CN101647805A - Glucosamine chewable tablet used for relieving and preventing osteoarthritis and preparation method thereof - Google Patents
Glucosamine chewable tablet used for relieving and preventing osteoarthritis and preparation method thereof Download PDFInfo
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- CN101647805A CN101647805A CN200910169812A CN200910169812A CN101647805A CN 101647805 A CN101647805 A CN 101647805A CN 200910169812 A CN200910169812 A CN 200910169812A CN 200910169812 A CN200910169812 A CN 200910169812A CN 101647805 A CN101647805 A CN 101647805A
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- glucosamine
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Abstract
The invention discloses a glucosamine chewable tablet used for relieving and preventing osteoarthritis and a preparation method thereof. The glucosamine chewable tablet comprises active ingredients and auxiliary materials, wherein the active ingredients comprise glucosamine, vitamin C and dimethyl sulfone, the glucosamine is glucosamine sulfate or glucosamine hydrochloride or glucosamine phosphateor mixture of the glucosamine sulfate and the glucosamine hydrochloride and the glucosamine phosphate; and the auxiliary materials comprise excipient, bonding agent, flavouring agent and lubricant. The glucosamine chewable table is slowly disintegrated and released without entering the gastrointestinal tract through the chewing and is absorbed through the increment of the taking number, therefore, the medicine effect is improved, and the discomfort of a patient with poor gastrointestinal tract function, caused by a deglutible tablet accelerating the gastrointestine load, is reduced. The glucosamine chewable tablet has the advantages of good mouth feel, high bioavailability, more convenient taking, convenient carrying and the like, and can fully play a role of the product.
Description
Technical field
The invention belongs to glucosamine Medicines and Health Product technical field, be specifically related to a kind of glucosamine chewable tablet and preparation method that is used to alleviate and prevent osteoarthritis.
Background technology
Treatment osteoarthritis method has Drug therapy, operative treatment, physical therapy, physical exercise therapy and other auxiliary treatment etc.Wherein, use at most with drug therapy, non-steroidal drug is the present medicine of most common treatment osteoarthritis clinically, comprises ibuprofen, diclofenac, meloxicam, nabumetone etc.Though this medicine is that effectively it is not the medicine at the osteoarthritis cause of disease for mitigation symptoms.The mechanism of action of non-steroidal anti-inflammatory class medicine mainly is to reach antiinflammatory, analgesic activity by suppressing Cycloxygenase, yet, the side effect of non-steroidal anti-inflammatory drug is also apparent in view, such as side effect of digestive tract, renal function injury etc., especially life-time service just may produce the hemorrhage and ulcer of gastrointestinal.Modern scientific research shows, glucosamine is treatment and prevention osteoarthritis medicine, it optionally acts on osteoarthritis, have treatment and the effect of repairing connective tissue, anti-inflammatory analgetic, its anti-inflammatory analgetic effect is similar to nonsteroidal anti inflammatory medicine (as ibuprofen), but do not have the latter's untoward reaction such as gastrorrhagia, and toleration is good.But, present glucosamine hydrochloride generally all is oral gastric solubility deglutition type preparation, medicine can not be absorbed rapidly, onset is slower, and take inconvenience, for the patient of old man and dysphagia, conventional tablet is often taken difficulty especially, increase the weight of gastrointestinal burden and cause discomfort, take medicine for a long time even can make it produce the psychological phenomenon of refusing to take medicine.In addition, the just release of disintegrate slowly makes glucosamine not high in the bioavailability of human body in the time of need arriving gastrointestinal tract owing to medicine.
Summary of the invention
The purpose of this invention is to provide a kind of glucosamine chewable tablet and preparation method that is used to alleviate and prevent osteoarthritis, digestive and absorptive functions person in middle and old age's arthritis and arthralgia patient thereof poor, the difficulty of swallowing can be taken easily, improve glucosamine at human bioavailability.
Technical solution of the present invention is to comprise active component and adjuvant, it is characterized in that described active component is glucosamine, vitamin C and dimethyl sulfone, and glucosamine is glucosamine sulphate or hydrochlorate or phosphate or its mixture; Vitamin C is vitamin C or its sodium salt, calcium salt, magnesium salt or extract or its mixture that contains natural complex C; Adjuvant comprises excipient, binding agent, correctives and lubricant, described excipient is one or more the combination in starch, sorbitol, microcrystalline Cellulose, white sugar, lactose, dextrin, the mannitol, and binding agent is one or more the combination in polyvinylpyrrolidone, sodium carboxymethyl cellulose, starch, the hydroxypropyl emthylcellulose; Correctives is one or more the combination in sorbitol, mannitol, white sugar, glucose, citric acid, xylitol, protein sugar, aspartame, stevioside, Fructus Momordicae extract, starch, cyclamate, saccharin sodium, anhydrous citric acid, black cocoa powder, the edible essence; Lubricant is one or more the combination in magnesium stearate, micropowder silica gel, the Pulvis Talci.
The weight proportion of each component of the present invention is as follows: 1～300 part of glucosamine, 1～100 part of dimethyl sulfone, 1～100 part of vitamin C, 1～500 part of excipient, 1～600 part of correctives, 1～300 part of binding agent, 1～10 part of lubricant.
The present invention is used to alleviate and prevent the preparation method of the glucosamine chewable tablet of osteoarthritis, and glucosamine was pulverized 80～100 mesh sieves, granulates with binder solution, and drying is crossed 12～20 mesh sieves with this granule; To add the lubricant compacting behind granule and vitamin C, dimethyl sulfone, excipient and the correctives mix homogeneously in flakes.
It is just slow that disintegrate discharges when the present invention makes medicine need not gastrointestinal tract by chewing, make dose take number of times and solved the absorption problem by increase, improved the drug effect of active drug, the patient who has reduced the gastrointestinal function difference is owing to the sheet of swallowing increases the weight of the discomfort that the gastrointestinal burden causes, have plurality of advantages such as mouthfeel is good, bioavailability is high, can give full play to product efficacy, and is convenient, easy to carry more.
The specific embodiment
Chewable tablet is that a class can be chewed the tablet under the posterior phraynx in the oral cavity, and size is general identical with conventional tablet, can make difform special-shaped sheet as required.Tablet is convenient to swallow after chewing, and the tablet surface area increases, and can promote medicine dissolving, absorption in vivo.For the medicine of difficult disintegrate, make chewable tablet and can quicken its disintegrate, improve drug effect.
Vitamin C can help the smooth and easy formation of collagen protein in the intraarticular cartilage, and the primary structure of cartilage inside is consolidated, and studies show that simultaneously dimethyl sulfone or vitamin C use separately, and its immunoregulation effect is all not as both compound.
The selection of binding agent: some drugs itself or adjuvant mix afterwards inadhesion or stickiness is less, can adopt the aqueous solution of hydrophilic polymeies such as polyvinylpyrrolidone and hydroxypropyl emthylcellulose is binding agent, wherein commonly used with polyvinylpyrrolidone, seldom adopt starch slurry.It is bigger to adopt polyvinylpyrrolidone to do the particle surface hydrophilic that binding agent makes, and moisture easily infiltrates label and makes its quick disintegrate stripping behind the tabletting.Should consider the suitable composition and the ratio of binding agent during preparation, be beneficial to the disintegrate of tablet.
Below by embodiment the present invention is done further to specify, but be not limited only to following example.
Embodiment 1 glucosamine sulphate 200g
Polyvinylpyrrolidone 3g
Vitamin C 20g
Dimethyl sulfone 50g
Starch 20g
White sugar 100g
Sorbitol 450g
Mannitol 220g
Aspartame 2g
Edible essence 10g
Anhydrous citric acid 20g
Magnesium stearate 5g
Glucosamine sulphate was pulverized 80～100 mesh sieves, granulate with polyvinylpyrrolidone, drying is crossed 12～20 mesh sieves with this granule; To add the magnesium stearate compacting behind granule and vitamin C, dimethyl sulfone, starch, white sugar, sorbitol, mannitol, aspartame, edible essence and the anhydrous citric acid mix homogeneously in flakes.
Contain white sugar among the embodiment 1, be the sugar-containing type glucosamine chewable tablet, mouthfeel is good.
Embodiment 2 glucosamine sulphate 100g
Glucosamine hydrochloride 100g
Polyvinylpyrrolidone 30g
Vitamin C 20g
Dimethyl sulfone 50g
Starch 15g
Sorbitol 509g
Mannitol 265g
Xylitol 20g
Edible essence 30g
Magnesium stearate 8g
Glucosamine sulphate and hydrochlorate were pulverized 80～100 mesh sieves, granulate with polyvinylpyrrolidone, drying is crossed 12～20 mesh sieves with this granule; To add the magnesium stearate compacting behind granule and vitamin C, dimethyl sulfone, starch, sorbitol, mannitol, xylitol, the edible essence mix homogeneously in flakes.
Do not contain white sugar among the embodiment 2, be the Sugarless type glucosamine chewable tablet, especially be fit to as special populations such as diabeticss.
Claims (3)
1, a kind of glucosamine chewable tablet that is used to alleviate and prevent osteoarthritis, comprise active component and adjuvant, it is characterized in that described active component is glucosamine, vitamin C and dimethyl sulfone, glucosamine is glucosamine sulphate or hydrochlorate or phosphate or its mixture; Vitamin C is vitamin C or its sodium salt, calcium salt, magnesium salt or extract or its mixture that contains natural complex C; Adjuvant comprises excipient, binding agent, correctives and lubricant, described excipient is one or more the combination in starch, sorbitol, microcrystalline Cellulose, white sugar, lactose, dextrin, the mannitol, and binding agent is one or more the combination in polyvinylpyrrolidone, sodium carboxymethyl cellulose, starch, the hydroxypropyl emthylcellulose; Correctives is one or more the combination in sorbitol, mannitol, white sugar, glucose, citric acid, xylitol, protein sugar, aspartame, stevioside, Fructus Momordicae extract, starch, cyclamate, saccharin sodium, anhydrous citric acid, black cocoa powder, the edible essence; Lubricant is one or more the combination in magnesium stearate, micropowder silica gel, the Pulvis Talci.
2, a kind of glucosamine chewable tablet that is used to alleviate and prevent osteoarthritis according to claim 1 is characterized in that the weight proportion of described each component is as follows:
1～300 part of glucosamine
1～100 part of dimethyl sulfone
1～100 part of vitamin C
1～500 part of excipient
1～600 part of correctives
1～300 part of binding agent
1～10 part of lubricant
3, a kind of preparation method that is used to alleviate and prevent the glucosamine chewable tablet of osteoarthritis according to claim 1, it is characterized in that: glucosamine was pulverized 80～100 mesh sieves, granulate with binder solution, drying is crossed 12～20 mesh sieves with this granule; To add the lubricant compacting behind granule and vitamin C, dimethyl sulfone, excipient and the correctives mix homogeneously in flakes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101698128A CN101647805B (en) | 2009-09-04 | 2009-09-04 | Glucosamine chewable tablet used for relieving and preventing osteoarthritis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009101698128A CN101647805B (en) | 2009-09-04 | 2009-09-04 | Glucosamine chewable tablet used for relieving and preventing osteoarthritis and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101647805A true CN101647805A (en) | 2010-02-17 |
| CN101647805B CN101647805B (en) | 2012-07-18 |
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| CN2009101698128A Active CN101647805B (en) | 2009-09-04 | 2009-09-04 | Glucosamine chewable tablet used for relieving and preventing osteoarthritis and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102631367A (en) * | 2012-01-16 | 2012-08-15 | 上海益诺思生物技术有限公司 | Composition with good curative effect by aiming at various osteoarthritis symptoms |
| CN103356700A (en) * | 2012-03-26 | 2013-10-23 | 朱晓明 | Joint maintaining ointment |
| CN104666264A (en) * | 2015-02-12 | 2015-06-03 | 浙江诚意药业股份有限公司 | Chitosamine hydrochloride chewable tablet and preparation method thereof |
| WO2015085957A1 (en) * | 2013-12-13 | 2015-06-18 | 星耀控股有限公司 | Composition for treating osteoarthritis |
| CN105265698A (en) * | 2015-06-11 | 2016-01-27 | 王洪波 | Sea cucumber coffee chewable tablet |
| CN108159006A (en) * | 2017-12-27 | 2018-06-15 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of aspirin eugenol ester chewable tablets and preparation method thereof |
| US20190269614A1 (en) * | 2016-10-28 | 2019-09-05 | Guangxi Sanpotel Health Industry Co. Ltd | Chewable tablet containing vitamin c sodium and preparation method thereof |
| CN110680808A (en) * | 2019-11-08 | 2020-01-14 | 山东润德生物科技有限公司 | Amino sugar chewable tablet and preparation method thereof |
| CN115040490A (en) * | 2022-07-04 | 2022-09-13 | 山东润德生物科技有限公司 | Glucosamine chewable tablet and preparation method and application thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002028400A1 (en) * | 2000-10-03 | 2002-04-11 | Nutraceutics Limited | A therapeutic formulation containing glucosamine, methylsulfonymethane and eventually ascorbic acid and manganese |
| CN1817348A (en) * | 2006-03-10 | 2006-08-16 | 北京阜康仁生物制药科技有限公司 | Medicinal composition with glycosamine hydrochloride and cartilagin sulfate as active components, its preparation and use thereof |
| CN1899300A (en) * | 2006-06-30 | 2007-01-24 | 北京润德康医药技术有限公司 | Medicinal composition using amino glucose hydrochloride and chondroitin sulfate as active components and its preparing method and use |
| CN100596278C (en) * | 2007-05-24 | 2010-03-31 | 张义兴 | Medicinal composition for preventing and treating senile osteoarthropathy |
| CN101322551A (en) * | 2007-08-31 | 2008-12-17 | 辽源雷霓森药业有限公司 | Combination for increasing bone density and repairing articular cartilage |
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2009
- 2009-09-04 CN CN2009101698128A patent/CN101647805B/en active Active
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102631367A (en) * | 2012-01-16 | 2012-08-15 | 上海益诺思生物技术有限公司 | Composition with good curative effect by aiming at various osteoarthritis symptoms |
| CN103356700A (en) * | 2012-03-26 | 2013-10-23 | 朱晓明 | Joint maintaining ointment |
| CN103356700B (en) * | 2012-03-26 | 2014-10-29 | 朱晓明 | Joint maintaining ointment |
| WO2015085957A1 (en) * | 2013-12-13 | 2015-06-18 | 星耀控股有限公司 | Composition for treating osteoarthritis |
| CN104666264A (en) * | 2015-02-12 | 2015-06-03 | 浙江诚意药业股份有限公司 | Chitosamine hydrochloride chewable tablet and preparation method thereof |
| CN104666264B (en) * | 2015-02-12 | 2018-05-15 | 浙江诚意药业股份有限公司 | A kind of aminoglucose hydrochloride chewable tablets and preparation method thereof |
| CN105265698A (en) * | 2015-06-11 | 2016-01-27 | 王洪波 | Sea cucumber coffee chewable tablet |
| US20190269614A1 (en) * | 2016-10-28 | 2019-09-05 | Guangxi Sanpotel Health Industry Co. Ltd | Chewable tablet containing vitamin c sodium and preparation method thereof |
| CN108159006A (en) * | 2017-12-27 | 2018-06-15 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of aspirin eugenol ester chewable tablets and preparation method thereof |
| CN110680808A (en) * | 2019-11-08 | 2020-01-14 | 山东润德生物科技有限公司 | Amino sugar chewable tablet and preparation method thereof |
| CN110680808B (en) * | 2019-11-08 | 2021-04-13 | 山东润德生物科技有限公司 | Amino sugar chewable tablet and preparation method thereof |
| CN115040490A (en) * | 2022-07-04 | 2022-09-13 | 山东润德生物科技有限公司 | Glucosamine chewable tablet and preparation method and application thereof |
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| CN101647805B (en) | 2012-07-18 |
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Application publication date: 20100217 Assignee: Jiangsu Aland Nourishment Co.,Ltd. Assignor: Jiangshan Pharmaceutical Co., Ltd., Jiangsu Prov. Contract record no.: 2013320000489 Denomination of invention: Glucosamine chewable tablet used for relieving and preventing osteoarthritis and preparation method thereof Granted publication date: 20120718 License type: Exclusive License Record date: 20130604 |
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Owner name: JIANGSU ALAND NOURISHMENT CO., LTD. Free format text: FORMER OWNER: JIANGSHAN PHARMACEUTICAL CO., LTD., JIANGSU PROV. Effective date: 20131022 |
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Effective date of registration: 20131022 Address after: 214500, Jiangshan Road, Jiangsu, Jingjiang 20 Patentee after: Jiangsu Aland Nourishment Co.,Ltd. Address before: 214500, Jiangshan Road, Jiangsu, Jingjiang 20 Patentee before: Jiangshan Pharmaceutical Co., Ltd., Jiangsu Prov. |