CN101653466A - Composition for treating cancers - Google Patents
Composition for treating cancers Download PDFInfo
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- CN101653466A CN101653466A CN200910194634A CN200910194634A CN101653466A CN 101653466 A CN101653466 A CN 101653466A CN 200910194634 A CN200910194634 A CN 200910194634A CN 200910194634 A CN200910194634 A CN 200910194634A CN 101653466 A CN101653466 A CN 101653466A
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- acanthopanacis senticosi
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Abstract
The invention relates to a traditional Chinese medicine composition for treating cancers, which contains three active components, including chan garment, acanthopanax and tolypocladium sinensis mycelia, wherein the cancers include solid tumor, preferably liver cancer, lung cancer, breast cancer, esophagus cancer, stomach cancer, nasopharyngeal cancer, ovarian cancer, bladder cancer, rectal cancer,skin cancer and lymphoma, and further preferably liver cancer; particularly, the traditional Chinese medicine composition has specially and obviously effect of treating liver cancer with cirrhosis and ascites. The chan garment, acanthopanax and tolypocladium sinensis mycelia preparation not only has amazing treating effect on tumors as diseases upsetting human beings, but also utilizes the chan garment generated by the naturally molting phenomenon of a bufonid, thereby not only effectively utilizing resources, but also protecting the ecological environment.
Description
Technical field
The present invention relates to use a kind of compositions for the treatment of cancer, cutin clothing film under Bufo siccus sloughs off naturally specifically is that toad clothing associating Radix Et Caulis Acanthopanacis Senticosi and Cordyceps mycelium are treated cancer, and wherein said composition can be made dosage forms such as capsule, electuary, tablet, drop and oral liquid as required.
Background technology
Cancer is a big illness of dangerous human life's health, traditional Western medicine therapy can only make its disease be able to temporary transient alleviation to a certain extent, also can not reach the purpose of curing fully far away, herbal treatment and health care therapy are just relying on its unique curative effect to cause people's attention gradually in the treatment for cancer process, yet, rationally utilize existing resource to take between the resource-constrained of Chinese crude drug.
Clothing film under Bufo siccus sloughs off naturally, promptly the toad clothing has antitumor action to be described in applicant CN1679635A.Find that through painstaking research in a few years toad clothing and the combination of other Chinese crude drugs are used for the treatment of cancer, have unexpected therapeutic effect.
Radix Et Caulis Acanthopanacis Senticosi has the antineoplastic drug action, and its main antineoplastic drug effect partly is saponin, polysaccharide etc.In recent years owing to find tumor necrosis factor (tumor necrosis factor, TNF) can surmount the kind boundary oncocyte is had tangible cytotoxicity, the research of the parties concerned is comparatively active always, existing report, ginseng polysaccharide, immune ribonucleic acid etc. can bring out mice and produce active stronger TNF.With TNF is index, use crystal violet staining assay, after detection ASI induces mice, tumor necrosis factor in its serum and to the lethal effect of target cell, find that Radix Et Caulis Acanthopanacis Senticosi injection can induce endogenous TNF in vivo, regulate immunologic function, induce the activity of interleukin-2 and enhancing natural killer cell, the superiority that have the selectivity height, has no side effect.
Cordyceps is the famous and precious Mycophyta Chinese herbal medicine of China, no matter be that natural cs or its mycelium all have calmness, resisting fatigue, anti-hypoxia, enhance immunity, antiinflammatory, anti-arrhythmia, antitumor until the effect of androgen sample.
The film coated tablet Wushensu sheet treatment tumor that useful cantharidin analog, Radix Et Caulis Acanthopanacis Senticosi polysaccharide, 3 kinds of Chinese medicine ingredients compatibilities of Cordyceps are made in the prior art.The applicant finds that through years of researches its effect for the treatment of cancer of compositions that preparation is made in toad clothing, Radix Et Caulis Acanthopanacis Senticosi, Cordyceps mycelium combination is particularly considerable.
Summary of the invention
One of main purpose of the present invention provides a kind of compositions, be used for the treatment of cancer, the said preparation compositions comprises toad clothing, Radix Et Caulis Acanthopanacis Senticosi and three kinds of active component of Cordyceps mycelium, and the ratio of the weight of three kinds of active component in compositions is the toad clothing: Radix Et Caulis Acanthopanacis Senticosi: Cordyceps mycelium is 2: 1: 1.
Two of main purpose of the present invention is above-mentioned compositions that contain toad clothing, Radix Et Caulis Acanthopanacis Senticosi and Cordyceps mycelium of preparation taking convenience, and said preparation is prepared into common formulations: the form as capsule, tablet, electuary, drop or oral liquid can make things convenient for patient to take.Certainly these preparations can be used as drug administration and also can be used as health food and take.
The specific embodiment
Treat cancer with the present composition that contains toad clothing, Radix Et Caulis Acanthopanacis Senticosi and Cordyceps mycelium, wherein said cancer is a solid tumor, preferred hepatocarcinoma, pulmonary carcinoma, breast carcinoma, esophageal carcinoma, gastric cancer, nasopharyngeal carcinoma, ovarian cancer, bladder cancer, rectal cancer, skin carcinoma and lymphoma, further preferred hepatocarcinoma, the liver cancer efficacy that liver cirrhosis and ascites have particularly occurred is especially obvious.
The toad clothing that contains of the present invention, the compositions of Radix Et Caulis Acanthopanacis Senticosi and Cordyceps mycelium can the cost of manufacture those skilled in the art being seen various dosage forms usually, as capsule, electuary, tablet, drop and oral liquid etc., wherein absorb usually with the toad clothing in order to be easy to body, Radix Et Caulis Acanthopanacis Senticosi and Cordyceps mycelium powder are broken to be that particle diameter is at 1200 order to 5000 purpose toad clothing, Radix Et Caulis Acanthopanacis Senticosi and Cordyceps mycelium superfine powder, particle diameter is at 1200 orders-5000 purpose toad clothing, Radix Et Caulis Acanthopanacis Senticosi and Cordyceps mycelium superfine powder can obtain by following manner, the mode of certain this acquisition only plays illustrational effect in the present invention, the present invention is not constituted any technical restriction:
Get the natural toad clothing that collects, remove impurity, be placed on continuous drying in 60 degrees centigrade of drying baker, when water content less than 10%, preferably less than 5%, be more preferably less than at 2% o'clock and pulverize, cross 50 order to 100 mesh sieves, toad clothing coarse powder; Take by weighing " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " coarse powder and 50 order to 100 purpose toad clothing coarse powder mixing stirrings, to mix and stir the further pulverizing again of back medicated powder, get 1200 order to 5000 order toad clothing, Radix Et Caulis Acanthopanacis Senticosi and Cordyceps mycelium superfine powder, preferred 1200 order to 2000 order toad clothing, Radix Et Caulis Acanthopanacis Senticosi and Cordyceps mycelium superfine powder, be placed on 60 degrees centigrade the interior continuous drying of drying baker, make water content less than 2%, the plastic bag of packing into, sealing, standby.
Cordyceps mycelium is to adopt from Qinghai cajaput area to produce separating obtained Clavicipitaceae fungus peacilomyce hepiahi strain Cs-4 bacterial strain the fresh Cordyceps fungus, through the mycelial dried powder of liquid submerged fermentation gained.
Embodiment
Embodiment 1: capsule finished product
Take by weighing toad clothing 1250 grams, remove impurity, be placed on 60 degrees centigrade the interior continuous drying of drying baker, water content was pulverized less than 5% o'clock, cross 50 order to 100 mesh sieves, get toad clothing coarse powder; Take by weighing each 625 gram and 50 order to 100 purpose toad clothing coarse powder mixing stirrings of " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " coarse powder, to mix and stir the further pulverizing again of back medicated powder, get 1200 order to 5000 order toad clothing, Radix Et Caulis Acanthopanacis Senticosi and Cordyceps mycelium superfine powder, be placed on 60 degrees centigrade the interior continuous drying of drying baker, make water content less than 2%, the plastic bag of packing into, sealing, standby.Take by weighing 1200 order to 5000 order toad clothing, Radix Et Caulis Acanthopanacis Senticosi, Cordyceps mycelium superfine powder 1000 grams, be distributed into 5000 capsules, every contains crude drug 0.2 gram; With above-mentioned capsulation, sealing, irradiation sterilization is capsule finished product.
Embodiment 2: the electuary finished product
Take by weighing 1200 order to 5000 order toad clothing, Radix Et Caulis Acanthopanacis Senticosi and Cordyceps mycelium superfine powder 1000 grams of embodiment 1 gained, added the cane sugar powder 2000 gram mixing and stirring of 80 mesh sieves; An amount of with disintegrating agent, mixing is made soft material, pushes 8 order to 12 mesh sieves and makes granule, be placed on 60 degrees centigrade the interior continuous drying of drying baker, make water content less than 2%,, get the granule that sieves after 6 order to 10 mesh sieves, reuse 60 mesh sieves sieve goes segmentation with material all in one piece, divide the aluminium plastic composite material packing of packing into, every bag contains crude drug 1.5 grams, sealing, irradiation sterilization, the electuary finished product.
Embodiment 3, the present invention contain the anti-tumor experiment of the Chinese medicine composition of toad clothing, Radix Et Caulis Acanthopanacis Senticosi, Cordyceps mycelium
1. test objective:
Observe: " Mylabris, Radix Et Caulis Acanthopanacis Senticosi, Cordyceps mycelium " prescription compares the curative effect of Mice Bearing Lewis Lung Cancer, S180 sarcoma and H22 hepatocarcinoma separately hereinafter to be referred as " No. 2, prescription " and " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " hereinafter to be referred as " No. 1, prescription ", " toad clothing, Radix Et Caulis Acanthopanacis Senticosi, Cordyceps mycelium " of the present invention prescription.
2. be subjected to the reagent thing:
Title: " No. 1, prescription ", " No. 2, prescription ", " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium ".
The unit of providing: Chanbao Organism Science and Technology Co., Ltd., Shanghai
Sample preparation: get the respective amount sample, add a small amount of Tween 80 hydrotropy, add 0.5%CMC-Na solution more gradually to aequum (each dosage 0.5ml/ Mus).
3. laboratory animal:
3.1 source kind strain: Kunming mouse, the quality certification number are: " Shanghai is moving closes the card word No. 201 ".C
57The BL/6 mice is by the supply of Chinese Academy of Sciences Experimental Animal Center, and the quality certification number is: " Shanghai is moving closes the card word No. 85 ".
3.2 body weight: 19.5 ± 1.5 grams
3.3 sex: take Kunming mouse, male and female half and half, every batch of test is used with a kind of sex.
3.4 number of animals: every group of 10 Kunming mouses.Each test group and positive controls are 10 for every group, and negative control group is 20.
4. tumor source: mice Lewi s pulmonary carcinoma, S180 sarcoma, H22 liver cancer model, go down to posterity by Chanbao Organism Science and Technology Co., Ltd., Shanghai and to keep.
5. dosage setting:
Clinical trial: respectively establish a dosage group, be 4g/kg dosage, the therapeutic scheme of ig * 10qd.Positive controls cyclophosphamide (CTX) 15mg/kg, negative control group is given corresponding solvent.Mitomycin 2mg/kg
6. dosage regimen: test group and matched group are gastric infusion, once a day, and continuous ten days.
7. experimental control:
Negative control is given coordinative solvent.
Positive control is cyclophosphamide (CTX), and the injectable powder that Hua Lian, Shanghai pharmacy group company produces is prepared with normal saline; The mitomycin injectable powder, Haimen pharmaceutical factory produces.
8. test key step:
8.1 the clinical trial to S180 sarcoma and H22 hepatocarcinoma axil subcutaneous vaccination solid tumor: get eugonic solid tumor mice, aseptic condition takes out tumor down, is prepared into 1-2 * 10 with the homogenate method
7/ ml cell suspension, with the right axil subcutaneous vaccination of the every Mus of corresponding host 0.2ml/ only, next day is by the administration of EXPERIMENTAL DESIGN scheme, put to death each treated animal about ten days, cut open and get tumor and weigh, calculate tumor control rate: tumor control rate=[the average tumor weight of (the average tumor of the average tumor weight-administration of matched group group is heavy)/matched group] * 100 by following formula
8.2 the subcutaneous vaccination of Mice Bearing Lewis Lung Cancer toes is tested: get eugonic solid tumor mice, aseptic condition takes out tumor down, is prepared into 1-2 * 10 with the homogenate method
7/ ml cell suspension, with the right toes subcutaneous vaccination of the every Mus of corresponding host 0.05ml/ only, about ten day put to death each treated animal by the administration of EXPERIMENTAL DESIGN scheme next day, cuts open to get lotus tumor toes and weigh, and calculates tumor control rate by following formula:
Tumor control rate=[on average heavy-blank toes are on average heavy for (matched group lotus tumor toes on average heavy-administration group lotus tumor toes are on average heavy)/matched group lotus tumor toes] * 100
Table 1. sample is to one of inhibition test of Mice Bearing Lewis Lung Cancer (toes subcutaneous vaccination)
| Group | Dosage g/kg | Dosage regimen | Number of animals beginning/end | Body weight beginning/end | Heavy X * the SD of lotus tumor toes | Tumour inhibiting rate % |
| " No. 1, prescription " | ??4 | ??ig×10qd | ??10/10 | ??20.1/24.1 | ??0.358±0.07 *** | ??61.09 |
| " No. 2, prescription " | ??4 | ??ig×10qd | ??10/10 | ??20.0/24.5 | ??0.255±0.06 *** | ??72.28 |
| " toad clothing " | ??4 | ??ig×10qd | ??10/10 | ??20.3/24.3 | ??0.585±0.07 *** | ??36.41 |
| " Radix Et Caulis Acanthopanacis Senticosi " | ??4 | ??ig×10qd | ??10/10 | ??20.2/24.2 | ??0.620±0.05 *** | ??32.61 |
| " Cordyceps mycelium " | ??4 | ??ig×10qd | ??10/10 | ??20.1/24.1 | ??0.593±0.06 *** | ??32.70 |
| ??CTX | ??0.015 | ??ip×7qd | ??10/10 | ??20.1/20.6 | ??0.352±0.01 *** | ??61.74 |
| Negative control | Coordinative solvent | ??ig×10qd | ??20/20 | ??20.2/24.9 | ??0.920±0.11 |
Compare * * * P＜0.01 with negative control group
Table 2 sample is to two of the inhibition test of Mice Bearing Lewis Lung Cancer (toes subcutaneous vaccination)
| Group | Dosage g/kg | Dosage regimen | Number of animals beginning/end | Body weight beginning/end | Heavy X * the SD of lotus tumor toes | Tumour inhibiting rate % |
| " No. 1, prescription " | ??4 | ??ig×10qd | ??10/10 | ??20.0/24.3 | ??0.374±0.06 *** | ??60.04 |
| " No. 2, prescription " | ??4 | ??ig×10qd | ??10/10 | ??20.1/24.4 | ??0.261±0.05 *** | ??72.16 |
| " toad clothing " | ??4 | ??ig×10qd | ??10/10 | ??20.2/24.6 | ??0.572±0.06 *** | ??38.88 |
| " Radix Et Caulis Acanthopanacis Senticosi " | ??4 | ??ig×10qd | ??10/10 | ??20.3/24.4 | ??0.619±0.05 *** | ??33.87 |
| " Cordyceps mycelium " | ??4 | ??ig×10qd | ??10/10 | ??20.2/24.6 | ??0.598±0.07 *** | ??36.11 |
| ??CTX | ??0.015 | ??ip×7qd | ??10/10 | ??20.2/20.7 | ??0.349±0.01 *** | ??62.71 |
| Negative control | Coordinative solvent | ??ig×10qd | ??20/20 | ??20.1/25.1 | ??0.936±0.10 |
Compare * * * P＜0.01 with negative control group
Table 3. sample is to one of clinical trial of mice S180 sarcoma
| Group | Dosage g/kg | Dosage regimen | Number of animals beginning/end | Body weight beginning/end | Heavy X * the SD of tumor | Tumour inhibiting rate % |
| " No. 1, prescription " | ??4 | ??ig×10qd | ??10/10 | ??19.5/24.0 | ??1.13±0.14 *** | ??61.03 |
| " No. 2, prescription " | ??4 | ??ig×10qd | ??10/10 | ??19.6/24.3 | ??0.85±0.19 *** | ??70.69 |
| " toad clothing " | ??4 | ??ig×10qd | ??10/10 | ??19.7/24.3 | ??1.89±0.17 *** | ??34.83 |
| " Radix Et Caulis Acanthopanacis Senticosi " | ??4 | ??ig×10qd | ??10/10 | ??19.6/24.4 | ??1.90±0.15 *** | ??34.48 |
| " Cordyceps mycelium " | ??4 | ??ig×10qd | ??10/10 | ??19.5/24.2 | ??1.95±0.19 *** | ??32.76 |
| ??CTX | ??0.015 | ??ip×7qd | ??10/10 | ??19.8/19.9 | ??1.26±0.12 *** | ??56.55 |
| Negative control | Coordinative solvent | ??ig×10qd | ??20/20 | ??19.5/24.5 | ??2.90±0.37 |
Compare * * * P＜0.01 with negative control group
Table 4. sample is to two of the clinical trial of mice S180 sarcoma
| Group | Dosage g/kg | Dosage regimen | Number of animals beginning/end | Body weight beginning/end | Heavy X * the SD of tumor | Tumour inhibiting rate % |
| " No. 1, prescription " | ??4 | ??ig×10qd | ??10/10 | ??20.6/25.4 | ??1.29±0.14 *** | ??58.52 |
| " No. 2, prescription " | ??4 | ??ig×10qd | ??10/10 | ??20.5/25.3 | ??0.93±0.18 *** | ??70.10 |
| " toad clothing " | ??4 | ??ig×10qd | ??10/10 | ??20.8/26.7 | ??1.97±0.17 *** | ??36.66 |
| " Radix Et Caulis Acanthopanacis Senticosi " | ??4 | ??ig×10qd | ??10/10 | ??20.4/26.4 | ??2.01±0.16 *** | ??35.37 |
| " Cordyceps mycelium " | ??4 | ??ig×10qd | ??10/10 | ??20.3/26.5 | ??2.18±0.15 *** | ??29.90 |
| ??CTX | ??0.015 | ??ip×7qd | ??10/10 | ??20.8/20.9 | ??1.45±0.11 *** | ??53.37 |
| Negative control | Coordinative solvent | ??ig×10qd | ??20/20 | ??20.7/26.5 | ??3.11±0.30 |
Compare * * * P＜0.01 with negative control group
Table 5. sample is to one of inhibition test of mice H22 hepatocarcinoma
| Group | Dosage g/kg | Dosage regimen | Number of animals beginning/end | Body weight beginning/end | Heavy X * the SD of tumor | Tumour inhibiting rate % |
| " No. 1, prescription " | ??4 | ??ig×10qd | ??10/10 | ??18.8/25.2 | ??1.08±0.18 *** | ??58.94 |
| " No. 2, prescription " | ??4 | ??ig×10qd | ??10/10 | ??18.7/25.4 | ??0.79±0.26 *** | ??69.96 |
| " toad clothing " | ??4 | ??ig×10qd | ??10/10 | ??18.6/25.3 | ??1.69±0.28 *** | ??35.74 |
| " Radix Et Caulis Acanthopanacis Senticosi " | ??4 | ??ig×10qd | ??10/10 | ??18.9/26.0 | ??1.73±0.27 *** | ??34.22 |
| " Cordyceps mycelium " | ??4 | ??ig×10qd | ??10/10 | ??18.9/25.8 | ??1.81±0.24 *** | ??31.18 |
| ??CTX | ??0.015 | ??ip×7qd | ??10/10 | ??18.8/20.1 | ??1.18±0.14 *** | ??55.13 |
| Negative control | Coordinative solvent | ??ig×10qd | ??20/20 | ??18.8/25.4 | ??2.63±0.27 |
Compare P＜0.01 with negative control group
Table 6. sample is to two of the inhibition test of mice H22 hepatocarcinoma
| Group | Dosage g/kg | Dosage regimen | Number of animals beginning/end | Body weight beginning/end | Heavy X * the SD of tumor | Tumour inhibiting rate % |
| " No. 1, prescription " | ??4 | ??ig×10qd | ??10/10 | ??19.4/24.2 | ??1.17±0.22 *** | ??59.93 |
| " No. 2, prescription " | ??4 | ??ig×10qd | ??10/10 | ??19.5/24.9 | ??0.81±0.17 *** | ??72.26 |
| " toad clothing " | ??4 | ??ig×10qd | ??10/10 | ??19.2/24.7 | ??1.79±0.24 *** | ??38.70 |
| " Radix Et Caulis Acanthopanacis Senticosi " | ??4 | ??ig×10qd | ??10/10 | ??19.4/24.9 | ??1.83±0.21 *** | ??37.33 |
| " Cordyceps mycelium " | ??4 | ??ig×10qd | ??10/10 | ??19.3/24.8 | ??1.98±0.20 *** | ??32.19 |
| ??CTX | ??0.015 | ??ip×7qd | ??10/10 | ??19.2/20.5 | ??1.27±0.13 *** | ??56.51 |
| Negative control | Coordinative solvent | ??ig×10qd | ??20/20 | ??19.1/25.2 | ??2.92±0.26 |
Compare P＜0.01 with negative control group
9. result of the test:
" No. 1, prescription ", " No. 2, prescription ", " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " sample are irritated stomach single-dose one day to kunming mice and are respectively with the therapeutic scheme of 4g/kg dosage ig * qd twice examination experimental result tumour inhibiting rate to the subcutaneous vaccination of mice Lewi s pulmonary carcinoma toes: 61.09%, 60.04%; 72.28%, 72.16%; 36.41%, 38.88%; 32.61%, 33.87%; 32.70%, 36.11%, see table 1,2 for details." No. 1, prescription ", " No. 2, prescription ", " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " sample are respectively 61.03%, 58.52% to S180 sarcoma experimental result tumour inhibiting rate; 70.69%, 70.10%; 34.83%, 36.66%; 34.48%, 35.37%; 32.76%, 29.90%, see table 3,4 for details.And " No. 1, prescription ", " No. 2, prescription ", " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " sample to the anti-tumor experiment of H22 hepatocarcinoma as a result tumour inhibiting rate be respectively 58.94%, 59.93%; 69.96%, 72.26%; 35.74%, 38.70%; 34.22%, 37.33%; 31.18%, 32.19%, see table 5,6 for details.
10. test brief summary:
It is similar to negative control group that " 10.1. No. 1, prescription ", " No. 2, prescription ", " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " sample the weight of animals when clinical trial changes, so the prompting sample has certain safety.
10.2. the test of " No. 1, prescription " experiment antitumor reaches about 60% Mice Bearing Lewis Lung Cancer, S180 sarcoma and H22 liver-cancer solid tumor antitumous effect; The test of " No. 2, prescription " experiment antitumor reaches about 70% Mice Bearing Lewis Lung Cancer, S180 sarcoma and H22 liver-cancer solid tumor antitumous effect; The test of " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " experiment antitumor reaches about 35% Mice Bearing Lewis Lung Cancer, S180 sarcoma and H22 liver-cancer solid tumor antitumous effect.And experiment all has repeatability.Experimental result shows that " No. 2, prescription " sample truly has stronger antitumor action, has certain DEVELOPMENT PROSPECT.
Implement 4. medical records for example
4.1 patients with lung cancer: Cao man Tongzhou the sea is quiet people from town of 65 years old Jiangsu Province
The patient begins in by the end of April, 2008 in, the sputum mixed with blood phenomenon of unknown cause frequently occurs, and the cough of companion's severe, under back layman's the urgency, come Nantong City slack tide tumour hospital on May 6th, 2008 and check that be diagnosed as the right lung central type carcinoma of lung, tumor is 5.2 * 4.0cm.Because it is late that the state of an illness is made a definite diagnosis, patient is relatively poor in addition, has lost the chance of operation, begins to carry out chemotherapy after the week, but chemotherapy only two days later, and serious toxic and side effects has just appearred in patient, can't take food, and vomiting is severe, beat and shiver, leukocyte index decreased to 3800 stops chemotherapy.Back examination clothes " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, 3 times on the one, one time 1 gram, obeyed back 30 days, patient's appetite is clearly better, and the cough frequency also obviously reduces, beginning dosage examination clothes after month, 3 times on the one, one time 2 gram, after 60 days, patient oneself goes tumour hospital's check, lung tumors is reduced into 3.2 * 2.1cm, leukocyte index 6200.The last check in 18, of 08 on December is shown: lung tumors is 2.2 * 1.5cm, do not have and shift, and leukocyte index 7300, existing patient moves towards rehabilitation gradually, takes care of oneself, and can do some simple housework.
4.2 patients with lung cancer: so-and-so Fructus Mume west, woman 59 years old changzhou city people from village of Pan
The patient is 06 year second half year, and cough is more than, after treatment in time.In February, 07, the state of an illness still is degradating trend, cough companion hemoptysis, chest pain, hypopnea.Check in the Changzhou First People's Hospital that on April 25th, 07 CT shows: the lung right lower lobe has an obvious lump, companion's hydrothorax is diagnosed as pulmonary carcinoma.Received treatment in hospital April 26.April 30, the patient carries out the lung tumor resection operation, and postoperative is accepted chemotherapy twice.Because the intensive toxic and side effects of chemotherapy, leukopenia to 3500 can not continue chemotherapy, uses treatment by Chinese herbs instead.JIUYUE 26 days, under younger brother's's (younger brother is a traditional Chinese medical science) of patient agreement, begin clothes " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, 4 times on the one, one time 1.5 gram, after 20 days, conditions of patients begins stable gradually, the hemoptysis phenomenon alleviates gradually, and appetite is clearly better.Serve on 60 days, chest pain, cough phenomenon alleviate greatly, and hydrothorax disappears, and breathes unimpeded.Followed up a case by regular visits to through 1 year half, it is normal that the patient recovers substantially.
4.3 liver cancer patient: Liu so-and-so man 55 years old changzhou the film circle people from sub-district, city
The patient feels liver's pain often on January 22nd, 2008, does not take notice of that at the beginning next pain is more and more frequent gradually, does not have appetite, and out of spirits, sensation is felt sick, vomiting, and health is poor day by day.Under daughter accompanies, came the Changzhou First People's Hospital on January 25 and check that CT shows liver's malignant tumor, two tumors of lump size 8.6 * 8.8CM, 5.6 * 4.2CM, albumen is lower than normal value, AFP because the patient body condition is poor, can't carry out interventional therapy greater than 3000.Second day household advises that the patient tries clothes " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, and 3 times on the one, one time 1 gram serve on back 30 days, and pain alleviates gradually, and appetite also makes moderate progress.Serve on 60 days, go to the Changzhou First People's Hospital to check, CT shows: liver's tumor is reduced into 5.3 * 3.8CM, 3.8 * 2.2CM, and albumen recovers normal value, and AFP 1200, pain relief, and liver's ascites disappears; Took continuously 120 days, go the Changzhou First People's Hospital check, CT shows: liver's tumor is reduced into 3.3 * 2.6CM, 2.5 * 1.1CM, albumen recovers normal value, and AFP is less than 20, and pain disappears, liver's ascites disappears, other every indexs are all normal, and the doctor tells that cancerous cell has recovered normally in patient's body, and tumor is downright bad.
4.4 esophageal carcinoma Chen woman 50 years old Jiangsu Tang Jia people from town, Haimen City
After the patient suffered from " esophageal carcinoma " operative treatment in 2004, feel dysphagia in August, 2007, feel sick and hepatalgia, cervical region has the lump of egg size, and matter is hard, diagnoses through the Shanghai Changhai Hospital inspection: " esophageal carcinoma recurrence, hepatic metastases ".The stream juice of can only taking food in March, 2008, the companion feels sick, hepatalgia, the about 5.5 * 3cm of neck region lump, matter is not movable firmly.Began examination clothes " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions on March 12nd, 2008,3 times on the one, one time 2 gram serve on about 30 days, and hepatalgia alleviates gradually, and sleep takes a turn for the better.Followed up a case by regular visits to patient's word in high spirits on October 26, do not have and feel sick, vomit phenomenon, hepatalgia disappears, and the neck region lump hands is touched obviously to have and become flexible and dwindle sensation.The patient takes care of oneself now, stable disease, and the cervical region lymph tumor disappears, and lives the same life of healthy people.
4.5 gastric cancer Meng so-and-so my child people from lane, Nantong city
The patient is in March, 2007, and stomach is indistinctly uncomfortable, anorexia, and tumour hospital is diagnosed as by Nantong: early gastric cancer.Carried out the gastric cancer operation on April 5, it is more successful to perform the operation.After 9 months, carry out the CT check on February 9th, 2008 in Yangpu, Shanghai central hospital, the report prompting: right lung is seen a plurality of lesser tubercle, mediastinal lymph node enlargement.Diagnosis: the postoperative gastric cancer lung shifts.On January 14th, 2008 was lived in Nantong tumour hospital, carried out chemotherapy, did not see to be clearly better.The patient begins to take " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions at the beginning of 2 months, 3 times on the one, one time 2 gram, serve on 20 days after, patient oneself physical recovery is very fast.After continue to take " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, serve on 43 days, every days 6 gram, the side effect of sensation chemotherapy obviously alleviates, and feels sick, phenomenons such as vomiting, alopecia disappear.Check on May 21, the CT finding: lung tuberosity and anter (contrast) tuberosity obviously dwindles.On JIUYUE 12nd, 2008, and CT reports demonstration: multiple nodules disappears in the former lung, and conditions of patients is effectively controlled.The patient is in after treatment now.
4.6 the esophageal carcinoma lung shifts Luo Dian town, Baoshan District, 43 years old male Shanghai City of Huang people
The patient is in October, 06, and having a meal often has the sense of obstruction, and back number of times is more and more frequent, once in a while feels pain.November 5, making a definite diagnosis through the detailed inspection of hospital of Shanghai lung section is that esophageal carcinoma shifts pulmonary carcinoma, hospital's suggestion is not performed an operation, the all non-constant of health, the mental status, chemotherapy can not be born, and the Chinese medicine of 1 wheat harvesting period of opening in Shanghai efforts of everyone medical herbs room has been eaten in the treatment by Chinese herbs of can only going home to adopt, yet Chinese medicine does not allow the patient feel to take a turn for the better, and uncomfortable in chest on the contrary, cough increases the weight of gradually.The patient produces desperate thought at the beginning of 07, refuses a treatment in month.On February 14th, 07 began to take " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, 3 times on the one, one time 2 gram, serve on 28 days after, it is pleasant that the people feels, whole people feels spiritedness, appetite increases, uncomfortable in chest, cough alleviates.Serve on 90 days, restrain every days 6, and weight ratio had increased by 12 jin in the past.The it doesn't matter people of patient is away for a stroll now, looks for friend to chat, and does not a bit see it being a cancer patient.
4.7 52 years old Shanghai Minhang District people of so-and-so woman of gastric cancer Yu
The patient is in December, 2006, because epigastrium is glutted, and dull pain one wheat harvesting period.January 7 in 2007, the Nikkei Shanghai PET/CT of People's Armed Police hospital general diagnosis of scans was a gastric cancer, found that there are the focus about 5cm, a plurality of positions such as neoplasm metastasis lymph, head of pancreas, abdominal cavity in lesser gastric curvature portion.Be control tumor growth and diffusion transfer, the patient has additional nutrients earlier, improves immunologic function, so that carry out chemotherapy." toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions are taken in examination, 4 times on the one, one time 2 gram, after one month, the patient has rosy cheeks, body weight obviously increases, after hear that chemotherapy has very big side effect, just abandon chemotherapy, continue to take " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, about lesser gastric curvature tumor 3cm, the tumor at a plurality of positions such as lymph, head of pancreas, abdominal cavity disappeared after the Shanghai People's Armed Police PET/CT of hospital general scanning is checked in 1 year.Be an obviously patient of band tumor existence now.Follow up a case by regular visits to more than a year, the patient can take part in the work.
4.8 41 years old Wuxi Yan Qiaozhen people of so-and-so man of lymphatic cancer Qiu
The patient finds that at the beginning of 08 left side cervical region and left abdomen thigh respectively have tumor, with hands touch no tenderness, matter is hard, after the People's Hospital, Wuxi is diagnosed as " malignant lymphoma ", the lymphoma size is respectively 3.5 * 3.3cm and 2.5 * 2.0cm, hospital does not take operative treatment, and the suggestion chemotherapy is because household economy is not rich, the patient abandons chemotherapy, and changing has the Chinese medicine expectant treatment.March 24 began to take " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, 4 times on the one, one time 1.5 gram, behind the one and a half months, hands is touched left side cervical region and left abdomen thigh to be had obviously and dwindles.Serve on 75 days, go the check of the People's Hospital, Wuxi, the left neck tumor is contracted to 1.5 * 1.5cm, and abdomen thigh tumor disappears substantially.Stop later on after a while, begin in April, 2009 to consolidate and take " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, 3 times on the one, one time 1 gram, June 30 the daily inspection result: left neck lump size: 0.5 * 0.4cm, and do not have any transfer sign.
4.9 hepatocarcinoma companion lung spleen bone marrow extensively shifts 69 years old Nanjing Pukou District people of Chen woman
The patient begins to feel that in January, 2007 right upper quadrant of the abdomen goes up painful, think it is for many years gastropathy, some stomach medicines of housecoat can be As time goes on, and the state of an illness does not only take a turn for the better, more and more serious on the contrary, the people also becomes thin more than 10 jin, and the patient realizes that situation is not very good, goes to the Pukou District the People's Hospital to be CT, and check pathological section, be diagnosed as hepatocarcinoma and many places such as lung spleen bone marrow shift, lose the surgical engine meeting, only carry out chemotherapy, add that owing to the age is higher the side effect of chemotherapy is too big, just chemotherapy 1 time, just occur feeling sick, vomiting, appetite is very poor, and leukocyte reduces to 3500, have to go home to take good care of, lie on a bed all day.On April 9th, 07 began to take " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, 4 times on the one, one time 1 gram, miracle has occurred after one month, feels sick, vomiting, pain phenomenon alleviate gradually.The own escalated dose of patient, 4 times on the one, one time 2 gram has serve on 2 months, and glowing with health, energetic, body weight obviously increases, and through following up a case by regular visits to 2 years, the patient takes care of oneself more, is some housework and normal person and does not have difference, does not also do inspection.
4.10 cancer of pancreas shifts liver, stomach is worn so-and-so woman 45 years old Jiangsu Gou Dun town, Funing County, Yancheng people
The patient was in 2008 8, and jaundice is had a surplus January, upper left abdomen severe pain, and with feeling sick, vomitting, the liver and gall hospital diagnosis is through east, Shanghai: cancer of pancreas shifts the liver stomach function regulating.The patient loses the surgical engine meeting, only carries out chemotherapy, and chemotherapy just begins for the 3rd time, and leukocyte just will arrive 3200, abandon chemotherapy, and hospital says and goes home to have additional nutrients, and takes a good rest, and the back of going home earns a bare living by stream juice.November 18 began to take " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, 3 times on the one, one time 1.5 gram, behind the two weeks, the people feels spiritedness, it is also many day by day to have a meal, the own escalated dose of patient on January 13 in 2009,4 times on the one, one time 2 gram, went the check of east, Shanghai liver and gall hospital on April 1, the tumor at pancreas, the original position of liver stomach function regulating is dwindled, and the doctor tells the patient that miracle has occurred, leukocyte rises to 6800, AFP is less than 50, weight increase 8 jin, everyway is fine.
4.11 47 years old people from Ningbo City, Zhejiang Province of so-and-so woman of rectal cancer king
The patient is in November, 2007 dyschesia, and Longhua, Shanghai hospital diagnosis is a rectal cancer, and the patient refuses operative treatment, eats of Chinese patent medicine and guards, and stool band blood progressively occurring sticking freezing, and have an intense pain and be difficult to fall asleep all night in February, 2008.Same month 18 began to take " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, 3 times on the one, one time 2 gram, pain alleviates gradually after 4 weeks, it is normal that stool recovers gradually, 6 jin of weight increase oneself can hold up implantation to walk about, through the treatment in 8 weeks, patient's pain disappears, spirit appetite is clearly better, and it is normal that stool recovers fully, can do housework.Following up a case by regular visits to the patient in March, 2009 lives and can take care of oneself.
4.12 ovarian cancer turns round and look at so-and-so the woman people of Zhengjiang City of 52 years old Jiangsu Province
The patient feels lower abdomen pain in May, 08, and stomachache, and inappetence feels run-down, after Jiangsu Prov. Tumour Hospital's CT examination shows; There are 7.5 * 6.5cm and two tumors of 5.6 * 4.5cm in the ovary position, is diagnosed as ovarian cancer, carries out 3 wheat harvesting period hospitalization, through chemotherapy repeatedly, leukocyte index decreased to 3600, the state of an illness increases the weight of, feel sick, exert one's utmost effort, what does not all feel like eating, body weight obviously reduces, and has to abandon chemotherapy.At the beginning of 9 months the same years, have the psychology of trying in arms, examination clothes " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, 4 times on the one, one time 1 gram serve on 1 wheat harvesting period, and the patient feels weight increase, people's spiritedness, go to the People's Hospital, Zhengjiang City to check that ovary position tumor is reduced into 6.1 * 4.0cm and two tumors of 3.4 * 2.1cm, back escalated dose respectively, 4 times on the one, one time 2 gram continued to take 75 days, went in February, 2009 the People's Hospital, Zhengjiang City to check, ovary position tumor is reduced into 3.4 * 2.2cm and 1.5 * 1.1cm respectively, and all other indexs are all normal.
4.13 52 years old jiangsu wuxi people of so-and-so woman of breast carcinoma week
The patient finds left side shoulder congestion and swelling pain in October, 2007, to Wuxi four-player people hospital by ultrasound diagnosis, find that left breast has a plurality of low echo lumps, maximum about 5.3 * 4.4cm, obscurity boundary, form is irregular, the internal echo inequality, come the inspection of Shanghai tumour hospital on October 20 and be diagnosed as malignant breast carcinomas, left subaxillary lymphadenectasis." toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions are obeyed in examination by the end of October, 4 times on the one, one time 1 gram, serve on 1 wheat harvesting period, the red and swollen disappearance of patient left side shoulder, the tumor of left side breast maximum is reduced into 3.5 * 2.9cm, continues to take " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions 6 months, the mammary neoplasms complete obiteration.
4.14 the cancer of pancreas field so-and-so woman Dong Yuan people from residential district of 73 years old Jintan City
The patient is at the beginning of 06, begin to occur that jaundice, urine are Umber, stool is phenomenons such as canescence, weight loss, inappetence, stomachache, check through Jintan Traditional Chinese Medical Hospital, be diagnosed as cancer of pancreas, tumor is about 2.4 * 2.1cm, and the doctor advises chemotherapy, and the patient can't bear the misery that chemotherapy is brought, behind the end of chemotherapy, refusal continues chemotherapy for the first time.Examination on March 5th, 2006 clothes " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, 4 times on the one, one time 1 gram, serve on 1 wheat harvesting period, serve on 1 month, patient's mental status takes a turn for the better, appetite increases, pain disappears substantially, serve on 3 months, weight increase 12 jin, check result is shown through Jintan institute of traditional Chinese medicine: tumor is inhibited fully, be reduced into 1.9 * 1.6cm, physical recovery is good, and every index is all normal.Doctor's suggestion goes home to continue recuperation, continues to strengthen and takes " toad clothing ", " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " superfine powder compositions, reaches better therapeutic effect.Through following up a case by regular visits to 3 years, the patient can take part in the work more.
Significant curative effect has bigger DEVELOPMENT PROSPECT to the compositions that contains toad clothing, " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " of the present invention having shown unique aspect the treatment cancer.
Claims (5)
1, a kind of compositions that is used for the treatment of cancer, it contains toad clothing, Radix Et Caulis Acanthopanacis Senticosi and three kinds of active component of Cordyceps mycelium.
2, compositions as claimed in claim 1, wherein the cancer of being treated is a solid tumor.
3, compositions as claimed in claim 1, wherein said toad clothing, Radix Et Caulis Acanthopanacis Senticosi and Cordyceps mycelium are that 1200 orders-5000 purpose superfine powder form exists with particle diameter.
4, compositions as claimed in claim 1, wherein the ratio of toad clothing, Radix Et Caulis Acanthopanacis Senticosi and the Cordyceps mycelium weight in compositions is 2: 1: 1.
5, preparation of compositions method as claimed in claim 1, it is characterized in that it being to be prepared from: the toad clothing that takes by weighing respective amount with following method, remove impurity, be placed on 60 degrees centigrade the interior continuous drying of drying baker, water content was pulverized less than 10% o'clock, cross 50 order to 100 mesh sieves, get toad clothing coarse powder; Take by weighing " Radix Et Caulis Acanthopanacis Senticosi " and " Cordyceps mycelium " coarse powder and 50 order to 100 purpose toad clothing coarse powder mixing stirrings of respective amount, to mix and stir the further pulverizing again of back medicated powder, get 1200 order to 5000 order toad clothing, Radix Et Caulis Acanthopanacis Senticosi and Cordyceps mycelium superfine powder, be placed on 60 degrees centigrade the interior continuous drying of drying baker, make water content less than 2%, get product.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078351A (en) * | 2011-01-07 | 2011-06-01 | 上海蟾宝生物科技有限公司 | Composition for treating cancer |
| CN102078352A (en) * | 2011-01-07 | 2011-06-01 | 上海蟾宝生物科技有限公司 | Composition for treating cancers |
| CN102379901A (en) * | 2011-10-18 | 2012-03-21 | 杨鸣泽 | Toad-cortex ultra-micro powder soft capsule and preparation method thereof |
| CN102813681A (en) * | 2012-08-27 | 2012-12-12 | 刘春红 | Preparation method of Cordyceps-toad skin composition |
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2009
- 2009-08-27 CN CN2009101946344A patent/CN101653466B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078351A (en) * | 2011-01-07 | 2011-06-01 | 上海蟾宝生物科技有限公司 | Composition for treating cancer |
| CN102078352A (en) * | 2011-01-07 | 2011-06-01 | 上海蟾宝生物科技有限公司 | Composition for treating cancers |
| CN102078352B (en) * | 2011-01-07 | 2012-07-04 | 上海蟾宝生物科技有限公司 | Composition for treating cancers |
| CN102078351B (en) * | 2011-01-07 | 2012-08-29 | 上海蟾宝生物科技有限公司 | Composition for treating cancer |
| CN102379901A (en) * | 2011-10-18 | 2012-03-21 | 杨鸣泽 | Toad-cortex ultra-micro powder soft capsule and preparation method thereof |
| CN102813681A (en) * | 2012-08-27 | 2012-12-12 | 刘春红 | Preparation method of Cordyceps-toad skin composition |
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Assignee: Zhonglian venture capital (Beijing) International Traditional Chinese medicine science and Technology Development Co Ltd Assignor: Chanbao Organism Science and Technology Co., Ltd., Shanghai Contract record no.: 2011990000416 Denomination of invention: Composition for treating cancers Granted publication date: 20110216 License type: Exclusive License Open date: 20100224 Record date: 20110607 |
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