetoprole M.126 C.I.14 Kill mite sulphur grand (diafenthiuron)
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.15 C.I.15 acetoprole M.127 C.I.15 Kill mite sulphur grand (diafenthiuron)
M.16 C.I.16 acetoprole M.128 C.I.16 Kill mite sulphur grand (diafenthiuron)
M.17 C.I.1 Frontline (fipronil) M.129 C.I.1 Buprofezin (buprofezin)
M.18 C.I.2 Frontline (fipronil) M.130 C.I.2 Buprofezin (buprofezin)
M.19 C.I.3 Frontline (fipronil) M.131 C.I.3 Buprofezin (buprofezin)
M.20 C.I.4 Frontline (fipronil) M.132 C.I.4 Buprofezin (buprofezin)
M.21 C.I.5 Frontline (fipronil) M.133 C.I.5 Buprofezin (buprofezin)
M.22 C.I.6 Frontline (fipronil) M.134 C.I.6 Buprofezin (buprofezin)
M.23 C.I.7 Frontline (fipronil) M.135 C.I.7 Buprofezin (buprofezin)
M.24 C.I.8 Frontline (fipronil) M.136 C.I.8 Buprofezin (buprofezin)
M.25 C.I.9 Frontline (fipronil) M.137 C.I.9 Buprofezin (buprofezin)
M.26 C.I.10 Frontline (fipronil) M.138 C.I.10 Buprofezin (buprofezin)
M.27 C.I.11 Frontline (fipronil) M.139 C.I.11 Buprofezin (buprofezin)
M.28 C.I.12 Frontline (fipronil) M.140 C.I.12 Buprofezin (buprofezin)
M.29 C.I.13 Frontline (fipronil) M.141 C.I.13 Buprofezin (buprofezin)
M.30 C.I.14 Frontline (fipronil) M.142 C.I.14 Buprofezin (buprofezin)
M.31 C.I.15 Frontline (fipronil) M.143 C.I.15 Buprofezin (buprofezin)
M.32 C.I.16 Frontline (fipronil) M.144 C.I.16 Buprofezin (buprofezin)
M.33 C.I.1 Imidacloprid (imidacloprid) M.145 C.I.1 Pyridaben (pyridaben)
M.34 C.I.2 Imidacloprid (imidacloprid) M.146 C.I.2 Pyridaben (pyridaben)
M.35 C.I.3 Imidacloprid (imidacloprid) M.147 C.I.3 Pyridaben (pyridaben)
M.36 C.I.4 Imidacloprid (imidacloprid) M.148 C.I.4 Pyridaben (pyridaben)
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.37 C.I.5 Imidacloprid (imidacloprid) M.149 C.I.5 Pyridaben (pyridaben)
M.38 C.I.6 Imidacloprid (imidacloprid) M.150 C.I.6 Pyridaben (pyridaben)
M.39 C.I.7 Imidacloprid (imidacloprid) M.151 C.I.7 Pyridaben (pyridaben)
M.40 C.I.8 Imidacloprid (imidacloprid) M.152 C.I.8 Pyridaben (pyridaben)
M.41 C.I.9 Imidacloprid (imidacloprid) M.153 C.I.9 Pyridaben (pyridaben)
M.42 C.I.10 Imidacloprid (imidacloprid) M.154 C.I.10 Pyridaben (pyridaben)
M.43 C.I.11 Imidacloprid (imidacloprid) M.155 C.I.11 Pyridaben (pyridaben)
M.44 C.I.12 Imidacloprid (imidacloprid) M.156 C.I.12 Pyridaben (pyridaben)
M.45 C.I.13 Imidacloprid (imidacloprid) M.157 C.I.13 Pyridaben (pyridaben)
M.46 C.I.14 Imidacloprid (imidacloprid) M.158 C.I.14 Pyridaben (pyridaben)
M.47 C.I.15 Imidacloprid (imidacloprid) M.159 C.I.15 Pyridaben (pyridaben)
M.48 C.I.16 Imidacloprid (imidacloprid) M.160 C.I.16 Pyridaben (pyridaben)
M.49 C.I.1 Olivomitecidin (abamectin) M.161 C.I.1 Spiromesifen (spiromesifen)
M.50 C.I.2 Olivomitecidin (abamectin) M.162 C.I.2 Spiromesifen (spiromesifen)
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.51 C.I.3 Olivomitecidin (abamectin) M.163 C.I.3 Spiromesifen (spiromesifen)
M.52 C.I.4 Olivomitecidin (abamectin) M.164 C.I.4 Spiromesifen (spiromesifen)
M.53 C.I.5 Olivomitecidin (abamectin) M.165 C.I.5 Spiromesifen (spiromesifen)
M.54 C.I.6 Olivomitecidin (abamectin) M.166 C.I.6 Spiromesifen (spiromesifen)
M.55 C.I.7 Olivomitecidin (abamectin) M.167 C.I.7 Spiromesifen (spiromesifen)
M.56 C.I.8 Olivomitecidin (abamectin) M.168 C.I.8 Spiromesifen (spiromesifen)
M.57 C.I.9 Olivomitecidin (abamectin) M.169 C.I.9 Spiromesifen (spiromesifen)
M.58 C.I.10 Olivomitecidin (abamectin) M.170 C.I.10 Spiromesifen (spiromesifen)
M.59 C.I.11 Olivomitecidin (abamectin) M.171 C.I.11 Spiromesifen (spiromesifen)
M.60 C.I.12 Olivomitecidin (abamectin) M.172 C.I.12 Spiromesifen (spiromesifen)
M.61 C.I.13 Olivomitecidin (abamectin) M.173 C.I.13 Spiromesifen (spiromesifen)
M.62 C.I.14 Olivomitecidin (abamectin) M.174 C.I.14 Spiromesifen (spiromesifen)
M.63 C.I.15 Olivomitecidin (abamectin) M.175 C.I.15 Spiromesifen (spiromesifen)
M.64 C.I.16 Olivomitecidin (abamectin) M.176 C.I.16 Spiromesifen (spiromesifen)
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.65 C.I.1 Anthranilamide (anthranilamide) II.A 13.1 M.177 C.I.1 Chlorantraniliprole (Chlorantraniliprole)
M.66 C.I.2 Anthranilamide (anthranilamide) II.A 13.1 M.178 C.I.2 Chlorantraniliprole (Chlorantraniliprole)
M.67 C.I.3 Anthranilamide (anthranilamide) II.A 13.1 M.179 C.I.3 Chlorantraniliprole (Chlorantraniliprole)
M.68 C.I.4 Anthranilamide (anthranilamide) II.A 13.1 M.180 C.I.4 Chlorantraniliprole (Chlorantraniliprole)
M.69 C.I.5 Anthranilamide (anthranilamide) II.A 13.1 M.181 C.I.5 Chlorantraniliprole (Chlorantraniliprole)
M.70 C.I.6 Anthranilamide (anthranilamide) II.A 13.1 M.182 C.I.6 Chlorantraniliprole (Chlorantraniliprole)
M.71 C.I.7 Anthranilamide (anthranilamide) II.A 13.1 M.183 C.I.7 Chlorantraniliprole (Chlorantraniliprole)
M.72 C.I.8 Anthranilamide (anthranilamide) II.A 13.1 M.184 C.I.8 Chlorantraniliprole (Chlorantraniliprole)
M.73 C.I.9 Anthranilamide (anthranilamide) II.A 13.1 M.185 C.I.9 Chlorantraniliprole (Chlorantraniliprole)
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.74 C.I.10 Anthranilamide (anthranilamide) II.A 13.1 M.186 C.I.10 Chlorantraniliprole (Chlorantraniliprole)
M.75 C.I.11 Anthranilamide (anthranilamide) II.A 13.1 M.187 C.I.11 Chlorantraniliprole (Chlorantraniliprole)
M.76 C.I.12 Anthranilamide (anthranilamide) II.A 13.1 M.188 C.I.12 Chlorantraniliprole (Chlorantraniliprole)
M.77 C.I.13 Anthranilamide (anthranilamide) II.A 13.1 M.189 C.I.13 Chlorantraniliprole (Chlorantraniliprole)
M.78 C.I.14 Anthranilamide (anthranilamide) II.A 13.1 M.190 C.I.14 Chlorantraniliprole (Chlorantraniliprole)
M.79 C.I.15 Anthranilamide (anthranilamide) II.A 13.1 M.191 C.I.15 Chlorantraniliprole (Chlorantraniliprole)
M.80 C.I.16 Anthranilamide (anthranilamide) II.A 13.1 M.192 C.I.16 Chlorantraniliprole (Chlorantraniliprole)
M.81 C.I.1 Decis (deltamethrin) M.193 C.I.1 The worm amine (flufenerim) of crowing
M.82 C.I.2 Decis (deltamethrin) M.194 C.I.2 The worm amine (flufenerim) of crowing
M.83 C.I.3 Decis (deltamethrin) M.195 C.I.3 The worm amine (flufenerim) of crowing
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.84 C.I.4 Decis (deltamethrin) M.196 C.I.4 The worm amine (flufenerim) of crowing
M.85 C.I.5 Decis (deltamethrin) M.197 C.I.5 The worm amine (flufenerim) of crowing
M.86 C.I.6 Decis (deltamethrin) M.198 C.I.6 The worm amine (flufenerim) of crowing
M.87 C.I.7 Decis (deltamethrin) M.199 C.I.7 The worm amine (flufenerim) of crowing
M.88 C.I.8 Decis (deltamethrin) M.200 C.I.8 The worm amine (flufenerim) of crowing
M.89 C.I.9 Decis (deltamethrin) M.201 C.I.9 The worm amine (flufenerim) of crowing
M.90 C.I.10 Decis (deltamethrin) M.202 C.I.10 The worm amine (flufenerim) of crowing
M.91 C.I.11 Decis (deltamethrin) M.203 C.I.11 The worm amine (flufenerim) of crowing
M.92 C.I.12 Decis (deltamethrin) M.204 C.I.12 The worm amine (flufenerim) of crowing
M.93 C.I.13 Decis (deltamethrin) M.205 C.I.13 The worm amine (flufenerim) of crowing
M.94 C.I.14 Decis (deltamethrin) M.206 C.I.14 The worm amine (flufenerim) of crowing
M.95 C.I.15 Decis (deltamethrin) M.207 C.I.15 The worm amine (flufenerim) of crowing
M.96 C.I.16 Decis (deltamethrin) M.208 C.I.16 The worm amine (flufenerim) of crowing
M.97 C.I.1 Metaflumizone (metaflumizone) M.209 C.I.1 Nail body cypermethrin (α cypermethrin)
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.98 C.I.2 Metaflumizone (metaflumizone) M.210 C.I.2 Nail body cypermethrin (α cypermethrin)
M.99 C.I.3 Metaflumizone (metaflumizone) M.211 C.I.3 Nail body cypermethrin (α cypermethrin)
M.100 C.I.4 Metaflumizone (metaflumizone) M.212 C.I.4 Nail body cypermethrin (α cypermethrin)
M.101 C.I.5 Metaflumizone (metaflumizone) M.213 C.I.5 Nail body cypermethrin (α cypermethrin)
M.102 C.I.6 Metaflumizone (metaflumizone) M.214 C.I.6 Nail body cypermethrin (α cypermethrin)
M.103 C.I.7 Metaflumizone (metaflumizone) M.215 C.I.7 Nail body cypermethrin (α cypermethrin)
M.104 C.I.8 Metaflumizone (metaflumizone) M.216 C.I.8 Nail body cypermethrin (α cypermethrin)
M.105 C.I.9 Metaflumizone (metaflumizone) M.217 C.I.9 Nail body cypermethrin (α cypermethrin)
M.106 C.I.10 Metaflumizone (metaflumizone) M.218 C.I.10 Nail body cypermethrin (α cypermethrin)
M.107 C.I.11 Metaflumizone (metaflumizone) M.219 C.I.11 Nail body cypermethrin (α cypermethrin)
M.108 C.I.12 Metaflumizone (metaflumizone) M.220 C.I.12 Nail body cypermethrin (α cypermethrin)
M.109 C.I.13 Metaflumizone (metaflumizone) M.221 C.I.13 Nail body cypermethrin (α cypermethrin)
M.110 C.I.14 Metaflumizone (metaflumizone) M.222 C.I.14 Nail body cypermethrin (α cypermethrin)
M.111 C.I.15 Metaflumizone (metaflumizone) M.223 C.I.15 Nail body cypermethrin (α cypermethrin)
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.112 C.I.16 Metaflumizone (metaflumizone) M.224 C.I.16 Nail body cypermethrin (α cypermethrin)
M.113 C.I.1 Clothianidin (clothianidine) M.225 C.I.1 Diacloden (thiamethoxam)
M.114 C.I.2 Clothianidin (clothianidine) M.226 C.I.2 Diacloden (thiamethoxam)
M.115 C.I.3 Clothianidin (clothianidine) M.227 C.I.3 Diacloden (thiamethoxam)
M.116 C.I.4 Clothianidin (clothianidine) M.228 C.I.4 Diacloden (thiamethoxam)
M.117 C.I.5 Clothianidin (clothianidine) M.229 C.I.5 Diacloden (thiamethoxam)
M.118 C.I.6 Clothianidin (clothianidine) M.230 C.I.6 Diacloden (thiamethoxam)
M.119 C.I.7 Clothianidin (clothianidine) M.231 C.I.7 Diacloden (thiamethoxam)
M.120 C.I.8 Clothianidin (clothianidine) M.232 C.I.8 Diacloden (thiamethoxam)
M.121 C.I.9 Clothianidin (clothianidine) M.233 C.I.9 Diacloden (thiamethoxam)
M.122 C.I.10 Clothianidin (clothianidine) M.234 C.I.10 Diacloden (thiamethoxam)
M.123 C.I.11 Clothianidin (clothianidine) M.235 C.I.11 Diacloden (thiamethoxam)
M.124 C.I.12 Clothianidin (clothianidine) M.236 C.I.12 Diacloden (thiamethoxam)
M.125 C.I.13 Clothianidin (clothianidine) M.237 C.I.13 Diacloden (thiamethoxam)
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.126 C.I.14 Clothianidin (clothianidine) M.238 C.I.14 Diacloden (thiamethoxam)
M.127 C.I.15 Clothianidin (clothianidine) M.239 C.I.15 Diacloden (thiamethoxam)
M.128 C.I.16 Clothianidin (clothianidine) M.240 C.I.16 Diacloden (thiamethoxam)
M.129 C.I.1 Flonicamid (flonicamid) M.241 C.I.1 Spiral shell worm ethyl ester (spirotetramat)
M.130 C.I.2 Flonicamid (flonicamid) M.242 C.I.2 Spiral shell worm ethyl ester (spirotetramat)
M.131 C.I.3 Flonicamid (flonicamid) M.243 C.I.3 Spiral shell worm ethyl ester (spirotetramat)
M.132 C.I.4 Flonicamid (flonicamid) M.244 C.I.4 Spiral shell worm ethyl ester (spirotetramat)
M.133 C.I.5 Flonicamid (flonicamid) M.245 C.I.5 Spiral shell worm ethyl ester (spirotetramat)
M.134 C.I.6 Flonicamid (flonicamid) M.246 C.I.6 Spiral shell worm ethyl ester (spirotetramat)
M.135 C.I.7 Flonicamid (flonicamid) M.247 C.I.7 Spiral shell worm ethyl ester (spirotetramat)
M.136 C.I.8 Flonicamid (flonicamid) M.248 C.I.8 Spiral shell worm ethyl ester (spirotetramat)
M.137 C.I.9 Flonicamid (flonicamid) M.249 C.I.9 Spiral shell worm ethyl ester (spirotetramat)
M.138 C.I.10 Flonicamid (flonicamid) M.250 C.I.10 Spiral shell worm ethyl ester (spirotetramat)
M.139 C.I.11 Flonicamid (flonicamid) M.251 C.I.11 Spiral shell worm ethyl ester (spirotetramat)
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.140 C.I.12 Flonicamid (flonicamid) M.252 C.I.12 Spiral shell worm ethyl ester (spirotetramat)
M.141 C.I.13 Flonicamid (flonicamid) M.253 C.I.13 Spiral shell worm ethyl ester (spirotetramat)
M.142 C.I.14 Flonicamid (flonicamid) M.254 C.I.14 Spiral shell worm ethyl ester (spirotetramat)
M.143 C.I.15 Flonicamid (flonicamid) M.255 C.I.15 Spiral shell worm ethyl ester (spirotetramat)
M.144 C.I.16 Flonicamid (flonicamid) M.256 C.I.16 Spiral shell worm ethyl ester (spirotetramat)
M.145 C.I.1 Pymetrozine (pymetrozine) M.257 C.I.1 pyrifluquinazone
M.146 C.I.2 Pymetrozine (pymetrozine) M.258 C.I.2 pyrifluquinazone
M.147 C.I.3 Pymetrozine (pymetrozine) M.259 C.I.3 pyrifluquinazone
M.148 C.I.4 Pymetrozine (pymetrozine) M.260 C.I.4 pyrifluquinazone
M.149 C.I.5 Pymetrozine (pymetrozine) M.261 C.I.5 pyrifluquinazone
M.150 C.I.6 Pymetrozine (pymetrozine) M.262 C.I.6 pyrifluquinazone
M.151 C.I.7 Pymetrozine (pymetrozine) M.263 C.I.7 pyrifluquinazone
M.152 C.I.8 Pymetrozine (pymetrozine) M.264 C.I.8 pyrifluquinazone
M.153 C.I.9 Pymetrozine (pymetrozine) M.265 C.I.9 pyrifluquinazone
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.154 C.I.10 Pymetrozine (pymetrozine) M.266 C.I.10 pyrifluquinazone
M.155 C.I.11 Pymetrozine (pymetrozine) M.267 C.I.11 pyrifluquinazone
M.156 C.I.12 Pymetrozine (pymetrozine) M.268 C.I.12 pyrifluquinazone
M.157 C.I.13 Pymetrozine (pymetrozine) M.269 C.I.13 pyrifluquinazone
M.158 C.I.14 Pymetrozine (pymetrozine) M.270 C.I.14 pyrifluquinazone
M.159 C.I.15 Pymetrozine (pymetrozine) M.271 C.I.15 pyrifluquinazone
M.160 C.I.16 Pymetrozine (pymetrozine) M.272 C.I.16 pyrifluquinazone
M.161 C.I.1 The fluoro-3-methoxyl group-benzsulfamide of 2-cyano group-N-ethyl-4- M.273 C.I.1 2-cyano group-N-ethyl-3-methoxyl group-benzsulfamide
M.162 C.I.2 The fluoro-3-methoxyl group-benzsulfamide of 2-cyano group-N-ethyl-4- M.274 C.I.2 2-cyano group-N-ethyl-3-methoxyl group-benzsulfamide
M.163 C.I.3 The fluoro-3-methoxyl group-benzsulfamide of 2-cyano group-N-ethyl-4- M.275 C.I.3 2-cyano group-N-ethyl-3-methoxyl group-benzsulfamide
M.164 C.I.4 The fluoro-3-methoxyl group-benzsulfamide of 2-cyano group-N-ethyl-4- M.276 C.I.4 2-cyano group-N-ethyl-3-methoxyl group-benzsulfamide
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.165 C.I.5 The fluoro-3-methoxyl group-benzsulfamide of 2-cyano group-N-ethyl-4- M.277 C.I.5 2-cyano group-N-ethyl-3-methoxyl group-benzsulfamide
M.166 C.I.6 The fluoro-3-methoxyl group-benzsulfamide of 2-cyano group-N-ethyl-4- M.278 C.I.6 2-cyano group-N-ethyl-3-methoxyl group-benzsulfamide
M.167 C.I.7 The fluoro-3-methoxyl group-benzsulfamide of 2-cyano group-N-ethyl-4- M.279 C.I.7 2-cyano group-N-ethyl-3-methoxyl group-benzsulfamide
M.168 C.I.8 The fluoro-3-methoxyl group-benzsulfamide of 2-cyano group-N-ethyl-4- M.280 C.I.8 2-cyano group-N-ethyl-3-methoxyl group-benzsulfamide
M.169 C.I.9 The fluoro-benzsulfamide of 2-cyano group-3-difluoro-methoxy-N-ethyl-4- M.281 C.I.9 2-cyano group-3-difluoro-methoxy-N-ethyl-benzsulfamide
M.170 C.I.10 The fluoro-benzsulfamide of 2-cyano group-3-difluoro-methoxy-N-ethyl-4- M.282 C.I.10 2-cyano group-3-difluoro-methoxy-N-ethyl-benzsulfamide
M.171 C.I.11 The fluoro-benzsulfamide of 2-cyano group-3-difluoro-methoxy-N-ethyl-4- M.283 C.I.11 2-cyano group-3-difluoro-methoxy-N-ethyl-benzsulfamide
M.172 C.I.12 The fluoro-benzsulfamide of 2-cyano group-3-difluoro-methoxy-N-ethyl-4- M.284 C.I.12 2-cyano group-3-difluoro-methoxy-N-ethyl-benzsulfamide
M.173 C.I.13 The fluoro-benzsulfamide of 2-cyano group-3-difluoro-methoxy-N-ethyl-4- M.285 C.I.13 2-cyano group-3-difluoro-methoxy-N-ethyl-benzsulfamide
Mixture Compound I Compound I I Mixture Compound I Compound I I
M.174 C.I.14 The fluoro-benzsulfamide of 2-cyano group-3-difluoro-methoxy-N-ethyl-4- M.286 C.I.14 2-cyano group-3-difluoro-methoxy-N-ethyl-benzsulfamide
M.175 C.I.15 The fluoro-benzsulfamide of 2-cyano group-3-difluoro-methoxy-N-ethyl-4- M.287 C.I.15 2-cyano group-3-difluoro-methoxy-N-ethyl-benzsulfamide
M.176 C.I.16 The fluoro-benzsulfamide of 2-cyano group-3-difluoro-methoxy-N-ethyl-4- M.288 C.I.16 2-cyano group-3-difluoro-methoxy-N-ethyl-benzsulfamide
The especially preferred Compound I I that wherein organizes in addition A is N-ethyl-2, and the Compound I of 2-dimethyl propylene acid amides-2-(the chloro-α of 2,6-bis-, α, the fluoro-p-methylphenyl of α-tri-) hydrazone and formula I is the mixture of the present invention of the compound of table C.
The especially preferred Compound I I that wherein organizes in addition A is N-ethyl-2, and the Compound I of the chloro-1-methyl cyclopropane-carboxylic acid amides-2-of 2-bis-(the chloro-α of 2,6-bis-, α, the fluoro-p-methylphenyl of α-tri-) hydrazone and formula I is the mixture of the present invention of the compound of table C.
Insect
The mixture of reactive compound I and II, or simultaneously, i.e. associating or the reactive compound I and the II that separately use have remarkable effect to following object insect:
Lepidopterous insects (Lepidoptera (Lepidoptera)), for example black cutworm (Agrotis ypsilon), white line dart moth of turnip (Agrotis segetum), kapok worm (Alabama argillacea), Anticarsia (Anticarsiagemmatalis), Argyresthia conjugella, fork Autographa spp (Autographa gamma), tree looper (Bupalus piniarius), Cacoecia murinana, Capua reticulana, Cheimatobia brumata, dragon spruce Choristoneura spp (Choristoneura fumiferana), Choristoneura occidentalis, striped rice borer (Cirphis unipuncta), codling moth (Cydiapomonella), pine caterpillars (Dendrolimus pini), Diaphania nitidalis, Southwest Maize bar crambid (Diatraea grandiosella), Egyptian brill noctuid (Earias insulana), South America maize seedling phycitid (Elasmopalpus lignosellus), ligustrum fine tortricidae (Eupoecilia ambiguella), Evetriabouliana, Feltia subterranea, galleria mellonella waxmoth (Galleria mellonella), Lee's Grapholita spp (Grapholitha funebrana), oriental fruit moth (Grapholitha molesta), cotton bollworm (Heliothis armigera), tobacco budworm (Heliothis virescens), corn earworm (Heliothiszea), Oeobia undalis (Hellula undalis), Hibernia defoliaria, fall webworm (Hyphantriacunea), apple ermine moth (Hyponomeuta malinellus), tomato worm moth (Keiferialycopersicella), Lambdina fiscellaria, beet armyworm (Laphygma exigua), coffee leafminer (Leucoptera coffeella), pear leaf blister moth (Leucoptera scitella), Lithocolletisblancardella, grape berry steinernema (Lobesia botrana), beet webworm (Loxostegesticticalis), gypsymoth (Lymantria dispar), lymantria monacha (Lymantria monacha), peach leaf miner (Lyonetia clerkella), malacosoma neustria (Malacosoma neustria), tomato moth (Mamestra brassicae), Douglas fir poison moth (Orgyia pseudotsugata), corn borer (Ostrinianubilalis), small noctuid (Panolis flammea), cotton pink bollworm (Pectinophoragossypiella), boundary noctuid (Peridroma saucia), circle palm boat moth (Phalera bucephala), tobacco split worm (Phthorimaea operculella), citrus leaf-miner (Phyllocnistis citrella), Pieris brassicae (Pieris brassicae), the green noctuid of clover (Plathypena scabra), diamond-back moth (Plutellaxylostella), soybean noctuid (Pseudoplusia includens), Rhyacionia frustrana, Scrobipalpula absoluta, gelechiid (Sitotroga cerealella), grape berry moth (Sparganothis pilleriana), fall army worm (Spodoptera frugiperda), sea spodoptera (Spodoptera littoralis), prodenia litura (Spodoptera litura), Thaumatopoeapityocampa, green oak moth (Tortrix viridana), cabbage looper (Trichoplusia ni) and Zeiraphera canadensis,
Beetle (coleoptera (Coleoptera)), the narrow lucky fourth of for example pears (Agrilus sinuatus), vertical bar click beetle (Agriotes lineatus), dark-coloured click beetle (Agriotes obscurus), Amphimallussolstitialis, Anisandrus dispar, Mexico's cotton boll resembles (Anthonomus grandis), apple flower resembles (Anthonomus pomorum), Aphthona euphoridae, Athoushaemorrhoidalis, Atomaria linearis (Atomaria linearis), vertical pit cutting pin small moth (Blastophagus piniperda), Blitophaga undata, broad bean weevil (Bruchusrufimanus), pea weevil (Bruchus pisorum), Lens culinaris resembles (Bruchus lentis) in Europe, apple volume resembles (Byctiscus betulae), Cassida nebulosa (Cassida nebulosa), Cerotomatrifurcata, golden flower cockchafer (Cetonia aurata), Chinese cabbage seed tortoise resembles (Ceuthorrhynchusassimilis), blister beetle tortoise resembles (Ceuthorrhynchus napi), beet shin flea beetle (Cnaetocnematibialis), Conoderus vespertinus, asparagus scotellaris (Crioceris asparagi), Ctenicera ssp., Diabrotica longicornis, Diabrotica semipunctata, Diabrotica12-punctata, South America chrysomelid (Diabrotica speciosa), corn root leaf A (Diabroticavirgifera), mexican bean ladybird (Epilachna varivestis), tobacco flea beetle (Epitrixhirtipennis), cotton ash covers and resembles mutation (Eutinobothrus brasiliensis), Europe hylobius abietis (Hylobius abietis), Egyptian cloverleaf resembles (Hypera brunneipennis), alfalfa leaf resembles (Hypera postica), ips typographus (Ips typographus), tobacco scotellaris (Lemabilineata), black angle scotellaris (Lema melanopus), colorado potato beetles (Leptinotarsadecemlineata), Limonius californicus, rice water weevil (Lissorhoptrusoryzophilus), Melanotus communis, rape nitidulid (Meligethes aeneus), great Li gill cockchafer (Melolontha hippocastani), gill cockchafer in May (Melolontha melolontha), Oulema oryzae (Oulema oryzae), vine black ear beak resembles (Ortiorrhynchus sulcatus), Otiorhynchus spp (Otiorrhynchus ovatus), horseradish ape chrysomelid (Phaedon cochleariae), leaf of pear tree resembles (Phyllobius pyri), Phyllotreta chrysocephala, food phyllobranchia cockchafer belongs to (Phyllophaga sp.), rutelian (Phyllopertha horticola) is sent out in flower garden, the light sufficient flea beetle of soybean (Phyllotreta nemorum), Phyllotreta striolata (Phyllotreta striolata), Japanese beetle (Popillia japonica), pea leaf resembles (Sitona lineatus) and grain weevil (Sitophilus granaria), fly, mosquito (diptera (Diptera)), for example Aedes aegypti (Aedes aegypti), aedes albopictus (Aedesalbopictus), perversely disturb yellow-fever mosquito (Aedes vexans), Mexico fruit bat (Anastrepha ludens), anopheles maculipennis (Anopheles maculipennis), Anopheles crucians, white sufficient anopheles (Anopheles albimanus), anopheles costalis (Anopheles gambiae), Anophelesfreeborni, Hainan Island anopheles leucosphyrus leucosphyrus (Anopheles leucosphyrus), Yunnan anopheles minius (Anopheles minimus), anopheles quadrimaculatus (Anopheles quadrimaculatus), calliphora erythrocephala (Calliphora vicina), Mediterranean fruitfly (Ceratitis capitata), maggot disease gold fly (Chrysomyabezziana), Chrysomya hominivorax, Chrysomya macellaria, deerfly (Chrysops discalis), Chrysops silacea, Chrysops atlanticus, screwfly (Cochliomyia hominivorax), Chinese sorghum cecidomyiia (Contarinia sorghicola), cordylobia anthropophaga maggot (Cordylobia anthropophaga), furious storehouse midge (Culicoides furens), northern house (Culex pipiens), spot mosquito (Culex nigripalpus), Culex quinquefasciatus (Culexquinquefasciatus), matchmaker's spot mosquito (Culex tarsalis), Culiseta inornata, Culisetamelanura, melon fly (Dacus cucurbitae), dacus oleae (Dacus oleae), rape leave cecidomyiia (Dasineura brassicae), Delia antique, wheat field kind fly (Delia coarctata), delia platura (Delia platura), fly (Delia radicum) is planted on wild cabbage ground, Dermatobia hominis, little Mao latrine fly (Fannia canicularis), Geomyza Tripunctata, horse botfly (Gasterophilusintestinalis), glossina morsitans (Glossina morsitans), glossina palpalis (Glossina palpalis), Glossina fuscipes, glue tsetse fly (Glossina tachinoides), Haematobia irritans, Haplodiplosis equestris, Hippelates (Hippelates spp.), Peanut Fields delia platura (Hylemyia platura), heel fly (Hypoderma lineata), Leptoconops torrens, vegetable leafminer (Liriomyza sativae), U.S. Liriomyza (Liriomyza trifolii), Luciliacaprina, lucilia cuprina (Lucilia cuprina), lucilia sericata (Lucilia sericata), Lycoriapectoralis, Mansonia titillanus, wheat cecidomyiia (Mayetiola destructor), housefly (Muscadomestica), false stable fly (Muscina stabulans), oestrosis of sheep (Oestrus ovis), Opomyzaflorum, Europe wheat stem maggot (Oscinella frit), henbane seed spring fly (Pegomya hysocyami), onion fly (Phorbia antiqua), radish fly (Phorbia brassicae), wheat field kind fly (Phorbiacoarctata), phlebotomus argentipes (Phlebotomus argentipes), Psorophora columbiae, carrot fly (Psila rosae), Psorophora discolor, Prosimulium mixtum, cherry fruit fly (Rhagoletis cerasi), Rhagoletis pomonella (Rhagoletis pomonella), Sarcophaga haemorrhoidalis (Sarcophaga haemorrhoidalis), flesh fly belongs to (Sarcophaga), Simulium vittatum, tatukira (Stomoxys calcitrans), the gadfly (Tabanus bovinus), Tabanus atratus, red former horsefly (Tabanus lineola), Tabanus similis, Tipula oleracea and European daddy-longlegs (Tipula paludosa),
Thrips (thrips (Thysanoptera)), for example orchid thrips (Dichromothrips corbetti), Dichromothrips ssp., cigarette brown thrip (Frankliniella fusca), honeysuckle thrips (Frankliniella occidentalis), east flower thrips (Frankliniella tritici), the hard thrips of tangerine (Scirtothrips citri), rice thrips (Thrips oryzae), palm thrips (Thrips palmi) and onion thrips (Thrips tabaci);
Termite (Isoptera (Isoptera)), for example Calotermes flavicollis, Leucotermes flavipes, golden yellow different termite (Heterotermes aureus), yellow limb reticulitermes flavipe (Reticulitermes flavipes), U.S. little black reticulitermes flavipe (Reticulitermes virginicus), Europe reticulitermes flavipe (Reticulitermeslucifugus), Sang Te reticulitermes flavipe (Reticulitermes santonensis), Reticulitermesgrassei, Termes natalensis and Workers of Coptotermes formosanus Shiraki (Coptotermes formosanus), cockroach (Blattaria (Blattaria)-Blattodea), for example Groton bug (Blattella germanica), Blattella asahinae, American cockroach (Periplaneta americana), the large Lian (Periplaneta japonica) of Japan, brown blattaria (Periplaneta brunnea), Periplanetafuligginosa, Australia blattaria (Periplaneta australasiae) and oriental cockroach (Blattaorientalis),
Bedbug, aphid, leafhopper, white honeybee, coccid, cicada (Semiptera (Hemiptera)), for example, intend green stinkbug (Acrosternum hilare), corn chinch bug (Blissus leucopterus), blackspot cigarette fleahopper (Cyrtopeltis notatus), red cotton bug (Dysdercus cingulatus), Dysdercusintermedius, wheat Eurygasterspp (Eurygaster integriceps), tobacco stinkbug (Euschistusimpictiventris), cotton red bell beak coried (Leptoglossus phyllopus), America tarnished plant bug (Lygus lineolaris), tarnished plant bug (Lygus pratensis), green rice bug (Nezara viridula), beet is intended lace bug (Piesma quadrata), Solubea insularis, Thyanta perditor, Acyrthosiphon onobrychis, adelge laricis (Adelges laricis), Aphidulanasturtii, aphis fabae (Aphis fabae), strawberry root aphid (Aphis forbesi), apple aphid (Aphispomi), cotten aphid (Aphis gossypii), North America tea bamboo trunk aphid (Aphis grossulariae), Xi Naide aphid (Aphis schneideri), leaf roll aphid (Aphis spiraecola), elder aphid (Aphis sambuci), acyrthosiphum pisim (Acyrthosiphon pisum), eggplant is without net aphid (Aulacorthum solani), Bemisia argentifolii (Bemisia argentifolii), welted thistle short-tail aphid (Brachycaudus cardui), Lee's short-tail aphid (Brachycaudus helichrysi), Brachycaudus persicae, peach short-tail aphid (Brachycaudus prunicola), cabbage aphid (Brevicoryne brassicae), Capitophorushorni, Cerosipha gossypii, knurl nail hair aphid (Chaetosiphon fragaefolii) in strawberry, the hidden knurl aphid of tea bit of a bridle (Cryptomyzus ribis), abies nordmanniana vertebra adelgid (Dreyfusianordmannianae), dragon spruce vertebra adelgid (Dreyfusia piceae), Ju Genxi rounded tail aphid (Dysaphisradicola), Dysaulacorthum pseudosolani, rounded tail aphid (Dysaphisplantaginea) before car, the western rounded tail aphid of pears (Dysaphis pyri), broad bean Empoasca spp (Empoasca fabae), mealy plum aphid (Hyalopterus pruni), Hyperomyzus lactucae, English grain aphid (Macrosiphum avenae), root of Beijing euphorbia Macrosiphus spp (Macrosiphum euphorbiae), rose pipe aphid (Macrosiphon rosae), nest Lay is repaiied tail aphid (Megoura viciae), Melanaphis pyrarius, wheat is without net aphid (Metopolophium dirhodum), Myzodes persicae, shallot knurl volume aphid (Myzus ascalonicus), Myzus cerasi, Lee's knurl aphid (Myzus varians), black tea bit of a bridle is patched up Macrosiphus spp (Nasonovia ribis-nigri), rice fulgorid (Nilaparvata lugens), suspensor goitre woolly aphid (Pemphigus bursarius), sugarcane plant hopper (Perkinsiella saccharicida), phorodon aphid (Phorodon humuli), apple leaf sucker (Psylla mali), pear sucker (Psylla piri), shallot knurl moth aphid (Rhopalomyzus ascalonicus), corn leaf aphids (Rhopalosiphum maidis), the cereal pipe aphid (Rhopalosiphum padi) of overflowing, apple grass Rhopalosiphum spp (Rhopalosiphum insertum), Sappaphis mala, Sappaphis mali, greenbug (Schizaphis graminum), Schizoneura lanuginosa, English grain aphid (Sitobion avenae), trialeurodes vaporariorum (Trialeurodes vaporariorum), black citrus aphid (Toxoptera aurantiiand), grape phylloxera (Viteus vitifolii), bed bug (Cimex lectularius), cimex hemipterus (Cimexhemipterus), Reduvius senilis, Triatoma belongs to and Arilus critatus,
Ant, honeybee, wasp, sawfly (Hymenoptera (Hymenoptera)), for example Xinjiang cabbage sawfly (Athalia rosae), leaf cutting ant (Atta cephalotes), Atta capiguara, leaf cutting ant (Attacephalotes), Atta laevigata, Atta robusta, Atta sexdens, Atta texana, lift abdomen ant and belong to (Crematogaster), Hoplocampa minuta, Hoplocampatestudinea, black wool ant (Lasius niger), monomorium pharaonis (Monomorium pharaonis), Solenopsis geminata (Solenopsis geminate), red fire ant (Solenopsis invicta), black fiery ant (Solenopsis richteri), the fiery ant in south (Solenopsis xyloni), red ant (Pogonomyrmex barbatus), Pogonomyrmex californicus, Pheidolemegacephala, velvet ant (Dasymutilla occidentalis), bombus (Bombus), hornet (Vespula squamosa), Paravespula vulgaris, Paravespulapennsylvanica, Paravespula germanica, Ji wasp (Dolichovespulamaculata), yellow limit wasp (Vespa crabro), wasp (Polistes rubiginosa), Campodontus floridanus and Argentine ant (Linepithema humile),
Cricket, grasshopper, locust (orthoptera (Orthoptera)), for example residential house Chinese mugwort Xi (Achetadomestica), mole cricket (Gryllotalpa gryllotalpa), migratory locusts (Locusta migratoria), the black locust of double cut (Melanoplus bivittatus), the black locust of red foot (Melanoplus femurrubrum), the black locust of Mexico (Melanoplus mexicanus), black locust (Melanoplus sanguinipes) migrates, the stone black locust (Melanoplus spretus) that dwells, the red locust of striped (Nomadacris septemfasciata), America desert locust (Schistocerca americana), desert locust (Schistocerca gregaria), Morocco halberd line locust (Dociostaurus maroccanus), front yard disease kitchen range Zhong (Tachycinesasynamorus), plug is received jar (unit of capacitance) dolly locust (Oedaleus senegalensis), Zonozerusvariegatus, Africa sugarcane locust (Hieroglyphus daganensis), Kraussariaangulifera, Italy locust (Calliptamus italicus), grass dwell locust (Chortoicetesterminifera) and brown in Australia intended migratory locusts (Locustana pardalina),
Spider guiding principle (Arachnoidea)), for example, as spider (Acarina (Acarina)), Argasidae (Argasidae), Ying Pi section (Ixodidae) and Sarcoptidae (Sarcoptidae), as long star tick (Amblyommaamericanum), torrid zone flower tick (Amblyomma variegatum), Ambryommamaculatum, adobe tick (Argas persicus), ox tick (Boophilus annulatus), Boophilus decoloratus, boophilus microplus (Boophilus microplus), Dermacentorsilvarum, Dermacentor andersoni (Dermacentor andersoni), the large leather tick in America (Dermacentorvariabilis), Hyalomma truncatum, castor bean tick (Ixodes ricinus), Ixodesrubicundus, Blacklegged tick (Ixodes scapularis), ixodes holocyclus (Ixodes holocyclus), ixodes pacificus (Ixodes pacificus), Ornithodorus moubata, Ornithodorushermsi, Ornithodorus turicata, ornithonyssus bacoti (Ornithonyssus bacoti), Otobiusmegnini, Dermanyssus gallinae (Dermanyssus gallinae), sheep scabies disease (Psoroptes ovis), Rhipicephalus sanguineus, Rhipicephalus appendiculatus, Rhipicephalusevertsi, Sarcoptes scabiei hominis (Sarcoptes scabiei), goitre mite (Eriophyidae) belongs to, as thorn apple rust mite (Aculus schlechtendali), Phyllocoptrata oleivora and Eriophyes sheldoni, thin mite (Tarsonemidae) belongs to, as Phytonemus pallidus and Polyphagotarsonemus latus Banks (Polyphagotarsonemus latus), false spider mite (Tenuipalpidae) belongs to, as purplish red short hairs mite (Brevipalpus phoenicis), tetranychid (Tetranychidae) belongs to, as Tetranychus cinnabarinus (Tetranychuscinnabarinus), kamisawa tetranychus (Tetranychus kanzawai), Pacific Ocean tetranychid (Tetranychuspacificus), cotton spider mites (Tetranychus telarius) and T.urticae Koch (Tetranychus urticae), apple tetranychus (Panonychus ulmi), mandarin orange Ju tetranychid (Panonychus citri) and meadow unguiculus mite (Oligonych us pratensis), Araneida (Araneida), for example poisonous spiders (Latrodectusmactans) and brown silk spider (Loxosceles reclusa),
Flea (Siphonaptera (Siphonaptera)), for example cat flea (Ctenocephalides felis), dog flea (Ctenocephalides canis), Xanthopsyllacheopis (Xenopsylla cheopis), Pulex irritans (Pulexirritans), chigo (Tunga penetrans) and ceratophyllus fasciatus (Nosopsyllus fasciatus), silverfish, family silverfish (Thysanoptera (Thysanura)), for example silverfiss (Lepisma saccharina) and spot silverfish (Thermobia domestica), centipede (chilopoda (Chilopoda)), for example Scutigera coleoptrata, thousand-legger (Diplopoda (Diplopoda)), for example Narceus belongs to, Qu octopus (Dermaptera (Dermaptera)), for example European earwig (forficula auricularia), lice (hair Anoplura (Phthiraptera)), for example pediculus humanus capitis (Pediculus humanus capitis), pediculus humanus corporis (Pediculus humanus corporis), crab louse (Pthirus pubis), haematopinus eurysternus (Haematopinus eurysternus), haematopinus suis (Haematopinus suis), Linognathus vituli (Linognathus vituli), Bovicola bovis, chicken lice (Menopon gallinae), Menacanthus stramineus and Solenopotes capillatus.
Plant nematode, for example root-knot nematode, peanut root-knot nematode (Meloidogyne arenaria), Meloidogyne chitwoodi (Meloidogyne chitwoodi), Meloidogyne exigua, northern root-knot nematode (Meloidogyne hapla), Meloidogyne incognita (Meloidogyne incognita), javanese root knot nematode (Meloidogyne javanica) and other Meloidogyne (Meloidogyne); Cyst nematode, globodera rostochiensis (Globodera rostochiensis), G.pallida (Globoderapallida), tobacco Cyst nematode (Globodera tabacum) and other ball cyst belong to (Globodera); Cereal Cyst nematode (Heterodera avenae), soybean cyst nematode Heterodera glycines (Heterodera glycines), beet Cyst nematode (Heterodera schachtii), clover Cyst nematode (Heterodera trifolii) and other Heterodera (Heterodera); Plant edema during pregnancy goitre nematode, Anguina funesta, wheat anguina (Anguina tritici) and other Turbatrix (Anguina); Cauline leaf nematode, leaf bud nematode (Aphelenchoides besseyi), strawberry aphelenchoides (Aphelenchoides fragariae), chrysanthemum aphelenchoides (Aphelenchoides ritzemabosi) and other Aphelenchoides (Aphelenchoides); Thorn nematode, weeds thorn nematode (Belonolaimus longicaudatus) and other acupuncture Turbatrix (Belonolaimus); Loose ends worm, pine wood nematode (Bursaphelenchusxylophilus) and other Bursaphelenchus (Bursaphelenchus); Annular nematode, ring grain Turbatrix (Criconema), little loop wire Eimeria (Criconemella), Criconemoides (Criconemoides) and Middle Ring Line Eimeria (Mesocriconema); Bulb eelworm, rot stem nematodes (Ditylenchusdestructor), sweet potato stem nematode (Ditylenchus dipsaci), mushroom mycelium nematode (Ditylenchusmyceliophagus) and other Ditylenchus (Ditylenchus); Cone nematode, cone Turbatrix (Dolichodorus); Spirality nematode, Heliocotylenchus multicinctus and other Helicotylenchus genus, Rotylenchus robustus and other (Rotylenchus) genus that spirals; Sheath nematode, sheath Turbatrix (Hemicycliophora) and Hemicriconemoides belong to; Hirshmanniella belongs to; Hat nematode, Hoploaimus columbus, Hoploaimus galeatus and other rifle nematode (Hoplolaimus) belong to; Pseudo-root-knot nematode, abnormal pearl nematode (Nacobbusaberrans) and other pearl curve Eimeria (Nacobbus); Needlework worm, Longidorus elongatus and other minute hand Turbatrix (Longidorus); Penetrate needlework worm, hour hand Turbatrix (Paratylenchus); Pratylenchus, Pratylenchus brachyurus, coffee pratylenchus (Pratylenchus coffeae), Pratylenchus curvitatus, Pratylenchus goodeyi, Pratylenchus neglectus, puncture pratylenchus (Pratylenchus penetrans), ramie Pratylenchidae (Pratylenchusscribneri), disability pratylenchus (Pratylenchus vulnus), corn Pratylenchidae (Pratylenchus zeae) and other pratylenchus belong to (Pratylenchus); Radinaphelenchuscocophilus and other Radinaphelenchus belong to; Hole nematode, radopholus similes thorne (Radopholus similis) and other perforation line Eimeria (Radopholus); Kidney shape nematode, banana kidney shape nematode (Rotylenchus reniformis) and other Turbatrix that spirals (Rotylenchus); Scutellonema belongs to; Undesirable root nematode, Trichodorus primitivus and other burr Turbatrix (Trichodorus); Small plan burr nematode (Paratrichodorus minor) and other plan burr belong to (Paratrichodorus); The long nematode of resistance, Tylenchorhynchus claytoni, Tylenchorhynchus dubius and other Tylenchorhynchus (Tylenchorhynchus) and Merlinius belong to; Citrus nematode, partly puncture nematode (Tylenchulus semipenetrans) and other Tylenchida of citrus belongs to (Tylenchulus); Sword nematode, X. radicicola (Xiphinemaamericanum), dagger nematode (Xiphinema index), splits tail sword nematode (Xiphinemadiversicaudatum) and other Xiphinema (Xiphinema); And other plant nematode belongs to.
In addition, mixture of the present invention is particularly useful for preventing and treating Lepidoptera (Lepidoptera), coleoptera (Coleoptera), diptera (Diptera), thrips (Thysanoptera) and Semiptera (Hemiptera).
Mixture of the present invention is used in particular for preventing and treating thrips (Thysanoptera) and Semiptera (Hemiptera), especially Semiptera (Hemiptera).
Preparaton
Mixture of the present invention can change into normal compound agent, for example solution, emulsion, suspension, pulvis, powder, paste and particle.Type of service depends on and is specifically intended to object; Should ensure in each case the meticulous of the compounds of this invention and distribute equably.
Preparaton in a known way, for example by by active component with the auxiliary agent that is suitable for agrochemical formulation as solvent and/or carrier, emulsifier if necessary, surfactant and dispersant, preservative, defoamer, antifreezing agent, for seed treatment preparaton also optional gelling agent mix and prepare and (for example see US 3, 060, 084, EP-A 707445 (liquid concentrate), Browning, " Agglomeration ", Chemical Engineering, on December 4th, 1967, 147-48, Perry ' s ChemicalEngineer ' s Handbook, the 4th edition, McGraw-Hill, New York, 1963, 8-57 and each page subsequently, WO 91/13546, US 4, 172, 714, US 4, 144, 050, US 3, 920, 442, US 5, 180, 587, US 5, 232, 701, US 5, 208, 030, GB 2, 095, 558, US 3, 299, 566, Klingman, Weed Control as a Science, John Wiley and Sons, Inc., NewYork, 1961, Hance etc., Weed Control Handbook, the 8th edition, BlackwellScientific Publications, Oxford, 1989 and Mollet, H., Grubemann, A., Formulation technology, Wiley VCH Verlag GmbH, Weinheim (Germany), 2001, 2.D.A.Knowles, Chemistry and Technology ofAgrochemical Formulations, Kluwer Academic Publishers, Dordrecht, 1998 (ISBN 0-7514-0443-8).
The example of applicable solvent is water, arsol (as Solvesso product, dimethylbenzene), paraffin (as mineral oil fractions), alcohols (as methyl alcohol, butanols, amylalcohol, benzylalcohol), ketone (as cyclohexanone, gamma-butyrolacton), pyrrolidones (N-methyl-pyrrolidones (NMP), NOP (NOP)), acetic acid esters (ethylene acetate), dihydroxylic alcohols, fatty acid dimethylformamide, fatty acid and fatty acid ester.Can also use in principle solvent mixture.
Applicable emulsifier is nonionic and anion emulsifier (as polyoxyethylene aliphatic alcohol ether, alkylsulfonate and arylsulphonate).
The example of dispersant is lignin sulfite waste liquor and methylcellulose.
Applicable surfactant used is lignosulphonic acid, naphthalene sulfonic acids, phenolsulfonic acid, the alkali metal salt of dibutyl naphthalene sulfonic acids, alkali salt and ammonium salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, aliphatic alcohol sulfate, fatty acid and sulphated fatty alcohol glycol ether, also has the condensation product of sulfonated naphthalene and naphthalene derivatives and formaldehyde, the condensation product of naphthalene or naphthalene sulfonic acids and phenol and formaldehyde, NONIN HS 240, ethoxylation isooctylphenol, octyl phenol, nonyl phenol, alkyl phenyl polyglycol ether, tributyl phenyl polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol, alcohol and fatty alcohol ethylene epoxide condensation product, ethoxylated castor oil, polyoxyethylene alkyl ether, ethoxylation polyoxypropylene, laruyl alcohol polyglycol ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
Being suitable for preparation can Direct spraying solution, the material of emulsion, paste or oil dispersion be in to high boiling mineral oil fractions as kerosene or diesel oil, also has the oil of coal tar and plant or animal origin, aliphatic series, ring-type and aromatic hydrocarbon are as toluene, dimethylbenzene, paraffin, tetrahydronaphthalene, alkylated naphthalene or their derivative, methyl alcohol, ethanol, propyl alcohol, butanols, cyclohexanol, cyclohexanone, isophorone, height polar solvent is as methyl-sulfoxide, 1-METHYLPYRROLIDONE and water.
Also antifreezing agent can be added in preparaton as glycerine, ethylene glycol, propane diols and bactericide.
Applicable defoamer is for example the defoamer based on silicon or dolomol.
Applicable preservative is for example dichlorophen.
The example of gelling agent is Irish moss
Powder, broadcast sowing with material and pulvis can by active substance is mixed with solid carrier or together with grind and prepare.
Particle can be prepared by reactive compound and solid carrier are adhered to as coating particle, impregnated granules and homogeneous particle.
Solid carrier example is that ore deposit soil is as silica gel, silicate, talcum, kaolin, activated clay (attaclay), lime stone, lime, chalk, bole, loess, clay, dolomite, diatomite, calcium sulphate, magnesium sulfate, magnesia, the synthetic material grinding, fertilizer is if the product of ammonium sulfate, ammonium phosphate, ammonium nitrate, urea and plant origin is as flour, bark powder, wood powder and shuck powder, cellulose powder and other solid carrier.
Preparaton comprises 0.01-95 % by weight conventionally, preferably the reactive compound of 0.1-90 % by weight.In this case, reactive compound is with 90-100%, and preferably the purity of 95-100% (according to NMR spectrum) is used.
With regard to seed treatment, various preparatons can dilute 2-10 doubly, and causing the i.e. concentration with preparation is 0.01-60 % by weight, preferably 0.1-40 % by weight reactive compound.
Mixture of the present invention can be by spraying, atomization, dusting, broadcast sowing or water direct use, use with its preparaton form or type of service prepared therefrom, for example with directly can spray solution, powder, suspension or dispersion, emulsion, oil dispersion, paste, can dusting product, broadcast sowing and use by material or particle form.Type of service depends on the object being intended to completely; They are under any circumstance all intended to guarantee that reactive compound of the present invention distributes as far as possible best.
Moisture type of service can be by adding water to be prepared by emulsion concentrates, paste or wettable powder (sprayable powder, oil dispersion).In order to prepare emulsion, stick with paste or oil dispersion, can be by wetting agent, tackifier, dispersant or emulsifier by material directly or be dissolved in after oil or solvent homogenizing in water.But if also can prepare by active substance, wetting agent, tackifier, dispersant or emulsifier and suitable, concentrate and this concentrate of solvent or oil composition are suitable for dilute with water.
Activity compound concentration in off-the-shelf can change in relative wide region.They are generally 0.0001-10 % by weight, preferably 0.01-1 % by weight.
Reactive compound also can be successfully used to ultra low volume method (ULV), wherein can use to comprise to exceed the preparaton of 95 % by weight reactive compounds or even can in the situation that there is no additive, use reactive compound.
Under classify preparaton example as:
1. dilute with water and the product of foliage applying.With regard to seed treatment, this product can dilute or be undiluted and be applied to seed.
A) water-soluble concentrate (SL, LS)
10 weight portion reactive compounds are dissolved in 90 weight parts waters or water-soluble solvent.As selection, add wetting agent or other auxiliary agent.Reactive compound dissolves through water dilution, obtains thus having the preparaton of 10% (w/w) reactive compound.
B) dispersed concentrate (DC)
By 20 weight portion reactive compounds along with adding 10 weight portion dispersants to be dissolved in 70 weight portion cyclohexanone as PVP(polyvinyl pyrrolidone).Dilute with water obtains dispersion, obtains thus having the preparaton of 20% (w/w) reactive compound.
C) emulsifiable concentrate (EC)
15 weight portion reactive compounds are dissolved in 75 weight portion dimethylbenzene along with adding calcium dodecyl benzene sulfonate and castor oil ethoxylate (5 weight portions in every kind of situation).Dilute with water obtains emulsion, obtains thus having the preparaton of 15% (w/w) reactive compound.
D) emulsion (EW, EO, ES)
25 weight portion reactive compounds are dissolved in 35 weight portion dimethylbenzene along with adding calcium dodecyl benzene sulfonate and castor oil ethoxylate (5 weight portions in every kind of situation).For example, this mixture is introduced in 30 weight parts waters and make homogeneous latex emulsion by mulser (Ultraturrax).Dilute with water obtains emulsion, obtains thus having the preparaton of 25% (w/w) reactive compound.
E) suspension (SC, OD, FS)
In agitating ball mill, 20 weight portion reactive compounds are pulverized to obtain thin reactive compound suspension along with adding 10 weight portion dispersants, wetting agent and 70 weight parts waters or organic solvent.Dilute with water obtains the stable suspension of reactive compound, obtains thus having the preparaton of 20% (w/w) reactive compound.
F) water-dispersible granule and water-soluble granular (WG, SG)
By 50 weight portion reactive compounds along with adding 50 weight portion dispersants and wetting agent meticulous grind and pass through commercial plant (for example extruder, spray tower, fluid bed) make water dispersible or water-soluble granular.Dilute with water obtains stabilising dispersions or the solution of reactive compound, obtains thus having the preparaton of 50% (w/w) reactive compound.
G) water dispersible or water-soluble powder (WP, SP, SS, WS)
75 weight portion reactive compounds are ground along with adding 25 weight portion dispersants, wetting agent and silica gel in rotor-stator grinder.Dilute with water obtains stabilising dispersions or the solution of reactive compound, obtains thus having the preparaton of 75% (w/w) reactive compound.
H) gel formulation (GF)
In agitating ball mill, 20 weight portion reactive compounds are pulverized to obtain thin reactive compound suspension along with adding 10 weight portion dispersants, 1 weight portion gelling agent wetting agent and 70 weight parts waters or organic solvent.Dilute with water obtains the stable suspension of reactive compound, obtains thus having the preparaton of 20% (w/w) reactive compound.
2. the product of foliage applying without dilution.With regard to seed treatment, this product can dilute or be undiluted and be applied to seed.
I) can dusting powder (DP, DS)
Fully mix by the grinding in small, broken bits of 5 weight portion reactive compound and with 95% kaolin in small, broken bits.What this obtained having 5% (w/w) reactive compound can dusting product.
J) particle (GR, FG, GG, MG)
By the grinding in small, broken bits of 0.5 weight portion reactive compound and in conjunction with 95.5% carrier, obtain thus having the preparaton of 0.5% (w/w) reactive compound.Current methods is extrude, spray dry or bed process.This obtains not diluted and is applied to the particle on blade face.
K) ULV solution (UL)
10 weight portion reactive compounds are dissolved in to 90 weight portion organic solvents as in dimethylbenzene.This obtains having the product that is applied to blade face without dilution of 10% (w/w) reactive compound.
Various types of oil, wetting agent, adjuvant, weed killer herbicide, fungicide, other agricultural chemicals or bactericide can be added in active component, if suitable, just before next-door neighbour uses, add (bucket mixes).These reagent conventionally with reagent of the present invention with 1: 10-10: 1 weight ratio is mixed.
Use
Compound I and one or more Compound I I can simultaneously, combine or separate, or use successively, and the in the situation that of separate administration, order does not affect the result of prophylactico-therapeutic measures conventionally.
Mixture of the present invention directly or with the form of composition uses as seed, soil, surface, material or space by process insect or to be protected in case plant, the propagulum of insect infestations with the reactive compound of insecticidal effective dose.Use can be subject to as seed, soil, surface, material or space plant, propagulum before infestation by insect and after carry out.
The present invention also comprises a kind of method of combating animal pests; it comprises makes animal pest, its habitat, breeding spot, food source or animal pest grow cultivated plant, seed, soil, region, material or the environment that maybe may grow, or to be protected in case animal invasion and attack or material, plant, seed, soil, surface or the space of infecting contact with the mixture of at least one reactive compound II with at least one reactive compound I/ of insecticidal effective dose.
Compound I and one or more Compound I I are conventionally with 500: 1-1: 100, preferably 20: 1-1: 50, particularly 5: 1-1: 20 weight ratio is used.
Depend on required effect, the rate of application of mixture of the present invention is 5-2000g/ha, preferably 50-1500g/ha, particularly 50-750g/ha.
Mixture of the present invention is by contacting and ingesting effectively.
According to the preferred embodiment of the invention, mixture of the present invention uses by soil application.Soil application is especially advantageously used in antagonism ant, termite, cricket or cockroach.
Other preferred embodiment according to the present invention, for for resisting non-crop pests as for ant, termite, wasp, fly, mosquito, cricket, locust or cockroach, makes bait preparation by mixture of the present invention.
Bait can be liquid, solid or semisolid preparation (for example gel).
Other side of the present invention for when prepare mixture, is preferably used pure reactive compound I and II, can add wherein as resisted harmful fungoid or having other reactive compound or growth regulator or the fertilizer of activity of weeding.
The present composition can be in addition containing except above listed other active component those.For example fungicide, weed killer herbicide, fertilizer is as ammonium nitrate, urea, potash and perphosphate, phytotoxin and plant growth regulator and safener.These extra compositions can use in order or be combined with above-mentioned composition, can also before being close to use, add (bucket mixes) if suitable.For example can be before or after processing with other active component with the present composition plant of spraying.
Mixture of the present invention can be applied to any or all developing stage, for example ovum, larva, pupa and adult.Insect can be contacted and be prevented and treated by the composition that makes the mixture of the present invention of target pest, its food source, habitat, Huo Qi place, breeding spot and insecticidal effective dose or comprise mixture.
" place " means insect growth or possibility growing plants, seed, soil, region, material or environment.
Conventionally, " insecticidal effective dose " means to realize the observable effect of growing, the amount of the composition that comprises necrosis, death, blocks, prevents and remove, destroys or reduce the required mixture of the present invention of effect of the organic appearance of target and activity or comprise mixture.Insecticidal effective dose can change for the present invention's various mixtures/combinations used.The insecticidal effective dose of mixtures/combinations also will be according to the condition prevailing variation such as insecticidal effect and duration, weather, target species, place, mode of administration as required.
The composition of mixture of the present invention or these mixtures also can be used for protective plant with protection against insect, mite or nematosis or infects, and it comprises soil or the water of contact plant or plant growth.
Mixture of the present invention is by two kinds of contacts (via soil, glass, wall, bed necessaries (bed net), carpet, plant part or animal part) and ingest (bait or plant part) and by trophallaxis and transfer and effectively.
Preferred application process, for being applied in water body, is used via soil, crack and breach, pasture, dunghill, sewer, in water, and on floor, wall, or by periphery spray application and bait.
Other preferred embodiment according to the present invention, for for resisting non-crop pests as for ant, termite, wasp, fly, mosquito, cricket, locust or cockroach, makes bait preparation by mixture of the present invention.
Bait can be liquid, solid or semisolid preparation (for example gel).In composition, bait used is to stimulating insect to have the product of enough attractions as ant, termite, wasp, fly, mosquito, cricket etc. or cockroach eat it.This attractant can be easy to select in the feeding stimulant recognized or puppet and/or sex pheromone from this area.
For example, also comprised the surface in processing shed and house by the method for insect-borne infectious disease (malaria, dengue fever and yellow fever, Filariasis and leishmaniasis) with mixture of the present invention and the control of their correspondent composition, air-atomizing and dipping curtain, tent, clothing part, bed necessaries, tsetse fly trap etc.The Pesticidal combination that is applied to fiber, fabric, knit goods, nonwoven, mesh material or paper tinsel and oilcloth preferably comprises the composition that comprises mixture of the present invention, optional repellant and at least one adhesive.
Mixture of the present invention and the composition that comprises them can be used for protecting wooden materials as tree, post-and-paling, sleeper etc. with building as house, outer room, factory; and construction material, furniture, leather, fiber, vinyl goods, electric wire and cable etc. do not damage by ant and/or termite, and do not damage crop or mankind's (for example, in the time that insect is invaded house and public building) for preventing and treating ant and termite.
In soil treatment or be applied to insect shelter or nest in the situation that, the amount of active component is the every 100m of 0.0001-500g 2, the preferably every 100m of 0.001-20g 2.
In material protection, conventional rate of application is for example the every m of 0.01-1000g reactive compound 2process material, be desirably the every m of 0.1-50g 2.
The Pesticidal combination being used in material soaking contains 0.001-95 % by weight, preferably 0.1-45 % by weight, more preferably at least one repellant of 1-25 % by weight and/or insecticide conventionally.
For being used in bait composition, the common content of active component is 0.001-15 % by weight, is desirably 0.001-5 % by weight reactive compound.Composition therefor also can comprise other additive as the solvent of active material, aromatic, preservative, dyestuff or bitters.Its attraction also can strengthen by special color, shape or structure.
For the use in spray composite, the content of mixture of active principles is 0.001-80 % by weight, preferably 0.01-50 % by weight, most preferably 0.01-15 % by weight.
For the use in processing crop plants, the rate of application of mixture of active principles of the present invention can be 0.1-4000g per hectare, is desirably 25-600g per hectare, is more desirably 50-500g per hectare.
In the context of the invention, term plant refers to the propagating materials of whole plant, plant part or plant.
Mixture of the present invention and the composition that comprises them are being prevented and treated various cultivated plants as Cereal, root crop, oil crop, vegetables, spices, ornamental plants, for example hard wheat and other wheat, barley, oat, rye, corn (field corn and sweet corn/sweet and field corn), soybean, oil crop, crucifer, cotton, sunflower, banana, rice, rape seed rape, turnip rape, sugar beet, fodder beet, eggplant, potato, dogstail, lawn, turf, fodder grass, tomato, leek, pumpkin/pumpkin, cabbage, iceberg lettuce, pepper, cucumber, muskmelon, Brassicas, muskmelon, French beans, pea, garlic, onion, the seed of carrot, tuberous plant is as potato, sugarcane, tobacco, glucose, petunia, heroubill/mouse palm heroubill, particular importance in a large amount of insects on pansy and garden balsam.
The plant of available mixture process of the present invention comprises all gene improved plants or genetically modified plants, for example, due to cultivation, comprise gene engineering method and the crop of herbicide-tolerant or fungicide or insecticide effect, or for example can produce by traditional breeding method and/or mutant, or produce and there is the plant of improving performance compared with existing plant by recombinant program.
Term " plant propagation material " is to be understood that all generating portions that represent plant, and for example seed and vegetative vegetable material for example, as cutting and stem tuber (potato), and it can be used for a large amount of plants.This comprises seed, root, fruit, stem tuber, napiform root, rhizome, branch, seedling bud and other plant part.Also can be included in rice shoot and the young plant after germinateing or after emerging, transplanted from soil.These plant propagation materials can or be used the preventative processing of plant protection compound in the time of plantation or transplanting in the past.
Term " cultivated plant " should be understood to comprise by the plant of cultivation, sudden change or gene engineering modification.Gene improved plant is that genetic material is by using the modification of DNA recombinant technique to make to be difficult under natural surroundings by crossbreeding, sudden change or the plant of naturally recombinating and obtaining.Conventionally, one or more genes have been integrated in the genetic material of gene improved plant to improve some performance of plant.This gene modification for example also includes, but are not limited to by glycosylation or polymer addition as prenyl, acetylization or farnesylation structure division or PEG structure division and traditional modified protein after target (oligomeric-or polypeptide) (for example, as Biotechnol Prog.2001 Jul-Aug; 17 (4): 720-8., Protein Eng Des Sel.2004Jan; 17 (1): 57-66, Nat Protoc.2007; 2 (5): 1225-35., Curr Opin Chem Biol.2006 Oct; 10 (5): 487-91.Epub 2006 Aug28., Biomaterials.2001 Mar; 22 (5): 405-17, Bioconjug Chem.2005Jan-Feb; 16 (1): 113-21 is disclosed).
Term " cultivated plant " is to be understood that and also comprises because conventional breeding method or gene engineering have been given concrete classes of herbicides as hydroxyl-phenylpyruvic acid dioxygenase (HPPD) inhibitor, acetolactate synthestase (ALS) inhibitor (is for example shown in US 6 as sulfonylurea, 222, 100, WO 01/82685, WO00/26390, WO 97/41218, WO 98/02526, WO 98/02527, WO 04/106529, WO 05/20673, WO 03/14357, WO 03/13225, WO 03/14356, WO 04/16073) or imidazolone (for example see US 6, 222, 100, WO 01/82685, WO 00/26390, WO97/41218, WO 98/02526, WO 98/02527, WO 04/106529, WO 05/20673, WO 03/14357, WO 03/13225, WO 03/14356, WO 04/16073), sclerotinite 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS) inhibitor for example, as glyphosate (glyphosate) (being shown in WO 92/00377), glutamine synthelase (GS) inhibitor for example, (is for example shown in US 5 as careless ammonium phosphine (glufosinate) (seeing EP-A-0242236, EP-A-242246) or oxynil weed killer herbicide, 559,024) use indefatigable plant.Several cultivated plants are endowed herbicide tolerant by conventional breeding method (sudden change), for example, tolerate imidazolone as imazamox (Imazamox) rape in summer (Canola).Gene engineering method is for giving cultivated plant if soybean, cotton, corn, beet and rape weed killer herbicide are as glyphosate (glyphosate) and careless ammonium phosphine (glufosinate) tolerance, and some of them are in trade name (glyphosate (glyphosate)) and (careless ammonium phosphine (glufosinate)) is lower commercially available.
Term " cultivated plant " is to be understood that and also comprises by using DNA recombinant technique can synthesize one or more insect-killing proteins, especially knownly belong to bacillus from bacterium, particularly those of bacillus thuringiensis (Bacillus thuringiensis), for example endotoxin is as CryIA (b), CryIA (c), CryIF, CryIF (a2), CryIIA (b), CryIIIA, CryIIIB (b1) or ry9c; Vegetative insecticidal protein (vIP) is as the plant of VIP1, VIP2, VIP3 or VIP3A; Bacterium is planted a colony the insect-killing protein of nematode as polished rod Pseudomonas (Photorhabdus spp.) or different Bacillus (Xenorhabdusspp.); The toxin being produced by animal is as scorpion toxin, spider toxin, wasp toxin, or other insect-specific neurotoxin; By mycetogenetic toxin, as streptomycete toxin, phytolectin is as pears or barley lectin element; Agglutinin; Protease inhibitors is as trypsin inhibitor, serpin, potato tubers albumen (patatin), cystatin (cystatin) or antipain; Ribosome-inactivating protein matter (RIP) is as ricin, corn-RIP, abrin, Seeds of Luffa cylindrica albumen (luffin), Saponaria officinalis toxin (saporin) or red bryony toxalbumin (bryodin); Steroid metabolism enzyme is as 3-hydroxy steroid oxidase, ecdysteroid-IDP-glycosyl transferase, cholesterol oxidase, moulting hormone inhibitor or HMG-CoA-reductase; Iron channel blocker is as sodium or calcium channel blocker; Juvenile hormone esterase; Diuretic hormone acceptor (helicokinin acceptor); Stilben synzyme, bibenzyl synzyme, chitinase or dextranase.In the context of the invention, these insect-killing proteins or toxin should clearly be interpreted as front toxin, mixed protein, block or modified protein.Mixed protein is characterised in that the new combination (for example seeing WO 02/015701) in protein territory.The gene improved plant that this toxin maybe can synthesize this toxin is for example disclosed in EP-A 374753, WO 93/007278, WO 95/34656, EP-A 427529, EP-A 451878, WO 03/018810 and WO03/052073.The method of producing this gene improved plant is generally well known by persons skilled in the art, and is for example disclosed in above-mentioned publication.These insect-killing proteins that are contained in gene improved plant are given the plant protection that produces these protein in case the arthropodan harmful insect of some sorted group; particularly beetle (coleoptera (Coleoptera)), fly (diptera (Diptera)) and butterfly and moth (Lepidoptera (Lepidoptera)), and plant nematode (nematoda (Nematoda)).
Term " cultivated plant " is to be understood that and also comprises by using DNA recombinant technique can synthesize one or more protein to improve the resistance of those plants to bacterium, virus or fungal pathogens or the plant of tolerance.The example of this protein is so-called " pathogenicity related protein " (PR protein, for example see EP-A 0392225), (for example it expresses resistant gene that phytophthora infestans (Phytophthora infestans) is worked to disease resistance of plant gene, be derived from the potato cultivar of Mexico wild potato Solanum bulbocastanum) or T4-lyso-zym (for example can synthesize these protein, have raising to bacterium as the potato cultivar of the resistance of Erwinia amylvora).The method of producing this gene improved plant is generally well known by persons skilled in the art, and is for example disclosed in above-mentioned publication.
Term " cultivated plant " is to be understood that and also comprises by using DNA recombinant technique for example can synthesize one or more protein, to improve the output (biomass production, grain yield, content of starch, oil content or protein content) of those plants, drought-resistant, salt or the environmental factor of other limiting growth or the plant of resistance to insect and fungi, bacterium or viral pathogen.
Term " cultivated plant " is to be understood that and also comprises by using content of material or the novel substance content of DNA recombinant technique containing improvement amount, particularly improve the mankind or zootrophic plant, for example, (for example produce the oily crop of sanatory long-chain omega-fatty acid or unsaturated ω-9 fatty acid rape).
Term " cultivated plant " is to be understood that and also comprises by using DNA recombinant technique content of material or the novel substance content containing improvement amount, particularly improves the plant that raw material is produced, for example produce raising amount amylopectin potato (for example potato).
Some mixtures of the present invention there is systemic action and therefore can be used for protective plant branch in case foliar pest and for the processing of seed and root in case soil pests.
Seed treatment
Therefore, mixture of the present invention be suitable for seed treatment with protection seed in case insect pest, the plant roots that the particularly raw insect pest of soil, and protection produces and branch are in case soil pests and blade face insect.
Plant roots and branch that preferably protection produces.
More preferably protect the branch of gained plant in case perforation and sucking property insect.
Therefore; the present invention includes a kind of protection seed with protection against insect, particularly soil insect, and protect rice shoot root and branch with protection against insect; the particularly method of soil and blade face insect, described method is included in before sowing and/or vernalization makes seed contact with mixture of the present invention later.The particularly preferably method of protective plant root and branch, more preferably protective plant branch is in case perforation and the method for sucking property insect, and most preferably protective plant branch is in case the method for aphid.
Term seed comprises the propagulum of seed and all kinds, includes but not limited to real seed, cutting, sucker, bulb, napiform root, fruit, stem tuber, grain, transplants, slitting etc., means in preferred embodiments real seed.
Term seed treatment comprises all applicable seed processing technologies known in the art, and for example seed dressing, seed coating, seed dusting, seed soak and pellet seeds.
The present invention also comprises the seed that is coated with or contains reactive compound.Term " is coated with and/or contains " ordinary representation active component major part in the time using and being positioned on breeding product surface, although depend on application process, greater or lesser part composition can infiltrate in breeding product.In the time that (again) plants described breeding product, it can absorb active component.
Applicable seed is Cereal, root crop, oil crop, vegetables, spices, the seed of ornamental plants, for example hard wheat and other wheat, barley, oat, rye, corn (field corn and sugared corn/sweet corn and field corn), soybean, oil crop, crucifer, cotton, sunflower, banana, rice, oilseed rape, turnip rape, sugar beet, fodder beet, eggplant, potato, grass, lawn, turf, fodder grass, tomato, leek, pumpkin/pumpkin, wild cabbage, iceberg lettuce, pepper, cucumber, muskmelon, Brassicas, muskmelon, French beans, pea, garlic, onion, carrot, tuberous plant is as potato, sugarcane, tobacco, grape, petunia, heroubill/mouse palm heroubill, the seed of pansy and impatiens.
In addition, mixture of the present invention also can be used for due to cultivation, comprises genetic engineering method, can herbicide-tolerant or the seed treatment of the plant of fungicide or insecticide.
For example, active mixture can be used for the resistance to sulfonylureas that is selected from, imidazolone, in the seed treatment of the plant of the weed killer herbicide of grass ammonium phosphine (glufosinate-ammonium) or glyphosate isopropyl ammonium (glyphosate-isopropyl ammonium) and similar active substance, (for example see EP-A-0242236, EP-A-242246) (WO 92/00377) (EP-A-0257993, US 5, 013, 659), or make the genetically modified crops plant of bacillus thuringiensis (Bacillus thuringiensis toxins) (Bt toxin) of resistance to certain insect of plant as cotton (EP-A-0142924 for producing, EP-A-0193259).
In addition, mixture of the present invention also can be used for for example producing by traditional breeding method and/or mutant, or is produced and had compared with existing plant in the plant seed processing that improves performance by recombinant program.For example for example describe the recombinant modification of a large amount of crop plants, so that the situation of synthetic starch conversion (WO 92/11376, WO 92/14827, WO 91/19806) in plant, or there is the recombinant modification (WO 91/13972) of the genetically modified crops plant of modified fat acid composition.
The seed treatment of mixture is applied in before plant seeding and plant emerges in the past by spraying or being undertaken by dusting seed.
In seed treatment, corresponding preparaton is used by the mixture process seed of the present invention by effective dose.Here, the rate of application of reactive compound is generally 0.1g-10kg/100kg seed, preferably 1g-5kg/100kg seed, particularly 1g-2.5kg/100kg seed.For concrete crop, as lettuce, ratio may be higher.
The composition that is particularly useful for seed treatment is for example:
A solubility concentrates thing (SL, LS)
D emulsion (EW, EO, ES)
E suspension (SC, OD, FS)
F water-dispersible granule and water-soluble granular (WG, SG)
G water dispersible pow-ders and water-soluble powder (WP, SP, WS)
H gel formulation (GF)
I can dusting powder (DP, DS)
Conventional seed treatment preparaton for example comprises flowable concentrate FS, solution LS, dry treatment powder DS, slurry treatment water dispersible pow-ders WS, water-soluble powder SS and emulsion ES and EC and gel formulation GF.These preparatons can dilute or be undiluted and be applied to seed.Be applied to seed before sowing, or be directly applied on seed or after vernalization and carry out.
In preferred embodiments, FS preparaton is for seed treatment.FS preparaton can comprise 1-800g/l active component, 1-200g/l surfactant, 0-200g/l antifreezing agent, 0-400g/l adhesive, 0-200g/l pigment and 1 liter of solvent at the most, preferred water conventionally.
The FS preparaton that is preferred for the formula I compound of seed treatment comprises 0.1-80 % by weight (1-800g/l) active component conventionally, at least one surfactant of 0.1-20 % by weight (1-200g/l), for example 0.05-5 % by weight wetting agent and 0.5-15 % by weight dispersant, 20 % by weight at the most, for example 5-20 % by weight antifreezing agent, 0-15 % by weight, for example 1-15 % by weight pigment and/or dyestuff, 0-40 % by weight, for example 1-40 % by weight adhesive (sticker/adhesive), optionally 5 % by weight at the most, for example 0.1-5 % by weight thickener, optional 0.1-2% defoamer, optionally for example 0.01-1 % by weight preservative as biocide, antioxidant etc., filler/the excipient of 100 % by weight at the most.
Seed treatment preparaton also can additionally comprise adhesive and optional colorants.
Can add adhesive to process the adhesion strength of active material on seed later to improve.Applicable adhesive be block copolymer EO/PO surfactant and polyvinyl alcohol, polyvinylpyrrolidone, polyacrylate, polymethacrylates, polybutene, polyisobutene, polystyrene, polyvinylamine, polyvinyl lactam, polymine ( ), polyethers, polyurethane, polyvinyl acetate, tylose and be derived from the copolymer of these polymer.
Optionally, in preparaton, also can comprise colouring agent.The colouring agent or the dyestuff that are suitable for seed treatment preparaton are Rhodamin B, C.I. paratonere (Pigment Red) 112, C.I. solvent red (Solvent Red) 1, alizarol saphirol (pigment blue) 15:4, alizarol saphirol (pigment blue) 15:3, alizarol saphirol (pigment blue) 15:2, alizarol saphirol (pigment blue) 15:1, alizarol saphirol (pigmentblue) 80, pigment yellow (pigment yellow) 1, pigment yellow (pigment yellow) 13, paratonere (Pigment Red) 112, paratonere (Pigment Red) 48:2, paratonere (Pigment Red) 48:1, paratonere (Pigment Red) 57:1, paratonere (Pigment Red) 53:1, pigment orange (pigmentorange) 43, pigment orange (pigment orange) 34, pigment orange (pigment orange) 5, naphthol green (pigment green) 36, naphthol green (pigment green) 7, Pigment white (pigment white) 6, pigment brown (pigment brown) 25, purple (the basic violet) 10 of alkalescence, purple (the basic violet) 49 of alkalescence, acid red (acid red) 51, acid red (acid red) 52, acid red (acid red) 14, acid blue (acid blue) 9, Indian yellow (acid yellow) 23, red (the basic red) 10 of alkalescence, red (basicred) 108 of alkalescence.
The invention still further relates to the seed that comprises mixture of the present invention.The amount of Compound I or its agricultural salt will be conventionally at 0.1g-10kg/100kg seed, and preferably 1g-5kg/100kg seed, particularly changes in 1-1000g/100kg seed.
Animal health
Mixture of the present invention be also specially adapted to resist in animal and animal on parasite.
Therefore, object of the present invention also provides the parasitic new method in control animal and on animal.Another object of the present invention is to provide the agricultural chemicals safer for animal.Another object of the present invention further provides the animal agricultural chemicals that can use with the dosage lower than existing agricultural chemicals.Another object of the present invention is to provide the animal agricultural chemicals that parasite is provided to long-term aftereffect control.
The invention still further relates to the compound containing the formula I of antiparasitic effective dose for resisting animal and parasites on animals or its enantiomer or can salt for animals and can accept the composition of carrier.
The present invention a kind of processing is also provided, prevents and treats, prevents and watches for animals in case parasitic infestation and the method that infects, and it comprises the mixture of the present invention of antiparasitic effective dose or the composition oral that comprises it, part or parenteral or is applied to animal.
The present invention also provide a kind of for the treatment of, prevent and treat, prevent or watch for animals in case parasitic infestation or infect and the preparation method of the composition of the mixture of the present invention that comprises antiparasitic effective dose or the composition that comprises it.
The activity of compound of antagonism pest do not advise they be suitable for preventing and treating in animal and animal on body in-and vermin, this requirements for example bends down in Orally administered situation, non-emetic dosage, and metabolism compatibility, hypotoxicity and the safety operation of animal.
Surprisingly found that mixture of the present invention is suitable for resisting in animal and animal on body in-and vermin.
Mixture of the present invention and the composition that comprises them are preferred for control and prevent that animal from comprising that warm blooded animal (comprising the mankind) and fish are not attacked and infect.They are for example suitable for control and prevent that mammal is as ox, sheep, pig, camel, deer, horse, pig, poultry, rabbit, goat, dog and cat, buffalo, donkey, fallow deer and instruction deer, and hairiness animal is as ermine, chinchilla and racoon, birds are if hen, goose, turkey and duck and fish are if fresh-water fishes and saltwater fish are as the invasion and attack in salmon, carp and eel with infect.
Mixture of the present invention and the composition that comprises them are preferred for control and prevent domestic animal as the invasion and attack in dog or cat and infect.
Infecting in warm blooded animal and fish includes but not limited to louse, stings lice, tick, nose fly, ked, thorn fly, muscoid fly, fly, myiasitic fly larva, trombiculid, midge worm, mosquito and flea.
Mixture of the present invention and the composition that comprises them are suitable in interior suction and/or non-interior suction control body and/or vermin.They have activity for all or some developing stage.
Mixture of the present invention is particularly useful for antagonist epizoa.
Mixture of the present invention resists especially respectively the parasite of following order and genus:
Flea (Siphonaptera (Siphonaptera)), for example cat flea (Ctenocephalides felis), dog flea (Ctenocephalides canis), Xanthopsyllacheopis (Xenopsylla cheopis), Pulex irritans (Pulexirritans), chigo (Tunga penetrans) and ceratophyllus fasciatus (Nosopsyllus fasciatus), cockroach (Blattaria (Blattaria-Blattodea)), for example Groton bug (Blattella germanica), Blattella asahinae, american cockroach (Periplaneta americana), the large Lian (Periplaneta japonica) of Japan, brown blattaria (Periplaneta brunnea), Periplanetafuligginosa, Australia blattaria (Periplaneta australasiae) and oriental cockroach (Blattaorientalis),
Fly, mosquito (diptera (Diptera)), for example Aedes aegypti (Aedes aegypti), aedes albopictus (Aedesalbopictus), perversely disturb yellow-fever mosquito (Aedes vexans), Mexico fruit bat (Anastrepha ludens), anopheles maculipennis (Anopheles maculipennis), Anopheles crucians, white sufficient anopheles (Anopheles albimanus), anopheles costalis (Anopheles gambiae), Anophelesfreeborni, Hainan Island anopheles leucosphyrus leucosphyrus (Anopheles leucosphyrus), Yunnan anopheles minius (Anopheles minimus), anopheles quadrimaculatus (Anopheles quadrimaculatus), calliphora erythrocephala (Calliphora vicina), maggot disease gold fly (Chrysomya bezziana), Chrysomyahominivorax, Chrysomya macellaria, deerfly (Chrysops discalis), Chrysopssilacea, Chrysops atlanticus, screwfly (Cochliomyia hominivorax), Cordylobia anthropophaga, furious storehouse midge (Culicoides furens), northern house (Culexpipiens), spot mosquito (Culex nigripalpus), Culex quinquefasciatus (Culex quinquefasciatus), matchmaker's spot mosquito (Culex tarsalis), Culiseta inornata, Culiseta melanura, Dermatobiahominis, little Mao latrine fly (Fannia canicularis), horse botfly (Gasterophilus intestinalis), glossina morsitans (Glossina morsitans), glossina palpalis (Glossina palpalis), Glossina fuscipes, glue tsetse fly (Glossina tachinoides), Haematobia irritans, Haplodiplosisequestris, Hippelates (Hippelates spp.), heel fly (Hypoderma lineata), Leptoconops torrens, Lucilia caprina, lucilia cuprina (Lucilia cuprina), lucilia sericata (Lucilia sericata), Lycoria pectoralis, Mansonia (Mansonia spp.), housefly (Muscadomestica), false stable fly (Muscina stabulans), oestrosis of sheep (Oestrus ovis), phlebotomus argentipes (Phlebotomus argentipes), Psorophora columbiae, Psorophora discolor, Prosimulium mixtum, Sarcophaga haemorrhoidalis (Sarcophaga haemorrhoidalis), flesh fly belongs to (Sarcophaga sp.), Simulium vittatum, tatukira (Stomoxys calcitrans), Tabanus bovinus, Tabanus atratus, red former horsefly (Tabanus lineola) and Tabanussimilis,
Lice (hair Anoplura (Phthiraptera)), for example pediculus humanus capitis (Pediculus humanus capitis), pediculus humanus corporis (Pediculus humanus corporis), crab louse (Pthirus pubis), haematopinus eurysternus (Haematopinus eurysternus), haematopinus suis (Haematopinus suis), Linognathus vituli (Linognathus vituli), Bovicolabovis, chicken lice (Menopon gallinae), Menacanthusstramineus and Solenopotes capillatus.
Tick and parasitic mite class (Parasitiformes (Parasitiformes)): tick (tick order (Ixodida)), for example Blacklegged tick (Ixodes scapularis), ixodes holocyclus (Ixodes holocyclus), ixodes pacificus (Ixodespacificus), Rhiphicephalus sanguineus, Dermacentor andersoni (Dermacentor andersoni), the large leather tick in America (Dermacentor variabilis), long star tick (Amblyommaamericanum), Ambryomma maculatum, Ornithodorus hermsi, Ornithodorus turicata and parasitic mites (Mesostigmata (Mesostigmata)), for example ornithonyssus bacoti (Ornithonyssus bacoti) and Dermanyssus gallinae (Dermanyssus gallinae),
Width mite suborder (Actinedida) (Prostigmata (Prostigmata)) and flour mite suborder (Acaridida) (Astigmata (Astigmata)), for example honeybee shield mite belongs to (Acarapis spp.), Cheyletiella (Cheyletiellaspp.), Ornithocheyletia spp., Myobia spp., Psorergates spp., hair follicle Eimeria (Demodex spp.), Trombidium (Trombicula spp.), Listrophorus spp., Tyroglyphus (Acarus spp.), Tyrophagus (Tyrophagus spp.), Caloglyphus (Caloglyphusspp.), Hypodectes spp., Pterolichus spp., Psoroptes (Psoroptes spp.), foot mite belongs to (Chorioptes spp.), ear Psoroptes (Otodectes spp.), itch mite belongs to (Sarcoptes spp.), scab mite belongs to (Notoedres spp.), knee mite belongs to (Knemidocoptes spp.), Cytodites spp. and Laminosioptes spp,
Bedbug (Semiptera (Heteropterida)): bed bug (Cimex lectularius), cimex hemipterus (Cimex hemipterus), Reduvius senilis, Triatoma genus, Rhodnius (Rhodniusspp.), Panstrongylus belong to and Arilus critatus
Anoplurida, for example Haematopinus (Haematopinus spp.), jaw lice belongs to (Linognathus spp.), Pediculus (Pediculus spp.), Phtirus spp. and pipe lice belong to (Solenopotes spp.), Mallophagida (Arnblycerina and Ischnocerina suborder), for example Trimenopon spp., chicken lice belongs to (Menopon spp.), duck lice belongs to (Trinoton spp.), sheep lice belongs to (Bovicola spp.), Werneckiella spp., Lepikentron spp., Trichodectes (Trichodectes spp.) and cat Linognathus (Felicola spp.),
Roundworm nematoda:
Wipeworms and trichinosis (Trichinosis) are (Trichosyringida), for example Mao Xing worm section (Trichinellidae) (Trichinella (Trichinella spp.)), (Trichocephalidae (Trichuridae)) Trichocephalus (Trichuris spp.), Hepaticola (Capillaria spp)
Rod order (Rhabditida), for example Rhabditis (Rhabditis spp), excrement rhabditida belong to (Strongyloides spp.), Helicephalobus spp,
Strongylid order (Strongylida), for example Strongylus (Strongylus spp.), Ancylostoma (Ancylostoma spp.), Necator americanus (Necator americanus), Bunostomum trigonoce phalum (Bunostomum spp.) (Hookworm), Trichostrongylus (Trichostrongylus spp.), haemonchus contortus (Haemonchus contortus.), Ostertagia (Ostertagia spp.), cooper Turbatrix (Cooperia spp.), Nematodirus (Nematodirus spp.), Dictyocaulus (Dictyocaulus spp.), cup mouth belongs to (Cyathostoma spp.), Oesophagostomum belongs to (Oesophagostomum spp.), stephanurus dentatus (Stephanurus dentatus), pig coiled hair nematode (Ollulanus spp.), summer Bert Turbatrix (Chabertia spp.), stephanurus dentatus (Stephanurus dentatus), sygamus trachea (Syngamus trachea), hookworm Turbatrix (Ancylostoma spp.), Ancylostoma (Uncinaria spp.), first belong to (Globocephalusspp.) of ball, Necator (Necator spp.), rear circle belongs to (Metastrongylus spp.), Miao Le belongs to nematode (Muellerius capillaris), Protostrongylus (Protostrongylus spp.), blood vessel skein Eimeria (Angiostrongylus spp.), Parelaphostrongylus spp., Aleurostrongylusabstrusus and dioctophyme renale (Dioctophyma renale),
Roundworm (Ascaridida) in intestines, for example ascaris lumbricoides (Ascaris lumbricoides), ascaris suum (Ascaris suum), chicken roundworm (Ascaridia galli), Parascaris equorum (Parascaris equorum), pinworm (Enterobius vermicularis) (Threadworm), ascaris alata (Toxocara canis), lion bow roundworm (Toxascaris leonine), Skrjabinema (Skrjabinema spp.) and oxyuris equi (Oxyuris equi)
Camallanida (Camallanida), for example Guinea worm (Dracunculus medinensis) (guinea worm),
Spirurata (Spirurida), for example Thelazia (Thelazia spp.), Wuchereria (Wuchereria spp.), cloth Shandong Filaria (Brugia spp.), Onchocerca (Onchocercaspp.), Dirofilari spp.a, bivalve Filaria (Dipetalonema spp.), setaria (Setaria spp.), velvet Eimeria (Elaeophora spp.), Spirocerca lupi and soft line belong to (Habron ema spp.)
Thorniness has a worm (Acanthocephala), for example Acanthocephalus spp., Macracanthorhychus hirudinaceus (Macracanthorhynchus hirudinaceus) and Oncicola spp,
Planaria (Plathelminthes):
Flukes (fluke (Trematoda)), for example Faciola spp., Fascioloides magna, and grow genus (Paragonimus spp.), two-chamber belongs to (Dicrocoelium spp.), fasciolopsis buski (Fasciolopsis buski), clonorchis sinensis (Clonorchis sinensis), Schistosoma (Schistosoma spp.), hair is finished genus (Trichobilharzia spp.), there is thriving shape fluke (Alariaalata), Pneumoneces (Paragonimus spp.) and Nanocyetes spp,
Cercomeromorpha, especially tapeworms (tapeworms (Tapeworms)), for example Diphyllobothrium (Diphyllobothrium spp.), Tenia spp., Echinococcus (Echinococcus spp.), diphlidium caninum (Dipylidium caninum), Multiceps (Multiceps spp.), Hymenolepis (Hymenolepis spp.), Mesocestoides (Mesocestoides spp.), Vampirolepisspp., Mo Nici belongs to (Moniezia spp.), naked head belongs to (Anoplocephala spp.), Sirometraspp., naked head belongs to (Anoplocephala spp.) and Hymenolepis (Hymenolepis spp.).
Mixture of the present invention and be used in particular for the insect of control from diptera (Diptera), Siphonaptera (Siphonaptera) and tick order (Ixodida) containing their composition.
In addition, especially preferably mixture of the present invention and the composition containing them are used for resisting mosquito.
Mixture of the present invention and to be used for resisting fly containing their composition be another preferred embodiment of the present invention.
In addition, especially preferably mixture of the present invention and the composition containing them are used for resisting flea.
Mixture of the present invention and to be used for resisting tick containing their composition be another preferred embodiment of the present invention.
Mixture of the present invention and be also particularly useful for antagonist entozoa (roundworm nematode, thorniness have a worm and planaria) containing their composition.
Administration preventability and therapeutic are carried out.
The administration of reactive compound is direct or oral with the dosage form being applicable to, part/skin or parenteral carry out.
For the oral administration of warm blooded animal, mixture of the present invention can be mixed with to animal feed, animal feed premix thing, animal feed concentrate, pill, solution, paste, suspension, immersion liquid (drenches), gel, tablet, bolus and capsule.In addition, mixture of the present invention can deliver medicine to animal in its drinking water.For oral administration, selected dosage should provide the formula I compound in 0.01-100mg/kg the weight of animals/sky to animal, preferably 0.5-100mg/kg the weight of animals/sky.
As selection, mixture of the present invention can parenteral in animal, for example, by (intraruminal), intramuscular, intravenous or hypodermic injection in chamber.For hypodermic injection, formula I compound dispersibles or is dissolved in physiology and can accept in carrier.As selection, mixture of the present invention can be mixed with subcutaneous administration implant.In addition, formula I compound can cutaneous penetration in animal.For parenteral, the dosage of selection should offer animal with the reactive compound in 0.01-100mg/kg the weight of animals/sky.
Mixture of the present invention also can be with immersion liquid (dips), pulvis, powder, necklace, list (medallions), spray, shampoo, dip in point (spot-on) and pour (pour-on) preparaton and the form of ointment or oil-in-water or water-in-oil emulsion is locally applied to animal.For local application, immersion liquid and spray contain 0.5-5 conventionally, 000ppm, preferably 1-3,000ppm reactive compound.In addition, active compound combinations can be mixed with animal, particularly quadruped and pastes as ox and sheep ear.
Applicable preparation is:
-solution as oral administration solution, dilution after for the concentrate of oral administration, on skin or the solution of body cavity, pour-on formulations, gel;
-oral or emulsion and suspension that percutaneous drug delivery is used; Semisolid preparation;
The preparaton that-reactive compound is processed in ointment base or in oil-in-water or water-in-oil emulsion base;
-solid pharmaceutical preparation is as powder, premix or concentrate, particle, ball, sheet, bolus, capsule; Aerosol and inhalant, and containing the moulded products of reactive compound.
The composition that is suitable for injection is by being dissolved in active component in applicable solvent and optionally adding other composition to prepare as acid, alkali, buffer salt, preservative and solubilizer.Filtering solution sterile filling.
Applicable solvent is that physiology can tolerate solvent as water, and alkanol is as ethanol, butanols, benzylalcohol, glycerine, propane diols, polyethylene glycol, N-methyl-pyrrolidones, 2-Pyrrolidone and composition thereof.
Reactive compound can optionally be dissolved in the physiology that is suitable for injecting and can tolerate in plant or artificial oil.
Applicable solubilizer is the solvent that promotes reactive compound to dissolve in primary solvent or prevent its precipitation.Example is polyvinylpyrrolidone, polyvinyl alcohol, polyoxyethylated castor oil and polyoxy ethylization sorbitan ester.
Applicable preservative is benzylalcohol, Acetochlorone, p-hydroxybenzoate and n-butanol.
The direct administration of oral administration solution.Concentrate at beforehand dilution to oral administration after working concentration.Oral administration solution and concentrate are according to state-of-art and as above prepare about the description of injection solution, wherein do not need sterile procedure.
For the solution drip on skin, be coated with, rub in, spray or spray.
According to state-of-art and according to preparing about the description of injection solution above, wherein do not need sterile procedure for the solution on skin.
Other applicable solvent is polypropylene glycol, phenylethanol, phenoxetol, ester is as ethyl acetate or butyl ester, Ergol, ether is if aklylene glycol alkyl ether is as DPGME, and ketone is as acetone, methyl ethyl ketone, aromatic hydrocarbon, plant and artificial oil, dimethyl formamide, dimethylacetylamide, TC (transcutol), glyceryl alcohol contracting acetone (solketal), propylene carbonate and composition thereof.
During preparation can advantageously add thickener.Applicable thickener be inorganic thickening agent as bentonite, colloidal silicic acid, aluminum monostearate, organic thickening agent is as cellulose derivatives, polyvinyl alcohol and their copolymer, acrylate and methacrylate.
Gel is applied to or is coated on skin or introduces in body cavity.Gel by by by processing and prepare with enough thickeners as the solution of preparing as described in injection solution situation, produce the transparent material with soft creamlike consistency.Thickener used is the thickener providing above.
Pour-on formulations pours or is sprayed in the finite region of skin, reactive compound skin permeation and in pick up effect.
Pour-on formulations is prepared by dissolving in the solvent that makes reactive compound and can tolerate at applicable skin or solvent mixture, suspension or emulsification.If be applicable to, add other auxiliary agent as colouring agent, bio-absorbable promotion material, antioxidant, light stabilizer, sticker.
Applicable solvent is: water, alkanol, glycol, polyethylene glycol, polypropylene glycol, glycerine, aromatic alcohol is as benzylalcohol, phenylethanol, phenoxetol, ester is as ethyl acetate, butyl acetate, Ergol, ether is if aklylene glycol alkyl ether is as DPGME, diethylene glycol single-butyl ether, ketone is as acetone, methyl ethyl ketone, cyclic carbonate is as propylene carbonate, ethylene carbonate, aromatics and/or aliphatic hydrocarbon, plant or artificial oil, DMF, dimethylacetylamide, alkyl pyrrolidones is as methyl pyrrolidone, n-butylpyrrolioine ketone or n-octyl pyrrolidones, 1-METHYLPYRROLIDONE, 2-Pyrrolidone, 2, 2-dimethyl-4-oxygen base-methylene-1, 3-dioxy-penta ring and glycerol formal.
Applicable colouring agent is to be allowed for animal above and all colouring agents of solubilized or suspension.
Applicable absorption enhancement material is for example DMSO, and dope is as isopropyl myristate, n-nonanoic acid dipropylene glycol ester, silicone oil and with the copolymer of polyethers, fatty acid ester, triglyceride, fatty alcohol.
Applicable antioxidant is that sulphite or metabisulfite are as inclined to one side potassium bisulfite, ascorbic acid, butylated hydroxytoluene, butylated hydroxy anisole, vitamin e.
Applicable light stabilizer is for example 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID (novantisolic acid).
Applicable sticker is for example that cellulose derivatives, starch derivatives, polyacrylate, natural polymer are as alginates, gelatin.
Emulsion can be oral, skin or as injection administration.
Emulsion is Water-In-Oil type or oil-in-water type.
If they are by being dissolved in reactive compound in hydrophobic or aqueous favoring and preparing as colouring agent, absorption enhancement material, preservative, antioxidant, light stabilizer, tackify material make its homogenizing by applicable emulsifier and suitable other auxiliary agent with the solvent of other phase.
The hydrophobic phase (oil) being applicable to is:
Atoleine, silicone oil, crude vegetal is as sesame oil, apricot kernel oil, castor oil, synthetic glycerine three acid esters as caprylic/capric two glyceride, there is chain length C 8-C 12vegetable fatty acid or other be selected from especially the triglyceride mixture of natural acid, the partial glyceride mixture of saturated or unsaturated fatty acid that also can hydroxyl, C 8-C 10the monoglyceride of fatty acid and two glyceride, fatty acid ester is as ethyl stearte, adipic acid-di-n butyryl ester, lauric acid hexyl ester, dipropylene glycol pelargonate (dipropyleneglycol perlargonate), the branching fatty acid of medium chain and chain length C 16-C 18the ester of saturated fatty alcohol, isopropyl myristate, isopropyl palmitate, chain length C 12-C 18the caprylic/capric ester of saturated fatty alcohol, isopropyl stearate, oleic acid oil base ester, decyl oleate, ethyl oleate, ethyl lactate, wax fatty acid ester is as synthetic duck oil gland fat, dibutyl phthalate, diisopropyl adipate, with the ester admixture that relates to the latter, fatty alcohol is as different tridecanol, 2-octyl dodecanol, cetostearyl alcohol, oleyl alcohol, and fatty acid is as oleic acid and composition thereof.
Applicable aqueous favoring is: water, alcohol is as propane diols, glycerine, sorbitol and composition thereof.
Applicable emulsifier is: non-ionic surface active agent is as GREMAPHOR GS32, polyethoxylated dehydrated sorbitol mono-fatty acid ester, sorbitan monostearate, glyceryl monostearate, polyoxy ethyl stearate, alkyl phenol polyglycol ether; Amphoteric surfactant is as N-lauryl-p-imino-diacetic propionic acid two-sodium or lecithin; Anion surfactant is as NaLS, fatty alcohol ether sulphate, list/dialkyl group polyglycol ether orthophosphate monoethanolamine salt; Cation activity surfactant is as cetyl trimethyl ammonium chloride.
Other auxiliary agent being applicable to is: strengthen the material of viscosity and stable emulsion, for example mixture of copolymer, polyethylene glycol, wax, colloidal silicic acid or the described material of carboxymethyl cellulose, methylcellulose and other cellulose and starch derivatives, polyacrylate, alginates, gelatin, gum Arabic, polyvinylpyrrolidone, polyvinyl alcohol, methyl vinyl ether and maleic anhydride.
Suspension can oral or local/percutaneous drug delivery.They are by suspending reactive compound in suspending agent, add other auxiliary agent promote material, preservative, antioxidant, light stabilizer and prepare as wetting agent, colouring agent, bio-absorbable if suitable.
Liquid suspension is all homogeneous solvents and solvent mixture.
The emulsifier of applicable wetting agent (dispersant) for providing above.
Other auxiliary agent that can mention is above those that provide.
Semisolid preparation can oral or local/percutaneous drug delivery.They are different from above-mentioned suspension and emulsion part and are their more high viscosity.
For preparing solid pharmaceutical preparation, by reactive compound and applicable mixed with excipients, add auxiliary agent if suitable, and form desired form.
Applicable excipient is the solid, inert material that all physiology can tolerate.Used those are inorganic and organic substance.Inorganic substances are for example that sodium chloride, carbonate are as calcium carbonate, bicarbonate, aluminium oxide, titanium oxide, silicic acid, clay, precipitation or cabosil or phosphate.Organic substance is for example that sugar, cellulose, food and feed are as milk powder, animal powder, flour and fragment, starch.
Applicable auxiliary agent is preservative, antioxidant and/or above-mentioned colouring agent.
Other applicable auxiliary agent is lubricant and glidant if dolomol, stearic acid, talcum, bentonite, short decomposed substance are if starch or crospolyvinylpyrrolidone, adhesive are as starch, gelatin or linear polyethylene pyrrolidones, and dry adhesives is as microcrystalline cellulose.
Conventionally, " antiparasitic effective dose " means to realize the observable effect of growing, and comprises necrosis, death, blocks, prevents and remove, destroys or reduce the amount of the required active component of effect of the organic appearance of target and activity.Antiparasitic effective dose can change for the present invention's various compound/composition used.The antiparasitic effective dose of composition also will be according to the condition prevailing variation such as desinsection effect and duration, target species, mode of administration as required.
Can be used for the reactive compound that composition of the present invention can comprise about 0.001-95wt% mixture of the present invention conventionally.
Conventionally advantageously with 0.5-100mg/kg every day, preferably the total amount of 1-50mg/kg every day is used the reactive compound of mixture of the present invention.
Use preparation with 10ppm to 80 % by weight, preferably 0.1-65 % by weight, more preferably 1-50 % by weight, most preferably the concentration of 5-40 % by weight contains parasite, the reactive compound of the mixture of the present invention that preferred body epizoa is worked.
Before using, the preparation of dilution is with 0.5-90 % by weight, and preferably the concentration of 1-50 % by weight is containing the reactive compound of the mixture of the present invention that vermin is worked.
In addition, preparation is with 10ppm to 2 % by weight, preferably 0.05-0.9 % by weight, the reactive compound that very particularly preferably concentration of 0.005-0.25 % by weight comprises the entozoal mixture of the present invention of antagonist.
In the preferred embodiment of the invention, the composition skin/local application that comprises mixture of the present invention.
In other preferred embodiment, local application with containing the moulded products of compound as necklace, list (medallions), ear paste, be fixed on the band of body part, and the form of adhesive strip and paper tinsel is carried out.
Conventionally advantageously during three weeks with 10-300mg/kg, preferably 20-200mg/kg, the total amount that most preferably 25-160mg/kg processes the body weight of animal is used the solid formulations of the reactive compound that discharges mixture of the present invention.
For preparing moulded products, use thermoplasticity and flexiplast and elastomer and thermoplastic elastomer (TPE).Applicable plastics and elastomer are polyvinyl resin, polyurethane, polyacrylate, epoxy resin, cellulose, cellulose derivatives, polyamide and the polyester fully compatible with I compound.The details of the preparation procedure of plastics and elastomer and moulded products for example provide in WO 03/086075.
Biopotency
Synergy can be described as the interaction that the combined effect of two or more compounds is wherein greater than each effect sum of each compound.According to control percentage, two existence that mix the synergy between partner (X and Y) can be used Colby formula (Colby, S.R., 1967, CalculatingSynergistic and Antagonistic Responses in Herbicide Combinations, Weeds, 15,20-22) calculate:
E = X + Y - XY 100
In the time that the combination control efficiency of observing is greater than the combination control efficiency (E) of expection, combined effect is Synergistic.
The compounds of this invention, mixture or the composition preventing efficiency to concrete insect is illustrated in following test.But the control of insect protection being provided by compound, mixture or composition is not limited to these kinds.In some cases, the combination of discovery the compounds of this invention and other invertebrate pest control compound or reagent has cooperative synergism effect to some important invertebrate pests.
Between mixture or composition, synergistic analysis is used Colby formula to determine.
Biological Examples of the present invention
Test B.1
For assessment, by contact or interior suction measure control vetch aphid (nest Lay is repaiied tail aphid (Megouraviciae)), experimental rig is made up of the titer plate containing wide French beans blade.
Compound or mixture are used to the solution preparation containing 75 % by weight water and 25 % by weight DMSO.Use the Miniature atomizer of customization that the preparation compound of variable concentrations or mixture are repeated to be sprayed on blade for twice with 2.5 μ l.
For experimental mixture in these trials, mix partner by two kinds of same volume and be mixed together with desired concn respectively.
After using, by air-dry blade and 5-8 adult aphid is placed on the blade in microtitre plate hole.Then make aphid suck the blade of processing and at 23 ± 1 DEG C, under 50 ± 5%RH (relative moisture), inoculate 5 days.Then visual assessment aphid lethality and fertility.For the mixture of test, the results are shown in table B.1.1 and B.1.2.
Table B.1.1
compound C .I.1
Vetch aphid ppm Average control %
Spiral shell worm ethyl ester (spirotetramat)+Compound C .I.1 0+0.8 0
100+0 50
100+0.8 100 ＊
*according to the collaborative control efficiency of Colby formula
Table B.1.2
compound C .I.2
Vetch aphid ppm Average control %
Pyridaben (pyridaben)+Compound C .I.2 0+0.8 0
200+0 50
200+0.8 100 ＊
Nail body cypermethrin (alphacypermethrin)+Compound C .I.2 0+0.8 0
2+0 0
2+0.8 75 ＊
Frontline (Fipronil)+Compound C .I.2 2+0 25
0+0.8 0
2+0.8 100 ＊
*according to the collaborative control efficiency of Colby formula
Test B.2
For assessment, by interior suction measure control black peach aphid (black peach aphid (Myzus persicae)), experimental rig is made up of the titer plate containing liquid artificial food under artificial membrane.
Compound or mixture are used to the solution preparation containing 75 % by weight water and 25 % by weight DMSO.Use the suction pipe of customization that the preparation compound of variable concentrations or mixture are repeated to 2 times with in suction pipe suction aphid food.
For experimental mixture in these trials, mix partner by two kinds of same volume and be mixed together with desired concn respectively.
After using, 5-8 adult aphid is placed in the artificial membrane in microtitre plate hole.Then make aphid suck the food of processing and at 23 ± 1 DEG C, under 50 ± 5%RH, inoculate 3 days.Then visual assessment aphid lethality and fertility.For test mixture, the results are shown in table B.2 in.
Table B.2
Black peach aphid ppm Average control %
Diacloden (Thiamethoxam)+Compound C .I.1 0+4 50
0.08+0 0
0.08+4 100 ＊
Chlorantraniliprole (Rynaxypyr)+Compound C .I.1 0+20 50
0.08+0 0
0.08+20 100 ＊
Spiral shell worm ethyl ester (spirotetramat)+Compound C .I.1 0+4 0
4+0 0
4+4 100 ＊
*according to the collaborative control efficiency of Colby formula
Test B.3
For the control of assessment boll weevil (Mexico's cotton boll resembles (Anthonomus grandis)), experimental rig is made up of the hole-titer plate that resembles (A.grandis) ovum containing insect food and 20-30 Mexico's cotton boll.
Compound or mixture are used to the solution preparation containing 75 % by weight water and 25 % by weight DMSO.Use the Miniature atomizer of customization that the preparation compound of variable concentrations or mixture are repeated to be sprayed at for twice on insect food with 20 μ l.
For experimental mixture in these trials, mix partner by two kinds of same volume and be mixed together with desired concn respectively.
After using, titer plate, at 23 ± 1 DEG C, is inoculated to 5 days under 50 ± 5%RH.Then visual assessment ovum and larval mortality.For test mixture, the results are shown in table B.3 in.
Table B.3
Boll weevil ppm On average (control %)
Imidacloprid (Imidacloprid)+Compound C .I.1 0+20 0
2+0 25
2+20 62.5 ＊
*according to the collaborative control efficiency of Colby formula
Test B.4
For the control of assessment medfly (Mediterranean fruitfly) (Mediterranean fruitfly (Ceratitiscapitata)), experimental rig is by forming containing the hole-titer plate of insect food and 50-80 Mediterranean fruitfly (C.capitata) ovum.
Compound or mixture are used to the solution preparation containing 75 % by weight water and 25 % by weight DMSO.Use the Miniature atomizer of customization that the preparation compound of variable concentrations or mixture are repeated to be sprayed at for twice on insect food with 5 μ l.
For experimental mixture in these trials, mix partner by two kinds of same volume and be mixed together with desired concn respectively.
After using, titer plate, at 28 ± 1 DEG C, is inoculated to 5 days under 80 ± 5%RH.Then visual assessment ovum and larval mortality.For the mixture of test, the results are shown in table B.4.1. and B.4.2.
Table B.4.1.
Medfly (Mediterranean fruitfly) ppm On average (control %)
Pyridaben (pyridaben)+Compound C .I.1 0+4 0
Medfly (Mediterranean fruitfly) ppm On average (control %)
200+0 50
200+4 100 ＊
Nail body cypermethrin (alpha-cypermethrin)+Compound C .I.1 0+20 0
0.4+0 0
0.4+20 50 ＊
*according to the collaborative control efficiency of Colby formula
Table B.4.2.
Medfly (Mediterranean fruitfly) ppm On average (control %)
Imidacloprid (imidacloprid)+Compound C .I.2 0+10 0
4+0 0
4+10 75 ＊
Compound I I.A 13.1+ Compound C .I.2 0+20 0
0.4+0 0
0.4+20 75 ＊
*according to the collaborative control efficiency of Colby formula
Other pilot system that can be used for assessing cooperative synergism effect is for example:
Test B.5
For assessment, by contact or the interior suction measure control standing grain pipe aphid (bird cherry aphid) (cereal overflow pipe aphid (Rhopalosiphum padi)) of overflowing, experimental rig is made up of the titer plate that contains barley leaves.
Compound or mixture are used to the solution preparation containing 75 % by weight water and 25 % by weight DMSO.Use the Miniature atomizer of customization that the preparating mixture of variable concentrations is repeated to be sprayed on blade for twice with 2.5 μ l.
For experimental mixture in these trials, mix partner by two kinds of same volume and be mixed together with desired concn respectively.
After using, by air-dry blade and 5-8 adult aphid is placed on the blade in microtitre plate hole.Then make aphid suck the blade of processing and inoculate 3-5 days under 25 ± 1 DEG C and 80 ± 5% indoor humidities.Then visual assessment aphid lethality and fertility.
Test B.6
For the control of assessment tobacco budworm (tobacco budworm (Heliothis virescens)), experimental rig is by forming containing the hole-titer plate of insect food and 15-25 tobacco budworm (H.virescens) ovum.
Compound or mixture are used to the solution preparation containing 75 % by weight water and 25 % by weight DMSO.Use the Miniature atomizer of customization that the preparating mixture of variable concentrations is repeated to be sprayed at for twice on insect food with 10 μ l.
For experimental mixture in these trials, mix partner by two kinds of same volume and be mixed together with desired concn respectively.
After using, titer plate is inoculated to 5 days under 28 ± 1 DEG C and 80 ± 5% indoor humidities.Then visual assessment ovum and larval mortality.

Claims (22)

1. comprise the pesticide combination of following component as reactive compound using cooperative effective quantity:
1) the active cyano group sulfenimide Compound I of at least one formula I:
Wherein:
G is selected from:
The wherein tie point in # expression I;
R 1for Cl or CF 3
And
R 2be selected from hydrogen, chlorine, CH 3or C 2h 5; With
2) at least one is selected from following reactive compound II: Frontline,
The weight ratio of its Chinese style I reactive compound I and reactive compound II is 20:1-1:50.
2. according to the pesticide combination of claim 1, the substituent R of wherein said formula I Compound I 1there is following implication:
R 1for CF 3.
3. according to the pesticide combination of claim 1, the substituent R of wherein said formula I Compound I 1there is following implication:
R 1for Cl.
4. according to the pesticide combination of any one in claim 1-3, the substituting group of wherein said formula I Compound I has following implication:
G is G 1
And
R 2for CH 3.
5. according to the pesticide combination of any one in claim 1-3, the substituting group of wherein said formula I Compound I has following implication:
G is G 1
And
R 2for hydrogen, chlorine or C 2h 5.
6. according to the pesticide combination of any one in claim 1-3, its weight ratio with 5:1-1:20 contained I reactive compound I and reactive compound II.
7. according to the pesticide combination of claim 4, its weight ratio with 5:1-1:20 contained I reactive compound I and reactive compound II.
8. according to the pesticide combination of claim 5, its weight ratio with 5:1-1:20 contained I reactive compound I and reactive compound II.
9. protective plant is with protection against insect, mite or nematosis or the method that infects, and it comprises makes the soil of plant or plant growth or water contact with the mixture according to any one in claim 1-8 of insecticidal effective dose.
10. a method for control insect, spider or the nematode of non-therapeutic purposes, it comprises makes insect, mite or nematode or their food source or their place contact with the mixture according to any one in claim 1-8 of insecticidal effective dose.
11. as the method for claim 10, and wherein said place is habitat or the breeding spot of described insect, mite or nematode.
12. methods as described in any one in claim 9-11, the wherein said mixture according to any one in claim 1-8 is used with the amount of 5-2000g/ha.
Protect the method for seed for 13. 1 kinds, it comprises makes seed contact with the mixture according to any one in claim 1-8 of insecticidal effective dose.
14. according to the method for claim 13, and wherein the mixture as described in any one in claim 1-8 is used with the amount of 0.1g-10kg/100kg seed.
15. 1 kinds by being applied to seed and processing the method for seed with the amount of 0.1g-10kg/100kg seed according to the mixture of any one in claim 1-8.
Watching for animals in case parasitic infestation or the method that infects of 16. 1 kinds of non-therapeutic purposes, it comprises the mixture according to any one in claim 1-8 of antiparasitic effective dose is delivered medicine to the animal that needs it.
17. according to the mixture of any one in claim 1-8 the purposes in the medicine of the animal that is subject to parasitic infestation for the preparation for the treatment of or infect.
18. methods as described in any one in claim 9-11,13 and 16, wherein as the formula I reactive compound I defining in claim 1-8 any one and reactive compound II simultaneously, i.e. associating or separately, or use successively.
19. according to the mixture of any one in claim 1-8 for the preparation of antagonism animal in and animal on parasitic medicine in purposes.
20. are used for resisting the purposes in the parasitic veterinary drug on animal and animal according to the mixture of any one in claim 1-8 in production.
21. according to the mixture of any one in claim 1-8 the purposes in the medicine for the preparation for the treatment of antagonism insect, spider or nematode.
22. 1 kinds comprise liquid or solid carrier and according to agricultural chemicals or the parasite killing composition of the mixture of any one in claim 1-8.
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