CN101652360B - 硝基咪唑低氧造影剂 - Google Patents

硝基咪唑低氧造影剂 Download PDF

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Publication number
CN101652360B
CN101652360B CN200880011415.1A CN200880011415A CN101652360B CN 101652360 B CN101652360 B CN 101652360B CN 200880011415 A CN200880011415 A CN 200880011415A CN 101652360 B CN101652360 B CN 101652360B
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alkyl
compound
alkylidene group
conr
group
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Expired - Fee Related
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CN200880011415.1A
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English (en)
Chinese (zh)
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CN101652360A (zh
Inventor
H·C·科尔布
J·C·沃尔什
U·B·甘加达马斯
F·卡里米
H·C·帕吉特
D·卡西
高志勇
梁千瓦
T·L·科利耶
B·A·杜克洛斯
赵铁铭
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Siemens Molecular Imaging Ltd
Molecular Templates Inc
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Siemens Medical Solutions USA Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN200880011415.1A 2007-04-05 2008-04-04 硝基咪唑低氧造影剂 Expired - Fee Related CN101652360B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US92193207P 2007-04-05 2007-04-05
US60/921,932 2007-04-05
US96425407P 2007-08-10 2007-08-10
US60/964,254 2007-08-10
PCT/US2008/059505 WO2008124651A2 (en) 2007-04-05 2008-04-04 Nitro-imidazole hypoxia imaging agents

Publications (2)

Publication Number Publication Date
CN101652360A CN101652360A (zh) 2010-02-17
CN101652360B true CN101652360B (zh) 2014-06-25

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Country Status (7)

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US (2) US7807394B2 (cg-RX-API-DMAC10.html)
EP (1) EP2132200B1 (cg-RX-API-DMAC10.html)
JP (1) JP5347164B2 (cg-RX-API-DMAC10.html)
KR (1) KR101523257B1 (cg-RX-API-DMAC10.html)
CN (1) CN101652360B (cg-RX-API-DMAC10.html)
CA (1) CA2683433C (cg-RX-API-DMAC10.html)
WO (1) WO2008124651A2 (cg-RX-API-DMAC10.html)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101523257B1 (ko) * 2007-04-05 2015-05-27 쓰레솔드 파마슈티컬스, 인코포레이티드 니트로-이미다졸 저산소증 영상화제
CN101709060B (zh) * 2009-12-02 2013-05-01 北京师范大学 一种f-三唑环-聚乙二醇-甲硝唑化合物及其制备方法
AU2011213568B2 (en) 2010-02-08 2016-05-12 Lantheus Medical Imaging, Inc. Methods and apparatus for synthesizing imaging agents, and intermediates thereof
US9023316B2 (en) 2010-04-08 2015-05-05 Siemens Medical Solutions Usa, Inc. Synthesis of 18F-labeled tracers in hydrous organic solvents
US10639608B2 (en) 2010-04-08 2020-05-05 Siemens Medical Solutions Usa, Inc. System, device and method for preparing tracers and transferring materials during radiosynthesis
CN101921263A (zh) * 2010-04-16 2010-12-22 兰州大学 2-硝基咪唑衍生物及其用途和制备方法
CN106977429B (zh) 2010-05-11 2021-08-24 蓝瑟斯医学影像公司 用于合成和使用造影剂的组合物、方法和系统
DK2753605T3 (da) 2011-09-09 2019-06-17 Lantheus Medical Imaging Inc Sammensætninger, fremgangsmåder, og systemer til syntesen og anvendelsen af billeddannelsesmidler
US9061143B2 (en) 2011-10-14 2015-06-23 Sumitomo Heavy Industries, Ltd. Charged particle beam irradiation system and charged particle beam irradiation planning method
EP2793871A4 (en) * 2011-12-23 2015-07-22 Auckland Uniservices Ltd COMPOUNDS AND METHODS FOR SELECTIVE IMAGING AND / OR ABLATION
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
ES2580334T3 (es) 2014-01-13 2016-08-23 Yang, Guanghua Composiciones de dendrímeros, métodos de síntesis, y sus usos
KR20170058360A (ko) * 2014-09-25 2017-05-26 니혼 메디피직스 가부시키가이샤 신장 이미징제
WO2016179117A1 (en) * 2015-05-01 2016-11-10 Vanderbilt University Composition and method for detecting hypoxia
US10695450B2 (en) 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
CN106977501A (zh) * 2017-03-20 2017-07-25 华东师范大学 一种基于2‑硝基咪唑‑1‑烷基醇的低氧激活前药
FR3068695B1 (fr) * 2017-07-05 2019-08-16 Centre National De La Recherche Scientifique Composes utiles comme agent d'imagerie de l'hypoxie
CA3076256A1 (en) * 2017-09-19 2019-03-28 The Governors Of The University Of Alberta Markers, conjugates, compositions and methods for hypoxia imaging, mapping, and therapy
WO2019056098A1 (en) * 2017-09-19 2019-03-28 The Governors Of The University Of Alberta BIOREDUCTION-ACTIVATED COMPOUNDS, THEIR PRODRUGS, RADIOPHARMACEUTICAL PRODUCTS, COMPOSITIONS AND THEIR APPLICATIONS IN THE MULTIMODAL THERANOSTIC MANAGEMENT OF HYPOXIA, INCLUDING CANCER
WO2021138540A1 (en) 2020-01-03 2021-07-08 Berg Llc Polycyclic amides as ube2k modulators for treating cancer
CN111233821B (zh) * 2020-01-20 2022-12-27 上海交通大学医学院附属仁济医院 含3-羟基苯甲酸基团的新抗霉素衍生物及其制备方法和应用
CN114478489B (zh) * 2022-01-18 2023-04-28 中国科学院精密测量科学与技术创新研究院 一种氟-19修饰的硝基咪唑化合物及其衍生物的制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004249A1 (en) * 1994-08-05 1996-02-15 Sri International Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
US5674693A (en) * 1994-03-18 1997-10-07 Natural Pharmacia International Inc. Derivatives of 2-nitro-imidazoles as hypoxic cell markers
WO2001012575A1 (en) * 1999-08-11 2001-02-22 Universite Catholique De Louvain Methods for preparing perfluorinated [18f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101523257B1 (ko) * 2007-04-05 2015-05-27 쓰레솔드 파마슈티컬스, 인코포레이티드 니트로-이미다졸 저산소증 영상화제

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674693A (en) * 1994-03-18 1997-10-07 Natural Pharmacia International Inc. Derivatives of 2-nitro-imidazoles as hypoxic cell markers
WO1996004249A1 (en) * 1994-08-05 1996-02-15 Sri International Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
WO2001012575A1 (en) * 1999-08-11 2001-02-22 Universite Catholique De Louvain Methods for preparing perfluorinated [18f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection

Also Published As

Publication number Publication date
US20090010846A1 (en) 2009-01-08
EP2132200B1 (en) 2016-03-23
US7807394B2 (en) 2010-10-05
WO2008124651A2 (en) 2008-10-16
CN101652360A (zh) 2010-02-17
CA2683433C (en) 2016-10-11
WO2008124651A3 (en) 2009-04-02
US20110002850A1 (en) 2011-01-06
CA2683433A1 (en) 2008-10-16
JP2010523596A (ja) 2010-07-15
KR101523257B1 (ko) 2015-05-27
US7977361B2 (en) 2011-07-12
KR20090130106A (ko) 2009-12-17
JP5347164B2 (ja) 2013-11-20
EP2132200A2 (en) 2009-12-16

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Owner name: SIEMENS MOLECULAR IMAGING CO., LTD.

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